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Protein

Cytochrome b-245 heavy chain

Gene

CYBB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi101Iron (heme axial ligand)Curated1
Metal bindingi115Iron (heme axial ligand)Curated1
Metal bindingi209Iron (heme axial ligand)Curated1
Metal bindingi222Iron (heme axial ligand)Curated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi338 – 344FADSequence analysis7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: BHF-UCL
  • heme binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: BHF-UCL
  • superoxide-generating NADPH oxidase activity Source: BHF-UCL
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processElectron transport, Ion transport, Transport
LigandFAD, Flavoprotein, Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

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SIGNORi
P04839

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
5962 HsNOx02

Transport Classification Database

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TCDBi
5.B.1.1.1 the phagocyte (gp91(phox)) nadph oxidase family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b-245 heavy chain (EC:1.-.-.-)
Alternative name(s):
CGD91-phox
Cytochrome b(558) subunit beta
Short name:
Cytochrome b558 subunit beta
Heme-binding membrane glycoprotein gp91phox
NADPH oxidase 2
Neutrophil cytochrome b 91 kDa polypeptide
Superoxide-generating NADPH oxidase heavy chain subunit
gp91-1
gp91-phox
p22 phagocyte B-cytochrome
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYBBImported
Synonyms:NOX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165168.7

Human Gene Nomenclature Database

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HGNCi
HGNC:2578 CYBB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300481 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04839

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 8CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 48ExtracellularSequence analysisAdd BLAST19
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 102CytoplasmicSequence analysisAdd BLAST33
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 169ExtracellularSequence analysisAdd BLAST46
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 200CytoplasmicSequence analysis10
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 261ExtracellularSequence analysisAdd BLAST40
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 570CytoplasmicSequence analysisAdd BLAST288

