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UniProtKB - P04818 (TYSY_HUMAN)

Entry version 207 (08 May 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Thymidylate synthase

Gene

TYMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei50dUMPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei195NucleophileBy similarity1
Binding sitei2185,10-methylenetetrahydrofolateBy similarity1
Binding sitei226dUMPBy similarity1
Binding sitei3125,10-methylenetetrahydrofolate; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi175 – 176dUMP; shared with dimeric partnerBy similarity2
Nucleotide bindingi215 – 218dUMPBy similarity4
Nucleotide bindingi256 – 258dUMPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processNucleotide biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS11096-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.45 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-69205 G1/S-Specific Transcription

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P04818

SIGNOR Signaling Network Open Resource

More...SIGNORi		P04818

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00575

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P04818

UniLectin database of carbohydrate-binding proteins

More...UniLectini		P04818

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYMS
Synonyms:TS
ORF Names:OK/SW-cl.29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12441 TYMS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188350 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P04818

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7298

MalaCards human disease database

More...MalaCardsi		TYMS

Open Targets

More...OpenTargetsi		ENSG00000176890

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		240839 5-fluorouracil toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA359

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1952

Drug and drug target database

More...DrugBanki		DB03800 2'-deoxyuridylic acid
DB05308 ANX-510
DB01101 Capecitabine
DB00322 Floxuridine
DB00544 Fluorouracil
DB00441 Gemcitabine
DB00563 Methotrexate
DB08478 N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
DB05116 NB1011
DB05457 OSI-7904L
DB00642 Pemetrexed
DB06813 Pralatrexate
DB00293 Raltitrexed
DB01643 Thymidine-5'-Phosphate
DB00432 Trifluridine
DB00440 Trimethoprim

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2642

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TYMS

Domain mapping of disease mutations (DMDM)

More...DMDMi		136611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001409012 – 313Thymidylate synthaseAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P04818

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P04818

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P04818

PeptideAtlas

More...PeptideAtlasi		P04818

PRoteomics IDEntifications database

More...PRIDEi		P04818

ProteomicsDB human proteome resource

More...ProteomicsDBi		51747

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P04818-1 [P04818-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P04818

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P04818

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176890 Expressed in 204 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P04818 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P04818 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002784

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113149, 56 interactors

Protein interaction database and analysis system

More...IntActi		P04818, 9 interactors

Molecular INTeraction database

More...MINTi		P04818

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315644

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P04818

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HVYX-ray1.90A/B/C/D26-313[»]
1HW3X-ray2.00A1-313[»]
1HW4X-ray2.06A1-313[»]
1HZWX-ray2.00A/B1-313[»]
1I00X-ray2.50A/B1-313[»]
1JU6X-ray2.89A/B/C/D1-313[»]
1JUJX-ray3.00A/B/C/D1-313[»]
1YPVX-ray1.80A1-313[»]
2ONBX-ray2.70A1-313[»]
2RD8X-ray2.50A/B1-313[»]
2RDAX-ray2.67A/B/C/D/E/F1-313[»]
3EAWX-ray1.86X1-313[»]
3EBUX-ray2.05A1-313[»]
3ED7X-ray1.56A26-313[»]
3EDWX-ray1.75X1-313[»]
3EF9X-ray3.20A1-313[»]
3EGYX-ray2.18X1-313[»]
3EHIX-ray2.00X1-313[»]
3EJLX-ray3.20A/B/C/D1-313[»]
3GG5X-ray2.77A/B/C/D1-313[»]
3GH0X-ray1.56A1-313[»]
3GH2X-ray1.75X1-313[»]
3H9KX-ray2.65A/B/C/D/E1-313[»]
3HB8X-ray2.74A/B/C/D/E1-313[»]
3N5EX-ray2.26A/B1-313[»]
3N5GX-ray2.27A1-313[»]
3OB7X-ray2.75A/B/C/D/E1-313[»]
4E28X-ray2.30A1-313[»]
4FGTX-ray2.00A1-311[»]
4G2OX-ray2.25X1-313[»]
4G6WX-ray2.30X1-313[»]
4GD7X-ray2.29A1-313[»]
4GYHX-ray3.00A1-313[»]
4H1IX-ray3.10A/B/C/D1-313[»]
4JEFX-ray2.31A26-311[»]
4KPWX-ray2.03A1-313[»]
4O1UX-ray2.26A/B1-313[»]
4O1XX-ray2.32A/B/C/D1-313[»]
4UP1X-ray2.99A/B/C/D1-313[»]
5HS3X-ray3.10A/B/C/D/E/F26-313[»]
5WRNX-ray2.39A/B/C/D/E/F26-313[»]
5X4WX-ray2.10A1-313[»]
5X4XX-ray2.31A1-313[»]
5X4YX-ray2.20A1-313[»]
5X5AX-ray2.39A/B/C/D/E/F26-313[»]
5X5DX-ray2.00A/B/C/D/E/F26-313[»]
5X5QX-ray2.79A/B/C/D/E/F26-313[»]
5X66X-ray1.99A/B/C/D/E/F26-313[»]
5X67X-ray2.13A/B26-313[»]
5X69X-ray2.69A/B/C/D/E/F26-313[»]

