Guanine nucleotide-binding protein G(i) subunit alpha-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G-protein beta/gamma-subunit complex binding Source: GO_Central
• G-protein coupled receptor binding Source: GO_Central
• GTPase activity Source: GO_Central
• GTP binding Source: Reactome
• metal ion binding Source: UniProtKB-KW

GO - Biological processⁱ

• adenosine receptor signaling pathway Source: GO_Central
• adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
• adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: GO_Central
• cell cycle Source: UniProtKB-KW
• cell division Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17635935
• cell proliferation Source: Ensembl
• gamma-aminobutyric acid signaling pathway Source: GO_Central
• G-protein coupled acetylcholine receptor signaling pathway Source: Ensembl
• G-protein coupled receptor signaling pathway Source: Reactome
• negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Source: Ensembl
• negative regulation of adenylate cyclase activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9637720
• negative regulation of apoptotic signaling pathway Source: Ensembl
• negative regulation of calcium ion-dependent exocytosis Source: Ensembl
• negative regulation of protein tyrosine phosphatase activity Source: Ensembl
• negative regulation of synaptic transmission Source: Ensembl
• positive regulation of cell migration Source: Ensembl
• positive regulation of cell proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21079996
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of insulin receptor signaling pathway Source: Ensembl
• positive regulation of NAD(P)H oxidase activity Source: Ensembl
• positive regulation of neural precursor cell proliferation Source: Ensembl
• positive regulation of renal sodium excretion Source: Ensembl
• positive regulation of superoxide anion generation Source: Ensembl
• positive regulation of urine volume Source: Ensembl
• positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
• protein folding Source: Reactome
• regulation of calcium ion transport Source: Ensembl
• response to nutrient Source: ProtIncTraceable author statementⁱ
  • 8587610
• signal transduction Source: ProtIncTraceable author statementⁱ
  • 7961880
  • 9637720

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• G-protein coupled receptor binding Source: GO_Central

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 6 described isoforms and 2 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV 
        60         70         80         90        100
KQMKIIHEDG YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPSR 
       110        120        130        140        150
ADDARQLFAL SCTAEEQGVL PDDLSGVIRR LWADHGVQAC FGRSREYQLN 
       160        170        180        190        200
DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV KTTGIVETHF TFKDLHFKMF 
       210        220        230        240        250
DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE MNRMHESMKL 
       260        270        280        290        300
FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSPLTICFPE YTGANKYDEA 
       310        320        330        340        350
ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK 

DCGLF                                                  

        10         20         30         40         50
MEYAGHLPAS SAQGTILACT SCTGAGESGK STIVKQMKII HEDGYSEEEC 
        60         70         80         90        100
RQYRAVVYSN TIQSIMAIVK AMGNLQIDFA DPSRADDARQ LFALSCTAEE 
       110        120        130        140        150
QGVLPDDLSG VIRRLWADHG VQACFGRSRE YQLNDSAAYY LNDLERIAQS 
       160        170        180        190        200
DYIPTQQDVL RTRVKTTGIV ETHFTFKDLH FKMFDVGGQR SERKKWIHCF 
       210        220        230        240        250
EGVTAIIFCV ALSAYDLVLA EDEEMNRMHE SMKLFDSICN NKWFTDTSII 
       260        270        280        290        300
LFLNKKDLFE EKITHSPLTI CFPEYTGANK YDEAASYIQS KFEDLNKRKD 
       310        320        330 
TKEIYTHFTC ATDTKNVQFV FDAVTDVIIK NNLKDCGLF             

        10         20         30         40         50
MRGAGESGKS TIVKQMKIIH EDGYSEEECR QYRAVVYSNT IQSIMAIVKA 
        60         70         80         90        100
MGNLQIDFAD PSRADDARQL FALSCTAEEQ GVLPDDLSGV IRRLWADHGV 
       110        120        130        140        150
QACFGRSREY QLNDSAAYYL NDLERIAQSD YIPTQQDVLR TRVKTTGIVE 
       160        170        180        190        200
THFTFKDLHF KMFDVGGQRS ERKKWIHCFE GVTAIIFCVA LSAYDLVLAE 
       210        220        230        240        250
DEEMNRMHES MKLFDSICNN KWFTDTSIIL FLNKKDLFEE KITHSPLTIC 
       260        270        280        290        300
FPEYTGANKY DEAASYIQSK FEDLNKRKDT KEIYTHFTCA TDTKNVQFVF 
       310 
DAVTDVIIKN NLKDCGLF                                    

        10         20         30         40         50
MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV 
        60         70         80         90        100
KQMKIIHEDG YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPSR 
       110        120        130        140        150
ADDARQLFAL SCTAEEQGVL PDDLSGVIRR LWADHGVQAC FGRSREYQLN 
       160        170        180        190        200
DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV KTTGIVETHF TFKDLHFKMF 
       210        220        230        240        250
DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE MNRMHESMKL 
       260        270        280        290        300
FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSPLTICFPE YTGANKYDEA 
       310        320        330        340        350
ASYIQSKFED LNKRKDTKEI YTHFTCATDT KSRKLFRETY LKLSGPDQHP 
       360 
HPSPAPAPPL SSDSVP                                      

        10         20         30         40         50
MTEGVKTLGW TKQKGGCHWG RSEGAGESGK STIVKQMKII HEDGYSEEEC 
        60         70         80         90        100
RQYRAVVYSN TIQSIMAIVK AMGNLQIDFA DPSRADDARQ LFALSCTAEE 
       110        120        130        140        150
QGVLPDDLSG VIRRLWADHG VQACFGRSRE YQLNDSAAYY LNDLERIAQS 
       160        170        180        190        200
DYIPTQQDVL RTRVKTTGIV ETHFTFKDLH FKMFDVGGQR SERKKWIHCF 
       210        220        230        240        250
EGVTAIIFCV ALSAYDLVLA EDEEMNRMHE SMKLFDSICN NKWFTDTSII 
       260        270        280        290        300
LFLNKKDLFE EKITHSPLTI CFPEYTGANK YDEAASYIQS KFEDLNKRKD 
       310        320        330 
TKEIYTHFTC ATDTKNVQFV FDAVTDVIIK NNLKDCGLF             

        10         20         30         40         50
MKIIHEDGYS EEECRQYRAV VYSNTIQSIM AIVKAMGNLQ IDFADPSRAD 
        60         70         80         90        100
DARQLFALSC TAEEQGVLPD DLSGVIRRLW ADHGVQACFG RSREYQLNDS 
       110        120        130        140        150
AAYYLNDLER IAQSDYIPTQ QDVLRTRVKT TGIVETHFTF KDLHFKMFDV 
       160        170        180        190        200
GGQRSERKKW IHCFEGVTAI IFCVALSAYD LVLAEDEEMN RMHESMKLFD 
       210        220        230        240        250
SICNNKWFTD TSIILFLNKK DLFEEKITHS PLTICFPEYT GANKYDEAAS 
       260        270        280        290        300
YIQSKFEDLN KRKDTKEIYT HFTCATDTKN VQFVFDAVTD VIIKNNLKDC 

GLF                                                    

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