UniProtKB - P04798 (CP1A1_HUMAN)
Protein
Cytochrome P450 1A1
Gene
CYP1A1
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).10 Publications
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]4 PublicationsEC:1.14.14.14 PublicationsThis reaction proceeds in the backward4 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 4-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 6α-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 15α-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 16α-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsThis reaction proceeds in the forward3 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 4-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 6α-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 7α-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 15α-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinol + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-retinal + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinal + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-retinoate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O1 PublicationEC:4.2.1.1521 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
heme1 Publication
Kineticsi
- KM=8 µM for all-trans retinol1 Publication
- KM=9.5 µM for 17beta-estradiol (2-hydroxylation)1 Publication
- KM=11.8 µM for 17beta-estradiol (4-hydroxylation)1 Publication
- KM=79 µM for 17beta-estradiol (6alpha-hydroxylation)1 Publication
- KM=19.6 µM for 17beta-estradiol (15alpha-hydroxylation)1 Publication
- KM=12.2 µM for estrone (2-hydroxylation)1 Publication
- KM=22.6 µM for estrone (4-hydroxylation)1 Publication
- KM=86 µM for estrone (6alpha-hydroxylation)1 Publication
- KM=85 µM for estrone (15alpha-hydroxylation)1 Publication
- Vmax=507 pmol/min/nmol enzyme toward all-trans retinol1 Publication
- Vmax=0.6 pmol/min/pmol enzyme toward 17beta-estradiol (2-hydroxylation)1 Publication
- Vmax=0.02 pmol/min/pmol enzyme toward 17beta-estradiol (4-hydroxylation)1 Publication
- Vmax=3.6 pmol/min/pmol enzyme toward 17beta-estradiol (6alpha-hydroxylation)1 Publication
- Vmax=0.9 pmol/min/pmol enzyme toward 17beta-estradiol (15alpha-hydroxylation)1 Publication
- Vmax=0.4 pmol/min/pmol enzyme toward estrone (2-hydroxylation)1 Publication
- Vmax=0.1 pmol/min/pmol enzyme toward estrone (4-hydroxylation)1 Publication
- Vmax=0.2 pmol/min/pmol enzyme toward estrone (6alpha-hydroxylation)1 Publication
- Vmax=1.2 pmol/min/pmol enzyme toward estrone (15alpha-hydroxylation)1 Publication
: Steroid hormone biosynthesis Pathwayi
This protein is involved in Steroid hormone biosynthesis.4 PublicationsView all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.
Pathwayi: fatty acid metabolism
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.5 PublicationsView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Pathwayi: retinol metabolism
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 224 | Substrate1 Publication | 1 | |
Metal bindingi | 457 | Iron (heme axial ligand)1 Publication | 1 |
GO - Molecular functioni
- arachidonic acid monooxygenase activity Source: UniProtKB
- aromatase activity Source: UniProtKB-EC
- demethylase activity Source: Ensembl
- enzyme binding Source: Ensembl
- estrogen 16-alpha-hydroxylase activity Source: UniProtKB
- estrogen 2-hydroxylase activity Source: UniProtKB
- flavonoid 3'-monooxygenase activity Source: Ensembl
- heme binding Source: InterPro
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
- hydroperoxy icosatetraenoate dehydratase activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
- monooxygenase activity Source: GO_Central
- oxidoreductase activity Source: BHF-UCL
- oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
- oxygen binding Source: ProtInc
- vitamin D 24-hydroxylase activity Source: BHF-UCL
GO - Biological processi
- 9-cis-retinoic acid biosynthetic process Source: Ensembl
- aging Source: Ensembl
- amine metabolic process Source: Ensembl
- camera-type eye development Source: Ensembl
- cell population proliferation Source: Ensembl
- cellular response to copper ion Source: Ensembl
- cellular response to organic cyclic compound Source: MGI
- coumarin metabolic process Source: Ensembl
- dibenzo-p-dioxin catabolic process Source: Ensembl
- digestive tract development Source: Ensembl
- drug metabolic process Source: BHF-UCL
- epoxygenase P450 pathway Source: Reactome
- estrogen metabolic process Source: UniProtKB
- ethylene metabolic process Source: Reactome
- fatty acid metabolic process Source: UniProtKB
- flavonoid metabolic process Source: Ensembl
- hepatocyte differentiation Source: Ensembl
- hydrogen peroxide biosynthetic process Source: Ensembl
- insecticide metabolic process Source: Ensembl
- lipid hydroxylation Source: BHF-UCL
