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Protein

Metallothionein-1A

Gene

MT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • metal ion binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1A
Short name:
MT-1A
Alternative name(s):
Metallothionein-IA
Short name:
MT-IA
Gene namesi
Name:MT1A
Synonyms:MT1S
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000205362.10
HGNCiHGNC:7393 MT1A
MIMi156350 gene
neXtProtiNX_P04731

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4489
OpenTargetsiENSG00000205362
PharmGKBiPA31198

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

Polymorphism and mutation databases

BioMutaiMT1A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972341 – 61Metallothionein-1AAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP04731
PaxDbiP04731
PeptideAtlasiP04731
PRIDEiP04731
ProteomicsDBi51737

PTM databases

PhosphoSitePlusiP04731

Expressioni

Gene expression databases

BgeeiENSG00000205362 Expressed in 84 organ(s), highest expression level in liver
CleanExiHS_MT1A

Organism-specific databases

HPAiCAB002161
CAB013056

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

Protein-protein interaction databases

BioGridi110595, 1 interactor
IntActiP04731, 4 interactors
MINTiP04731
STRINGi9606.ENSP00000290705

Structurei

3D structure databases

ProteinModelPortaliP04731
SMRiP04731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG009063
InParanoidiP04731
KOiK14739
OMAiCESACKD
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P04731-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC
60
KGASEKCSCC A
Length:61
Mass (Da):6,120
Last modified:November 24, 2009 - v2
Checksum:i8FBA7C54EE8B6A13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06072727T → N2 PublicationsCorresponds to variant dbSNP:rs11640851Ensembl.1
Natural variantiVAR_05943651K → R. Corresponds to variant dbSNP:rs8052394Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA Translation: AAA59586.1
AY028617 mRNA Translation: AAK26162.1
AF348995 mRNA Translation: AAO32955.1
AC026461 Genomic DNA No translation available.
BC029475 mRNA Translation: AAH29475.1
CCDSiCCDS32454.1
PIRiA24502 SMHU1A
RefSeqiNP_005937.2, NM_005946.2
UniGeneiHs.655199

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362
GeneIDi4489
KEGGihsa:4489
UCSCiuc002ejq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA Translation: AAA59586.1
AY028617 mRNA Translation: AAK26162.1
AF348995 mRNA Translation: AAO32955.1
AC026461 Genomic DNA No translation available.
BC029475 mRNA Translation: AAH29475.1
CCDSiCCDS32454.1
PIRiA24502 SMHU1A
RefSeqiNP_005937.2, NM_005946.2
UniGeneiHs.655199

3D structure databases

ProteinModelPortaliP04731
SMRiP04731
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110595, 1 interactor
IntActiP04731, 4 interactors
MINTiP04731
STRINGi9606.ENSP00000290705

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

PTM databases

PhosphoSitePlusiP04731

Polymorphism and mutation databases

BioMutaiMT1A

Proteomic databases

MaxQBiP04731
PaxDbiP04731
PeptideAtlasiP04731
PRIDEiP04731
ProteomicsDBi51737

Protocols and materials databases

DNASUi4489
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362
GeneIDi4489
KEGGihsa:4489
UCSCiuc002ejq.5 human

Organism-specific databases

CTDi4489
DisGeNETi4489
EuPathDBiHostDB:ENSG00000205362.10
GeneCardsiMT1A
H-InvDBiHIX0021628
HGNCiHGNC:7393 MT1A
HPAiCAB002161
CAB013056
MIMi156350 gene
neXtProtiNX_P04731
OpenTargetsiENSG00000205362
PharmGKBiPA31198
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG009063
InParanoidiP04731
KOiK14739
OMAiCESACKD
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

ChiTaRSiMT1A human
GeneWikiiMetallothionein_1A
GenomeRNAii4489
PROiPR:P04731
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205362 Expressed in 84 organ(s), highest expression level in liver
CleanExiHS_MT1A

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1A_HUMAN
AccessioniPrimary (citable) accession number: P04731
Secondary accession number(s): Q86YX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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