UniProtKB - P04862 (C_SENDZ)
C' protein
P/V/C
Functioni
Miscellaneous
Caution
GO - Biological processi
- suppression by virus of host STAT1 activity Source: UniProtKB
- suppression by virus of host STAT2 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: C' protein |
Gene namesi | Name:P/V/C |
Organismi | Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) |
Taxonomic identifieri | 11198 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Respirovirus › |
Virus hosti | Cavia cutleri (Guinea pig) [TaxID: 10144] Cricetidae sp. (Hamster) [TaxID: 36483] Mus musculus (Mouse) [TaxID: 10090] Rattus norvegicus (Rat) [TaxID: 10116] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm 2 Publications Note: Protein C' seems to localize around the Golgi.1 Publication
- Host cytoplasm 2 Publications
- Virion Note: The C protein is found in virion at a ratio of approximately 40 molecules per virion, presumably associated with the nucleocapsid.1 Publication
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- virion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasm, VirionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 – 30 | EDE → AAA: 11% loss of binding to L protein in protein C'. 1 Publication | 3 | |
Mutagenesisi | 88 – 91 | KIID → AIIA: Complete loss of STAT1-binding and RNA synthesis inhibition by C protein. 80% loss of binding to L protein in protein C'. 2 Publications | 4 | |
Mutagenesisi | 125 – 126 | EE → AA: Complete loss of STAT1-binding in protein C. No effect on binding to L protein in protein C'. 2 Publications | 2 | |
Mutagenesisi | 140 – 143 | ETPE → ATPA: 60% loss of binding to L protein in protein C'. 1 Publication | 4 | |
Mutagenesisi | 150 – 153 | MRED → AREA: Complete loss of STAT1-binding and RNA synthesis inhibition by C protein. 2 Publications | 4 | |
Mutagenesisi | 162 – 165 | KTER → ATAA: Complete loss of STAT1-binding, anti-IFN activity and RNA synthesis inhibition by protein C. 67% loss of binding to L protein in C' protein. 2 Publications | 4 | |
Mutagenesisi | 168 | R → A: 63% loss of binding to L protein in protein C'. 1 Publication | 1 | |
Mutagenesisi | 172 – 174 | RGE → AGA: 10% loss of binding to L protein. 1 Publication | 3 | |
Mutagenesisi | 181 | F → S: Complete loss of STAT1-binding by C protein. 49% loss of binding to L protein. 2 Publications | 1 | |
Mutagenesisi | 184 – 187 | RYEE → AYAA: Complete loss of STAT1-binding and RNA synthesis inhibition by C protein. 62% loss of binding to L protein. 2 Publications | 4 | |
Mutagenesisi | 203 – 204 | EE → AA: 17% loss of binding to L protein. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed; by hostBy similarity | |||
ChainiPRO_0000039411 | 2 – 215 | C' proteinAdd BLAST | 214 |
Post-translational modificationi
Interactioni
Subunit structurei
The different isoforms interact (via C-terminus) with unphosphorylated and phosphorylated human STAT1 (via N-terminus), favoring the formation of parallel STAT1 homodimers (PubMed:11442634, PubMed:26339056). The different isoforms do not interact with host STAT2 (PubMed:11442634, PubMed:26339056). C protein interacts with L protein; this interaction has an inhibitory effect on viral transcription and replication (PubMed:9281506, PubMed:11543662).
4 PublicationsBinary interactionsi
P04862
With | #Exp. | IntAct |
---|---|---|
Chuk [Q60680] from Mus musculus. | 2 | EBI-8848010,EBI-646245 |
Protein-protein interaction databases
IntActi | P04862, 2 interactors |
MINTi | P04862 |
Structurei
Secondary structure
3D structure databases
SMRi | P04862 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 34 | DisorderedBy similarityAdd BLAST | 23 | |
Regioni | 15 – 22 | Involved in self-degradation and in host STAT1 degradationBy similarity | 8 |
Domaini
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR002608, Paramyxo_C |
Pfami | View protein in Pfam PF01692, Paramyxo_C, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative initiation. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASATLTAWI KMPSFLKKIL KLRGRRQEDE SRSRMLSDSS MLSCRVNQLT
60 70 80 90 100
SEGTEAGSTT PSTLPKDQAL LIEPKVRAKE KSQHRRPKII DQVRRVESLG
110 120 130 140 150
EQASQRQKHM LETLINKIYT GPLGEELVQT LYLRIWAMEE TPESLKILQM
160 170 180 190 200
REDIRDQVLK MKTERWLRTL IRGEKTKLKD FQKRYEEVHP YLMKEKVEQV
210
IMEEAWSLAA HIVQE
The sequence of this isoform differs from the canonical sequence as follows:
1-11: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-40: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018946 | 1 – 40 | Missing in isoform Y2 protein. CuratedAdd BLAST | 40 | |
Alternative sequenceiVSP_018945 | 1 – 34 | Missing in isoform Y1 protein. CuratedAdd BLAST | 34 | |
Alternative sequenceiVSP_018944 | 1 – 11 | Missing in isoform C protein. CuratedAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00087 Genomic RNA Translation: CAA24947.1 |
PIRi | A04041, MNNZSV |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00087 Genomic RNA Translation: CAA24947.1 |
PIRi | A04041, MNNZSV |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3WWT | X-ray | 2.00 | B | 109-215 | [»] | |
SMRi | P04862 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P04862, 2 interactors |
MINTi | P04862 |
Family and domain databases
InterProi | View protein in InterPro IPR002608, Paramyxo_C |
Pfami | View protein in Pfam PF01692, Paramyxo_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C_SENDZ | |
Accessioni | P04862Primary (citable) accession number: P04862 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | October 7, 2020 | |
This is version 77 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families