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UniProtKB - P04632 (CPNS1_HUMAN)

Entry version 212 (13 Nov 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Calpain small subunit 1

Gene

CAPNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi112Calcium 1By similarity1
Metal bindingi114Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi119Calcium 1By similarity1
Metal bindingi137Calcium 4By similarity1
Metal bindingi152Calcium 2By similarity1
Metal bindingi154Calcium 2By similarity1
Metal bindingi156Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi158Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi163Calcium 2By similarity1
Metal bindingi182Calcium 3By similarity1
Metal bindingi184Calcium 3By similarity1
Metal bindingi186Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi188Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi193Calcium 3By similarity1
Metal bindingi225Calcium 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi108 – 1191PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi152 – 1632PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi182 – 1933PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.53 2681
3.4.22.B24 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-6809371 Formation of the cornified envelope
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain small subunit 1
Short name:
CSS1
Alternative name(s):
Calcium-activated neutral proteinase small subunit
Short name:
CANP small subunit
Calcium-dependent protease small subunit
Short name:
CDPS
Calcium-dependent protease small subunit 1
Calpain regulatory subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPNS1
Synonyms:CAPN4, CAPNS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1481 CAPNS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114170 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P04632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		826

Open Targets

More...OpenTargetsi		ENSG00000126247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26067

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P04632

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2111357

Drug and drug target database

More...DrugBanki		DB02570 PD150606

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAPNS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		115612

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000737131 – 268Calpain small subunit 1Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei179N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-470
CPTAC-471

Encyclopedia of Proteome Dynamics

More...EPDi		P04632

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P04632

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P04632

MaxQB - The MaxQuant DataBase

More...MaxQBi		P04632

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P04632

PeptideAtlas

More...PeptideAtlasi		P04632

PRoteomics IDEntifications database

More...PRIDEi		P04632

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51727

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P04632

2D gel databases

USC-OGP 2-DE database

More...OGPi		P04632

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00025084

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P04632

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P04632

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P04632

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P04632

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126247 Expressed in 235 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P04632 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P04632 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA006872

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107276, 65 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2674 M-Calpain complex
CPX-4302 mu-Calpain complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P04632

Protein interaction database and analysis system

More...IntActi		P04632, 35 interactors

Molecular INTeraction database

More...MINTi		P04632

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246533

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P04632

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04632

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P04632

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 125EF-hand 1; atypicalPROSITE-ProRule annotationAdd BLAST35
Domaini139 – 172EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini169 – 204EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini205 – 233EF-hand 4PROSITE-ProRule annotationAdd BLAST29
Domaini234 – 268EF-hand 5PROSITE-ProRule annotationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 66Gly-rich (hydrophobic)Add BLAST66
Compositional biasi10 – 26Poly-GlyAdd BLAST17
Compositional biasi35 – 56Poly-GlyAdd BLAST22
Compositional biasi78 – 83Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.By similarity
EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0037 Eukaryota
ENOG410YKQK LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155478

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000063658

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04632

KEGG Orthology (KO)

More...KOi		K08583

Database of Orthologous Groups

More...OrthoDBi		1330600at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04632

TreeFam database of animal gene trees

More...TreeFami		TF314682

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029642 CAPN4
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

The PANTHER Classification System

More...PANTHERi		PTHR46735:SF1 PTHR46735:SF1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

P04632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG 
        60         70         80         90        100
GGGGGGTAMR ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ 
       110        120        130        140        150
FRRLFAQLAG DDMEVSATEL MNILNKVVTR HPDLKTDGFG IDTCRSMVAV 
       160        170        180        190        200
MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ FDTDRSGTIC SSELPGAFEA 
       210        220        230        240        250
AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF RAFKSLDKDG 
       260 
TGQIQVNIQE WLQLTMYS
Length:268
Mass (Da):28,316
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17B87A8E47A90632
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B7C0A0A075B7C0_HUMAN
Calpain small subunit 1
CAPNS1
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGQ5A0A0C4DGQ5_HUMAN
Calpain small subunit 1
CAPNS1
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELJ7K7ELJ7_HUMAN
Calpain small subunit 1
CAPNS1
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKD8K7EKD8_HUMAN
Calpain small subunit 1
CAPNS1
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIV0K7EIV0_HUMAN
Calpain small subunit 1
CAPNS1
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM73K7EM73_HUMAN
Calpain small subunit 1
CAPNS1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMQ1K7EMQ1_HUMAN
Calpain small subunit 1
CAPNS1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPR7U3KPR7_HUMAN
Calpain small subunit 1
CAPNS1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQE2U3KQE2_HUMAN
Calpain small subunit 1
CAPNS1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3F9S4R3F9_HUMAN
Calpain small subunit 1
CAPNS1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5N → D in AAH64998 (PubMed:15489334).Curated1
Sequence conflicti27N → G in AAH64998 (PubMed:15489334).Curated1
Sequence conflicti34S → G in AAH64998 (PubMed:15489334).Curated1
Sequence conflicti261 – 268WLQLTMYS → VRTPILGYGCLGGPHPSALH TSSELQSPSSYFASRPWVRA KGLVLLGFPVLTLHPPLPSG CS in AAH11903 (PubMed:15489334).Curated8
Sequence conflicti267Y → F in AAH21933 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021089224M → V1 PublicationCorresponds to variant dbSNP:rs17878750Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04106 mRNA Translation: CAA27726.1
M31511
, M31502, M31503, M31504, M31505, M31506, M31507, M31508, M31509, M31510 Genomic DNA Translation: AAA35646.1
AK289606 mRNA Translation: BAF82295.1
BT009775 mRNA Translation: AAP88777.1
AY789642 Genomic DNA Translation: AAV40829.1
AD001527 Genomic DNA Translation: AAB51183.1
AC002984 Genomic DNA Translation: AAB81546.1
BC000592 mRNA Translation: AAH00592.1
BC007779 mRNA Translation: AAH07779.1
BC011903 mRNA Translation: AAH11903.1
BC017308 mRNA Translation: AAH17308.1
BC018931 mRNA Translation: AAH18931.1
BC021933 mRNA Translation: AAH21933.1
BC023643 mRNA Translation: AAH23643.1
BC064998 mRNA Translation: AAH64998.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12489.1

