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Entry version 218 (16 Oct 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Alpha-amylase 1

Gene

AMY1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.1 Publication EC:3.2.1.1

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi115CalciumCombined sources2 Publications1
Metal bindingi173Calcium; via carbonyl oxygenCombined sources2 Publications1
Metal bindingi182CalciumCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei210ChlorideCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei212Nucleophile1
Metal bindingi216Calcium; via carbonyl oxygenCombined sources2 Publications1
Active sitei248Proton donor1
Binding sitei313ChlorideCombined sources2 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei315Transition state stabilizerBy similarity1
Binding sitei352ChlorideCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism
LigandCalcium, Chloride, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189085 Digestion of dietary carbohydrate

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH13 Glycoside Hydrolase Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-amylase 1 (EC:3.2.1.11 Publication)
Alternative name(s):
1,4-alpha-D-glucan glucanohydrolase 1
Salivary alpha-amylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMY1A
Synonyms:AMY1
AND
Name:AMY1B
Synonyms:AMY1
AND
Name:AMY1C
Synonyms:AMY1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:474 AMY1A
HGNC:475 AMY1B
HGNC:476 AMY1C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104700 gene
104701 gene
104702 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04745

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
276
277
278

Open Targets

More...
OpenTargetsi
ENSG00000187733

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24783

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P04745

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2478

Drug and drug target database

More...
DrugBanki
DB03439 4,6-dideoxy-4-amino-alpha-D-glucose
DB03092 5-Hydroxymethyl-Chonduritol
DB02379 Beta-D-Glucose
DB03088 Pidolic Acid
DB13928 Semaglutide
DB04237 Tris(Hydroxyethyl)Aminomethane

DrugCentral

More...
DrugCentrali
P04745

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMY1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351933

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000140116 – 511Alpha-amylase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16Pyrrolidone carboxylic acidBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 101Combined sources2 Publications
Disulfide bondi85 ↔ 130Combined sources2 Publications
Disulfide bondi156 ↔ 175Combined sources2 Publications
Modified residuei365Deamidated asparagine; partial1 Publication1
Disulfide bondi393 ↔ 399Combined sources2 Publications
Modified residuei427Deamidated asparagine; partial; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi427N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi465 ↔ 477Combined sources2 Publications
Modified residuei474Deamidated asparagine; partial1 Publication1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04745

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P04745

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04745

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04745

PeptideAtlas

More...
PeptideAtlasi
P04745

PRoteomics IDEntifications database

More...
PRIDEi
P04745

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12608
51741

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
28

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04745

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04745

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04745

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P04745

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174876 Expressed in 50 organ(s), highest expression level in anatomical system

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04745 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04745 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004310
HPA045394
HPA045399
HPA046980

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MUC7Q8TAX72EBI-738586,EBI-738582

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106773, 7 interactors
106774, 2 interactors
106775, 42 interactors

Protein interaction database and analysis system

More...
IntActi
P04745, 31 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359100

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04745

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04745

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04745

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2212 Eukaryota
COG0366 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253313

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04745

KEGG Orthology (KO)

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KOi
K01176

Identification of Orthologs from Complete Genome Data

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OMAi
WCIVAGQ

Database of Orthologous Groups

More...
OrthoDBi
665362at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04745

TreeFam database of animal gene trees

More...
TreeFami
TF312850

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006048 A-amylase/branching_C
IPR031319 A-amylase_C
IPR006046 Alpha_amylase
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF02806 Alpha-amylase_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00110 ALPHAAMYLASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00642 Aamy, 1 hit
SM00632 Aamy_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P04745-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK
60 70 80 90 100
GFGGVQVSPP NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR
110 120 130 140 150
CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD
160 170 180 190 200
FNDGKCKTGS GDIENYNDAT QVRDCRLSGL LDLALGKDYV RSKIAEYMNH
210 220 230 240 250
LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG SKPFIYQEVI
260 270 280 290 300
DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
310 320 330 340 350
FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF
360 370 380 390 400
TRVMSSYRWP RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE
410 420 430 440 450
HRWRQIRNMV NFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT
460 470 480 490 500
FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED
510
PFIAIHAESK L
Length:511
Mass (Da):57,768
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7710BCAC83EBE8B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T085Q5T085_HUMAN
Alpha-amylase 1
AMY1B AMY1A
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T084Q5T084_HUMAN
Alpha-amylase 1
AMY1A AMY1B
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti285N → T in AAA57345 (PubMed:2442579).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M18786
, M18715, M18717, M18719, M18721, M18723, M18725, M18727, M18784 Genomic DNA Translation: AAA52279.1
AK292341 mRNA Translation: BAF85030.1
AL513482 Genomic DNA No translation available.
BC063129 mRNA Translation: AAH63129.1
BC069347 mRNA Translation: AAH69347.1
BC069463 mRNA Translation: AAH69463.1
BC092444 mRNA Translation: AAH92444.1
BC132985 mRNA Translation: AAI32986.1
BC132987 mRNA Translation: AAI32988.1
BC132995 mRNA Translation: AAI32996.1
BC132997 mRNA Translation: AAI32998.1
M18671 Genomic DNA Translation: AAA58368.1
M18674 Genomic DNA Translation: AAA16183.2
M19233, M17883 Genomic DNA Translation: AAA57345.1 Different termination.
M17884 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30782.1
CCDS30783.1
CCDS30784.1

