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Protein

Thyrotropin subunit beta

Gene

Tshb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Indispensable for the control of thyroid structure and metabolism.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • hormone-mediated signaling pathway Source: GO_Central
  • response to calcium ion Source: RGD
  • response to estrogen Source: RGD
  • response to vitamin A Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-209822 Glycoprotein hormones
R-RNO-209968 Thyroxine biosynthesis
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin subunit beta
Alternative name(s):
Thyroid-stimulating hormone subunit beta
Short name:
TSH-B
Short name:
TSH-beta
Thyrotropin beta chain
Gene namesi
Name:Tshb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3910 Tshb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001175421 – 132Thyrotropin subunit betaAdd BLAST112
PropeptideiPRO_0000011755133 – 1386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 72By similarity
Disulfide bondi36 ↔ 87By similarity
Disulfide bondi39 ↔ 125By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 103By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi108 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04652
PRIDEiP04652

Expressioni

Gene expression databases

BgeeiENSRNOG00000016793
ExpressionAtlasiP04652 baseline and differential
GenevisibleiP04652 RN

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022575

Structurei

3D structure databases

ProteinModelPortaliP04652
SMRiP04652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXJG Eukaryota
ENOG410YSY0 LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP04652
KOiK05251
OMAiTNYCTKP
OrthoDBiEOG091G0XFH
PhylomeDBiP04652
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVVLFSVL FALACGQVSS FCIPTEYMMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFTYR TVEIPGCPHH VAPYFSYPVA
110 120 130
LSCKCGKCNT DYSDCTHEAV KTNYCTKPQT FYLGGFSG
Length:138
Mass (Da):15,505
Last modified:May 1, 2007 - v2
Checksum:iF8AD7F2426DAEE09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16G → E in CAA25684 (PubMed:6086256).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01454 mRNA Translation: CAA25684.1
M10902 mRNA Translation: AAA42301.1
M13897 Genomic DNA Translation: AAB59720.1
M14450 Genomic DNA Translation: AAA99238.1
BC058488 mRNA Translation: AAH58488.1
D00578 mRNA Translation: BAA00456.1
PIRiA90954 TTRTB
RefSeqiNP_037248.2, NM_013116.2
UniGeneiRn.9966

Genome annotation databases

EnsembliENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793
GeneIDi25653
KEGGirno:25653
UCSCiRGD:3910 rat

Similar proteinsi

Entry informationi

Entry nameiTSHB_RAT
AccessioniPrimary (citable) accession number: P04652
Secondary accession number(s): Q6GTA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 1, 2007
Last modified: June 20, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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