Protein sequence database of the Protein Information Resource

More...PIRi		A26107 CIHUL

NCBI Reference Sequences

More...RefSeqi		NP_001003962.1, NM_001003962.2
NP_001289561.1, NM_001302632.1
NP_001289562.1, NM_001302633.1
NP_001740.1, NM_001749.3
XP_005259352.1, XM_005259295.1
XP_005259353.1, XM_005259296.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246533; ENSP00000246533; ENSG00000126247
ENST00000588815; ENSP00000464849; ENSG00000126247

Database of genes from NCBI RefSeq genomes

More...GeneIDi		826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:826

UCSC genome browser

More...UCSCi		uc002odi.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CaBP

Calpain

Calpains homepage
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04106 mRNA Translation: CAA27726.1
M31511
, M31502, M31503, M31504, M31505, M31506, M31507, M31508, M31509, M31510 Genomic DNA Translation: AAA35646.1
AK289606 mRNA Translation: BAF82295.1
BT009775 mRNA Translation: AAP88777.1
AY789642 Genomic DNA Translation: AAV40829.1
AD001527 Genomic DNA Translation: AAB51183.1
AC002984 Genomic DNA Translation: AAB81546.1
BC000592 mRNA Translation: AAH00592.1
BC007779 mRNA Translation: AAH07779.1
BC011903 mRNA Translation: AAH11903.1
BC017308 mRNA Translation: AAH17308.1
BC018931 mRNA Translation: AAH18931.1
BC021933 mRNA Translation: AAH21933.1
BC023643 mRNA Translation: AAH23643.1
BC064998 mRNA Translation: AAH64998.1
CCDSiCCDS12489.1
PIRiA26107 CIHUL
RefSeqiNP_001003962.1, NM_001003962.2
NP_001289561.1, NM_001302632.1
NP_001289562.1, NM_001302633.1
NP_001740.1, NM_001749.3
XP_005259352.1, XM_005259295.1
XP_005259353.1, XM_005259296.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KFUX-ray2.50S85-268[»]
1KFXX-ray3.15S85-268[»]
4PHJX-ray1.60A/B96-268[»]
4PHKX-ray2.05A/B96-268[»]
4PHMX-ray2.03A/B96-268[»]
4WQ2X-ray1.64A/B96-268[»]
4WQ3X-ray1.79A/B96-268[»]
5D69X-ray1.97A/B96-268[»]
SMRiP04632
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107276, 65 interactors
ComplexPortaliCPX-2674 M-Calpain complex
CPX-4302 mu-Calpain complex
CORUMiP04632
IntActiP04632, 35 interactors
MINTiP04632
STRINGi9606.ENSP00000246533

Chemistry databases

BindingDBiP04632
ChEMBLiCHEMBL2111357
DrugBankiDB02570 PD150606

PTM databases

iPTMnetiP04632
PhosphoSitePlusiP04632
SwissPalmiP04632

Polymorphism and mutation databases

BioMutaiCAPNS1
DMDMi115612

2D gel databases

OGPiP04632
REPRODUCTION-2DPAGEiIPI00025084
SWISS-2DPAGEiP04632

Proteomic databases

CPTACiCPTAC-470
CPTAC-471
EPDiP04632
jPOSTiP04632
MassIVEiP04632
MaxQBiP04632
PaxDbiP04632
PeptideAtlasiP04632
PRIDEiP04632
ProteomicsDBi51727
TopDownProteomicsiP04632

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		826

Genome annotation databases

EnsembliENST00000246533; ENSP00000246533; ENSG00000126247
ENST00000588815; ENSP00000464849; ENSG00000126247
GeneIDi826
KEGGihsa:826
UCSCiuc002odi.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		826
DisGeNETi826

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAPNS1
HGNCiHGNC:1481 CAPNS1
HPAiHPA006872
MIMi114170 gene
neXtProtiNX_P04632
OpenTargetsiENSG00000126247
PharmGKBiPA26067

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00940000155478
HOGENOMiHOG000063658
InParanoidiP04632
KOiK08583
OrthoDBi1330600at2759
PhylomeDBiP04632
TreeFamiTF314682

Enzyme and pathway databases

BRENDAi3.4.22.53 2681
3.4.22.B24 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-6809371 Formation of the cornified envelope
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAPNS1 human
EvolutionaryTraceiP04632

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CAPNS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		826
PharosiP04632

Protein Ontology

More...PROi		PR:P04632

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126247 Expressed in 235 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP04632 baseline and differential
GenevisibleiP04632 HS

Family and domain databases

InterProiView protein in InterPro
IPR029642 CAPN4
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR46735:SF1 PTHR46735:SF1, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPNS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04632
Secondary accession number(s): A8K0P1, Q8WTX3, Q96EW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 13, 2019
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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