- long-chain fatty acid biosynthetic process Source: Reactome
- maternal process involved in parturition Source: Ensembl
- omega-hydroxylase P450 pathway Source: Reactome
- oxidation-reduction process Source: BHF-UCL
- porphyrin-containing compound metabolic process Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- regulation of lipid metabolic process Source: Reactome
- response to antibiotic Source: Ensembl
- response to arsenic-containing substance Source: Ensembl
- response to drug Source: Ensembl
- response to food Source: Ensembl
- response to herbicide Source: Ensembl
- response to hyperoxia Source: Ensembl
- response to hypoxia Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to iron(III) ion Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to nematode Source: Ensembl
- response to virus Source: Ensembl
- response to vitamin A Source: Ensembl
- response to wounding Source: Ensembl
- retinol metabolic process Source: UniProtKB
- steroid biosynthetic process Source: UniProtKB-KW
- steroid metabolic process Source: BHF-UCL
- vitamin D metabolic process Source: BHF-UCL
Keywordsi
Molecular function | Lyase, Monooxygenase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P04798 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211981, Xenobiotics R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-9018681, Biosynthesis of protectins |
SABIO-RKi | P04798 |
SIGNORi | P04798 |
UniPathwayi | UPA00199 UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001329 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140465.13 |
HGNCi | HGNC:2595, CYP1A1 |
MIMi | 108330, gene |
neXtProti | NX_P04798 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
- Microsome membrane By similarity; Peripheral membrane protein By similarity
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Cytoplasm By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1543 |
OpenTargetsi | ENSG00000140465 |
PharmGKBi | PA27092 |
Miscellaneous databases
Pharosi | P04798, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2231 |
DrugBanki | DB08496, (R)-warfarin DB02342, 2-Methoxyestradiol DB00518, Albendazole DB01118, Amiodarone DB00381, Amlodipine DB00613, Amodiaquine DB00972, Azelastine DB04957, Azimilide DB04975, Banoxantrone DB06770, Benzyl alcohol DB01393, Bezafibrate DB00201, Caffeine DB09061, Cannabidiol DB01136, Carvedilol DB00608, Chloroquine DB00356, Chlorzoxazone DB00169, Cholecalciferol DB00568, Cinnarizine DB01407, Clenbuterol DB00636, Clofibrate DB00575, Clonidine DB00363, Clozapine DB00851, Dacarbazine DB06292, Dapagliflozin DB01254, Dasatinib DB00694, Daunorubicin DB04840, Debrisoquine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00633, Dexmedetomidine DB11511, Difloxacin DB05928, Dovitinib DB08846, Ellagic acid DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB00898, Ethanol DB04841, Flunarizine DB00499, Flutamide DB01095, Fluvastatin DB00176, Fluvoxamine DB00317, Gefitinib DB00889, Granisetron DB00502, Haloperidol DB12379, Indirubin DB01064, Isoprenaline DB11757, Istradefylline DB01167, Itraconazole DB01026, Ketoconazole DB00448, Lansoprazole DB00455, Loratadine DB04871, Lorcaserin DB09238, Manidipine DB00643, Mebendazole DB14009, Medical Cannabis DB01065, Melatonin DB00170, Menadione DB00553, Methoxsalen DB14011, Nabiximols DB00184, Nicotine DB01115, Nifedipine DB00325, Nitroprusside DB01059, Norfloxacin DB00338, Omeprazole DB00738, Pentamidine DB08922, Perospirone DB03783, Phenacetin DB01174, Phenobarbital DB00466, Picrotoxin DB01132, Pioglitazone DB01087, Primaquine DB00396, Progesterone DB00818, Propofol DB00571, Propranolol DB00550, Propylthiouracil DB00165, Pyridoxine DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB02709, Resveratrol DB00740, Riluzole DB08931, Riociguat DB06176, Romidepsin DB06654, Safinamide DB01591, Solifenacin DB00428, Streptozocin DB00605, Sulindac DB00675, Tamoxifen DB04905, Tesmilifene DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01041, Thalidomide DB00277, Theophylline DB00730, Thiabendazole DB01685, Topiroxostat DB00539, Toremifene DB00755, Tretinoin DB12245, Triclabendazole DB11155, Triclocarban DB00197, Troglitazone |
GuidetoPHARMACOLOGYi | 1318 |
Polymorphism and mutation databases
BioMutai | CYP1A1 |
DMDMi | 117139 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051627 | 1 – 512 | Cytochrome P450 1A1Add BLAST | 512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 67 | O-linked (GlcNAc) serineBy similarity | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P04798 |
MassIVEi | P04798 |
MaxQBi | P04798 |
PaxDbi | P04798 |
PeptideAtlasi | P04798 |
PRIDEi | P04798 |
ProteomicsDBi | 51744 [P04798-1] 654 655 |
PTM databases
GlyGeni | P04798, 1 site |
iPTMneti | P04798 |
PhosphoSitePlusi | P04798 |
Expressioni
Tissue specificityi
Lung, lymphocytes and placenta.
