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Protein

Metallothionein-1E

Gene

MT1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5661231 Metallothioneins bind metals

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metallothionein-1E
Short name:
MT-1E
Alternative name(s):
Metallothionein-IE
Short name:
MT-IE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MT1E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169715.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7397 MT1E

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
156351 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4493

Open Targets

More...
OpenTargetsi
ENSG00000169715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31202

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MT1E

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001972361 – 61Metallothionein-1EAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P04732

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04732

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04732

PeptideAtlas

More...
PeptideAtlasi
P04732

PRoteomics IDEntifications database

More...
PRIDEi
P04732

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51738
51739 [P04732-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P04732-1 [P04732-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04732

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169715 Expressed in 228 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_MT1E

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04732 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04732 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041152

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110599, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P04732, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04732

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04732

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JFS1 Eukaryota
ENOG41113QR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000110883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236262

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04732

KEGG Orthology (KO)

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KOi
K14739

Identification of Orthologs from Complete Genome Data

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OMAi
CKECKCA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0ZHV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04732

TreeFam database of animal gene trees

More...
TreeFami
TF336054

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS

The PANTHER Classification System

More...
PANTHERi
PTHR23299 PTHR23299, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00131 Metallothio, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00860 MTVERTEBRATE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57868 SSF57868, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P04732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC
60
KGASEKCSCC A
Length:61
Mass (Da):6,014
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E0A7C54F623A1D2
GO
Isoform 2 (identifier: P04732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-61: CCSCCPVGCAKCAQGCVCKGASEKCSCCA → ECGAISRNLG...WVLSSSQACY

Show »
Length:127
Mass (Da):13,863
Checksum:iA2D0802B85A161B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BU80H3BU80_HUMAN
Metallothionein
MT1E
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04160333 – 61CCSCC…CSCCA → ECGAISRNLGLWLRLGGNSR LALSASFWGTGLSLPSLPVS FPLQAFCPKFRWGRTAFFSW DTNPNCTPYGFRTELCQTKK SILWVWVLSSSQACY in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M10942 Genomic DNA Translation: AAA59587.1
AF495759 mRNA Translation: AAM15968.1
AF348996 mRNA Translation: AAO32956.2
AC026461 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82872.1
CH471092 Genomic DNA Translation: EAW82874.1
BC009699 mRNA Translation: AAH09699.1
BC062734 mRNA Translation: AAH62734.1
BC131609 mRNA Translation: AAI31610.1
S68949 mRNA Translation: AAB30082.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10764.2 [P04732-1]
CCDS86530.1 [P04732-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A22634 SMHU1E

NCBI Reference Sequences

More...
RefSeqi
NP_783316.2, NM_175617.3 [P04732-1]
XP_005256013.1, XM_005255956.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744893

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306061; ENSP00000307706; ENSG00000169715 [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715 [P04732-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4493

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4493

UCSC genome browser

More...
UCSCi
uc002ejl.5 human [P04732-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10942 Genomic DNA Translation: AAA59587.1
AF495759 mRNA Translation: AAM15968.1
AF348996 mRNA Translation: AAO32956.2
AC026461 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82872.1
CH471092 Genomic DNA Translation: EAW82874.1
BC009699 mRNA Translation: AAH09699.1
BC062734 mRNA Translation: AAH62734.1
BC131609 mRNA Translation: AAI31610.1
S68949 mRNA Translation: AAB30082.1
CCDSiCCDS10764.2 [P04732-1]
CCDS86530.1 [P04732-2]
PIRiA22634 SMHU1E
RefSeqiNP_783316.2, NM_175617.3 [P04732-1]
XP_005256013.1, XM_005255956.4
UniGeneiHs.744893

3D structure databases

ProteinModelPortaliP04732
SMRiP04732
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110599, 2 interactors
IntActiP04732, 1 interactor
STRINGi9606.ENSP00000307706

PTM databases

iPTMnetiP04732
PhosphoSitePlusiP04732

Polymorphism and mutation databases

BioMutaiMT1E

Proteomic databases

EPDiP04732
MaxQBiP04732
PaxDbiP04732
PeptideAtlasiP04732
PRIDEiP04732
ProteomicsDBi51738
51739 [P04732-2]
TopDownProteomicsiP04732-1 [P04732-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4493
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306061; ENSP00000307706; ENSG00000169715 [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715 [P04732-2]
GeneIDi4493
KEGGihsa:4493
UCSCiuc002ejl.5 human [P04732-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4493
DisGeNETi4493
EuPathDBiHostDB:ENSG00000169715.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MT1E

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0040616
HGNCiHGNC:7397 MT1E
HPAiHPA041152
MIMi156351 gene
neXtProtiNX_P04732
OpenTargetsiENSG00000169715
PharmGKBiPA31202

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
InParanoidiP04732
KOiK14739
OMAiCKECKCA
OrthoDBiEOG091G0ZHV
PhylomeDBiP04732
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MT1E human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MT1E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4493

Protein Ontology

More...
PROi
PR:P04732

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169715 Expressed in 228 organ(s), highest expression level in liver
CleanExiHS_MT1E
ExpressionAtlasiP04732 baseline and differential
GenevisibleiP04732 HS

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMT1E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04732
Secondary accession number(s): A2RRF7, Q86YX4, Q8TD51
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Metallothioneins
    Classification of metallothioneins and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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