Database of protein disorder

More...DisProti		DP00073

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04818

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P04818

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0673 Eukaryota
COG0207 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014786

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000257899

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04818

KEGG Orthology (KO)

More...KOi		K00560

Identification of Orthologs from Complete Genome Data

More...OMAi		KQYLDLC

Database of Orthologous Groups

More...OrthoDBi		1197342at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04818

TreeFam database of animal gene trees

More...TreeFami		TF353027

Family and domain databases

Conserved Domains Database

More...CDDi		cd00351 TS_Pyrimidine_HMase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.572.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00008 Thymidy_synth_bact, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00303 Thymidylat_synt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00108 THYMDSNTHASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55831 SSF55831, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03284 thym_sym, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00091 THYMIDYLATE_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P04818-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR 
        60         70         80         90        100
TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE 
       110        120        130        140        150
LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME 
       160        170        180        190        200
SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ 
       210        220        230        240        250
FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH 
       260        270        280        290        300
TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG 
       310 
YNPHPTIKME MAV
Length:313
Mass (Da):35,716
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i148D377F19915B6A
GO
Isoform 2 (identifier: P04818-2) [UniParc]FASTAAdd to basket
Also known as: delta4

The sequence of this isoform differs from the canonical sequence as follows:
     152-185: Missing.

Note: Expressed both in normal and cancerous tissues.
Show »
Length:279
Mass (Da):31,759
Checksum:i10B3A53DE10AB763
GO
Isoform 3 (identifier: P04818-3) [UniParc]FASTAAdd to basket
Also known as: delta2+3

The sequence of this isoform differs from the canonical sequence as follows:
     69-151: Missing.

Note: Expressed only in cancerous tissues.
Show »
Length:230
Mass (Da):26,140
Checksum:iD09F8316A504A02A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04774569 – 151Missing in isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_047746152 – 185Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X02308 mRNA Translation: CAA26178.1
D00596 Genomic DNA Translation: BAA00472.1
AB077207 mRNA Translation: BAB83676.1
AB077208 mRNA Translation: BAB83677.1
AB062290 mRNA Translation: BAB93473.1
AP001178 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01716.1
CH471113 Genomic DNA Translation: EAX01720.1
BC002567 mRNA Translation: AAH02567.1
BC013919 mRNA Translation: AAH13919.1
BC083512 mRNA Translation: AAH83512.1
D00517 Genomic DNA Translation: BAA00404.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11821.1 [P04818-1]
CCDS86658.1 [P04818-2]
CCDS86659.1 [P04818-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A23047 YXHUT

NCBI Reference Sequences

More...RefSeqi		NP_001062.1, NM_001071.2 [P04818-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323224; ENSP00000314727; ENSG00000176890 [P04818-2]
ENST00000323250; ENSP00000314902; ENSG00000176890 [P04818-3]
ENST00000323274; ENSP00000315644; ENSG00000176890 [P04818-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7298

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7298

UCSC genome browser

More...UCSCi		uc010dkb.2 human [P04818-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02308 mRNA Translation: CAA26178.1
D00596 Genomic DNA Translation: BAA00472.1
AB077207 mRNA Translation: BAB83676.1
AB077208 mRNA Translation: BAB83677.1
AB062290 mRNA Translation: BAB93473.1
AP001178 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01716.1
CH471113 Genomic DNA Translation: EAX01720.1
BC002567 mRNA Translation: AAH02567.1
BC013919 mRNA Translation: AAH13919.1
BC083512 mRNA Translation: AAH83512.1
D00517 Genomic DNA Translation: BAA00404.1
CCDSiCCDS11821.1 [P04818-1]
CCDS86658.1 [P04818-2]
CCDS86659.1 [P04818-3]
PIRiA23047 YXHUT
RefSeqiNP_001062.1, NM_001071.2 [P04818-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HVYX-ray1.90A/B/C/D26-313[»]
1HW3X-ray2.00A1-313[»]
1HW4X-ray2.06A1-313[»]
1HZWX-ray2.00A/B1-313[»]
1I00X-ray2.50A/B1-313[»]
1JU6X-ray2.89A/B/C/D1-313[»]
1JUJX-ray3.00A/B/C/D1-313[»]
1YPVX-ray1.80A1-313[»]
2ONBX-ray2.70A1-313[»]
2RD8X-ray2.50A/B1-313[»]
2RDAX-ray2.67A/B/C/D/E/F1-313[»]
3EAWX-ray1.86X1-313[»]
3EBUX-ray2.05A1-313[»]
3ED7X-ray1.56A26-313[»]
3EDWX-ray1.75X1-313[»]
3EF9X-ray3.20A1-313[»]
3EGYX-ray2.18X1-313[»]
3EHIX-ray2.00X1-313[»]
3EJLX-ray3.20A/B/C/D1-313[»]
3GG5X-ray2.77A/B/C/D1-313[»]
3GH0X-ray1.56A1-313[»]
3GH2X-ray1.75X1-313[»]
3H9KX-ray2.65A/B/C/D/E1-313[»]
3HB8X-ray2.74A/B/C/D/E1-313[»]
3N5EX-ray2.26A/B1-313[»]
3N5GX-ray2.27A1-313[»]
3OB7X-ray2.75A/B/C/D/E1-313[»]
4E28X-ray2.30A1-313[»]
4FGTX-ray2.00A1-311[»]
4G2OX-ray2.25X1-313[»]
4G6WX-ray2.30X1-313[»]
4GD7X-ray2.29A1-313[»]
4GYHX-ray3.00A1-313[»]
4H1IX-ray3.10A/B/C/D1-313[»]
4JEFX-ray2.31A26-311[»]
4KPWX-ray2.03A1-313[»]
4O1UX-ray2.26A/B1-313[»]
4O1XX-ray2.32A/B/C/D1-313[»]
4UP1X-ray2.99A/B/C/D1-313[»]
5HS3X-ray3.10A/B/C/D/E/F26-313[»]
5WRNX-ray2.39A/B/C/D/E/F26-313[»]
5X4WX-ray2.10A1-313[»]
5X4XX-ray2.31A1-313[»]
5X4YX-ray2.20A1-313[»]
5X5AX-ray2.39A/B/C/D/E/F26-313[»]
5X5DX-ray2.00A/B/C/D/E/F26-313[»]
5X5QX-ray2.79A/B/C/D/E/F26-313[»]
5X66X-ray1.99A/B/C/D/E/F26-313[»]
5X67X-ray2.13A/B26-313[»]
5X69X-ray2.69A/B/C/D/E/F26-313[»]
DisProtiDP00073
SMRiP04818
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113149, 56 interactors
IntActiP04818, 9 interactors
MINTiP04818
STRINGi9606.ENSP00000315644