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Granulomatous disease, chronic, X-linked (CGD)22 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
See also OMIM:306400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04726418W → C in CGD. 1
Natural variantiVAR_00787320G → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344455EnsemblClinVar.1
Natural variantiVAR_02561341Y → D in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344453EnsemblClinVar.1
Natural variantiVAR_04726554 – 55Missing in CGD. 1 Publication2
Natural variantiVAR_02561454R → M in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344479EnsemblClinVar.1
Natural variantiVAR_00787454R → S in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344456EnsemblClinVar.1
Natural variantiVAR_02561555A → D in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344480EnsemblClinVar.1
Natural variantiVAR_00884557A → E in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344481EnsemblClinVar.1
Natural variantiVAR_00787559C → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344457EnsemblClinVar.1
Natural variantiVAR_04726659C → W in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344488EnsemblClinVar.1
Natural variantiVAR_002432101H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854591EnsemblClinVar.1
Natural variantiVAR_007876101H → Y in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854594EnsemblClinVar.1
Natural variantiVAR_007877119H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344458EnsemblClinVar.1
Natural variantiVAR_002433156A → T in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854590EnsemblClinVar.1
Natural variantiVAR_047267179G → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344491EnsemblClinVar.1
Natural variantiVAR_047268193S → F in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344493EnsemblClinVar.1
Natural variantiVAR_047269205F → I in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344496EnsemblClinVar.1
Natural variantiVAR_007878209H → Q in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344459EnsemblClinVar.1
Natural variantiVAR_025616209H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344482EnsemblClinVar.1
Natural variantiVAR_002434209H → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854587EnsemblClinVar.1
Natural variantiVAR_007879215Missing in CGD. 2 Publications1
Natural variantiVAR_007880222H → N in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344460EnsemblClinVar.1
Natural variantiVAR_007881222H → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344462EnsemblClinVar.1
Natural variantiVAR_007882222H → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344460EnsemblClinVar.1
Natural variantiVAR_007883223G → L in CGD; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variants dbSNP:rs151344463 and dbSNP:rs151344464EnsemblEnsembl.1
Natural variantiVAR_025617224A → G in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344483EnsemblClinVar.1
Natural variantiVAR_002435225E → V in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344494EnsemblClinVar.1
Natural variantiVAR_007884244C → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344465EnsemblClinVar.1
Natural variantiVAR_002436244C → S in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854589EnsemblClinVar.1
Natural variantiVAR_002437244C → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854589EnsemblClinVar.1
Natural variantiVAR_047270298 – 302Missing in CGD. 1 Publication5
Natural variantiVAR_071861299K → N in CGD. 1 Publication1
Natural variantiVAR_016880303H → N in CGD; completely inhibits NADPH oxidase activity; NADPH oxidase assembly is abolished. 2 PublicationsCorresponds to variant dbSNP:rs137854595EnsemblClinVar.1
Natural variantiVAR_016881304P → R in CGD; reduces NADPH oxidase activity to 4% of wild-type; translocation to the membrane of the phagosome is only attenuated. 2 PublicationsCorresponds to variant dbSNP:rs137854596EnsemblClinVar.1
Natural variantiVAR_047271307T → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344489EnsemblClinVar.1
Natural variantiVAR_007885309E → K in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344466EnsemblClinVar.1
Natural variantiVAR_047272315Missing in CGD. 1 Publication1
Natural variantiVAR_007886322G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344467EnsemblClinVar.1
Natural variantiVAR_007887325I → F in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344468EnsemblClinVar.1
Natural variantiVAR_007888333S → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344469EnsemblClinVar.1
Natural variantiVAR_071862338H → D in CGD. 1 Publication1
Natural variantiVAR_025618338H → Y in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344484EnsemblClinVar.1
Natural variantiVAR_002438339P → H in CGD. 6 PublicationsCorresponds to variant dbSNP:rs151344470EnsemblClinVar.1
Natural variantiVAR_047273342L → Q in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344495EnsemblClinVar.1
Natural variantiVAR_025619344S → F in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344485EnsemblClinVar.1
Natural variantiVAR_007889356R → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344471EnsemblClinVar.1
Natural variantiVAR_002439389G → A in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854586EnsemblClinVar.1
Natural variantiVAR_025621389G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854586EnsemblClinVar.1
Natural variantiVAR_007890405M → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344472EnsemblClinVar.1
Natural variantiVAR_007891408G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344474EnsemblClinVar.1
Natural variantiVAR_007892408G → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344473EnsemblClinVar.1
Natural variantiVAR_078386409A → G in CGD. 1 Publication1
Natural variantiVAR_071863412G → E in CGD. 1 Publication1
Natural variantiVAR_002440415P → H in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854585EnsemblClinVar.1
Natural variantiVAR_007893415P → L in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854585EnsemblClinVar.1
Natural variantiVAR_025622420L → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344486EnsemblClinVar.1
Natural variantiVAR_007894422S → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344475EnsemblClinVar.1
Natural variantiVAR_007895453W → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344476EnsemblClinVar.1
Natural variantiVAR_068012488A → D in CGD. 1 Publication1
Natural variantiVAR_068013500D → E in CGD. 1 Publication1
Natural variantiVAR_002441500D → G in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854593EnsemblClinVar.1
Natural variantiVAR_047275505L → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344490EnsemblClinVar.1
Natural variantiVAR_007896516W → C in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344477EnsemblClinVar.1
Natural variantiVAR_025623516W → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344487EnsemblClinVar.1
Natural variantiVAR_007897534V → D in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344478EnsemblClinVar.1
Natural variantiVAR_007898537C → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344454EnsemblClinVar.1
Natural variantiVAR_047276546L → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344492EnsemblClinVar.1
Immunodeficiency 34 (IMD34)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of Mendelian susceptibility to mycobacterial disease, a rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals.
See also OMIM:300645
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065365178T → P in IMD34. 1 PublicationCorresponds to variant dbSNP:rs151344497EnsemblClinVar.1
Natural variantiVAR_065366231Q → P in IMD34. 1 PublicationCorresponds to variant dbSNP:rs151344498EnsemblClinVar.1

Keywords - Diseasei

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
1536

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CYBB

MalaCards human disease database

More...
MalaCardsi
CYBB
MIMi300645 phenotype
306400 phenotype

Open Targets

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OpenTargetsi
ENSG00000165168

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
379 Chronic granulomatous disease
319623 X-linked mendelian susceptibility to mycobacterial diseases due to CYBB deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27076

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1287627

Drug and drug target database

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DrugBanki
DB00514 Dextromethorphan

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
3002

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYBB

Domain mapping of disease mutations (DMDM)

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DMDMi
115211

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002101452 – 570Cytochrome b-245 heavy chainAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi132N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi149N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Glycosylationi240N-linked (GlcNAc...) asparagine1 Publication1
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication
Phosphorylated on Ser and Thr residues.1 Publication
Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P04839

