CYP1A1

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityⁱ

an alkane
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
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O₂
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reduced [NADPH—hemoprotein reductase]
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a primary alcohol
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See the description of this molecule in ChEBI.
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H⁺
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See the description of this molecule in ChEBI.
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H₂O
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See the description of this molecule in ChEBI.
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oxidized [NADPH—hemoprotein reductase]
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EC:1.14.14.1
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
an alkane
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O₂
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reduced [NADPH—hemoprotein reductase]
FMNH₂
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=
a primary alcohol
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H⁺
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H₂O
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oxidized [NADPH—hemoprotein reductase]
FMN
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Cofactorⁱ

heme1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	224	Substrate1 Publication		1
Metal bindingⁱ	457	Iron (heme axial ligand)1 Publication		1

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
demethylase activity Source: Ensembl
enzyme binding Source: Ensembl
estrogen 16-alpha-hydroxylase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
flavonoid 3'-monooxygenase activity Source: Ensembl
heme binding Source: InterPro
iron ion binding Source: InterPro
monooxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidoreductase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19219744
oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
oxygen binding
Source: ProtInc
Traceable author statementⁱ
- 1691986
vitamin D 24-hydroxylase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15546903

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

9-cis-retinoic acid biosynthetic process Source: Ensembl
aging Source: Ensembl
amine metabolic process Source: Ensembl
camera-type eye development Source: Ensembl
cell proliferation Source: Ensembl
cellular response to copper ion Source: Ensembl
cellular response to organic cyclic compound
Source: MGI
Inferred from direct assayⁱ
- 23275542
coumarin metabolic process Source: Ensembl
dibenzo-p-dioxin catabolic process Source: Ensembl
digestive tract development Source: Ensembl
drug metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19219744
epoxygenase P450 pathway Source: Reactome
ethylene metabolic process Source: Reactome
flavonoid metabolic process Source: Ensembl
hepatocyte differentiation Source: Ensembl
hydrogen peroxide biosynthetic process Source: Ensembl
insecticide metabolic process Source: Ensembl
lipid hydroxylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
long-chain fatty acid biosynthetic process Source: Reactome
maternal process involved in parturition Source: Ensembl
omega-hydroxylase P450 pathway Source: Reactome
oxidation-reduction process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19219744
porphyrin-containing compound metabolic process Source: Ensembl
positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
regulation of lipid metabolic process Source: Reactome
response to antibiotic Source: Ensembl
response to arsenic-containing substance Source: Ensembl
response to drug Source: Ensembl
response to food Source: Ensembl
response to herbicide Source: Ensembl
response to hyperoxia Source: Ensembl
response to hypoxia Source: Ensembl
response to immobilization stress Source: Ensembl
response to iron(III) ion Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to nematode Source: Ensembl
response to virus Source: Ensembl
response to vitamin A Source: Ensembl
response to wounding Source: Ensembl
steroid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
vitamin D metabolic process
Source: BHF-UCL
Inferred by curatorⁱ
- 15546903

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-211981 Xenobiotics R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9018681 Biosynthesis of protectins
SABIO-RKⁱ	P04798
SIGNORⁱ	P04798

Chemistry databases

SwissLipidsⁱ	SLP:000001329

SwissLipidsⁱ

SLP:000001329

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 1A1 (EC:1.14.14.1) Alternative name(s): CYPIA1 Cytochrome P450 form 6 Cytochrome P450-C Cytochrome P450-P1
Gene namesⁱ	Name:CYP1A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140465.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2595 CYP1A1
MIMⁱ	108330 gene
neXtProtⁱ	NX_P04798

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1543
Open Targets More...OpenTargetsⁱ	ENSG00000140465
PharmGKBⁱ	PA27092

