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Protein

Heat shock protein 83

Gene

Hsp83

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATPBy similarity1
Binding sitei81ATPBy similarity1
Binding sitei100ATPBy similarity1
Binding sitei126ATP; via amide nitrogenBy similarity1
Binding sitei385ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 83
Alternative name(s):
HSP 82
Gene namesi
Name:Hsp83
Synonyms:Hsp82
ORF Names:GA11622
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012701 Dpse\Hsp83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629341 – 717Heat shock protein 83Add BLAST717

Proteomic databases

PRIDEiP04809

Expressioni

Gene expression databases

BgeeiFBgn0012701 Expressed in 5 organ(s), highest expression level in female reproductive system

Interactioni

Subunit structurei

Homodimer. Interacts with shu (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7237.FBpp0274520

Structurei

3D structure databases

ProteinModelPortaliP04809
SMRiP04809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi713 – 717TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 263Poly-Lys4

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

InParanoidiP04809
KOiK04079
OMAiVKRHSEF
PhylomeDBiP04809

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P04809-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE
60 70 80 90 100
SLTDPSKLDS GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK
110 120 130 140 150
SGTKAFMEAL QAGADISMIG QFGVGFYSAY LIADRVTVTS KNNDDEQYVW
160 170 180 190 200
ESSAGGSFTV KADNSEPLGR GTKIVLYIKE DQTDYLEESK IKEIVNKHSQ
210 220 230 240 250
FIGYPIKLLV EKEREKEVSD DEADDEKKDD EAKKDMDTDE PKIEDVGEDE
260 270 280 290 300
DADKKDKDGK KKKTIKEKYT EDEELNKTKP IWTRNPDDIS QEEYGEFYKS
310 320 330 340 350
LTNDWEDHLC VKHFSVEGQL EFRALLFIPR RTPFDLFENQ KKRNNIKLYV
360 370 380 390 400
RRVFIMDNCE DLIPEYLNFI KGVVDSEDLP LNISREMLQQ NKVLKVIRKN
410 420 430 440 450
LVKKTMELIE ELTEDKENYK KFYEQFSKNL KLGVHEDSNN RAKLADFLRF
460 470 480 490 500
HTSASGDDFC SLSDYVSRMK ENQKHVYFIT GESKDQVSNS AFVERVKARG
510 520 530 540 550
FEVVYMTEPI DEYVIQHLKE YKGKQLVSVT KEGLELPEDE AEKKKREEDK
560 570 580 590 600
AKFEGLCKLM KSILDSKVEK VVVSNRLVDS PCCIVTSQFG WSANMERIMK
610 620 630 640 650
AQALRDTATM GYMAGKKQLE INPDHPIVEA LRQKADADKN DKAVKDLVIL
660 670 680 690 700
LFETSLLSSG FSLDSPQVHA SRIYRMIKLG LGIDEDEPMT TEDAHSGGDA
710
PGLVEDTEDA SHMEEVD
Length:717
Mass (Da):81,771
Last modified:May 30, 2006 - v2
Checksum:iBF46AF2207322273
GO

Sequence cautioni

The sequence EAL30982 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti171G → S in strain: pseudo8 and pseudo9. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA Translation: EAL30982.1 Sequence problems.
X03812 Genomic DNA Translation: CAA27439.1
AF006529 Genomic DNA Translation: AAC07914.1
AF006530 Genomic DNA Translation: AAC07915.1
AF006531 Genomic DNA Translation: AAC07916.1
AF006532 Genomic DNA Translation: AAC07917.1
AF006533 Genomic DNA Translation: AAC07918.1
AF006534 Genomic DNA Translation: AAC07919.1
AF006535 Genomic DNA Translation: AAC07920.1
AF006536 Genomic DNA Translation: AAC07921.1
AF006537 Genomic DNA Translation: AAC07922.1
AF006538 Genomic DNA Translation: AAC07923.1
AF006539 Genomic DNA Translation: AAC07924.1
PIRiC24827
RefSeqiXP_001353471.1, XM_001353435.3

Genome annotation databases

EnsemblMetazoaiFBtr0276082; FBpp0274520; FBgn0012701
GeneIDi4813013
KEGGidpo:Dpse_GA11622

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA Translation: EAL30982.1 Sequence problems.
X03812 Genomic DNA Translation: CAA27439.1
AF006529 Genomic DNA Translation: AAC07914.1
AF006530 Genomic DNA Translation: AAC07915.1
AF006531 Genomic DNA Translation: AAC07916.1
AF006532 Genomic DNA Translation: AAC07917.1
AF006533 Genomic DNA Translation: AAC07918.1
AF006534 Genomic DNA Translation: AAC07919.1
AF006535 Genomic DNA Translation: AAC07920.1
AF006536 Genomic DNA Translation: AAC07921.1
AF006537 Genomic DNA Translation: AAC07922.1
AF006538 Genomic DNA Translation: AAC07923.1
AF006539 Genomic DNA Translation: AAC07924.1
PIRiC24827
RefSeqiXP_001353471.1, XM_001353435.3

3D structure databases

ProteinModelPortaliP04809
SMRiP04809
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7237.FBpp0274520

Proteomic databases

PRIDEiP04809

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0276082; FBpp0274520; FBgn0012701
GeneIDi4813013
KEGGidpo:Dpse_GA11622

Organism-specific databases

FlyBaseiFBgn0012701 Dpse\Hsp83

Phylogenomic databases

InParanoidiP04809
KOiK04079
OMAiVKRHSEF
PhylomeDBiP04809

Miscellaneous databases

ChiTaRSiHsp83 fly

Gene expression databases

BgeeiFBgn0012701 Expressed in 5 organ(s), highest expression level in female reproductive system

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP83_DROPS
AccessioniPrimary (citable) accession number: P04809
Secondary accession number(s): O16059
, O16060, O16061, O16062, O16063, O16064, O16065, O16066, O16067, O18670, Q2M0F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 30, 2006
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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