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Protein

Aminopeptidase N

Gene

pepN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.1 Publication3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+3 PublicationsNote: Binds 1 zinc ion per subunit.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei121Substrate1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi297Zinc; catalytic1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei298Proton acceptor3 Publications1
Metal bindingi301Zinc; catalytic1
Metal bindingi320Zinc; catalytic1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei381Transition state stabilizerCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aminopeptidase activity Source: EcoliWiki
  • identical protein binding Source: IntAct
  • metallopeptidase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

  • peptide catabolic process Source: GO_Central
  • proteolysis Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10696-MONOMER
MetaCyc:EG10696-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.11.2 2026

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M01.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminopeptidase N (EC:3.4.11.23 Publications)
Alternative name(s):
Alpha-aminoacylpeptide hydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pepN
Ordered Locus Names:b0932, JW0915
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10696 pepN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

A quadruple peptidase disruption (pepA, pepB, pepD and pepN) does not grow in M9 minimal medium, does grow better when supplemented with casamino acids (PubMed:20067529).1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4325

Drug and drug target database

More...
DrugBanki
DB08506 N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000950692 – 870Aminopeptidase NAdd BLAST869

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P04825

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04825

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04825

PRoteomics IDEntifications database

More...
PRIDEi
P04825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4261880, 49 interactors
851583, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-10458N

Protein interaction database and analysis system

More...
IntActi
P04825, 13 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_1002

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04825

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1870
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DQ6X-ray1.50A1-870[»]
2DQMX-ray1.60A1-870[»]
2HPOX-ray1.65A1-870[»]
2HPTX-ray2.30A1-870[»]
2ZXGX-ray1.55A1-870[»]
3B2PX-ray2.00A1-870[»]
3B2XX-ray1.50A1-870[»]
3B34X-ray1.30A1-870[»]
3B37X-ray1.70A1-870[»]
3B3BX-ray1.85A1-870[»]
3KEDX-ray2.30A1-870[»]
3PUUX-ray2.15A1-870[»]
3QJXX-ray1.45A1-870[»]
4Q4EX-ray1.90A1-870[»]
4Q4IX-ray2.31A1-870[»]
4XMTX-ray2.00A4-870[»]
4XMUX-ray2.91A5-870[»]
4XMVX-ray2.92A5-870[»]
4XMWX-ray2.20A4-870[»]
4XMXX-ray2.30A5-870[»]
4XMZX-ray2.15A4-870[»]
4XN1X-ray2.20A4-870[»]
4XN2X-ray2.11A5-870[»]
4XN4X-ray1.99A5-870[»]
4XN5X-ray2.66A5-870[»]
4XN7X-ray2.22A5-870[»]
4XN8X-ray1.89A5-870[»]
4XN9X-ray2.80A5-870[»]
4XNAX-ray2.40A5-870[»]
4XNBX-ray1.95A5-870[»]
4XNDX-ray1.93A5-870[»]
4XO3X-ray2.00A5-870[»]
4XO4X-ray2.18A1-870[»]
4XO5X-ray1.98A5-870[»]
5MFRX-ray1.40A1-870[»]
5MFSX-ray1.57A1-870[»]
5MFTX-ray1.59A1-870[»]
5YO1X-ray2.50A1-870[»]
5YQ1X-ray1.58A1-870[»]
5YQ2X-ray1.60A1-870[»]
5YQBX-ray1.56A1-870[»]
6G8BX-ray2.37A1-870[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04825

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04825

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04825

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni261 – 265Substrate binding5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CD8 Bacteria
COG0308 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000257670

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04825

KEGG Orthology (KO)

More...
KOi
K01256

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04825

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09600 M1_APN_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.10, 1 hit
1.25.50.10, 1 hit
2.60.40.1840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038438 PepN_Ig-like_sf
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
IPR012779 Peptidase_M1_pepN
IPR024601 Peptidase_M1_pepN_C
IPR037144 Peptidase_M1_pepN_C_sf
IPR035414 Peptidase_M1_pepN_Ig-like
IPR027268 Peptidase_M4/M1_CTD_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11533 PTHR11533, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11940 DUF3458, 1 hit
PF17432 DUF3458_C, 1 hit
PF01433 Peptidase_M1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00756 ALADIPTASE