Chemistry databases

ChEMBLⁱ	CHEMBL2231
Drug and drug target database More...DrugBankⁱ	DB02342 2-Methoxyestradiol DB00316 Acetaminophen DB00518 Albendazole DB01118 Amiodarone DB00381 Amlodipine DB00613 Amodiaquine DB01169 Arsenic trioxide DB00972 Azelastine DB04957 Azimilide DB04975 Banoxantrone DB06770 Benzyl alcohol DB01393 Bezafibrate DB00201 Caffeine DB01136 Carvedilol DB00608 Chloroquine DB00356 Chlorzoxazone DB00169 Cholecalciferol DB00568 Cinnarizine DB01407 Clenbuterol DB01013 Clobetasol propionate DB00636 Clofibrate DB00882 Clomifene DB00575 Clonidine DB00363 Clozapine DB00851 Dacarbazine DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB04840 Debrisoquin DB01234 Dexamethasone DB00633 Dexmedetomidine DB00586 Diclofenac DB00804 Dicyclomine DB00470 Dronabinol DB08846 Ellagic Acid DB00530 Erlotinib DB00783 Estradiol DB00655 Estrone DB00898 Ethanol DB04841 Flunarizine DB00693 Fluorescein DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00317 Gefitinib DB00889 Granisetron DB00502 Haloperidol DB01064 Isoprenaline DB01167 Itraconazole DB01026 Ketoconazole DB00448 Lansoprazole DB04871 Lorcaserin DB00643 Mebendazole DB01065 Melatonin DB00170 Menadione DB00553 Methoxsalen DB01388 Mibefradil DB00184 Nicotine DB01115 Nifedipine DB00325 Nitroprusside DB01059 Norfloxacin DB00338 Omeprazole DB01092 Ouabain DB00526 Oxaliplatin DB00738 Pentamidine DB03783 Phenacetin DB01174 Phenobarbital DB00466 Picrotoxin DB00457 Prazosin DB01087 Primaquine DB00396 Progesterone DB00818 Propofol DB00571 Propranolol DB00165 Pyridoxine DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB02709 Resveratrol DB00740 Riluzole DB08931 Riociguat DB06176 Romidepsin DB00203 Sildenafil DB00428 Streptozocin DB00605 Sulindac DB00675 Tamoxifen DB04905 Tesmilifene DB00624 Testosterone DB01041 Thalidomide DB00277 Theophylline DB00730 Thiabendazole DB00208 Ticlopidine DB00539 Toremifene DB00755 Tretinoin DB00197 Troglitazone DB00162 Vitamin A DB00682 Warfarin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1318

Polymorphism and mutation databases

BioMutaⁱ	CYP1A1
DMDMⁱ	117139

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051627	1 – 512	Cytochrome P450 1A1Add BLAST		512

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	67	O-linked (GlcNAc) serineBy similarity		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P04798
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04798
PaxDbⁱ	P04798
PeptideAtlas More...PeptideAtlasⁱ	P04798
PRIDEⁱ	P04798
ProteomicsDBⁱ	51744

PTM databases

iPTMnetⁱ	P04798
PhosphoSitePlusⁱ	P04798

Expressionⁱ

Tissue specificityⁱ

Lung, lymphocytes and placenta.

Inductionⁱ

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Gene expression databases

Bgeeⁱ	ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP1A1
ExpressionAtlasⁱ	P04798 baseline and differential
Genevisibleⁱ	P04798 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB018654

HPAⁱ

CAB018654

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CMTM5	Q96DZ9	3	EBI-10194262,EBI-2548702
CMTM5	Q96DZ9-2	3	EBI-10194262,EBI-11522780

GO - Molecular functionⁱ

enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107923, 76 interactors
IntActⁱ	P04798, 1 interactor
STRINGⁱ	9606.ENSP00000369050

