UniProtKB - P04756 (ACHA_MOUSE)

BLAST

>sp|P04756|ACHA_MOUSE Acetylcholine receptor subunit alpha OS=Mus musculus OX=10090 GN=Chrna1 PE=1 SV=1
MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQL
INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDF
AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
ESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVII
PCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKR
IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWK
YVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG

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History
Entry version 174 (07 Nov 2018)
Sequence version 1 (13 Aug 1987)
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Protein

Acetylcholine receptor subunit alpha

Gene

Chrna1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functionⁱ

acetylcholine-gated cation-selective channel activity Source: MGI
transmembrane signaling receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cation transport Source: MGI
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle cell cellular homeostasis Source: MGI
musculoskeletal movement Source: MGI
nervous system process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuromuscular junction development Source: MGI
neuromuscular process Source: MGI
neuromuscular synaptic transmission Source: MGI
neuronal action potential Source: MGI
neuron cellular homeostasis Source: MGI
regulation of membrane potential
Source: MGI
Inferred from genetic interactionⁱ
- 2383398
response to nicotine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
skeletal muscle contraction Source: MGI
skeletal muscle tissue growth Source: MGI
synaptic transmission, cholinergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetylcholine receptor subunit alpha
Gene namesⁱ	Name:Chrna1 Synonyms:Acra
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:87885 Chrna1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 230	ExtracellularAdd BLAST	210
Transmembraneⁱ	231 – 255	HelicalAdd BLAST	25
Transmembraneⁱ	263 – 281	HelicalAdd BLAST	19
Transmembraneⁱ	297 – 316	HelicalAdd BLAST	20
Topological domainⁱ	317 – 428	CytoplasmicAdd BLAST	112
Transmembraneⁱ	429 – 447	HelicalAdd BLAST	19

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3137264

ChEMBLⁱ

CHEMBL3137264

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Add BLAST		20
ChainⁱPRO_0000000306	21 – 457	Acetylcholine receptor subunit alphaAdd BLAST		437

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	148 ↔ 162	1 Publication
Glycosylationⁱ	161	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	212 ↔ 213	Associated with receptor activation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P04756
PRIDEⁱ	P04756

PTM databases

iPTMnetⁱ	P04756
PhosphoSitePlusⁱ	P04756
SwissPalmⁱ	P04756

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027107 Expressed in 91 organ(s), highest expression level in tarsal region
ExpressionAtlasⁱ	P04756 baseline and differential
Genevisibleⁱ	P04756 MM

Interactionⁱ

Subunit structureⁱ

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains (PubMed:17643119). The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	197931, 4 interactors
ComplexPortalⁱ	CPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
Database of interacting proteins More...DIPⁱ	DIP-59594N
IntActⁱ	P04756, 2 interactors
Molecular INTeraction database More...MINTⁱ	P04756
STRINGⁱ	10090.ENSMUSP00000028515

Chemistry databases

BindingDBⁱ

P04756

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	22 – 32	Combined sources	11
Beta strandⁱ	37 – 39	Combined sources	3
Beta strandⁱ	49 – 64	Combined sources	16
Turnⁱ	65 – 68	Combined sources	4
Beta strandⁱ	69 – 81	Combined sources	13
Helixⁱ	89 – 92	Combined sources	4
Beta strandⁱ	97 – 100	Combined sources	4
Helixⁱ	102 – 104	Combined sources	3
Beta strandⁱ	110 – 112	Combined sources	3
Turnⁱ	116 – 118	Combined sources	3
Beta strandⁱ	128 – 131	Combined sources	4
Beta strandⁱ	135 – 138	Combined sources	4
Beta strandⁱ	141 – 150	Combined sources	10
Beta strandⁱ	153 – 156	Combined sources	4
Beta strandⁱ	159 – 170	Combined sources	12
Turnⁱ	173 – 175	Combined sources	3
Beta strandⁱ	176 – 181	Combined sources	6
Beta strandⁱ	194 – 210	Combined sources	17
Beta strandⁱ	218 – 229	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P04756
SMRⁱ	P04756
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P04756

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P04756
KEGG Orthology (KO) More...KOⁱ	K04803
OMAⁱ	DFAIIHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P04756
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04756-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELSTVLLLL GLCSAGLVLG SEHETRLVAK LFEDYSSVVR PVEDHREIVQ 
        60         70         80         90        100
VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI 
       110        120        130        140        150
PSEKIWRPDV VLYNNADGDF AIVKFTKVLL DYTGHITWTP PAIFKSYCEI 
       160        170        180        190        200
IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP ESDQPDLSNF MESGEWVIKE 
       210        220        230        240        250
ARGWKHWVFY SCCPTTPYLD ITYHFVMQRL PLYFIVNVII PCLLFSFLTS 
       260        270        280        290        300
LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF 
       310        320        330        340        350
TMVFVIASII ITVIVINTHH RSPSTHIMPE WVRKVFIDTI PNIMFFSTMK 
       360        370        380        390        400
RPSRDKQEKR IFTEDIDISD ISGKPGPPPM GFHSPLIKHP EVKSAIEGVK 
       410        420        430        440        450
YIAETMKSDQ ESNNAAEEWK YVAMVMDHIL LGVFMLVCLI GTLAVFAGRL 