Inductioni
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Gene expression databases
Bgeei | ENSG00000140465, Expressed in islet of Langerhans and 128 other tissues |
ExpressionAtlasi | P04798, baseline and differential |
Genevisiblei | P04798, HS |
Organism-specific databases
HPAi | ENSG00000140465, Group enriched (liver, lung, urinary bladder) |
Interactioni
Subunit structurei
Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.
By similarityBinary interactionsi
Hide detailsP04798
With | #Exp. | IntAct |
---|---|---|
CMTM5 [Q96DZ9] | 3 | EBI-10194262,EBI-2548702 |
CMTM5 - isoform 2 [Q96DZ9-2] | 3 | EBI-10194262,EBI-11522780 |
GO - Molecular functioni
- enzyme binding Source: Ensembl
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107923, 76 interactors |
IntActi | P04798, 48 interactors |
STRINGi | 9606.ENSP00000369050 |
Chemistry databases
BindingDBi | P04798 |
Miscellaneous databases
RNActi | P04798, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04798 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 40 | Mitochondrial targeting signalBy similarityAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00950000183037 |
HOGENOMi | CLU_1209426_0_0_1 |
InParanoidi | P04798 |
OMAi | DLTPEYG |
OrthoDBi | 1389393at2759 |
PhylomeDBi | P04798 |
TreeFami | TF105095 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008066, Cyt_P450_E_grp-I_CYP1 IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01683, EP450ICYP1A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P04798-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG
110 120 130 140 150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA
210 220 230 240 250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA
260 270 280 290 300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
310 320 330 340 350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF
460 470 480 490 500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EMT5 | E7EMT5_HUMAN | Hydroperoxy icosatetraenoate dehydr... | CYP1A1 | 483 | Annotation score: | ||
Q5J9B1 | Q5J9B1_HUMAN | Hydroperoxy icosatetraenoate dehydr... | CYP1A1 | 484 | Annotation score: | ||
A4F3V8 | A4F3V8_HUMAN | Hydroperoxy icosatetraenoate dehydr... | CYP1A1 | 175 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | I → M in AAA52139 (PubMed:3838385).Curated | 1 | |
Sequence conflicti | 235 | D → E in AAA52139 (PubMed:3838385).Curated | 1 | |
Sequence conflicti | 381 | F → L in CAA26458 (PubMed:2989797).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023194 | 45 | G → D3 PublicationsCorresponds to variant dbSNP:rs4646422Ensembl. | 1 | |
Natural variantiVAR_033817 | 66 | M → V. Corresponds to variant dbSNP:rs35035798Ensembl. | 1 | |
Natural variantiVAR_023195 | 78 | I → T2 PublicationsCorresponds to variant dbSNP:rs17861094EnsemblClinVar. | 1 | |
Natural variantiVAR_024706 | 93 | R → W1 PublicationCorresponds to variant dbSNP:rs2229150Ensembl. | 1 | |
Natural variantiVAR_024707 | 173 | T → R1 PublicationCorresponds to variant dbSNP:rs28399427Ensembl. | 1 | |
Natural variantiVAR_009280 | 279 | R → W1 PublicationCorresponds to variant dbSNP:rs34260157Ensembl. | 1 | |