Chemistry databases

BindingDBⁱ

P04798

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	47 – 49	Combined sources	3
Helixⁱ	52 – 55	Combined sources	4
Helixⁱ	59 – 70	Combined sources	12
Beta strandⁱ	72 – 78	Combined sources	7
Beta strandⁱ	81 – 86	Combined sources	6
Helixⁱ	89 – 96	Combined sources	8
Turnⁱ	97 – 99	Combined sources	3
Helixⁱ	100 – 103	Combined sources	4
Helixⁱ	110 – 114	Combined sources	5
Helixⁱ	116 – 118	Combined sources	3
Turnⁱ	121 – 123	Combined sources	3
Helixⁱ	129 – 145	Combined sources	17
Helixⁱ	158 – 179	Combined sources	22
Helixⁱ	186 – 203	Combined sources	18
Helixⁱ	212 – 218	Combined sources	7
Beta strandⁱ	219 – 221	Combined sources	3
Helixⁱ	224 – 228	Combined sources	5
Helixⁱ	233 – 235	Combined sources	3
Helixⁱ	238 – 242	Combined sources	5
Helixⁱ	246 – 271	Combined sources	26
Helixⁱ	281 – 292	Combined sources	12
Beta strandⁱ	296 – 298	Combined sources	3
Beta strandⁱ	300 – 302	Combined sources	3
Helixⁱ	304 – 308	Combined sources	5
Helixⁱ	310 – 334	Combined sources	25
Helixⁱ	337 – 350	Combined sources	14
Helixⁱ	359 – 364	Combined sources	6
Helixⁱ	366 – 379	Combined sources	14
Beta strandⁱ	394 – 396	Combined sources	3
Beta strandⁱ	399 – 401	Combined sources	3
Beta strandⁱ	406 – 410	Combined sources	5
Helixⁱ	411 – 415	Combined sources	5
Turnⁱ	418 – 420	Combined sources	3
Helixⁱ	429 – 432	Combined sources	4
Beta strandⁱ	435 – 437	Combined sources	3
Helixⁱ	441 – 444	Combined sources	4
Helixⁱ	453 – 455	Combined sources	3
Helixⁱ	460 – 477	Combined sources	18
Beta strandⁱ	478 – 481	Combined sources	4
Beta strandⁱ	495 – 497	Combined sources	3
Beta strandⁱ	506 – 510	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P04798
SMRⁱ	P04798
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153539
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG106944
InParanoidⁱ	P04798
KEGG Orthology (KO) More...KOⁱ	K07408
OMAⁱ	WEKCLVE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P04798
TreeFamⁱ	TF105095

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P04798-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG 
        60         70         80         90        100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG 
       110        120        130        140        150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD 
       160        170        180        190        200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA 
       210        220        230        240        250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA 
       260        270        280        290        300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
       310        320        330        340        350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV 
       360        370        380        390        400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 
       410        420        430        440        450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF 
       460        470        480        490        500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH 
       510 
ACCEHFQMQL RS

Length:512

Mass (Da):58,165

Last modified:April 1, 1988 - v1

Checksum:ⁱ3C62366044148EFD

GO

Isoform 2 (identifier: P04798-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
189-189: Y → T
190-512: Missing.

« Hide

        10         20         30         40         50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG 
        60         70         80         90        100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG 
       110        120        130        140        150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD 
       160        170        180 
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRT

Note: No experimental confirmation available.

Show »

Length:189

Mass (Da):20,788

Checksum:ⁱ6F774C4E9FC85427

GO

Isoform 3 (identifier: P04798-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-261: Missing.
419-512: Missing.

« Hide

        10         20         30         40         50
MQKMVKEHYK TFEKGHIRDI TDSLIEHCQE KQLDENANVQ LSDEKIINIV 
        60         70         80         90        100
LDLFGAGFDT VTTAISWSLM YLVMNPRVQR KIQEELDTVI GRSRRPRLSD 
       110        120        130        140        150
RSHLPYMEAF ILETFRHSSF VPFTIPHSTT RDTSLKGFYI PKGRCVFVNQ 

WQINHDQ

Note: No experimental confirmation available.

Show »