IELHQQG

Length:457

Mass (Da):51,939

Last modified:August 13, 1987 - v1

Checksum:ⁱ5CB606D144F29436

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	13	C → S in AAB53942 (Ref. 2) Curated		1
Sequence conflictⁱ	13	C → S no nucleotide entry (PubMed:2993547).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03986 mRNA Translation: CAA27624.1 M17640 mRNA Translation: AAB53942.1 AK029177 mRNA Translation: BAC26337.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16132.1
PIRⁱ	A24383 I49458
NCBI Reference Sequences More...RefSeqⁱ	NP_031415.2, NM_007389.5
UniGeneⁱ	Mm.4583

Genome annotation databases

Ensemblⁱ	ENSMUST00000028515; ENSMUSP00000028515; ENSMUSG00000027107
GeneIDⁱ	11435
KEGGⁱ	mmu:11435
UCSC genome browser More...UCSCⁱ	uc008kcy.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04756	Cholinergic receptor, nicotinic, alpha polypeptide 1 (Muscle)		MOUSE		457	UniRef100_P04756
Muscle nicotinic acetylcholine receptor (Fragment)		MOUSE		64

Protein	Similar proteins		Species	Score	Length	Source
P04756	Acetylcholine receptor subunit alpha		BOVIN		457	UniRef90_P04756
Acetylcholine receptor subunit alpha		RAT		457
Acetylcholine receptor subunit alpha (Fragment)		ERICO		84
Acetylcholine receptor subunit alpha (Fragment)		FELCA		84
Cholinergic receptor, nicotinic, alpha polypeptide 1 (Muscle)		MOUSE		457
+175

Protein	Similar proteins		Species	Score	Length	Source
P04756	Acetylcholine receptor subunit alpha	)	HUMAN		482	UniRef50_P02708
Acetylcholine receptor subunit alpha	)	TETCF		461
Acetylcholine receptor subunit alpha	)	TORMA		461
Acetylcholine receptor subunit alpha-1-A		XENLA		457
Acetylcholine receptor subunit alpha		BOVIN		457
+347

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03986 mRNA Translation: CAA27624.1 M17640 mRNA Translation: AAB53942.1 AK029177 mRNA Translation: BAC26337.1
CCDSⁱ	CCDS16132.1
PIRⁱ	A24383 I49458
RefSeqⁱ	NP_031415.2, NM_007389.5
UniGeneⁱ	Mm.4583

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2QC1	X-ray	1.94	B	21-231	[»]
	5HBV	X-ray	2.70	B	22-231	[»]
ProteinModelPortalⁱ	P04756
SMRⁱ	P04756
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	197931, 4 interactors
ComplexPortalⁱ	CPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
DIPⁱ	DIP-59594N
IntActⁱ	P04756, 2 interactors
MINTⁱ	P04756
STRINGⁱ	10090.ENSMUSP00000028515

Chemistry databases

BindingDBⁱ	P04756
ChEMBLⁱ	CHEMBL3137264

PTM databases

iPTMnetⁱ	P04756
PhosphoSitePlusⁱ	P04756
SwissPalmⁱ	P04756

Proteomic databases

PaxDbⁱ	P04756
PRIDEⁱ	P04756

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028515; ENSMUSP00000028515; ENSMUSG00000027107
GeneIDⁱ	11435
KEGGⁱ	mmu:11435
UCSCⁱ	uc008kcy.2 mouse

Organism-specific databases

CTDⁱ	1134
MGIⁱ	MGI:87885 Chrna1

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006756
HOVERGENⁱ	HBG003756
InParanoidⁱ	P04756
KOⁱ	K04803
OMAⁱ	DFAIIHE
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P04756
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

EvolutionaryTraceⁱ	P04756
Protein Ontology More...PROⁱ	PR:P04756
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027107 Expressed in 91 organ(s), highest expression level in tarsal region
ExpressionAtlasⁱ	P04756 baseline and differential
Genevisibleⁱ	P04756 MM

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHA_MOUSE
Accessionⁱ	P04756Primary (citable) accession number: P04756
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	August 13, 1987
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P04756 (ACHA_MOUSE)

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Acetylcholine receptor subunit alpha

Chrna1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