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Protein

Metallothionein-1F

Gene

MT1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • metal ion binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1F
Short name:
MT-1F
Alternative name(s):
Metallothionein-IF
Short name:
MT-IF
Gene namesi
Name:MT1F
ORF Names:PRO0376
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000198417.6
HGNCiHGNC:7398 MT1F
MIMi156352 gene
neXtProtiNX_P04733

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4494
OpenTargetsiENSG00000198417
PharmGKBiPA31203

Polymorphism and mutation databases

BioMutaiMT1F

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972371 – 61Metallothionein-1FAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP04733
MaxQBiP04733
PaxDbiP04733
PeptideAtlasiP04733
PRIDEiP04733
ProteomicsDBi51740

PTM databases

iPTMnetiP04733
PhosphoSitePlusiP04733

Expressioni

Gene expression databases

BgeeiENSG00000198417 Expressed in 232 organ(s), highest expression level in nephron tubule
CleanExiHS_MT1F
ExpressionAtlasiP04733 baseline and differential
GenevisibleiP04733 HS

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
NOP2P460873EBI-10209483,EBI-356811

Protein-protein interaction databases

BioGridi110600, 2 interactors
IntActiP04733, 1 interactor
STRINGi9606.ENSP00000334872

Structurei

3D structure databases

ProteinModelPortaliP04733
SMRiP04733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IUWR Eukaryota
ENOG4110PT3 LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000043048
InParanoidiP04733
KOiK14739
OMAiCICKAAS
PhylomeDBiP04733
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04733-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNCSCAAG VSCTCAGSCK CKECKCTSCK KSCCSCCPVG CSKCAQGCVC
60
KGASEKCSCC D
Length:61
Mass (Da):6,086
Last modified:August 13, 1987 - v1
Checksum:i7C7A61E180D8D1C8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRY8H3BRY8_HUMAN
Metallothionein
MT1F
44Annotation score:

Sequence cautioni

The sequence AAF23355 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10943 Genomic DNA Translation: AAA59588.1
M13003 Genomic DNA Translation: AAA36213.1
AF078844 mRNA Translation: AAF23355.1 Different initiation.
BC029453 mRNA Translation: AAH29453.1
CCDSiCCDS32456.1
PIRiB22634 SMHU1F
RefSeqiNP_001288201.1, NM_001301272.1
NP_005940.1, NM_005949.3
UniGeneiHs.513626

Genome annotation databases

EnsembliENST00000334350; ENSP00000334872; ENSG00000198417
GeneIDi4494
KEGGihsa:4494
UCSCiuc002ejt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10943 Genomic DNA Translation: AAA59588.1
M13003 Genomic DNA Translation: AAA36213.1
AF078844 mRNA Translation: AAF23355.1 Different initiation.
BC029453 mRNA Translation: AAH29453.1
CCDSiCCDS32456.1
PIRiB22634 SMHU1F
RefSeqiNP_001288201.1, NM_001301272.1
NP_005940.1, NM_005949.3
UniGeneiHs.513626

3D structure databases

ProteinModelPortaliP04733
SMRiP04733
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110600, 2 interactors
IntActiP04733, 1 interactor
STRINGi9606.ENSP00000334872

PTM databases

iPTMnetiP04733
PhosphoSitePlusiP04733

Polymorphism and mutation databases

BioMutaiMT1F

Proteomic databases

EPDiP04733
MaxQBiP04733
PaxDbiP04733
PeptideAtlasiP04733
PRIDEiP04733
ProteomicsDBi51740

Protocols and materials databases

DNASUi4494
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334350; ENSP00000334872; ENSG00000198417
GeneIDi4494
KEGGihsa:4494
UCSCiuc002ejt.4 human

Organism-specific databases

CTDi4494
DisGeNETi4494
EuPathDBiHostDB:ENSG00000198417.6
GeneCardsiMT1F
HGNCiHGNC:7398 MT1F
MIMi156352 gene
neXtProtiNX_P04733
OpenTargetsiENSG00000198417
PharmGKBiPA31203
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUWR Eukaryota
ENOG4110PT3 LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000043048
InParanoidiP04733
KOiK14739
OMAiCICKAAS
PhylomeDBiP04733
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

ChiTaRSiMT1F human
GeneWikiiMT1F
GenomeRNAii4494
PROiPR:P04733
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198417 Expressed in 232 organ(s), highest expression level in nephron tubule
CleanExiHS_MT1F
ExpressionAtlasiP04733 baseline and differential
GenevisibleiP04733 HS

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1F_HUMAN
AccessioniPrimary (citable) accession number: P04733
Secondary accession number(s): Q9UI97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Metallothioneins
    Classification of metallothioneins and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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