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UniProtKB - P04731 (MT1A_HUMAN)
Protein
Metallothionein-1A
Gene
MT1A
Organism
Homo sapiens (Human)
Status
Functioni
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 5 | Divalent metal cation 1; in cluster BBy similarity | 1 | |
Metal bindingi | 7 | Divalent metal cation 1; in cluster BBy similarity | 1 | |
Metal bindingi | 7 | Divalent metal cation 2; in cluster BBy similarity | 1 | |
Metal bindingi | 13 | Divalent metal cation 2; in cluster BBy similarity | 1 | |
Metal bindingi | 15 | Divalent metal cation 2; in cluster BBy similarity | 1 | |
Metal bindingi | 15 | Divalent metal cation 3; in cluster BBy similarity | 1 | |
Metal bindingi | 19 | Divalent metal cation 3; in cluster BBy similarity | 1 | |
Metal bindingi | 21 | Divalent metal cation 1; in cluster BBy similarity | 1 | |
Metal bindingi | 24 | Divalent metal cation 1; in cluster BBy similarity | 1 | |
Metal bindingi | 24 | Divalent metal cation 3; in cluster BBy similarity | 1 | |
Metal bindingi | 26 | Divalent metal cation 2; in cluster BBy similarity | 1 | |
Metal bindingi | 29 | Divalent metal cation 3; in cluster BBy similarity | 1 | |
Metal bindingi | 33 | Divalent metal cation 4; in cluster ABy similarity | 1 | |
Metal bindingi | 34 | Divalent metal cation 4; in cluster ABy similarity | 1 | |
Metal bindingi | 34 | Divalent metal cation 5; in cluster ABy similarity | 1 | |
Metal bindingi | 36 | Divalent metal cation 5; in cluster ABy similarity | 1 | |
Metal bindingi | 37 | Divalent metal cation 5; in cluster ABy similarity | 1 | |
Metal bindingi | 37 | Divalent metal cation 6; in cluster ABy similarity | 1 | |
Metal bindingi | 41 | Divalent metal cation 6; in cluster ABy similarity | 1 | |
Metal bindingi | 44 | Divalent metal cation 4; in cluster ABy similarity | 1 | |
Metal bindingi | 44 | Divalent metal cation 6; in cluster ABy similarity | 1 | |
Metal bindingi | 48 | Divalent metal cation 4; in cluster ABy similarity | 1 | |
Metal bindingi | 50 | Divalent metal cation 5; in cluster ABy similarity | 1 | |
Metal bindingi | 50 | Divalent metal cation 7; in cluster ABy similarity | 1 | |
Metal bindingi | 57 | Divalent metal cation 7; in cluster ABy similarity | 1 | |
Metal bindingi | 59 | Divalent metal cation 7; in cluster ABy similarity | 1 | |
Metal bindingi | 60 | Divalent metal cation 6; in cluster ABy similarity | 1 | |
Metal bindingi | 60 | Divalent metal cation 7; in cluster ABy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular response to cadmium ion Source: UniProtKB
- cellular response to copper ion Source: GO_Central
- cellular response to zinc ion Source: UniProtKB
- cellular zinc ion homeostasis Source: GO_Central
- detoxification of copper ion Source: GO_Central
- negative regulation of growth Source: UniProtKB
Keywordsi
Ligand | Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P04731 |
Reactomei | R-HSA-5661231, Metallothioneins bind metals |
SignaLinki | P04731 |
Names & Taxonomyi
Protein namesi | Recommended name: Metallothionein-1AShort name: MT-1A Alternative name(s): Metallothionein-IA Short name: MT-IA |
Gene namesi | Name:MT1A Synonyms:MT1S |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7393, MT1A |
MIMi | 156350, gene |
neXtProti | NX_P04731 |
VEuPathDBi | HostDB:ENSG00000205362 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4489 |
OpenTargetsi | ENSG00000205362 |
PharmGKBi | PA31198 |
Miscellaneous databases
Pharosi | P04731, Tbio |
Chemistry databases
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper DB00435, Nitric Oxide DB00526, Oxaliplatin DB12965, Silver DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | MT1A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197234 | 1 – 61 | Metallothionein-1AAdd BLAST | 61 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P04731 |
MassIVEi | P04731 |
MaxQBi | P04731 |
PaxDbi | P04731 |
PeptideAtlasi | P04731 |
PRIDEi | P04731 |
ProteomicsDBi | 51737 |
PTM databases
iPTMneti | P04731 |
PhosphoSitePlusi | P04731 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205362, Expressed in liver and 106 other tissues |
Organism-specific databases
HPAi | ENSG00000205362, Tissue enhanced (adipose tissue, liver) |
Interactioni
Subunit structurei
Monomer.
