Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylcholine receptor subunit gamma

Gene

Chrng

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit gamma
Gene namesi
Name:Chrng
Synonyms:Acrg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:87895 Chrng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 240ExtracellularSequence analysisAdd BLAST218
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Topological domaini330 – 476CytoplasmicSequence analysisAdd BLAST147
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3038460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000033523 – 519Acetylcholine receptor subunit gammaAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 164By similarity
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04760
PRIDEiP04760

PTM databases

PhosphoSitePlusiP04760

Expressioni

Tissue specificityi

At least in myotubes of skeletal muscle.

Developmental stagei

Both short and long isoforms are found in a 17 days old embryo, whereas the short isoform is the only isoform present in the newborn muscle.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
STRINGi10090.ENSMUSP00000027470

Chemistry databases

BindingDBiP04760

Structurei

3D structure databases

ProteinModelPortaliP04760
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP04760
PhylomeDBiP04760

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P04760-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGGQRPHLL LLLLAVCLGA QSRNQEERLL ADLMRNYDPH LRPAERDSDV
60 70 80 90 100
VNVSLKLTLT NLISLNEREE ALTTNVWIEM QWCDYRLRWD PKDYEGLWIL
110 120 130 140 150
RVPSTMVWRP DIVLENNVDG VFEVALYCNV LVSPDGCIYW LPPAIFRSSC
160 170 180 190 200
SISVTYFPFD WQNCSLIFQS QTYSTSEINL QLSQEDGQAI EWIFIDPEAF
210 220 230 240 250
TENGEWAIRH RPAKMLLDSV APAEEAGHQK VVFYLLIQRK PLFYVINIIA
260 270 280 290 300
PCVLISSVAI LIYFLPAKAG GQKCTVATNV LLAQTVFLFL VAKKVPETSQ
310 320 330 340 350
AVPLISKYLT FLMVVTILIV VNSVVVLNVS LRSPHTHSMA RGVRKLFLRL
360 370 380 390 400
LPQLLRMHVR PLAPAAVQDA RFRLQNGSSS GWPIMAREEG DLCLPRSELL
410 420 430 440 450
FRQRQRNGLV QAVLEKLENG PEVRQSQEFC GSLKQASPAI QACVDACNLM
460 470 480 490 500
ARARRQQSHF DSGNEEWLLV GRVLDRVCFL AMLSLFICGT AGIFLMAHYN
510
QVPDLPFPGD PRPYLPLPD
Length:519
Mass (Da):58,745
Last modified:August 13, 1987 - v1
Checksum:i3F435303564C8048
GO
Isoform Short (identifier: P04760-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-168: Missing.

Show »
Length:467
Mass (Da):52,866
Checksum:i03077383E5BA2E92
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQK4F8VQK4_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
519Annotation score:
I0B502I0B502_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
220Annotation score:
H8YHW6H8YHW6_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
146Annotation score:
A0A087WP27A0A087WP27_MOUSE
Acetylcholine receptor subunit gamm...
Chrng
255Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231V → G in AAB63431 (PubMed:3755765).Curated1
Sequence conflicti346L → V in AAB63431 (PubMed:3755765).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000072117 – 168Missing in isoform Short. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03818 mRNA Translation: CAA27442.1
X03819 mRNA Translation: CAA27443.1
M30514 mRNA Translation: AAB63431.1 Sequence problems.
M27455 Genomic DNA Translation: AAA70247.1
M22381 Genomic DNA Translation: AAA37152.1
S77465 mRNA Translation: AAB33997.2
CCDSiCCDS35651.1 [P04760-1]
PIRiI56566
UniGeneiMm.2810

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03818 mRNA Translation: CAA27442.1
X03819 mRNA Translation: CAA27443.1
M30514 mRNA Translation: AAB63431.1 Sequence problems.
M27455 Genomic DNA Translation: AAA70247.1
M22381 Genomic DNA Translation: AAA37152.1
S77465 mRNA Translation: AAB33997.2
CCDSiCCDS35651.1 [P04760-1]
PIRiI56566
UniGeneiMm.2810

3D structure databases

ProteinModelPortaliP04760
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
STRINGi10090.ENSMUSP00000027470

Chemistry databases

BindingDBiP04760
ChEMBLiCHEMBL3038460

PTM databases

PhosphoSitePlusiP04760

Proteomic databases

PaxDbiP04760
PRIDEiP04760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:87895 Chrng

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP04760
PhylomeDBiP04760

Miscellaneous databases

PROiPR:P04760
SOURCEiSearch...

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHG_MOUSE
AccessioniPrimary (citable) accession number: P04760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again