UniProtKB - P04652 (TSHB_RAT)
Protein
Thyrotropin subunit beta
Gene
Tshb
Organism
Rattus norvegicus (Rat)
Status
Functioni
Indispensable for the control of thyroid structure and metabolism.
GO - Molecular functioni
- hormone activity Source: RGD
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- hormone-mediated signaling pathway Source: GO_Central
- response to calcium ion Source: RGD
- response to estrogen Source: RGD
- response to vitamin A Source: RGD
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-RNO-209822, Glycoprotein hormones R-RNO-209968, Thyroxine biosynthesis R-RNO-375281, Hormone ligand-binding receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Thyrotropin subunit betaAlternative name(s): Thyroid-stimulating hormone subunit beta Short name: TSH-B Short name: TSH-beta Thyrotropin beta chain |
Gene namesi | Name:Tshb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3910, Tshb |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000011754 | 21 – 132 | Thyrotropin subunit betaAdd BLAST | 112 | |
PropeptideiPRO_0000011755 | 133 – 138 | 6 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 72 | By similarity | ||
Disulfide bondi | 36 ↔ 87 | By similarity | ||
Disulfide bondi | 39 ↔ 125 | By similarity | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 47 ↔ 103 | By similarity | ||
Disulfide bondi | 51 ↔ 105 | By similarity | ||
Disulfide bondi | 108 ↔ 115 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P04652 |
PTM databases
GlyGeni | P04652, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000016793, Expressed in brain and 18 other tissues |
ExpressionAtlasi | P04652, baseline and differential |
Genevisiblei | P04652, RN |
Interactioni
Subunit structurei
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
GO - Molecular functioni
- hormone activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022575 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2JW, Eukaryota |
GeneTreei | ENSGT00940000158152 |
HOGENOMi | CLU_126319_0_2_1 |
InParanoidi | P04652 |
OMAi | HVTPYFS |
OrthoDBi | 1362225at2759 |
PhylomeDBi | P04652 |
TreeFami | TF332940 |
Family and domain databases
CDDi | cd00069, GHB_like, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR001545, Gonadotropin_bsu IPR018245, Gonadotropin_bsu_CS |
PANTHERi | PTHR11515, PTHR11515, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
SMARTi | View protein in SMART SM00068, GHB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00261, GLYCO_HORMONE_BETA_1, 1 hit PS00689, GLYCO_HORMONE_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04652-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAVVLFSVL FALACGQVSS FCIPTEYMMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFTYR TVEIPGCPHH VAPYFSYPVA
110 120 130
LSCKCGKCNT DYSDCTHEAV KTNYCTKPQT FYLGGFSG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | G → E in CAA25684 (PubMed:6086256).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01454 mRNA Translation: CAA25684.1 M10902 mRNA Translation: AAA42301.1 M13897 Genomic DNA Translation: AAB59720.1 M14450 Genomic DNA Translation: AAA99238.1 BC058488 mRNA Translation: AAH58488.1 D00578 mRNA Translation: BAA00456.1 |
PIRi | A90954, TTRTB |
RefSeqi | NP_037248.2, NM_013116.2 |
Genome annotation databases
Ensembli | ENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793 |
GeneIDi | 25653 |
KEGGi | rno:25653 |
UCSCi | RGD:3910, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01454 mRNA Translation: CAA25684.1 M10902 mRNA Translation: AAA42301.1 M13897 Genomic DNA Translation: AAB59720.1 M14450 Genomic DNA Translation: AAA99238.1 BC058488 mRNA Translation: AAH58488.1 D00578 mRNA Translation: BAA00456.1 |
PIRi | A90954, TTRTB |
RefSeqi | NP_037248.2, NM_013116.2 |
3D structure databases
SMRi | P04652 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022575 |
PTM databases
GlyGeni | P04652, 1 site |
Proteomic databases
PaxDbi | P04652 |
Genome annotation databases
Ensembli | ENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793 |
GeneIDi | 25653 |
KEGGi | rno:25653 |
UCSCi | RGD:3910, rat |
Organism-specific databases
CTDi | 7252 |
RGDi | 3910, Tshb |
Phylogenomic databases
eggNOGi | ENOG502S2JW, Eukaryota |
GeneTreei | ENSGT00940000158152 |
HOGENOMi | CLU_126319_0_2_1 |
InParanoidi | P04652 |
OMAi | HVTPYFS |
OrthoDBi | 1362225at2759 |
PhylomeDBi | P04652 |
TreeFami | TF332940 |
Enzyme and pathway databases
Reactomei | R-RNO-209822, Glycoprotein hormones R-RNO-209968, Thyroxine biosynthesis R-RNO-375281, Hormone ligand-binding receptors |
Miscellaneous databases
PROi | PR:P04652 |
Gene expression databases
Bgeei | ENSRNOG00000016793, Expressed in brain and 18 other tissues |
ExpressionAtlasi | P04652, baseline and differential |
Genevisiblei | P04652, RN |
Family and domain databases
CDDi | cd00069, GHB_like, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR001545, Gonadotropin_bsu IPR018245, Gonadotropin_bsu_CS |
PANTHERi | PTHR11515, PTHR11515, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
SMARTi | View protein in SMART SM00068, GHB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00261, GLYCO_HORMONE_BETA_1, 1 hit PS00689, GLYCO_HORMONE_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSHB_RAT | |
Accessioni | P04652Primary (citable) accession number: P04652 Secondary accession number(s): Q6GTA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families