MaxQB - The MaxQuant DataBase

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MaxQBi
P04839

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P04839

PeptideAtlas

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PeptideAtlasi
P04839

PRoteomics IDEntifications database

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PRIDEi
P04839

ProteomicsDB human proteome resource

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ProteomicsDBi
51748

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1165

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P04839

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P04839

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04839

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in neutrophils (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165168 Expressed in 196 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

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CleanExi
HS_CYBB

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P04839 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04839 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051227

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex (PubMed:19028840, PubMed:3600769, PubMed:9224653). Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer (PubMed:28351984).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107916, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-42005N

Protein interaction database and analysis system

More...
IntActi
P04839, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367851

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04839

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P04839

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04839

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 286Ferric oxidoreductaseAdd BLAST233
Domaini287 – 397FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0039 Eukaryota
ENOG410XNZY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216669

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003760

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04839

KEGG Orthology (KO)

More...
KOi
K21421

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGQWLFI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G09RV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04839

TreeFam database of animal gene trees

More...
TreeFami
TF105354

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000778 Cyt_b245_heavy_chain
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR017938 Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00466 GP91PHOX

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51384 FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04839-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNWAVNEGL SIFVILVWLG LNVFLFVWYY RVYDIPPKFF YTRKLLGSAL
60 70 80 90 100
ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRV RRQLDRNLTF
110 120 130 140 150
HKMVAWMIAL HSAIHTIAHL FNVEWCVNAR VNNSDPYSVA LSELGDRQNE
160 170 180 190 200
SYLNFARKRI KNPEGGLYLA VTLLAGITGV VITLCLILII TSSTKTIRRS
210 220 230 240 250
YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTAESLAVHN ITVCEQKISE
260 270 280 290 300
WGKIKECPIP QFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV
310 320 330 340 350
VTHPFKTIEL QMKKKGFKME VGQYIFVKCP KVSKLEWHPF TLTSAPEEDF
360 370 380 390 400
FSIHIRIVGD WTEGLFNACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS
410 420 430 440 450
YEVVMLVGAG IGVTPFASIL KSVWYKYCNN ATNLKLKKIY FYWLCRDTHA
460 470 480 490 500
FEWFADLLQL LESQMQERNN AGFLSYNIYL TGWDESQANH FAVHHDEEKD
510 520 530 540 550
VITGLKQKTL YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAETLSKQS
560 570
ISNSESGPRG VHFIFNKENF
Length:570
Mass (Da):65,336
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E84051BD4000CE3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA27635 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA29327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14V → A (PubMed:2425263).Curated1
Sequence conflicti14V → A (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04726418W → C in CGD. 1
Natural variantiVAR_00787320G → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344455EnsemblClinVar.1
Natural variantiVAR_02561341Y → D in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344453EnsemblClinVar.1
Natural variantiVAR_04726554 – 55Missing in CGD. 1 Publication2
Natural variantiVAR_02561454R → M in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344479EnsemblClinVar.1
Natural variantiVAR_00787454R → S in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344456EnsemblClinVar.1
Natural variantiVAR_02561555A → D in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344480EnsemblClinVar.1
Natural variantiVAR_00884557A → E in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344481EnsemblClinVar.1
Natural variantiVAR_00787559C → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344457EnsemblClinVar.1
Natural variantiVAR_04726659C → W in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344488EnsemblClinVar.1
Natural variantiVAR_002432101H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854591EnsemblClinVar.1
Natural variantiVAR_007876101H → Y in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854594EnsemblClinVar.1
Natural variantiVAR_007877119H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344458EnsemblClinVar.1
Natural variantiVAR_002433156A → T in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854590EnsemblClinVar.1
Natural variantiVAR_065365178T → P in IMD34. 1 PublicationCorresponds to variant dbSNP:rs151344497EnsemblClinVar.1
Natural variantiVAR_047267179G → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344491EnsemblClinVar.1
Natural variantiVAR_047268193S → F in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344493EnsemblClinVar.1
Natural variantiVAR_047269205F → I in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344496EnsemblClinVar.1
Natural variantiVAR_007878209H → Q in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344459EnsemblClinVar.1
Natural variantiVAR_025616209H → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344482EnsemblClinVar.1
