UniProtKB - P04818 (TYSY_HUMAN)
Protein
Thymidylate synthase
Gene
TYMS
Organism
Homo sapiens (Human)
Status
Functioni
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.1 Publication
Catalytic activityi
- EC:2.1.1.45
: dTTP biosynthesis Pathwayi
This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 50 | dUMPBy similarity | 1 | |
Active sitei | 195 | NucleophileBy similarity | 1 | |
Binding sitei | 218 | 5,10-methylenetetrahydrofolateBy similarity | 1 | |
Binding sitei | 226 | dUMPBy similarity | 1 | |
Binding sitei | 312 | 5,10-methylenetetrahydrofolate; via carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 175 – 176 | dUMP; shared with dimeric partnerBy similarity | 2 | |
Nucleotide bindingi | 215 – 218 | dUMPBy similarity | 4 | |
Nucleotide bindingi | 256 – 258 | dUMPBy similarity | 3 |
GO - Molecular functioni
- drug binding Source: Ensembl
- folic acid binding Source: BHF-UCL
- protein homodimerization activity Source: Ensembl
- sequence-specific mRNA binding Source: CAFA
- thymidylate synthase activity Source: CAFA
- translation repressor activity, mRNA regulatory element binding Source: CAFA
GO - Biological processi
- aging Source: Ensembl
- cartilage development Source: Ensembl
- circadian rhythm Source: Ensembl
- developmental growth Source: Ensembl
- DNA biosynthetic process Source: BHF-UCL
- dTMP biosynthetic process Source: CAFA
- dTTP biosynthetic process Source: UniProtKB-UniPathway
- intestinal epithelial cell maturation Source: Ensembl
- liver regeneration Source: Ensembl
- methylation Source: UniProtKB-KW
- modulation by virus of host process Source: Ensembl
- negative regulation of translation Source: CAFA
- nucleobase-containing small molecule interconversion Source: Reactome
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
- response to cytokine Source: Ensembl
- response to drug Source: Ensembl
- response to ethanol Source: Ensembl
- response to folic acid Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to organophosphorus Source: UniProtKB
- response to progesterone Source: Ensembl
- response to toxic substance Source: Ensembl
- response to vitamin A Source: Ensembl
- tetrahydrofolate interconversion Source: BHF-UCL
- uracil metabolic process Source: Ensembl
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Nucleotide biosynthesis |
Enzyme and pathway databases
BioCyci | MetaCyc:HS11096-MONOMER |
BRENDAi | 2.1.1.45, 2681 |
PathwayCommonsi | P04818 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates R-HSA-69205, G1/S-Specific Transcription |
SABIO-RKi | P04818 |
SIGNORi | P04818 |
UniPathwayi | UPA00575 |
Protein family/group databases
MoonProti | P04818 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TYMS Synonyms:TS ORF Names:OK/SW-cl.29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000176890.15 |
HGNCi | HGNC:12441, TYMS |
MIMi | 188350, gene |
neXtProti | NX_P04818 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
- Mitochondrion matrix 1 Publication
- Mitochondrion inner membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial matrix Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7298 |
OpenTargetsi | ENSG00000176890 |
Orphaneti | 240839, 5-fluorouracil toxicity |
PharmGKBi | PA359 |
Miscellaneous databases
Pharosi | P04818, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1952 |
DrugBanki | DB03541, 10-Propargyl-5,8-Dideazafolic Acid DB07577, 2,4-Diamino-5-phenyl-6-ethylpyrimidine DB08734, 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE DB05308, ANX-510 DB01101, Capecitabine DB03800, Deoxyuridine monophosphate DB00322, Floxuridine DB00544, Fluorouracil DB00441, Gemcitabine DB00563, Methotrexate DB08479, N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide DB08478, N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide DB05457, OSI-7904L DB00642, Pemetrexed DB06813, Pralatrexate DB00293, Raltitrexed DB04530, S,S-(2-Hydroxyethyl)Thiocysteine DB09256, Tegafur DB09327, Tegafur-uracil DB05116, Thymectacin DB01643, Thymidine monophosphate DB00432, Trifluridine |
DrugCentrali | P04818 |
GuidetoPHARMACOLOGYi | 2642 |
Polymorphism and mutation databases
BioMutai | TYMS |
DMDMi | 136611 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000140901 | 2 – 313 | Thymidylate synthaseAdd BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 114 | PhosphoserineCombined sources | 1 | |
Cross-linki | 287 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 292 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 308 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P04818 |
jPOSTi | P04818 |
MassIVEi | P04818 |
PaxDbi | P04818 |
PeptideAtlasi | P04818 |
PRIDEi | P04818 |
ProteomicsDBi | 51747 [P04818-1] 75165 75166 |
TopDownProteomicsi | P04818-1 [P04818-1] |
PTM databases
iPTMneti | P04818 |
MetOSitei | P04818 |
PhosphoSitePlusi | P04818 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176890, Expressed in liver and 217 other tissues |
ExpressionAtlasi | P04818, baseline and differential |
Genevisiblei | P04818, HS |
Organism-specific databases
HPAi | ENSG00000176890, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Homodimer.
