UniProtKB - P04800 (CP3A1_RAT)
Protein
Cytochrome P450 3A1
Gene
Cyp3a1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 443 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- demethylase activity Source: RGD
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- steroid hydroxylase activity Source: GO_Central
- testosterone 6-beta-hydroxylase activity Source: RGD
GO - Biological processi
- aging Source: RGD
- drug metabolic process Source: RGD
- oxidative demethylation Source: RGD
- response to cadmium ion Source: RGD
- response to drug Source: RGD
- response to glucocorticoid Source: RGD
- response to metal ion Source: RGD
- response to nutrient Source: RGD
- steroid metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.1, 5301 |
Reactomei | R-RNO-211958, Miscellaneous substrates R-RNO-211981, Xenobiotics R-RNO-5423646, Aflatoxin activation and detoxification |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp3a1 Synonyms:Cyp3a-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628626, Cyp3a1 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: RGD
Other locations
- intracellular membrane-bounded organelle Source: RGD
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3323 |
DrugBanki | DB13746, Bioallethrin DB01645, Genistein DB00603, Medroxyprogesterone acetate DB08834, Tauroursodeoxycholic acid |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051783 | 1 – 504 | Cytochrome P450 3A1Add BLAST | 504 |
Proteomic databases
PaxDbi | P04800 |
PRIDEi | P04800 |
PTM databases
iPTMneti | P04800 |
PhosphoSitePlusi | P04800 |
Expressioni
Inductioni
By pregnenolone 16-alpha-carbonitrile (PNCN).
Interactioni
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065082 |
Chemistry databases
BindingDBi | P04800 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P04800 |
PhylomeDBi | P04800 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P04800-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLLSALTLE TWVLLAVVLV LLYGFGTRTH GLFKKQGIPG PKPLPFFGTV
60 70 80 90 100
LNYYMGLWKF DVECHKKYGK IWGLFDGQMP LFAITDTEMI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMGKAVSV AKDEEWKRYR ALLSPTFTSG RLKEMFPIIE
160 170 180 190 200
QYGDILVKYL KQEAETGKPV TMKKVFGAYS MDVITSTSFG VNVDSLNNPK
210 220 230 240 250
DPFVEKTKKL LRFDFFDPLF LSVVLFPFLT PIYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVYRMKETR LDSVQKHRVD FLQLMMNAHN DSKDKESHTA LSDMEITAQS
310 320 330 340 350
IIFIFAGYEP TSSTLSFVLH SLATHPDTQK KLQEEIDRAL PNKAPPTYDT
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI GNRLERVCKK DVEINGVFMP KGSVVMIPSY
410 420 430 440 450
ALHRDPQHWP EPEEFRPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL
460 470 480 490 500
MNMKLALTKV LQNFSFQPCK ETQIPLKLSR QGLLQPTKPI ILKVVPRDEI
ITGS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ06884 | Q06884_RAT | Unspecific monooxygenase | Cyp3a23/3a1 3a1, CYP3A1, CYP3A23, Cyp3a23, Cyp3a73 | 502 | Annotation score: | ||
A0A0G2JT98 | A0A0G2JT98_RAT | Unspecific monooxygenase | LOC100910877 Cyp3a23/3a1 | 502 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 207 | T → A in strain: Wistar. | 1 | |
Natural varianti | 213 | F → I in strain: Wistar. | 1 | |
Natural varianti | 232 | I → V in strain: Wistar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10161 mRNA Translation: AAA41035.1 X64401 mRNA Translation: CAA45743.1 M86850 Genomic DNA Translation: AAA41780.1 X62086 Genomic DNA No translation available. |
PIRi | A22631 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10161 mRNA Translation: AAA41035.1 X64401 mRNA Translation: CAA45743.1 M86850 Genomic DNA Translation: AAA41780.1 X62086 Genomic DNA No translation available. |
PIRi | A22631 |
3D structure databases
SMRi | P04800 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065082 |
Chemistry databases
BindingDBi | P04800 |
ChEMBLi | CHEMBL3323 |
DrugBanki | DB13746, Bioallethrin DB01645, Genistein DB00603, Medroxyprogesterone acetate DB08834, Tauroursodeoxycholic acid |
PTM databases
iPTMneti | P04800 |
PhosphoSitePlusi | P04800 |
Proteomic databases
PaxDbi | P04800 |
PRIDEi | P04800 |
Organism-specific databases
RGDi | 628626, Cyp3a1 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P04800 |
PhylomeDBi | P04800 |
Enzyme and pathway databases
BRENDAi | 1.14.14.1, 5301 |
Reactomei | R-RNO-211958, Miscellaneous substrates R-RNO-211981, Xenobiotics R-RNO-5423646, Aflatoxin activation and detoxification |
Miscellaneous databases
PROi | PR:P04800 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3A1_RAT | |
Accessioni | P04800Primary (citable) accession number: P04800 Secondary accession number(s): Q64580 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | August 12, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families