Natural variantiVAR_020122 | 286 | I → T. Corresponds to variant dbSNP:rs4987133EnsemblClinVar. | 1 | |
Natural variantiVAR_016937 | 331 | M → I in allele CYP1A1*6. 1 PublicationCorresponds to variant dbSNP:rs56313657Ensembl. | 1 | |
Natural variantiVAR_016938 | 448 | I → N in allele CYP1A1*8. 1 PublicationCorresponds to variant dbSNP:rs72547509Ensembl. | 1 | |
Natural variantiVAR_008342 | 461 | T → N in allele CYP1A1*4; displays similar catalytic efficiency toward estrogens when compared to the wild-type enzyme.. 4 PublicationsCorresponds to variant dbSNP:rs1799814Ensembl. | 1 | |
Natural variantiVAR_001243 | 462 | I → V in allele CYP1A1*2B and allele CYP1A1*2C; displays 5.7- and 12-fold increase in catalytic efficiency in the formation of 2-hydroxylated estrogens, 17beta-estradiol and estrone respectively.. 3 PublicationsCorresponds to variant dbSNP:rs1048943Ensembl. | 1 | |
Natural variantiVAR_016939 | 464 | R → C in allele CYP1A1*9. 1 PublicationCorresponds to variant dbSNP:rs41279188EnsemblClinVar. | 1 | |
Natural variantiVAR_016940 | 464 | R → S in allele CYP1A1*5. 1 PublicationCorresponds to variant dbSNP:rs41279188EnsemblClinVar. | 1 | |
Natural variantiVAR_033818 | 470 | F → V. Corresponds to variant dbSNP:rs36121583Ensembl. | 1 | |
Natural variantiVAR_016941 | 477 | R → W in allele CYP1A1*10. 2 PublicationsCorresponds to variant dbSNP:rs56240201Ensembl. | 1 | |
Natural variantiVAR_024708 | 482 | V → M1 PublicationCorresponds to variant dbSNP:rs28399429Ensembl. | 1 | |
Natural variantiVAR_016942 | 492 | P → R in allele CYP1A1*11. 2 PublicationsCorresponds to variant dbSNP:rs28399430Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053363 | 1 – 261 | Missing in isoform 3. 1 PublicationAdd BLAST | 261 | |
Alternative sequenceiVSP_053364 | 189 | Y → T in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_053365 | 190 – 512 | Missing in isoform 2. 1 PublicationAdd BLAST | 323 | |
Alternative sequenceiVSP_053366 | 419 – 512 | Missing in isoform 3. 1 PublicationAdd BLAST | 94 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02612 Genomic DNA Translation: CAA26458.1 K03191 mRNA Translation: AAA52139.1 X04300 Genomic DNA Translation: CAA27843.1 AF253322 Genomic DNA Translation: AAK25727.1 AM233518 mRNA Translation: CAJ80721.1 AM233519 mRNA Translation: CAJ80722.1 AM233520 mRNA Translation: CAJ80723.1 AK223113 mRNA Translation: BAD96833.1 AC091230 Genomic DNA No translation available. BC023019 mRNA Translation: AAH23019.1 M12079 mRNA Translation: AAA52152.1 AF040259 mRNA Translation: AAD10199.1 |
CCDSi | CCDS10268.1 [P04798-1] |
PIRi | A24797, O4HU6 |
RefSeqi | NP_000490.1, NM_000499.4 [P04798-1] NP_001306145.1, NM_001319216.1 NP_001306146.1, NM_001319217.1 [P04798-1] |
Genome annotation databases
Ensembli | ENST00000379727; ENSP00000369050; ENSG00000140465 [P04798-1] ENST00000395048; ENSP00000378488; ENSG00000140465 [P04798-1] ENST00000562201; ENSP00000455340; ENSG00000140465 [P04798-2] ENST00000564596; ENSP00000457668; ENSG00000140465 [P04798-3] ENST00000567032; ENSP00000456585; ENSG00000140465 [P04798-1] ENST00000569630; ENSP00000455051; ENSG00000140465 [P04798-2] |
GeneIDi | 1543 |
KEGGi | hsa:1543 |