Protein sequence database of the Protein Information Resource

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PIRi
A91543 ALHUS

NCBI Reference Sequences

More...
RefSeqi
NP_001008219.1, NM_001008218.1
NP_001008220.1, NM_001008219.2
NP_001008222.1, NM_001008221.1
NP_001333709.1, NM_001346780.1
NP_004029.2, NM_004038.3
XP_011539564.1, XM_011541262.1
XP_016856547.1, XM_017001058.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330330; ENSP00000330484; ENSG00000174876
ENST00000370079; ENSP00000359096; ENSG00000187733
ENST00000370080; ENSP00000359097; ENSG00000174876
ENST00000370083; ENSP00000359100; ENSG00000237763

Database of genes from NCBI RefSeq genomes

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GeneIDi
276
277
278

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:276
hsa:277
hsa:278

UCSC genome browser

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UCSCi
uc001duv.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Amylase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18786
, M18715, M18717, M18719, M18721, M18723, M18725, M18727, M18784 Genomic DNA Translation: AAA52279.1
AK292341 mRNA Translation: BAF85030.1
AL513482 Genomic DNA No translation available.
BC063129 mRNA Translation: AAH63129.1
BC069347 mRNA Translation: AAH69347.1
BC069463 mRNA Translation: AAH69463.1
BC092444 mRNA Translation: AAH92444.1
BC132985 mRNA Translation: AAI32986.1
BC132987 mRNA Translation: AAI32988.1
BC132995 mRNA Translation: AAI32996.1
BC132997 mRNA Translation: AAI32998.1
M18671 Genomic DNA Translation: AAA58368.1
M18674 Genomic DNA Translation: AAA16183.2
M19233, M17883 Genomic DNA Translation: AAA57345.1 Different termination.
M17884 Genomic DNA No translation available.
CCDSiCCDS30782.1
CCDS30783.1
CCDS30784.1
PIRiA91543 ALHUS
RefSeqiNP_001008219.1, NM_001008218.1
NP_001008220.1, NM_001008219.2
NP_001008222.1, NM_001008221.1
NP_001333709.1, NM_001346780.1
NP_004029.2, NM_004038.3
XP_011539564.1, XM_011541262.1
XP_016856547.1, XM_017001058.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C8QX-ray2.30A16-511[»]
1JXJX-ray1.99A16-511[»]
1JXKX-ray1.90A16-511[»]
1MFUX-ray2.00A17-511[»]
1MFVX-ray2.00A17-511[»]
1NM9X-ray2.10A16-511[»]
1Q4NX-ray2.07X16-511[»]
1SMDX-ray1.60A17-511[»]
1XV8X-ray3.00A/B16-511[»]
1Z32X-ray1.60X16-511[»]
3BLKX-ray2.00A16-511[»]
3BLPX-ray1.60X16-511[»]
3DHPX-ray1.50A16-511[»]
SMRiP04745
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106773, 7 interactors
106774, 2 interactors
106775, 42 interactors
IntActiP04745, 31 interactors
STRINGi9606.ENSP00000359100

Chemistry databases

BindingDBiP04745
ChEMBLiCHEMBL2478
DrugBankiDB03439 4,6-dideoxy-4-amino-alpha-D-glucose
DB03092 5-Hydroxymethyl-Chonduritol
DB02379 Beta-D-Glucose
DB03088 Pidolic Acid
DB13928 Semaglutide
DB04237 Tris(Hydroxyethyl)Aminomethane
DrugCentraliP04745

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

PTM databases

GlyConnecti28
iPTMnetiP04745
PhosphoSitePlusiP04745
SwissPalmiP04745
UniCarbKBiP04745

Polymorphism and mutation databases

BioMutaiAMY1A
DMDMi1351933

Proteomic databases

jPOSTiP04745
MassIVEiP04745
MaxQBiP04745
PaxDbiP04745
PeptideAtlasiP04745
PRIDEiP04745
ProteomicsDBi12608
51741

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
277
278

Genome annotation databases

EnsembliENST00000330330; ENSP00000330484; ENSG00000174876
ENST00000370079; ENSP00000359096; ENSG00000187733
ENST00000370080; ENSP00000359097; ENSG00000174876
ENST00000370083; ENSP00000359100; ENSG00000237763
GeneIDi276
277
278
KEGGihsa:276
hsa:277
hsa:278
UCSCiuc001duv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
276
277
278
DisGeNETi276
277
278

GeneCards: human genes, protein and diseases

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GeneCardsi
AMY1A
AMY1B
AMY1C
HGNCiHGNC:474 AMY1A
HGNC:475 AMY1B
HGNC:476 AMY1C
HPAiCAB004310
HPA045394
HPA045399
HPA046980
MIMi104700 gene
104701 gene
104702 gene
neXtProtiNX_P04745
OpenTargetsiENSG00000187733
PharmGKBiPA24783

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2212 Eukaryota
COG0366 LUCA
GeneTreeiENSGT00940000154802
HOGENOMiHOG000253313
InParanoidiP04745
KOiK01176
OMAiWCIVAGQ
OrthoDBi665362at2759
PhylomeDBiP04745
TreeFamiTF312850

Enzyme and pathway databases

BRENDAi3.2.1.1 2681
ReactomeiR-HSA-189085 Digestion of dietary carbohydrate

Miscellaneous databases

EvolutionaryTraceiP04745

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AMY1A
PharosiP04745

Protein Ontology

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PROi
PR:P04745

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174876 Expressed in 50 organ(s), highest expression level in anatomical system
ExpressionAtlasiP04745 baseline and differential
GenevisibleiP04745 HS

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006048 A-amylase/branching_C
IPR031319 A-amylase_C
IPR006046 Alpha_amylase
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF02806 Alpha-amylase_C, 1 hit
PRINTSiPR00110 ALPHAAMYLASE
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SM00632 Aamy_C, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMY1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04745
Secondary accession number(s): A6NJS5
, A8K8H6, Q13763, Q5T083
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1996
Last modified: October 16, 2019
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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