Length:157

Mass (Da):18,441

Checksum:ⁱD0AE3E0EEA55B854

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5J9B1	Q5J9B1_HUMAN	Cytochrome P450 Cytochrome P450, EC 1.14.14.1	CYP1A1	484	Annotation score:
E7EMT5	E7EMT5_HUMAN	Cytochrome P450 Cytochrome P450, EC 1.14.14.1	CYP1A1	483	Annotation score:
A4F3V8	A4F3V8_HUMAN	Cytochrome P450 1A1 Cytochrome P450 1A1	CYP1A1	175	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	I → M in AAA52139 (PubMed:3838385).Curated	1
Sequence conflictⁱ	235	D → E in AAA52139 (PubMed:3838385).Curated	1
Sequence conflictⁱ	381	F → L in CAA26458 (PubMed:2989797).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023194	45	G → D3 PublicationsCorresponds to variant dbSNP:rs4646422Ensembl.	1
Natural variantⁱVAR_033817	66	M → V. Corresponds to variant dbSNP:rs35035798Ensembl.	1
Natural variantⁱVAR_023195	78	I → T2 PublicationsCorresponds to variant dbSNP:rs17861094Ensembl.	1
Natural variantⁱVAR_024706	93	R → W1 PublicationCorresponds to variant dbSNP:rs2229150Ensembl.	1
Natural variantⁱVAR_024707	173	T → R1 PublicationCorresponds to variant dbSNP:rs28399427Ensembl.	1
Natural variantⁱVAR_009280	279	R → W1 PublicationCorresponds to variant dbSNP:rs34260157Ensembl.	1
Natural variantⁱVAR_020122	286	I → T. Corresponds to variant dbSNP:rs4987133Ensembl.	1
Natural variantⁱVAR_016937	331	M → I in allele CYP1A1*6. 1 PublicationCorresponds to variant dbSNP:rs56313657Ensembl.	1
Natural variantⁱVAR_016938	448	I → N in allele CYP1A1*8. 1 PublicationCorresponds to variant dbSNP:rs72547509Ensembl.	1
Natural variantⁱVAR_008342	461	T → N in allele CYP1A1*4. 3 PublicationsCorresponds to variant dbSNP:rs1799814Ensembl.	1
Natural variantⁱVAR_001243	462	I → V in allele CYP1A12B and allele CYP1A12C. 2 PublicationsCorresponds to variant dbSNP:rs1048943Ensembl.	1
Natural variantⁱVAR_016939	464	R → C in allele CYP1A1*9. 1 PublicationCorresponds to variant dbSNP:rs41279188Ensembl.	1
Natural variantⁱVAR_016940	464	R → S in allele CYP1A1*5. 1 PublicationCorresponds to variant dbSNP:rs41279188Ensembl.	1
Natural variantⁱVAR_033818	470	F → V. Corresponds to variant dbSNP:rs36121583Ensembl.	1
Natural variantⁱVAR_016941	477	R → W in allele CYP1A1*10. 2 PublicationsCorresponds to variant dbSNP:rs56240201Ensembl.	1
Natural variantⁱVAR_024708	482	V → M1 PublicationCorresponds to variant dbSNP:rs28399429Ensembl.	1
Natural variantⁱVAR_016942	492	P → R in allele CYP1A1*11. 2 PublicationsCorresponds to variant dbSNP:rs28399430Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053363	1 – 261	Missing in isoform 3. 1 PublicationAdd BLAST	261
Alternative sequenceⁱVSP_053364	189	Y → T in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_053365	190 – 512	Missing in isoform 2. 1 PublicationAdd BLAST	323
Alternative sequenceⁱVSP_053366	419 – 512	Missing in isoform 3. 1 PublicationAdd BLAST	94

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02612 Genomic DNA Translation: CAA26458.1 K03191 mRNA Translation: AAA52139.1 X04300 Genomic DNA Translation: CAA27843.1 AF253322 Genomic DNA Translation: AAK25727.1 AM233518 mRNA Translation: CAJ80721.1 AM233519 mRNA Translation: CAJ80722.1 AM233520 mRNA Translation: CAJ80723.1 AK223113 mRNA Translation: BAD96833.1 AC091230 Genomic DNA No translation available. BC023019 mRNA Translation: AAH23019.1 M12079 mRNA Translation: AAA52152.1 AF040259 mRNA Translation: AAD10199.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10268.1 [P04798-1]
PIRⁱ	A24797 O4HU6
NCBI Reference Sequences More...RefSeqⁱ	NP_000490.1, NM_000499.4 [P04798-1] NP_001306145.1, NM_001319216.1 NP_001306146.1, NM_001319217.1 [P04798-1]
UniGeneⁱ	Hs.72912

Genome annotation databases

Ensemblⁱ	ENST00000379727; ENSP00000369050; ENSG00000140465 [P04798-1] ENST00000395048; ENSP00000378488; ENSG00000140465 [P04798-1] ENST00000562201; ENSP00000455340; ENSG00000140465 [P04798-2] ENST00000564596; ENSP00000457668; ENSG00000140465 [P04798-3] ENST00000567032; ENSP00000456585; ENSG00000140465 [P04798-1] ENST00000569630; ENSP00000455051; ENSG00000140465 [P04798-2]
GeneIDⁱ	1543
KEGGⁱ	hsa:1543
UCSC genome browser More...UCSCⁱ	uc002ayp.4 human [P04798-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04798	Cytochrome P450		HUMAN		512	UniRef100_P04798
CYP1A1 isoform 8 (Fragment)		PANTR		175
Cytochrome P450		HUMAN		251
Cytochrome P450 1A1 (Fragment)		HUMAN		175
CYP1A1 isoform 7		PANTR		157
+1