Natural variantiVAR_002434209H → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854587EnsemblClinVar.1
Natural variantiVAR_007879215Missing in CGD. 2 Publications1
Natural variantiVAR_007880222H → N in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344460EnsemblClinVar.1
Natural variantiVAR_007881222H → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344462EnsemblClinVar.1
Natural variantiVAR_007882222H → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344460EnsemblClinVar.1
Natural variantiVAR_007883223G → L in CGD; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variants dbSNP:rs151344463 and dbSNP:rs151344464EnsemblEnsembl.1
Natural variantiVAR_025617224A → G in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344483EnsemblClinVar.1
Natural variantiVAR_002435225E → V in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344494EnsemblClinVar.1
Natural variantiVAR_065366231Q → P in IMD34. 1 PublicationCorresponds to variant dbSNP:rs151344498EnsemblClinVar.1
Natural variantiVAR_007884244C → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344465EnsemblClinVar.1
Natural variantiVAR_002436244C → S in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854589EnsemblClinVar.1
Natural variantiVAR_002437244C → Y in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854589EnsemblClinVar.1
Natural variantiVAR_047270298 – 302Missing in CGD. 1 Publication5
Natural variantiVAR_071861299K → N in CGD. 1 Publication1
Natural variantiVAR_016880303H → N in CGD; completely inhibits NADPH oxidase activity; NADPH oxidase assembly is abolished. 2 PublicationsCorresponds to variant dbSNP:rs137854595EnsemblClinVar.1
Natural variantiVAR_016881304P → R in CGD; reduces NADPH oxidase activity to 4% of wild-type; translocation to the membrane of the phagosome is only attenuated. 2 PublicationsCorresponds to variant dbSNP:rs137854596EnsemblClinVar.1
Natural variantiVAR_047271307T → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344489EnsemblClinVar.1
Natural variantiVAR_007885309E → K in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344466EnsemblClinVar.1
Natural variantiVAR_047272315Missing in CGD. 1 Publication1
Natural variantiVAR_007886322G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344467EnsemblClinVar.1
Natural variantiVAR_007887325I → F in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344468EnsemblClinVar.1
Natural variantiVAR_007888333S → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344469EnsemblClinVar.1
Natural variantiVAR_071862338H → D in CGD. 1 Publication1
Natural variantiVAR_025618338H → Y in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344484EnsemblClinVar.1
Natural variantiVAR_002438339P → H in CGD. 6 PublicationsCorresponds to variant dbSNP:rs151344470EnsemblClinVar.1
Natural variantiVAR_047273342L → Q in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344495EnsemblClinVar.1
Natural variantiVAR_025619344S → F in CGD. 3 PublicationsCorresponds to variant dbSNP:rs151344485EnsemblClinVar.1
Natural variantiVAR_007889356R → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344471EnsemblClinVar.1
Natural variantiVAR_025620364G → R2 PublicationsCorresponds to variant dbSNP:rs141756032EnsemblClinVar.1
Natural variantiVAR_002439389G → A in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854586EnsemblClinVar.1
Natural variantiVAR_025621389G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854586EnsemblClinVar.1
Natural variantiVAR_007890405M → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344472EnsemblClinVar.1
Natural variantiVAR_007891408G → E in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344474EnsemblClinVar.1
Natural variantiVAR_007892408G → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344473EnsemblClinVar.1
Natural variantiVAR_078386409A → G in CGD. 1 Publication1
Natural variantiVAR_071863412G → E in CGD. 1 Publication1
Natural variantiVAR_002440415P → H in CGD. 2 PublicationsCorresponds to variant dbSNP:rs137854585EnsemblClinVar.1
Natural variantiVAR_007893415P → L in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854585EnsemblClinVar.1
Natural variantiVAR_025622420L → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344486EnsemblClinVar.1
Natural variantiVAR_007894422S → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344475EnsemblClinVar.1
Natural variantiVAR_007895453W → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344476EnsemblClinVar.1
Natural variantiVAR_047274472G → S. Corresponds to variant dbSNP:rs13306300Ensembl.1
Natural variantiVAR_068012488A → D in CGD. 1 Publication1
Natural variantiVAR_068013500D → E in CGD. 1 Publication1
Natural variantiVAR_002441500D → G in CGD. 1 PublicationCorresponds to variant dbSNP:rs137854593EnsemblClinVar.1
Natural variantiVAR_047275505L → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344490EnsemblClinVar.1
Natural variantiVAR_007896516W → C in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344477EnsemblClinVar.1
Natural variantiVAR_025623516W → R in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344487EnsemblClinVar.1
Natural variantiVAR_025624517D → E1 PublicationCorresponds to variant dbSNP:rs151344452EnsemblClinVar.1
Natural variantiVAR_007897534V → D in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344478EnsemblClinVar.1
Natural variantiVAR_007898537C → R in CGD. 2 PublicationsCorresponds to variant dbSNP:rs151344454EnsemblClinVar.1
Natural variantiVAR_047276546L → P in CGD. 1 PublicationCorresponds to variant dbSNP:rs151344492EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04011 mRNA Translation: CAA27635.1 Different initiation.
AF469769
, AF469757, AF469758, AF469759, AF469760, AF469761, AF469762, AF469763, AF469764, AF469765, AF469766, AF469767, AF469768 Genomic DNA Translation: AAL76082.1
DQ314869 Genomic DNA Translation: ABC40728.1
AK289753 mRNA Translation: BAF82442.1
CH471141 Genomic DNA Translation: EAW59453.1
BC032720 mRNA Translation: AAH32720.1
X05895 Genomic DNA Translation: CAA29327.1 Sequence problems.
AB013904 Genomic DNA Translation: BAA34183.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14242.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S70773