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02414 pepN_proteo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQQPQAKYR HDYRAPDYQI TDIDLTFDLD AQKTVVTAVS QAVRHGASDA
60 70 80 90 100
PLRLNGEDLK LVSVHINDEP WTAWKEEEGA LVISNLPERF TLKIINEISP
110 120 130 140 150
AANTALEGLY QSGDALCTQC EAEGFRHITY YLDRPDVLAR FTTKIIADKI
160 170 180 190 200
KYPFLLSNGN RVAQGELENG RHWVQWQDPF PKPCYLFALV AGDFDVLRDT
210 220 230 240 250
FTTRSGREVA LELYVDRGNL DRAPWAMTSL KNSMKWDEER FGLEYDLDIY
260 270 280 290 300
MIVAVDFFNM GAMENKGLNI FNSKYVLART DTATDKDYLD IERVIGHEYF
310 320 330 340 350
HNWTGNRVTC RDWFQLSLKE GLTVFRDQEF SSDLGSRAVN RINNVRTMRG
360 370 380 390 400
LQFAEDASPM AHPIRPDMVI EMNNFYTLTV YEKGAEVIRM IHTLLGEENF
410 420 430 440 450
QKGMQLYFER HDGSAATCDD FVQAMEDASN VDLSHFRRWY SQSGTPIVTV
460 470 480 490 500
KDDYNPETEQ YTLTISQRTP ATPDQAEKQP LHIPFAIELY DNEGKVIPLQ
510 520 530 540 550
KGGHPVNSVL NVTQAEQTFV FDNVYFQPVP ALLCEFSAPV KLEYKWSDQQ
560 570 580 590 600
LTFLMRHARN DFSRWDAAQS LLATYIKLNV ARHQQGQPLS LPVHVADAFR
610 620 630 640 650
AVLLDEKIDP ALAAEILTLP SVNEMAELFD IIDPIAIAEV REALTRTLAT
660 670 680 690 700
ELADELLAIY NANYQSEYRV EHEDIAKRTL RNACLRFLAF GETHLADVLV
710 720 730 740 750
SKQFHEANNM TDALAALSAA VAAQLPCRDA LMQEYDDKWH QNGLVMDKWF
760 770 780 790 800
ILQATSPAAN VLETVRGLLQ HRSFTMSNPN RIRSLIGAFA GSNPAAFHAE
810 820 830 840 850
DGSGYLFLVE MLTDLNSRNP QVASRLIEPL IRLKRYDAKR QEKMRAALEQ
860 870
LKGLENLSGD LYEKITKALA
Length:870
Mass (Da):98,919
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C18C6BD8F2E5131
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76E → D in CAA27647 (PubMed:2869947).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04020 Genomic DNA Translation: CAA27647.1
X03709 Genomic DNA Translation: CAA27336.1
M15676 Genomic DNA Translation: AAA24318.1
U00096 Genomic DNA Translation: AAC74018.1
AP009048 Genomic DNA Translation: BAA35684.1
M15273 Genomic DNA Translation: AAA24317.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C64833 DPECN

NCBI Reference Sequences

More...
RefSeqi
NP_415452.1, NC_000913.3
WP_000193841.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74018; AAC74018; b0932
BAA35684; BAA35684; BAA35684

