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Protein

Nucleoprotein

Gene

N

Organism
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NP
Short name:
Protein N
Gene namesi
Name:N
Synonyms:NP
OrganismiMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11235 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000833 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • helical viral capsid Source: UniProtKB-KW
  • host cell cytoplasm Source: UniProtKB-SubCell
  • viral nucleocapsid Source: CACAO

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426541 – 523NucleoproteinAdd BLAST523

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds the P protein and thereby positions the polymerase on the template. Interacts with human FCGR2B protein (By similarity).By similarity

Structurei

3D structure databases

DisProtiDP00160
SMRiP04851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400NcoreBy similarityAdd BLAST400
Regioni1 – 375HomomultimerizationBy similarityAdd BLAST375
Regioni401 – 523NtailBy similarityAdd BLAST123
Regioni477 – 505P protein-bindingBy similarityAdd BLAST29

Domaini

Ncore is globular and carries regions required for N self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000BV

Family and domain databases

InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit

Sequencei

Sequence statusi: Complete.

P04851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLLRSLAL FKRNKDKPPI TSGSGGAIRG IKHIIIVPIP GDSSITTRSR
60 70 80 90 100
LLDRLVRLIG NPDVSGPKLT GALIGILSLF VESPGQLIQR ITDDPDVSIR
110 120 130 140 150
LLEVVQSDQS QSGLTFASRG TNMEDEADQY FSHDDPISSD QSRFGWFENK
160 170 180 190 200
EISDIEVQDP EGFNMILGTI LAQIWVLLAK AVTAPDTAAD SELRRWIKYT
210 220 230 240 250
QQRRVVGEFR LERKWLDVVR NIIAEDLSLR RFMVALILDI KRTPGNKPRI
260 270 280 290 300
AEMICDIDTY IVEAGLASFI LTIKFGIETM YPALGLHEFA GELSTLESLM
310 320 330 340 350
NLYQQMGKPA PYMVNLENSI QNKFSAGSYP LLWSYAMGVG VELENSMGGL
360 370 380 390 400
NFGRSYFDPA YFRLGQEMVR RSAGKVSSTL ASELGITAED ARLVSEIAMH
410 420 430 440 450
TTEDKISRAV GPRQAQVSFL QGDQSENELP RLGGKEDRRV KQSRGEARES
460 470 480 490 500
YRETGPSRAS DARAAHLPTG TPLDIDTASE SSQDPQDSRR SAEPLLSCKP
510 520
WQESRKNKAQ TRTPLQCTMT EIF
Length:523
Mass (Da):58,105
Last modified:August 13, 1987 - v1
Checksum:i51544BF86C349BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01999 mRNA Translation: CAA26031.1
K01711 Genomic RNA Translation: AAA75494.1 Sequence problems.
PIRiA04027 VHNZMV

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01999 mRNA Translation: CAA26031.1
K01711 Genomic RNA Translation: AAA75494.1 Sequence problems.
PIRiA04027 VHNZMV

3D structure databases

DisProtiDP00160
SMRiP04851
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000BV

Family and domain databases

InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCAP_MEASE
AccessioniPrimary (citable) accession number: P04851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 15, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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