NCBI Reference Sequences

More...
RefSeqi
NP_000388.2, NM_000397.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.292356

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378588; ENSP00000367851; ENSG00000165168

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1536

UCSC genome browser

More...
UCSCi
uc004ddr.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CYBBbase

CYBB deficiency database

Mendelian genes cytochrome b-245, beta polypeptide (CYBB)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04011 mRNA Translation: CAA27635.1 Different initiation.
AF469769
, AF469757, AF469758, AF469759, AF469760, AF469761, AF469762, AF469763, AF469764, AF469765, AF469766, AF469767, AF469768 Genomic DNA Translation: AAL76082.1
DQ314869 Genomic DNA Translation: ABC40728.1
AK289753 mRNA Translation: BAF82442.1
CH471141 Genomic DNA Translation: EAW59453.1
BC032720 mRNA Translation: AAH32720.1
X05895 Genomic DNA Translation: CAA29327.1 Sequence problems.
AB013904 Genomic DNA Translation: BAA34183.1
CCDSiCCDS14242.1
PIRiS70773
RefSeqiNP_000388.2, NM_000397.3
UniGeneiHs.292356

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A1FX-ray2.00A385-570[»]
ProteinModelPortaliP04839
SMRiP04839
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107916, 9 interactors
DIPiDIP-42005N
IntActiP04839, 3 interactors
STRINGi9606.ENSP00000367851

Chemistry databases

BindingDBiP04839
ChEMBLiCHEMBL1287627
DrugBankiDB00514 Dextromethorphan
GuidetoPHARMACOLOGYi3002

Protein family/group databases

PeroxiBasei5962 HsNOx02
TCDBi5.B.1.1.1 the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

GlyConnecti1165
iPTMnetiP04839
PhosphoSitePlusiP04839
SwissPalmiP04839

Polymorphism and mutation databases

BioMutaiCYBB
DMDMi115211

Proteomic databases

EPDiP04839
MaxQBiP04839
PaxDbiP04839
PeptideAtlasiP04839
PRIDEiP04839
ProteomicsDBi51748

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1536
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378588; ENSP00000367851; ENSG00000165168
GeneIDi1536
KEGGihsa:1536
UCSCiuc004ddr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1536
DisGeNETi1536
EuPathDBiHostDB:ENSG00000165168.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYBB
GeneReviewsiCYBB
HGNCiHGNC:2578 CYBB
HPAiHPA051227
MalaCardsiCYBB
MIMi300481 gene
300645 phenotype
306400 phenotype
neXtProtiNX_P04839
OpenTargetsiENSG00000165168
Orphaneti379 Chronic granulomatous disease
319623 X-linked mendelian susceptibility to mycobacterial diseases due to CYBB deficiency
PharmGKBiPA27076

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00940000160244
HOGENOMiHOG000216669
HOVERGENiHBG003760
InParanoidiP04839
KOiK21421
OMAiAGQWLFI
OrthoDBiEOG091G09RV
PhylomeDBiP04839
TreeFamiTF105354

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-6798695 Neutrophil degranulation
SIGNORiP04839

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYBB human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYBB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1536

Protein Ontology

More...
PROi
PR:P04839

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165168 Expressed in 196 organ(s), highest expression level in bone marrow
CleanExiHS_CYBB
ExpressionAtlasiP04839 baseline and differential
GenevisibleiP04839 HS

Family and domain databases

Gene3Di3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR000778 Cyt_b245_heavy_chain
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00466 GP91PHOX
SUPFAMiSSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCY24B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04839
Secondary accession number(s): A8K138, Q2PP16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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