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 110595, 1 interactor |
IntActi | P04731, 4 interactors |
MINTi | P04731 |
STRINGi | 9606.ENSP00000478425 |
Miscellaneous databases
RNActi | P04731, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | BetaAdd BLAST | 29 | |
Regioni | 30 – 61 | AlphaAdd BLAST | 32 |
Domaini
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4738, Eukaryota |
GeneTreei | ENSGT00950000182967 |
HOGENOMi | CLU_171204_2_0_1 |
InParanoidi | P04731 |
OMAi | VASCKCT |
TreeFami | TF336054 |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
i Sequence
Sequence statusi: Complete.
P04731-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC
60
KGASEKCSCC A
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060727 | 27 | T → N2 PublicationsCorresponds to variant dbSNP:rs11640851Ensembl. | 1 | |
Natural variantiVAR_059436 | 51 | K → R. Corresponds to variant dbSNP:rs8052394Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01383 Genomic DNA Translation: AAA59586.1 AY028617 mRNA Translation: AAK26162.1 AF348995 mRNA Translation: AAO32955.1 AC026461 Genomic DNA No translation available. BC029475 mRNA Translation: AAH29475.1 |
CCDSi | CCDS32454.1 |
PIRi | A24502, SMHU1A |
RefSeqi | NP_005937.2, NM_005946.2 |
Genome annotation databases
Ensembli | ENST00000290705.12; ENSP00000290705.8; ENSG00000205362.11 |
GeneIDi | 4489 |
KEGGi | hsa:4489 |
MANE-Selecti | ENST00000290705.12; ENSP00000290705.8; NM_005946.3; NP_005937.2 |
UCSCi | uc002ejq.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01383 Genomic DNA Translation: AAA59586.1 AY028617 mRNA Translation: AAK26162.1 AF348995 mRNA Translation: AAO32955.1 AC026461 Genomic DNA No translation available. BC029475 mRNA Translation: AAH29475.1 |
CCDSi | CCDS32454.1 |
PIRi | A24502, SMHU1A |
RefSeqi | NP_005937.2, NM_005946.2 |
3D structure databases
AlphaFoldDBi | P04731 |
SMRi | P04731 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110595, 1 interactor |
IntActi | P04731, 4 interactors |
MINTi | P04731 |
STRINGi | 9606.ENSP00000478425 |
Chemistry databases
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper DB00435, Nitric Oxide DB00526, Oxaliplatin DB12965, Silver DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
iPTMneti | P04731 |
PhosphoSitePlusi | P04731 |
Genetic variation databases
BioMutai | MT1A |
Proteomic databases
jPOSTi | P04731 |
MassIVEi | P04731 |
MaxQBi | P04731 |
PaxDbi | P04731 |
PeptideAtlasi | P04731 |
PRIDEi | P04731 |
ProteomicsDBi | 51737 |
Protocols and materials databases
Antibodypediai | 58438, 66 antibodies from 14 providers |
DNASUi | 4489 |
Genome annotation databases
Ensembli | ENST00000290705.12; ENSP00000290705.8; ENSG00000205362.11 |
GeneIDi | 4489 |
KEGGi | hsa:4489 |
MANE-Selecti | ENST00000290705.12; ENSP00000290705.8; NM_005946.3; NP_005937.2 |
UCSCi | uc002ejq.5, human |
Organism-specific databases
CTDi | 4489 |
DisGeNETi | 4489 |
GeneCardsi | MT1A |
HGNCi | HGNC:7393, MT1A |
HPAi | ENSG00000205362, Tissue enhanced (adipose tissue, liver) |
MIMi | 156350, gene |
neXtProti | NX_P04731 |
OpenTargetsi | ENSG00000205362 |
PharmGKBi | PA31198 |
VEuPathDBi | HostDB:ENSG00000205362 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4738, Eukaryota |
GeneTreei | ENSGT00950000182967 |
HOGENOMi | CLU_171204_2_0_1 |
InParanoidi | P04731 |
OMAi | VASCKCT |
TreeFami | TF336054 |
Enzyme and pathway databases
PathwayCommonsi | P04731 |
Reactomei | R-HSA-5661231, Metallothioneins bind metals |
SignaLinki | P04731 |
Miscellaneous databases
BioGRID-ORCSi | 4489, 48 hits in 997 CRISPR screens |
ChiTaRSi | MT1A, human |
GeneWikii | Metallothionein_1A |
GenomeRNAii | 4489 |
Pharosi | P04731, Tbio |
PROi | PR:P04731 |
RNActi | P04731, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205362, Expressed in liver and 106 other tissues |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MT1A_HUMAN | |
Accessioni | P04731Primary (citable) accession number: P04731 Secondary accession number(s): Q86YX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | November 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Metallothioneins
Classification of metallothioneins and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families