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 113149, 61 interactors |
IntActi | P04818, 14 interactors |
MINTi | P04818 |
STRINGi | 9606.ENSP00000315644 |
Chemistry databases
BindingDBi | P04818 |
Miscellaneous databases
RNActi | P04818, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04818 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04818 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidylate synthase family.Curated
Phylogenomic databases
eggNOGi | KOG0673, Eukaryota |
GeneTreei | ENSGT00390000014786 |
HOGENOMi | CLU_021669_0_2_1 |
InParanoidi | P04818 |
OMAi | KQYLDLC |
PhylomeDBi | P04818 |
TreeFami | TF353027 |
Family and domain databases
CDDi | cd00351, TS_Pyrimidine_HMase, 1 hit |
DisProti | DP00073 |
Gene3Di | 3.30.572.10, 1 hit |
HAMAPi | MF_00008, Thymidy_synth_bact, 1 hit |
InterProi | View protein in InterPro IPR023451, Thymidate_synth/dCMP_Mease IPR036926, Thymidate_synth/dCMP_Mease_sf IPR000398, Thymidylate_synthase IPR020940, Thymidylate_synthase_AS |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
PRINTSi | PR00108, THYMDSNTHASE |
SUPFAMi | SSF55831, SSF55831, 1 hit |
TIGRFAMsi | TIGR03284, thym_sym, 1 hit |
PROSITEi | View protein in PROSITE PS00091, THYMIDYLATE_SYNTHASE, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P04818-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR
60 70 80 90 100
TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE
110 120 130 140 150
LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME
160 170 180 190 200
SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ
210 220 230 240 250
FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH
260 270 280 290 300
TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
310
YNPHPTIKME MAV
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047745 | 69 – 151 | Missing in isoform 3. 1 PublicationAdd BLAST | 83 | |
Alternative sequenceiVSP_047746 | 152 – 185 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02308 mRNA Translation: CAA26178.1 D00596 Genomic DNA Translation: BAA00472.1 AB077207 mRNA Translation: BAB83676.1 AB077208 mRNA Translation: BAB83677.1 AB062290 mRNA Translation: BAB93473.1 AP001178 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01716.1 CH471113 Genomic DNA Translation: EAX01720.1 BC002567 mRNA Translation: AAH02567.1 BC013919 mRNA Translation: AAH13919.1 BC083512 mRNA Translation: AAH83512.1 D00517 Genomic DNA Translation: BAA00404.1 |
CCDSi | CCDS11821.1 [P04818-1] CCDS86658.1 [P04818-2] CCDS86659.1 [P04818-3] |
PIRi | A23047, YXHUT |
RefSeqi | NP_001062.1, NM_001071.2 [P04818-1] |
Genome annotation databases
Ensembli | ENST00000323224; ENSP00000314727; ENSG00000176890 [P04818-2] ENST00000323250; ENSP00000314902; ENSG00000176890 [P04818-3] ENST00000323274; ENSP00000315644; ENSG00000176890 [P04818-1] |
GeneIDi | 7298 |
KEGGi | hsa:7298 |
UCSCi | uc010dkb.2, human [P04818-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02308 mRNA Translation: CAA26178.1 D00596 Genomic DNA Translation: BAA00472.1 AB077207 mRNA Translation: BAB83676.1 AB077208 mRNA Translation: BAB83677.1 AB062290 mRNA Translation: BAB93473.1 AP001178 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01716.1 CH471113 Genomic DNA Translation: EAX01720.1 BC002567 mRNA Translation: AAH02567.1 BC013919 mRNA Translation: AAH13919.1 BC083512 mRNA Translation: AAH83512.1 D00517 Genomic DNA Translation: BAA00404.1 |