Chemistry databases

BindingDBiP04818
ChEMBLiCHEMBL1952
DrugBankiDB03800 2'-deoxyuridylic acid
DB05308 ANX-510
DB01101 Capecitabine
DB00322 Floxuridine
DB00544 Fluorouracil
DB00441 Gemcitabine
DB00563 Methotrexate
DB08478 N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
DB05116 NB1011
DB05457 OSI-7904L
DB00642 Pemetrexed
DB06813 Pralatrexate
DB00293 Raltitrexed
DB01643 Thymidine-5'-Phosphate
DB00432 Trifluridine
DB00440 Trimethoprim
GuidetoPHARMACOLOGYi2642

Protein family/group databases

MoonProtiP04818
UniLectiniP04818

PTM databases

iPTMnetiP04818
PhosphoSitePlusiP04818

Polymorphism and mutation databases

BioMutaiTYMS
DMDMi136611

Proteomic databases

EPDiP04818
jPOSTiP04818
PaxDbiP04818
PeptideAtlasiP04818
PRIDEiP04818
ProteomicsDBi51747
TopDownProteomicsiP04818-1 [P04818-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7298
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323224; ENSP00000314727; ENSG00000176890 [P04818-2]
ENST00000323250; ENSP00000314902; ENSG00000176890 [P04818-3]
ENST00000323274; ENSP00000315644; ENSG00000176890 [P04818-1]
GeneIDi7298
KEGGihsa:7298
UCSCiuc010dkb.2 human [P04818-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7298
DisGeNETi7298

GeneCards: human genes, protein and diseases

More...GeneCardsi		TYMS

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0021150
HGNCiHGNC:12441 TYMS
HPAiCAB002784
MalaCardsiTYMS
MIMi188350 gene
neXtProtiNX_P04818
OpenTargetsiENSG00000176890
Orphaneti240839 5-fluorouracil toxicity
PharmGKBiPA359

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0673 Eukaryota
COG0207 LUCA
GeneTreeiENSGT00390000014786
HOGENOMiHOG000257899
InParanoidiP04818
KOiK00560
OMAiKQYLDLC
OrthoDBi1197342at2759
PhylomeDBiP04818
TreeFamiTF353027

Enzyme and pathway databases

UniPathwayi
UPA00575

BioCyciMetaCyc:HS11096-MONOMER
BRENDAi2.1.1.45 2681
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-69205 G1/S-Specific Transcription
SABIO-RKiP04818
SIGNORiP04818

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TYMS human
EvolutionaryTraceiP04818

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Thymidylate_synthase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7298

Protein Ontology

More...PROi		PR:P04818

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000176890 Expressed in 204 organ(s), highest expression level in liver
ExpressionAtlasiP04818 baseline and differential
GenevisibleiP04818 HS

Family and domain databases

CDDicd00351 TS_Pyrimidine_HMase, 1 hit
Gene3Di3.30.572.10, 1 hit
HAMAPiMF_00008 Thymidy_synth_bact, 1 hit
InterProiView protein in InterPro
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PRINTSiPR00108 THYMDSNTHASE
SUPFAMiSSF55831 SSF55831, 1 hit
TIGRFAMsiTIGR03284 thym_sym, 1 hit
PROSITEiView protein in PROSITE
PS00091 THYMIDYLATE_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYSY_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04818
Secondary accession number(s): Q8WYK3, Q8WYK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
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