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0915
eco:b0932

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1342

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04020 Genomic DNA Translation: CAA27647.1
X03709 Genomic DNA Translation: CAA27336.1
M15676 Genomic DNA Translation: AAA24318.1
U00096 Genomic DNA Translation: AAC74018.1
AP009048 Genomic DNA Translation: BAA35684.1
M15273 Genomic DNA Translation: AAA24317.1
PIRiC64833 DPECN
RefSeqiNP_415452.1, NC_000913.3
WP_000193841.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DQ6X-ray1.50A1-870[»]
2DQMX-ray1.60A1-870[»]
2HPOX-ray1.65A1-870[»]
2HPTX-ray2.30A1-870[»]
2ZXGX-ray1.55A1-870[»]
3B2PX-ray2.00A1-870[»]
3B2XX-ray1.50A1-870[»]
3B34X-ray1.30A1-870[»]
3B37X-ray1.70A1-870[»]
3B3BX-ray1.85A1-870[»]
3KEDX-ray2.30A1-870[»]
3PUUX-ray2.15A1-870[»]
3QJXX-ray1.45A1-870[»]
4Q4EX-ray1.90A1-870[»]
4Q4IX-ray2.31A1-870[»]
4XMTX-ray2.00A4-870[»]
4XMUX-ray2.91A5-870[»]
4XMVX-ray2.92A5-870[»]
4XMWX-ray2.20A4-870[»]
4XMXX-ray2.30A5-870[»]
4XMZX-ray2.15A4-870[»]
4XN1X-ray2.20A4-870[»]
4XN2X-ray2.11A5-870[»]
4XN4X-ray1.99A5-870[»]
4XN5X-ray2.66A5-870[»]
4XN7X-ray2.22A5-870[»]
4XN8X-ray1.89A5-870[»]
4XN9X-ray2.80A5-870[»]
4XNAX-ray2.40A5-870[»]
4XNBX-ray1.95A5-870[»]
4XNDX-ray1.93A5-870[»]
4XO3X-ray2.00A5-870[»]
4XO4X-ray2.18A1-870[»]
4XO5X-ray1.98A5-870[»]
5MFRX-ray1.40A1-870[»]
5MFSX-ray1.57A1-870[»]
5MFTX-ray1.59A1-870[»]
5YO1X-ray2.50A1-870[»]
5YQ1X-ray1.58A1-870[»]
5YQ2X-ray1.60A1-870[»]
5YQBX-ray1.56A1-870[»]
6G8BX-ray2.37A1-870[»]
ProteinModelPortaliP04825
SMRiP04825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261880, 49 interactors
851583, 1 interactor
DIPiDIP-10458N
IntActiP04825, 13 interactors
STRINGi316385.ECDH10B_1002

Chemistry databases

BindingDBiP04825
ChEMBLiCHEMBL4325
DrugBankiDB08506 N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine

Protein family/group databases

MEROPSiM01.005

Proteomic databases

EPDiP04825
jPOSTiP04825
PaxDbiP04825
PRIDEiP04825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74018; AAC74018; b0932
BAA35684; BAA35684; BAA35684
GeneIDi947253
KEGGiecj:JW0915
eco:b0932
PATRICifig|1411691.4.peg.1342

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0690
EcoGeneiEG10696 pepN

Phylogenomic databases

eggNOGiENOG4105CD8 Bacteria
COG0308 LUCA
HOGENOMiHOG000257670
InParanoidiP04825
KOiK01256
PhylomeDBiP04825

Enzyme and pathway databases

BioCyciEcoCyc:EG10696-MONOMER
MetaCyc:EG10696-MONOMER
BRENDAi3.4.11.2 2026

Miscellaneous databases

EvolutionaryTraceiP04825

Protein Ontology

More...
PROi
PR:P04825

Family and domain databases

CDDicd09600 M1_APN_1, 1 hit
Gene3Di1.10.390.10, 1 hit
1.25.50.10, 1 hit
2.60.40.1840, 1 hit
InterProiView protein in InterPro
IPR038438 PepN_Ig-like_sf
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
IPR012779 Peptidase_M1_pepN
IPR024601 Peptidase_M1_pepN_C
IPR037144 Peptidase_M1_pepN_C_sf
IPR035414 Peptidase_M1_pepN_Ig-like
IPR027268 Peptidase_M4/M1_CTD_sf
PANTHERiPTHR11533 PTHR11533, 1 hit
PfamiView protein in Pfam
PF11940 DUF3458, 1 hit
PF17432 DUF3458_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE
TIGRFAMsiTIGR02414 pepN_proteo, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPN_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04825
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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