CCDSi | CCDS11821.1 [P04818-1] CCDS86658.1 [P04818-2] CCDS86659.1 [P04818-3] |
PIRi | A23047, YXHUT |
RefSeqi | NP_001062.1, NM_001071.2 [P04818-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HVY | X-ray | 1.90 | A/B/C/D | 26-313 | [»] | |
1HW3 | X-ray | 2.00 | A | 1-313 | [»] | |
1HW4 | X-ray | 2.06 | A | 1-313 | [»] | |
1HZW | X-ray | 2.00 | A/B | 1-313 | [»] | |
1I00 | X-ray | 2.50 | A/B | 1-313 | [»] | |
1JU6 | X-ray | 2.89 | A/B/C/D | 1-313 | [»] | |
1JUJ | X-ray | 3.00 | A/B/C/D | 1-313 | [»] | |
1YPV | X-ray | 1.80 | A | 1-313 | [»] | |
2ONB | X-ray | 2.70 | A | 1-313 | [»] | |
2RD8 | X-ray | 2.50 | A/B | 1-313 | [»] | |
2RDA | X-ray | 2.67 | A/B/C/D/E/F | 1-313 | [»] | |
3EAW | X-ray | 1.86 | X | 1-313 | [»] | |
3EBU | X-ray | 2.05 | A | 1-313 | [»] | |
3ED7 | X-ray | 1.56 | A | 26-313 | [»] | |
3EDW | X-ray | 1.75 | X | 1-313 | [»] | |
3EF9 | X-ray | 3.20 | A | 1-313 | [»] | |
3EGY | X-ray | 2.18 | X | 1-313 | [»] | |
3EHI | X-ray | 2.00 | X | 1-313 | [»] | |
3EJL | X-ray | 3.20 | A/B/C/D | 1-313 | [»] | |
3GG5 | X-ray | 2.77 | A/B/C/D | 1-313 | [»] | |
3GH0 | X-ray | 1.56 | A | 1-313 | [»] | |
3GH2 | X-ray | 1.75 | X | 1-313 | [»] | |
3H9K | X-ray | 2.65 | A/B/C/D/E | 1-313 | [»] | |
3HB8 | X-ray | 2.74 | A/B/C/D/E | 1-313 | [»] | |
3N5E | X-ray | 2.26 | A/B | 1-313 | [»] | |
3N5G | X-ray | 2.27 | A | 1-313 | [»] | |
3OB7 | X-ray | 2.75 | A/B/C/D/E | 1-313 | [»] | |
4E28 | X-ray | 2.30 | A | 1-313 | [»] | |
4FGT | X-ray | 2.00 | A | 1-311 | [»] | |
4G2O | X-ray | 2.25 | X | 1-313 | [»] | |
4G6W | X-ray | 2.30 | X | 1-313 | [»] | |
4GD7 | X-ray | 2.29 | A | 1-313 | [»] | |
4GYH | X-ray | 3.00 | A | 1-313 | [»] | |
4H1I | X-ray | 3.10 | A/B/C/D | 1-313 | [»] | |
4JEF | X-ray | 2.31 | A | 26-311 | [»] | |
4KPW | X-ray | 2.03 | A | 1-313 | [»] | |
4O1U | X-ray | 2.26 | A/B | 1-313 | [»] | |
4O1X | X-ray | 2.32 | A/B/C/D | 1-313 | [»] | |
4UP1 | X-ray | 2.99 | A/B/C/D | 1-313 | [»] | |
5HS3 | X-ray | 3.10 | A/B/C/D/E/F | 26-313 | [»] | |
5WRN | X-ray | 2.39 | A/B/C/D/E/F | 26-313 | [»] | |
5X4W | X-ray | 2.10 | A | 1-313 | [»] | |
5X4X | X-ray | 2.31 | A | 1-313 | [»] | |
5X4Y | X-ray | 2.20 | A | 1-313 | [»] | |
5X5A | X-ray | 2.39 | A/B/C/D/E/F | 26-313 | [»] | |
5X5D | X-ray | 2.00 | A/B/C/D/E/F | 26-313 | [»] | |
5X5Q | X-ray | 2.79 | A/B/C/D/E/F | 26-313 | [»] | |
5X66 | X-ray | 1.99 | A/B/C/D/E/F | 26-313 | [»] | |
5X67 | X-ray | 2.13 | A/B | 26-313 | [»] | |
5X69 | X-ray | 2.69 | A/B/C/D/E/F | 26-313 | [»] | |
6OJU | X-ray | 2.88 | A/B/C/D | 26-313 | [»] | |
6OJV | X-ray | 2.59 | A/B/C/D | 26-313 | [»] | |
6PF3 | X-ray | 2.39 | A/B/C/D | 26-313 | [»] | |
6PF4 | X-ray | 2.85 | A/B/C/D | 26-313 | [»] | |
6PF5 | X-ray | 2.39 | A/B/C/D | 26-313 | [»] | |
6PF6 | X-ray | 2.50 | A/B/C/D | 26-313 | [»] | |
6QXG | X-ray | 2.08 | A/B/C | 1-313 | [»] | |
6QXH | X-ray | 2.04 | A/B/C | 1-313 | [»] | |
6QYQ | X-ray | 2.25 | A/B/C/D | 1-313 | [»] | |
6R2E | X-ray | 2.55 | A/B/C/D/E/F/G/H | 1-313 | [»] | |
SMRi | P04818 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113149, 61 interactors |
IntActi | P04818, 14 interactors |
MINTi | P04818 |
STRINGi | 9606.ENSP00000315644 |
Chemistry databases
BindingDBi | P04818 |
ChEMBLi | CHEMBL1952 |
