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Protein

Acetylcholine receptor subunit beta

Gene

CHRNB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit beta
Gene namesi
Name:CHRNB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:27330 CHRNB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 245ExtracellularSequence analysisAdd BLAST221
Transmembranei246 – 270HelicalSequence analysisAdd BLAST25
Transmembranei278 – 295HelicalSequence analysisAdd BLAST18
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22
Topological domaini334 – 473CytoplasmicSequence analysisAdd BLAST140
Transmembranei474 – 492HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000000031425 – 505Acetylcholine receptor subunit betaAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi152 ↔ 166By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei394Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04758
PRIDEiP04758

Expressioni

Gene expression databases

BgeeiENSBTAG00000019242

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025624

Structurei

3D structure databases

ProteinModelPortaliP04758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP04758
KOiK04812
OMAiFIDGPNR
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPGALLLLL LGVLGAHLAP GARGSEAEGR LREKLFSGYD STVRPAREVG
60 70 80 90 100
DRVWVSIGLT LAQLISLNEK DEEMSTKVYL DLEWTDYRLS WDPEEHEGID
110 120 130 140 150
SLRISAESVW LPDVVLLNNN DGNFDVALDI NVVVSSDGSM RWQPPGIYRS
160 170 180 190 200
SCSIQVTYFP FDWQNCTMVF SSYSYDSSEV SLQTGLSPEG QERQEVYIHE
210 220 230 240 250
GTFIENGQWE IIHKPSRLIQ PSVDPRGGGE GRREEVTFYL IIRRKPLFYL
260 270 280 290 300
VNVIAPCILI TLLAIFVFYL PPDAGEKMGL SIFALLTLTV FLLLLADKVP
310 320 330 340 350
ETSLSVPIII KYLMFTMVLV TFSVILSVVV LNLHHRSPHT HQMPLWVRQI
360 370 380 390 400
FIHKLPLYLG LKRPKPERDQ MQEPPSIAPR DSPGSGWGRG TDEYFIRKPP
410 420 430 440 450
NDFLFPKPNR FQPELSAPDL RRFIDGPNRA VGLPPELREV VSSISYIARQ
460 470 480 490 500
LQEQEDHDVL KEDWQFVAMV VDRLFLWTFI IFTSVGTLVI FLDATYHLPP

ADPFP
Length:505
Mass (Da):57,352
Last modified:August 13, 1987 - v1
Checksum:iB003D552A6701ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00962 mRNA Translation: CAA25475.1
BC147876 mRNA Translation: AAI47877.1
PIRiS07227
RefSeqiNP_776941.1, NM_174516.2
XP_005220248.1, XM_005220191.3
UniGeneiBt.5107

Genome annotation databases

EnsembliENSBTAT00000025624; ENSBTAP00000025624; ENSBTAG00000019242
GeneIDi282179
KEGGibta:282179

Similar proteinsi

Entry informationi

Entry nameiACHB_BOVIN
AccessioniPrimary (citable) accession number: P04758
Secondary accession number(s): A6QL86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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