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Entry version 140 (08 May 2019)
Sequence version 2 (01 May 2007)
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Protein

Apolipoprotein A-I

Gene

Apoa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-114608 Platelet degranulation
R-RNO-1369062 ABC transporters in lipid homeostasis
R-RNO-2168880 Scavenging of heme from plasma
R-RNO-3000471 Scavenging by Class B Receptors
R-RNO-3000480 Scavenging by Class A Receptors
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-8963888 Chylomicron assembly
R-RNO-8963896 HDL assembly
R-RNO-8963901 Chylomicron remodeling
R-RNO-8964011 HDL clearance
R-RNO-8964058 HDL remodeling
R-RNO-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following chain:
Proapolipoprotein A-I
Short name:
ProapoA-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Apoa1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
2130 Apoa1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042533519 – 259Proapolipoprotein A-IAdd BLAST241
ChainiPRO_000000195425 – 259Apolipoprotein A-IAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei109Methionine sulfoxideBy similarity1
Modified residuei189Methionine sulfoxideBy similarity1
Modified residuei236Methionine sulfoxideBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.By similarity
Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04639

PRoteomics IDEntifications database

More...
PRIDEi
P04639

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P04639

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000045679 Expressed in 9 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04639 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APOA1BP and CLU.

Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin.

Interacts with NDRG1.

Interacts with SCGB3A2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ApobQ7TMA52EBI-2925493,EBI-15185298

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
247155, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-29911N

Protein interaction database and analysis system

More...
IntActi
P04639, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000065206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04639

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati67 – 881Add BLAST22
Repeati89 – 1102Add BLAST22
Repeati111 – 1213; half-lengthAdd BLAST11
Repeati122 – 1434Add BLAST22
Repeati144 – 1615; truncatedAdd BLAST18
Repeati162 – 1836Add BLAST22
Repeati184 – 2037; truncatedAdd BLAST20
Repeati204 – 2258Add BLAST22
Repeati226 – 2369; half-lengthAdd BLAST11
Repeati237 – 25910Add BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 25910 X approximate tandem repeatsAdd BLAST193

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWKR Eukaryota
ENOG410YGQ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04639

KEGG Orthology (KO)

More...
KOi
K08757

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEFQKKW

Database of Orthologous Groups

More...
OrthoDBi
1553412at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04639

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000074 ApoA_E

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01442 Apolipoprotein, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAAVLAVAL VFLTGCQAWE FWQQDEPQSQ WDRVKDFATV YVDAVKDSGR
60 70 80 90 100
DYVSQFESST LGKQLNLNLL DNWDTLGSTV GRLQEQLGPV TQEFWANLEK
110 120 130 140 150
ETDWLRNEMN KDLENVKQKM QPHLDEFQEK WNEEVEAYRQ KLEPLGTELH
160 170 180 190 200
KNAKEMQRHL KVVAEEFRDR MRVNADALRA KFGLYSDQMR ENLAQRLTEI
210 220 230 240 250
KNHPTLIEYH TKASDHLKTL GEKAKPALDD LGQGLMPVLE AWKAKIMSMI

DEAKKKLNA
Length:259
Mass (Da):30,062
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28538891B2E3A6CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28Missing in AAB58428 (PubMed:9415807).Curated1
Sequence conflicti28Missing in AAB58429 (PubMed:9415807).Curated1
Sequence conflicti28Missing in AAB58430 (PubMed:9415807).Curated1
Sequence conflicti93E → D in AAB58428 (PubMed:9415807).Curated1
Sequence conflicti93E → D in AAB58429 (PubMed:9415807).Curated1
Sequence conflicti93E → D in AAB58430 (PubMed:9415807).Curated1
Sequence conflicti105L → P in AAB58428 (PubMed:9415807).Curated1
Sequence conflicti105L → P in AAB58429 (PubMed:9415807).Curated1
Sequence conflicti105L → P in AAB58430 (PubMed:9415807).Curated1
Sequence conflicti146G → A in AAB58428 (PubMed:9415807).Curated1
Sequence conflicti146G → A in AAB58429 (PubMed:9415807).Curated1
Sequence conflicti146G → A in AAB58430 (PubMed:9415807).Curated1
Sequence conflicti201K → R in CAA25224 (PubMed:6426956).Curated1
Sequence conflicti214S → G in CAA25224 (PubMed:6426956).Curated1
Sequence conflicti218K → R in CAA25224 (PubMed:6426956).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M00001 mRNA Translation: AAA40749.1
X00558 mRNA Translation: CAA25224.1
J02597 Genomic DNA Translation: AAA40745.1
U79576 Genomic DNA Translation: AAB58428.1
U79577 Genomic DNA Translation: AAB58429.1
U79578 Genomic DNA Translation: AAB58430.1
BC089820 mRNA Translation: AAH89820.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A24700

NCBI Reference Sequences

More...
RefSeqi
NP_036870.1, NM_012738.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000074357; ENSRNOP00000065206; ENSRNOG00000045679

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25081

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M00001 mRNA Translation: AAA40749.1
X00558 mRNA Translation: CAA25224.1
J02597 Genomic DNA Translation: AAA40745.1
U79576 Genomic DNA Translation: AAB58428.1
U79577 Genomic DNA Translation: AAB58429.1
U79578 Genomic DNA Translation: AAB58430.1
BC089820 mRNA Translation: AAH89820.1
PIRiA24700
RefSeqiNP_036870.1, NM_012738.1

3D structure databases

SMRiP04639
ModBaseiSearch...

Protein-protein interaction databases

BioGridi247155, 1 interactor
DIPiDIP-29911N
IntActiP04639, 3 interactors
STRINGi10116.ENSRNOP00000065206

PTM databases

CarbonylDBiP04639
iPTMnetiP04639
PhosphoSitePlusiP04639

Proteomic databases

PaxDbiP04639
PRIDEiP04639

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074357; ENSRNOP00000065206; ENSRNOG00000045679
GeneIDi25081
KEGGirno:25081

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
335
RGDi2130 Apoa1

Phylogenomic databases

eggNOGiENOG410IWKR Eukaryota
ENOG410YGQ6 LUCA
GeneTreeiENSGT00950000182929
InParanoidiP04639
KOiK08757
OMAiDEFQKKW
OrthoDBi1553412at2759
PhylomeDBiP04639

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-1369062 ABC transporters in lipid homeostasis
R-RNO-2168880 Scavenging of heme from plasma
R-RNO-3000471 Scavenging by Class B Receptors
R-RNO-3000480 Scavenging by Class A Receptors
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-8963888 Chylomicron assembly
R-RNO-8963896 HDL assembly
R-RNO-8963901 Chylomicron remodeling
R-RNO-8964011 HDL clearance
R-RNO-8964058 HDL remodeling
R-RNO-975634 Retinoid metabolism and transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P04639

Gene expression databases

BgeeiENSRNOG00000045679 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiP04639 RN

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOA1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04639
Secondary accession number(s): O08877, O09054, Q5EBB2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 1, 2007
Last modified: May 8, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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