DrugBanki | DB03541, 10-Propargyl-5,8-Dideazafolic Acid DB07577, 2,4-Diamino-5-phenyl-6-ethylpyrimidine DB08734, 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE DB05308, ANX-510 DB01101, Capecitabine DB03800, Deoxyuridine monophosphate DB00322, Floxuridine DB00544, Fluorouracil DB00441, Gemcitabine DB00563, Methotrexate DB08479, N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide DB08478, N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide DB05457, OSI-7904L DB00642, Pemetrexed DB06813, Pralatrexate DB00293, Raltitrexed DB04530, S,S-(2-Hydroxyethyl)Thiocysteine DB09256, Tegafur DB09327, Tegafur-uracil DB05116, Thymectacin DB01643, Thymidine monophosphate DB00432, Trifluridine |
DrugCentrali | P04818 |
GuidetoPHARMACOLOGYi | 2642 |
Protein family/group databases
MoonProti | P04818 |
PTM databases
iPTMneti | P04818 |
MetOSitei | P04818 |
PhosphoSitePlusi | P04818 |
Polymorphism and mutation databases
BioMutai | TYMS |
DMDMi | 136611 |
Proteomic databases
EPDi | P04818 |
jPOSTi | P04818 |
MassIVEi | P04818 |
PaxDbi | P04818 |
PeptideAtlasi | P04818 |
PRIDEi | P04818 |
ProteomicsDBi | 51747 [P04818-1] 75165 75166 |
TopDownProteomicsi | P04818-1 [P04818-1] |
Protocols and materials databases
Antibodypediai | 3461, 1144 antibodies |
DNASUi | 7298 |
Genome annotation databases
Ensembli | ENST00000323224; ENSP00000314727; ENSG00000176890 [P04818-2] ENST00000323250; ENSP00000314902; ENSG00000176890 [P04818-3] ENST00000323274; ENSP00000315644; ENSG00000176890 [P04818-1] |
GeneIDi | 7298 |
KEGGi | hsa:7298 |
UCSCi | uc010dkb.2, human [P04818-1] |
Organism-specific databases
CTDi | 7298 |
DisGeNETi | 7298 |
EuPathDBi | HostDB:ENSG00000176890.15 |
GeneCardsi | TYMS |
HGNCi | HGNC:12441, TYMS |
HPAi | ENSG00000176890, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 188350, gene |
neXtProti | NX_P04818 |
OpenTargetsi | ENSG00000176890 |
Orphaneti | 240839, 5-fluorouracil toxicity |
PharmGKBi | PA359 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0673, Eukaryota |
GeneTreei | ENSGT00390000014786 |
HOGENOMi | CLU_021669_0_2_1 |
InParanoidi | P04818 |
OMAi | KQYLDLC |
PhylomeDBi | P04818 |
TreeFami | TF353027 |
Enzyme and pathway databases
UniPathwayi | UPA00575 |
BioCyci | MetaCyc:HS11096-MONOMER |
BRENDAi | 2.1.1.45, 2681 |
PathwayCommonsi | P04818 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates R-HSA-69205, G1/S-Specific Transcription |
SABIO-RKi | P04818 |
SIGNORi | P04818 |
Miscellaneous databases
BioGRID-ORCSi | 7298, 283 hits in 855 CRISPR screens |
ChiTaRSi | TYMS, human |
EvolutionaryTracei | P04818 |
GeneWikii | Thymidylate_synthase |
GenomeRNAii | 7298 |
Pharosi | P04818, Tclin |
PROi | PR:P04818 |
RNActi | P04818, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176890, Expressed in liver and 217 other tissues |
ExpressionAtlasi | P04818, baseline and differential |
Genevisiblei | P04818, HS |
Family and domain databases
CDDi | cd00351, TS_Pyrimidine_HMase, 1 hit |
DisProti | DP00073 |
Gene3Di | 3.30.572.10, 1 hit |
HAMAPi | MF_00008, Thymidy_synth_bact, 1 hit |
InterProi | View protein in InterPro IPR023451, Thymidate_synth/dCMP_Mease IPR036926, Thymidate_synth/dCMP_Mease_sf IPR000398, Thymidylate_synthase IPR020940, Thymidylate_synthase_AS |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
PRINTSi | PR00108, THYMDSNTHASE |
SUPFAMi | SSF55831, SSF55831, 1 hit |
TIGRFAMsi | TIGR03284, thym_sym, 1 hit |
PROSITEi | View protein in PROSITE PS00091, THYMIDYLATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TYSY_HUMAN | |
Accessioni | P04818Primary (citable) accession number: P04818 Secondary accession number(s): Q8WYK3, Q8WYK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM