Proto-oncogene Wnt-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL
• frizzled binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• morphogen activity Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: WormBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families."
    Voloshanenko O., Gmach P., Winter J., Kranz D., Boutros M.
    FASEB J. 31:4832-4844(2017) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia."
    Pizzatti L., Binato R., Cofre J., Gomes B.E., Dobbin J., Haussmann M.E., D'Azambuja D., Bouzas L.F., Abdelhay E.
    Genes Chromosomes Cancer 49:107-118(2010) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• animal organ regeneration Source: Ensembl
• astrocyte-dopaminergic neuron signaling Source: Ensembl
• beta-catenin destruction complex disassembly Source: Reactome
• bone development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "Mutations in WNT1 cause different forms of bone fragility."
    Keupp K., Beleggia F., Kayserili H., Barnes A.M., Steiner M., Semler O., Fischer B., Yigit G., Janda C.Y., Becker J., Breer S., Altunoglu U., Gruenhagen J., Krawitz P., Hecht J., Schinke T., Makareeva E., Lausch E.

    , Cankaya T., Caparros-Martin J.A., Lapunzina P., Temtamy S., Aglan M., Zabel B., Eysel P., Koerber F., Leikin S., Garcia K.C., Netzer C., Schoenau E., Ruiz-Perez V.L., Mundlos S., Amling M., Kornak U., Marini J., Wollnik B.
    Am. J. Hum. Genet. 92:565-574(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INVOLVEMENT IN BMND16, VARIANTS OI15 CYS-177 AND CYS-298, VARIANT OSTEOP TRP-235, CHARACTERIZATION OF VARIANT OI15 CYS-177, CHARACTERIZATION OF VARIANT OSTEOP TRP-235.
• branching involved in ureteric bud morphogenesis Source: Ensembl
• canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J. Biol. Chem. 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem. Soc. Trans. 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: BHF-UCL
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell proliferation in midbrain Source: Ensembl
• cellular response to peptide hormone stimulus Source: Ensembl
• central nervous system morphogenesis Source: BHF-UCL
• cerebellum formation Source: BHF-UCL
• diencephalon development Source: Ensembl
• embryonic axis specification Source: BHF-UCL
• embryonic brain development Source: Ensembl
• forebrain anterior/posterior pattern specification Source: Ensembl
• hematopoietic stem cell proliferation Source: Ensembl
• hepatocyte differentiation Source: Ensembl
• inner ear morphogenesis Source: Ensembl
• midbrain development Source: BHF-UCL
• midbrain-hindbrain boundary maturation during brain development Source: Ensembl
• myoblast fusion Source: Ensembl
• negative regulation of apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors."
    Longo K.A., Kennell J.A., Ochocinska M.J., Ross S.E., Wright W.S., MacDougald O.A.
    J. Biol. Chem. 277:38239-38244(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of BMP signaling pathway Source: AgBaseInferred from mutant phenotypeⁱ
  • "BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin."
    Zhang W.V., Stott N.S.
    Cell Commun. Adhes. 11:89-102(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell aging Source: BHF-UCLInferred from direct assayⁱ
  • "Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism."
    Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P., Brisken C.
    Proc. Natl. Acad. Sci. U.S.A. 103:3799-3804(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell-cell adhesion Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells."
    Yook J.I., Li X.Y., Ota I., Hu C., Kim H.S., Kim N.H., Cha S.Y., Ryu J.K., Choi Y.J., Kim J., Fearon E.R., Weiss S.J.
    Nat. Cell Biol. 8:1398-1406(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell-substrate adhesion Source: BHF-UCLInferred from direct assayⁱ
  • "Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism."
    Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P., Brisken C.
    Proc. Natl. Acad. Sci. U.S.A. 103:3799-3804(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: BHF-UCL
• negative regulation of oxidative stress-induced neuron death Source: Ensembl
• negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• negative regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuron fate determination Source: Ensembl
• positive regulation of cell population proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism."
    Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P., Brisken C.
    Proc. Natl. Acad. Sci. U.S.A. 103:3799-3804(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dermatome development Source: BHF-UCLInferred from direct assayⁱ
  • "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm."
    Lee C.S., Buttitta L.A., May N.R., Kispert A., Fan C.M.
    Development 127:109-118(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
• positive regulation of fibroblast proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts."
    Salazar K.D., Lankford S.M., Brody A.R.
    Am. J. Physiol. Lung Cell Mol. Physiol. 297:L1002-11(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors."
    Longo K.A., Kennell J.A., Ochocinska M.J., Ross S.E., Wright W.S., MacDougald O.A.
    J. Biol. Chem. 277:38239-38244(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lamellipodium assembly Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line."
    Zhang L., Li K., Lv Z., Xiao X., Zheng J.
    Pediatr. Surg. Int. 25:1065-1071(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Notch signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism."
    Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P., Brisken C.
    Proc. Natl. Acad. Sci. U.S.A. 103:3799-3804(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription."
    Strovel E.T., Wu D., Sussman D.J.
    J. Biol. Chem. 275:2399-2403(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• response to wounding Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas."
    McGowan S.L., Edelhauser H.F., Pfister R.R., Whikehart D.R.
    Mol. Vis. 13:1984-2000(2007) [PubMed] [Europe PMC] [Abstract]
• signal transduction in response to DNA damage Source: BHF-UCLInferred from direct assayⁱ
  • "Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism."
    Ayyanan A., Civenni G., Ciarloni L., Morel C., Mueller N., Lefort K., Mandinova A., Raffoul W., Fiche M., Dotto G.P., Brisken C.
    Proc. Natl. Acad. Sci. U.S.A. 103:3799-3804(2006) [PubMed] [Europe PMC] [Abstract]
• Spemann organizer formation Source: BHF-UCL
• spinal cord association neuron differentiation Source: Ensembl
• T cell differentiation in thymus Source: Ensembl
• ubiquitin-dependent SMAD protein catabolic process Source: Ensembl
• Wnt signaling pathway Source: Reactome
• Wnt signaling pathway, planar cell polarity pathway Source: Reactome
• Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• morphogen activity Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: WormBaseInferred from direct assayⁱ
  • "Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families."
    Voloshanenko O., Gmach P., Winter J., Kranz D., Boutros M.
    FASEB J. 31:4832-4844(2017) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGLWALLPGW VSATLLLALA ALPAALAANS SGRWWGIVNV ASSTNLLTDS 
        60         70         80         90        100
KSLQLVLEPS LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR 
       110        120        130        140        150
RWNCPTAPGP HLFGKIVNRG CRETAFIFAI TSAGVTHSVA RSCSEGSIES 
       160        170        180        190        200
CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF GREFVDSGEK GRDLRFLMNL 
       210        220        230        240        250
HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR AVGDVLRDRF 
       260        270        280        290        300
DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT 
       310        320        330        340        350
YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH 
       360        370
WCCHVSCRNC THTRVLHECL                                  

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 12
   Human chromosome 12: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families