UCSCi | uc002ayp.4, human [P04798-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP1A1 alleles |
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia CYP1A1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02612 Genomic DNA Translation: CAA26458.1 K03191 mRNA Translation: AAA52139.1 X04300 Genomic DNA Translation: CAA27843.1 AF253322 Genomic DNA Translation: AAK25727.1 AM233518 mRNA Translation: CAJ80721.1 AM233519 mRNA Translation: CAJ80722.1 AM233520 mRNA Translation: CAJ80723.1 AK223113 mRNA Translation: BAD96833.1 AC091230 Genomic DNA No translation available. BC023019 mRNA Translation: AAH23019.1 M12079 mRNA Translation: AAA52152.1 AF040259 mRNA Translation: AAD10199.1 |
CCDSi | CCDS10268.1 [P04798-1] |
PIRi | A24797, O4HU6 |
RefSeqi | NP_000490.1, NM_000499.4 [P04798-1] NP_001306145.1, NM_001319216.1 NP_001306146.1, NM_001319217.1 [P04798-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4I8V | X-ray | 2.60 | A/B/C/D | 35-512 | [»] | |
6DWM | X-ray | 2.85 | A/B/C/D | 35-512 | [»] | |
6DWN | X-ray | 3.00 | A/B/C/D | 35-512 | [»] | |
6O5Y | X-ray | 3.17 | A/B/C/D | 35-512 | [»] | |
SMRi | P04798 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107923, 76 interactors |
IntActi | P04798, 48 interactors |
STRINGi | 9606.ENSP00000369050 |
Chemistry databases
BindingDBi | P04798 |
ChEMBLi | CHEMBL2231 |
DrugBanki | DB08496, (R)-warfarin DB02342, 2-Methoxyestradiol DB00518, Albendazole DB01118, Amiodarone DB00381, Amlodipine DB00613, Amodiaquine DB00972, Azelastine DB04957, Azimilide DB04975, Banoxantrone DB06770, Benzyl alcohol DB01393, Bezafibrate DB00201, Caffeine DB09061, Cannabidiol DB01136, Carvedilol DB00608, Chloroquine DB00356, Chlorzoxazone DB00169, Cholecalciferol DB00568, Cinnarizine DB01407, Clenbuterol DB00636, Clofibrate DB00575, Clonidine DB00363, Clozapine DB00851, Dacarbazine DB06292, Dapagliflozin DB01254, Dasatinib DB00694, Daunorubicin DB04840, Debrisoquine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00633, Dexmedetomidine DB11511, Difloxacin DB05928, Dovitinib DB08846, Ellagic acid DB00530, Erlotinib DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00655, Estrone DB00898, Ethanol DB04841, Flunarizine DB00499, Flutamide DB01095, Fluvastatin DB00176, Fluvoxamine DB00317, Gefitinib DB00889, Granisetron DB00502, Haloperidol DB12379, Indirubin DB01064, Isoprenaline DB11757, Istradefylline DB01167, Itraconazole DB01026, Ketoconazole DB00448, Lansoprazole DB00455, Loratadine DB04871, Lorcaserin DB09238, Manidipine DB00643, Mebendazole DB14009, Medical Cannabis DB01065, Melatonin DB00170, Menadione DB00553, Methoxsalen DB14011, Nabiximols DB00184, Nicotine DB01115, Nifedipine DB00325, Nitroprusside DB01059, Norfloxacin DB00338, Omeprazole DB00738, Pentamidine DB08922, Perospirone DB03783, Phenacetin DB01174, Phenobarbital DB00466, Picrotoxin DB01132, Pioglitazone DB01087, Primaquine DB00396, Progesterone DB00818, Propofol DB00571, Propranolol DB00550, Propylthiouracil DB00165, Pyridoxine DB00908, Quinidine DB00468, Quinine DB01129, Rabeprazole DB02709, Resveratrol DB00740, Riluzole DB08931, Riociguat DB06176, Romidepsin DB06654, Safinamide DB01591, Solifenacin DB00428, Streptozocin |