Protein	Similar proteins		Species	Score	Length	Source
P04798	Cytochrome P450 1A1		MACFA		512	UniRef90_P04798
Cytochrome P450 1A1		MACMU		512
Cytochrome P450		HUMAN		512
CYP1A1 isoform 8 (Fragment)		PANTR		175
Cytochrome P450		RHIRO		524
+33
P04798-2	Cytochrome P450 family 1 subfamily A member 1		PANTR		230	UniRef90_P04798-2
Cytochrome P450 family 1 subfamily A member 1		PANPA		230
Cytochrome P450 1A1		HUMAN		229
Cytochrome P450 family 1 subfamily A member 1		GORGO		222
CYP1A1 isoform 10		PONAB		189
+1

Protein	Similar proteins		Species	Score	Length	Source
P04798	Cytochrome P450 1A2	)	HUMAN		516	UniRef50_P05177
Cytochrome P450 1A2		PONAB		516
Cytochrome P450 1A1		PAGMA		515
Cytochrome P450 1A4		CHICK		530
Cytochrome P450 1A1		OPSTA		521
+755
P04798-2	Cytochrome P450 family 1 subfamily A member 1		PANTR		230	UniRef50_P04798-2
Cytochrome P450 family 1 subfamily A member 1		PANPA		230
Cytochrome P450 1A1		HUMAN		229
Cytochrome P450 family 1 subfamily A member 1		GORGO		222
CYP1A1 isoform 10		PONAB		189
+6

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP1A1 alleles

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

CYP1A1 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02612 Genomic DNA Translation: CAA26458.1 K03191 mRNA Translation: AAA52139.1 X04300 Genomic DNA Translation: CAA27843.1 AF253322 Genomic DNA Translation: AAK25727.1 AM233518 mRNA Translation: CAJ80721.1 AM233519 mRNA Translation: CAJ80722.1 AM233520 mRNA Translation: CAJ80723.1 AK223113 mRNA Translation: BAD96833.1 AC091230 Genomic DNA No translation available. BC023019 mRNA Translation: AAH23019.1 M12079 mRNA Translation: AAA52152.1 AF040259 mRNA Translation: AAD10199.1
CCDSⁱ	CCDS10268.1 [P04798-1]
PIRⁱ	A24797 O4HU6
RefSeqⁱ	NP_000490.1, NM_000499.4 [P04798-1] NP_001306145.1, NM_001319216.1 NP_001306146.1, NM_001319217.1 [P04798-1]
UniGeneⁱ	Hs.72912

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4I8V	X-ray	2.60	A/B/C/D	35-512	[»]
	6DWM	X-ray	2.85	A/B/C/D	35-512	[»]
	6DWN	X-ray	3.00	A/B/C/D	35-512	[»]
ProteinModelPortalⁱ	P04798
SMRⁱ	P04798
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107923, 76 interactors
IntActⁱ	P04798, 1 interactor
STRINGⁱ	9606.ENSP00000369050

