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Protein

Metallothionein-1E

Gene

MT1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • cellular response to cadmium ion Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of growth Source: UniProtKB

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1E
Short name:
MT-1E
Alternative name(s):
Metallothionein-IE
Short name:
MT-IE
Gene namesi
Name:MT1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169715.14
HGNCiHGNC:7397 MT1E
MIMi156351 gene
neXtProtiNX_P04732

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4493
OpenTargetsiENSG00000169715
PharmGKBiPA31202

Polymorphism and mutation databases

BioMutaiMT1E

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972361 – 61Metallothionein-1EAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP04732
MaxQBiP04732
PaxDbiP04732
PeptideAtlasiP04732
PRIDEiP04732
ProteomicsDBi51738
51739 [P04732-2]
TopDownProteomicsiP04732-1 [P04732-1]

PTM databases

iPTMnetiP04732
PhosphoSitePlusiP04732

Expressioni

Gene expression databases

BgeeiENSG00000169715
CleanExiHS_MT1E
ExpressionAtlasiP04732 baseline and differential
GenevisibleiP04732 HS

Organism-specific databases

HPAiHPA041152

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110599, 2 interactors
IntActiP04732, 1 interactor
STRINGi9606.ENSP00000307706

Structurei

3D structure databases

ProteinModelPortaliP04732
SMRiP04732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
InParanoidiP04732
KOiK14739
OMAiCNCAGSC
OrthoDBiEOG091G0ZHV
PhylomeDBiP04732
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC
60
KGASEKCSCC A
Length:61
Mass (Da):6,014
Last modified:August 13, 1987 - v1
Checksum:i8E0A7C54F623A1D2
GO
Isoform 2 (identifier: P04732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-61: CCSCCPVGCAKCAQGCVCKGASEKCSCCA → ECGAISRNLG...WVLSSSQACY

Show »
Length:127
Mass (Da):13,863
Checksum:iA2D0802B85A161B6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04160333 – 61CCSCC…CSCCA → ECGAISRNLGLWLRLGGNSR LALSASFWGTGLSLPSLPVS FPLQAFCPKFRWGRTAFFSW DTNPNCTPYGFRTELCQTKK SILWVWVLSSSQACY in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10942 Genomic DNA Translation: AAA59587.1
AF495759 mRNA Translation: AAM15968.1
AF348996 mRNA Translation: AAO32956.2
AC026461 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82872.1
CH471092 Genomic DNA Translation: EAW82874.1
BC009699 mRNA Translation: AAH09699.1
BC062734 mRNA Translation: AAH62734.1
BC131609 mRNA Translation: AAI31610.1
S68949 mRNA Translation: AAB30082.1
CCDSiCCDS10764.2 [P04732-1]
PIRiA22634 SMHU1E
RefSeqiNP_783316.2, NM_175617.3 [P04732-1]
XP_005256013.1, XM_005255956.4 [P04732-2]
UniGeneiHs.744893

Genome annotation databases

EnsembliENST00000306061; ENSP00000307706; ENSG00000169715 [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715 [P04732-2]
GeneIDi4493
KEGGihsa:4493
UCSCiuc002ejl.5 human [P04732-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMT1E_HUMAN
AccessioniPrimary (citable) accession number: P04732
Secondary accession number(s): A2RRF7, Q86YX4, Q8TD51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 20, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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