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Protein

Acetylcholine receptor subunit alpha

Gene

Chrna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:Chrna1
Synonyms:Acra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:87885 Chrna1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 230ExtracellularAdd BLAST210
Transmembranei231 – 255HelicalAdd BLAST25
Transmembranei263 – 281HelicalAdd BLAST19
Transmembranei297 – 316HelicalAdd BLAST20
Topological domaini317 – 428CytoplasmicAdd BLAST112
Transmembranei429 – 447HelicalAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3137264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000030621 – 457Acetylcholine receptor subunit alphaAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi148 ↔ 1621 Publication
Glycosylationi161N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi212 ↔ 213Associated with receptor activation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04756
PRIDEiP04756

PTM databases

iPTMnetiP04756
PhosphoSitePlusiP04756
SwissPalmiP04756

Expressioni

Gene expression databases

BgeeiENSMUSG00000027107 Expressed in 91 organ(s), highest expression level in tarsal region
ExpressionAtlasiP04756 baseline and differential
GenevisibleiP04756 MM

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains (PubMed:17643119). The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi197931, 4 interactors
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
DIPiDIP-59594N
IntActiP04756, 2 interactors
MINTiP04756
STRINGi10090.ENSMUSP00000028515

Chemistry databases

BindingDBiP04756

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04756
SMRiP04756
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04756

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP04756
KOiK04803
OMAiDFAIIHE
OrthoDBiEOG091G0R20
PhylomeDBiP04756
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSTVLLLL GLCSAGLVLG SEHETRLVAK LFEDYSSVVR PVEDHREIVQ
60 70 80 90 100
VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI
110 120 130 140 150
PSEKIWRPDV VLYNNADGDF AIVKFTKVLL DYTGHITWTP PAIFKSYCEI
160 170 180 190 200
IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP ESDQPDLSNF MESGEWVIKE
210 220 230 240 250
ARGWKHWVFY SCCPTTPYLD ITYHFVMQRL PLYFIVNVII PCLLFSFLTS
260 270 280 290 300
LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF
310 320 330 340 350
TMVFVIASII ITVIVINTHH RSPSTHIMPE WVRKVFIDTI PNIMFFSTMK
360 370 380 390 400
RPSRDKQEKR IFTEDIDISD ISGKPGPPPM GFHSPLIKHP EVKSAIEGVK
410 420 430 440 450
YIAETMKSDQ ESNNAAEEWK YVAMVMDHIL LGVFMLVCLI GTLAVFAGRL

IELHQQG
Length:457
Mass (Da):51,939
Last modified:August 13, 1987 - v1
Checksum:i5CB606D144F29436
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13C → S in AAB53942 (Ref. 2) Curated1
Sequence conflicti13C → S no nucleotide entry (PubMed:2993547).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03986 mRNA Translation: CAA27624.1
M17640 mRNA Translation: AAB53942.1
AK029177 mRNA Translation: BAC26337.1
CCDSiCCDS16132.1
PIRiA24383
I49458
RefSeqiNP_031415.2, NM_007389.5
UniGeneiMm.4583

Genome annotation databases

EnsembliENSMUST00000028515; ENSMUSP00000028515; ENSMUSG00000027107
GeneIDi11435
KEGGimmu:11435
UCSCiuc008kcy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03986 mRNA Translation: CAA27624.1
M17640 mRNA Translation: AAB53942.1
AK029177 mRNA Translation: BAC26337.1
CCDSiCCDS16132.1
PIRiA24383
I49458
RefSeqiNP_031415.2, NM_007389.5
UniGeneiMm.4583

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QC1X-ray1.94B21-231[»]
5HBVX-ray2.70B22-231[»]
ProteinModelPortaliP04756
SMRiP04756
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197931, 4 interactors
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
DIPiDIP-59594N
IntActiP04756, 2 interactors
MINTiP04756
STRINGi10090.ENSMUSP00000028515

Chemistry databases

BindingDBiP04756
ChEMBLiCHEMBL3137264

PTM databases

iPTMnetiP04756
PhosphoSitePlusiP04756
SwissPalmiP04756

Proteomic databases

PaxDbiP04756
PRIDEiP04756

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028515; ENSMUSP00000028515; ENSMUSG00000027107
GeneIDi11435
KEGGimmu:11435
UCSCiuc008kcy.2 mouse

Organism-specific databases

CTDi1134
MGIiMGI:87885 Chrna1

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP04756
KOiK04803
OMAiDFAIIHE
OrthoDBiEOG091G0R20
PhylomeDBiP04756
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

EvolutionaryTraceiP04756
PROiPR:P04756
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027107 Expressed in 91 organ(s), highest expression level in tarsal region
ExpressionAtlasiP04756 baseline and differential
GenevisibleiP04756 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_MOUSE
AccessioniPrimary (citable) accession number: P04756
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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