Chemistry databases

BindingDBⁱ	P04798
ChEMBLⁱ	CHEMBL2231
DrugBankⁱ	DB02342 2-Methoxyestradiol DB00316 Acetaminophen DB00518 Albendazole DB01118 Amiodarone DB00381 Amlodipine DB00613 Amodiaquine DB01169 Arsenic trioxide DB00972 Azelastine DB04957 Azimilide DB04975 Banoxantrone DB06770 Benzyl alcohol DB01393 Bezafibrate DB00201 Caffeine DB01136 Carvedilol DB00608 Chloroquine DB00356 Chlorzoxazone DB00169 Cholecalciferol DB00568 Cinnarizine DB01407 Clenbuterol DB01013 Clobetasol propionate DB00636 Clofibrate DB00882 Clomifene DB00575 Clonidine DB00363 Clozapine DB00851 Dacarbazine DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB04840 Debrisoquin DB01234 Dexamethasone DB00633 Dexmedetomidine DB00586 Diclofenac DB00804 Dicyclomine DB00470 Dronabinol DB08846 Ellagic Acid DB00530 Erlotinib DB00783 Estradiol DB00655 Estrone DB00898 Ethanol DB04841 Flunarizine DB00693 Fluorescein DB00499 Flutamide DB01095 Fluvastatin DB00176 Fluvoxamine DB00317 Gefitinib DB00889 Granisetron DB00502 Haloperidol DB01064 Isoprenaline DB01167 Itraconazole DB01026 Ketoconazole DB00448 Lansoprazole DB04871 Lorcaserin DB00643 Mebendazole DB01065 Melatonin DB00170 Menadione DB00553 Methoxsalen DB01388 Mibefradil DB00184 Nicotine DB01115 Nifedipine DB00325 Nitroprusside DB01059 Norfloxacin DB00338 Omeprazole DB01092 Ouabain DB00526 Oxaliplatin DB00738 Pentamidine DB03783 Phenacetin DB01174 Phenobarbital DB00466 Picrotoxin DB00457 Prazosin DB01087 Primaquine DB00396 Progesterone DB00818 Propofol DB00571 Propranolol DB00165 Pyridoxine DB00908 Quinidine DB00468 Quinine DB01129 Rabeprazole DB02709 Resveratrol DB00740 Riluzole DB08931 Riociguat DB06176 Romidepsin DB00203 Sildenafil DB00428 Streptozocin DB00605 Sulindac DB00675 Tamoxifen DB04905 Tesmilifene DB00624 Testosterone DB01041 Thalidomide DB00277 Theophylline DB00730 Thiabendazole DB00208 Ticlopidine DB00539 Toremifene DB00755 Tretinoin DB00197 Troglitazone DB00162 Vitamin A DB00682 Warfarin
GuidetoPHARMACOLOGYⁱ	1318
SwissLipidsⁱ	SLP:000001329

PTM databases

iPTMnetⁱ	P04798
PhosphoSitePlusⁱ	P04798

Polymorphism and mutation databases

BioMutaⁱ	CYP1A1
DMDMⁱ	117139

Proteomic databases

EPDⁱ	P04798
MaxQBⁱ	P04798
PaxDbⁱ	P04798
PeptideAtlasⁱ	P04798
PRIDEⁱ	P04798
ProteomicsDBⁱ	51744

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1543
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379727; ENSP00000369050; ENSG00000140465 [P04798-1] ENST00000395048; ENSP00000378488; ENSG00000140465 [P04798-1] ENST00000562201; ENSP00000455340; ENSG00000140465 [P04798-2] ENST00000564596; ENSP00000457668; ENSG00000140465 [P04798-3] ENST00000567032; ENSP00000456585; ENSG00000140465 [P04798-1] ENST00000569630; ENSP00000455051; ENSG00000140465 [P04798-2]
GeneIDⁱ	1543
KEGGⁱ	hsa:1543
UCSCⁱ	uc002ayp.4 human [P04798-1]

Organism-specific databases

CTDⁱ	1543
DisGeNETⁱ	1543
EuPathDBⁱ	HostDB:ENSG00000140465.13
GeneCardsⁱ	CYP1A1
HGNCⁱ	HGNC:2595 CYP1A1
HPAⁱ	CAB018654
MIMⁱ	108330 gene
neXtProtⁱ	NX_P04798
OpenTargetsⁱ	ENSG00000140465
PharmGKBⁱ	PA27092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00940000153539
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG106944
InParanoidⁱ	P04798
KOⁱ	K07408
OMAⁱ	WEKCLVE
OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P04798
TreeFamⁱ	TF105095

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-211981 Xenobiotics R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9018681 Biosynthesis of protectins
SABIO-RKⁱ	P04798
SIGNORⁱ	P04798

Miscellaneous databases

ChiTaRSⁱ	CYP1A1 human
GeneWikiⁱ	Cytochrome_P450,_family_1,_member_A1
GenomeRNAiⁱ	1543
Protein Ontology More...PROⁱ	PR:P04798
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140465 Expressed in 111 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP1A1
ExpressionAtlasⁱ	P04798 baseline and differential
Genevisibleⁱ	P04798 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008066 Cyt_P450_E_grp-I_CYP1 IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01683 EP450ICYP1A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP1A1_HUMAN
Accessionⁱ	P04798Primary (citable) accession number: P04798 Secondary accession number(s): A4F3V9, A4F3W0, Q53G18
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	April 1, 1988
	Last modified:	December 5, 2018
	This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P04798 (CP1A1_HUMAN)

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Cytochrome P450 1A1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Mitochondrion

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