Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P04809 (HSP83_DROPS)

Entry version 155 (07 Apr 2021)
Sequence version 2 (30 May 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Heat shock protein 83

Gene

Hsp83

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39ATPBy similarity1
Binding sitei81ATPBy similarity1
Binding sitei100ATPBy similarity1
Binding sitei126ATP; via amide nitrogenBy similarity1
Binding sitei385ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock protein 83
Alternative name(s):
HSP 82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hsp83
Synonyms:Hsp82
ORF Names:GA11622
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri46245 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0012701, Dpse\Hsp83

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000629341 – 717Heat shock protein 83Add BLAST717

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P04809

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0012701, Expressed in female reproductive system and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with shu (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7237.FBpp0274520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04809

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi713 – 717TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi260 – 263Poly-Lys4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0019, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006684_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04809

Identification of Orthologs from Complete Genome Data

More...OMAi		IMDNCEQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04809

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.790, 1 hit
3.30.565.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00505, HSP90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR019805, Heat_shock_protein_90_CS
IPR037196, HSP90_C
IPR001404, Hsp90_fam
IPR020575, Hsp90_N
IPR020568, Ribosomal_S5_D2-typ_fold

The PANTHER Classification System

More...PANTHERi		PTHR11528, PTHR11528, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02518, HATPase_c, 1 hit
PF00183, HSP90, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002583, Hsp90, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00775, HEATSHOCK90

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00387, HATPase_c, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110942, SSF110942, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00298, HSP90, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P04809-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE 
        60         70         80         90        100
SLTDPSKLDS GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK 
       110        120        130        140        150
SGTKAFMEAL QAGADISMIG QFGVGFYSAY LIADRVTVTS KNNDDEQYVW 
       160        170        180        190        200
ESSAGGSFTV KADNSEPLGR GTKIVLYIKE DQTDYLEESK IKEIVNKHSQ 
       210        220        230        240        250
FIGYPIKLLV EKEREKEVSD DEADDEKKDD EAKKDMDTDE PKIEDVGEDE 
       260        270        280        290        300
DADKKDKDGK KKKTIKEKYT EDEELNKTKP IWTRNPDDIS QEEYGEFYKS 
       310        320        330        340        350
LTNDWEDHLC VKHFSVEGQL EFRALLFIPR RTPFDLFENQ KKRNNIKLYV 
       360        370        380        390        400
RRVFIMDNCE DLIPEYLNFI KGVVDSEDLP LNISREMLQQ NKVLKVIRKN 
       410        420        430        440        450
LVKKTMELIE ELTEDKENYK KFYEQFSKNL KLGVHEDSNN RAKLADFLRF 
       460        470        480        490        500
HTSASGDDFC SLSDYVSRMK ENQKHVYFIT GESKDQVSNS AFVERVKARG 
       510        520        530        540        550
FEVVYMTEPI DEYVIQHLKE YKGKQLVSVT KEGLELPEDE AEKKKREEDK 
       560        570        580        590        600
AKFEGLCKLM KSILDSKVEK VVVSNRLVDS PCCIVTSQFG WSANMERIMK 
       610        620        630        640        650
AQALRDTATM GYMAGKKQLE INPDHPIVEA LRQKADADKN DKAVKDLVIL 
       660        670        680        690        700
LFETSLLSSG FSLDSPQVHA SRIYRMIKLG LGIDEDEPMT TEDAHSGGDA 
       710 
PGLVEDTEDA SHMEEVD
Length:717
Mass (Da):81,771
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF46AF2207322273
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAL30982 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti171G → S in strain: pseudo8 and pseudo9. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH379069 Genomic DNA Translation: EAL30982.1 Sequence problems.
X03812 Genomic DNA Translation: CAA27439.1
AF006529 Genomic DNA Translation: AAC07914.1
AF006530 Genomic DNA Translation: AAC07915.1
AF006531 Genomic DNA Translation: AAC07916.1
AF006532 Genomic DNA Translation: AAC07917.1
AF006533 Genomic DNA Translation: AAC07918.1
AF006534 Genomic DNA Translation: AAC07919.1
AF006535 Genomic DNA Translation: AAC07920.1
AF006536 Genomic DNA Translation: AAC07921.1
AF006537 Genomic DNA Translation: AAC07922.1
AF006538 Genomic DNA Translation: AAC07923.1
AF006539 Genomic DNA Translation: AAC07924.1

Protein sequence database of the Protein Information Resource

More...PIRi		C24827

NCBI Reference Sequences

More...RefSeqi		XP_001353471.1, XM_001353435.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0276082; FBpp0274520; FBgn0012701

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4813013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dpo:Dpse_GA11622

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA Translation: EAL30982.1 Sequence problems.
X03812 Genomic DNA Translation: CAA27439.1
AF006529 Genomic DNA Translation: AAC07914.1
AF006530 Genomic DNA Translation: AAC07915.1
AF006531 Genomic DNA Translation: AAC07916.1
AF006532 Genomic DNA Translation: AAC07917.1
AF006533 Genomic DNA Translation: AAC07918.1
AF006534 Genomic DNA Translation: AAC07919.1
AF006535 Genomic DNA Translation: AAC07920.1
AF006536 Genomic DNA Translation: AAC07921.1
AF006537 Genomic DNA Translation: AAC07922.1
AF006538 Genomic DNA Translation: AAC07923.1
AF006539 Genomic DNA Translation: AAC07924.1
PIRiC24827
RefSeqiXP_001353471.1, XM_001353435.3

3D structure databases

SMRiP04809
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7237.FBpp0274520

Proteomic databases

PRIDEiP04809

Genome annotation databases

EnsemblMetazoaiFBtr0276082; FBpp0274520; FBgn0012701
GeneIDi4813013
KEGGidpo:Dpse_GA11622

Organism-specific databases

FlyBaseiFBgn0012701, Dpse\Hsp83

Phylogenomic databases

eggNOGiKOG0019, Eukaryota
HOGENOMiCLU_006684_1_3_1
InParanoidiP04809
OMAiIMDNCEQ
PhylomeDBiP04809

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Hsp83, fly

Gene expression databases

BgeeiFBgn0012701, Expressed in female reproductive system and 4 other tissues

Family and domain databases

Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505, HSP90, 1 hit
InterProiView protein in InterPro
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR019805, Heat_shock_protein_90_CS
IPR037196, HSP90_C
IPR001404, Hsp90_fam
IPR020575, Hsp90_N
IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528, PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518, HATPase_c, 1 hit
PF00183, HSP90, 1 hit
PIRSFiPIRSF002583, Hsp90, 1 hit
PRINTSiPR00775, HEATSHOCK90
SMARTiView protein in SMART
SM00387, HATPase_c, 1 hit
SUPFAMiSSF110942, SSF110942, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298, HSP90, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP83_DROPS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04809
Secondary accession number(s): O16059
, O16060, O16061, O16062, O16063, O16064, O16065, O16066, O16067, O18670, Q2M0F2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 30, 2006
Last modified: April 7, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again