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UniProtKB - P04625 (THA_CHICK)
Protein
Thyroid hormone receptor alpha
Gene
THRA
Organism
Gallus gallus (Chicken)
Status
Functioni
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 51 | Zinc 1By similarity | 1 | |
Metal bindingi | 54 | Zinc 1By similarity | 1 | |
Metal bindingi | 68 | Zinc 1By similarity | 1 | |
Metal bindingi | 71 | Zinc 1By similarity | 1 | |
Metal bindingi | 89 | Zinc 2By similarity | 1 | |
Metal bindingi | 95 | Zinc 2By similarity | 1 | |
Metal bindingi | 105 | Zinc 2By similarity | 1 | |
Metal bindingi | 108 | Zinc 2By similarity | 1 | |
Binding sitei | 226 | 3,3',5-triiodo-L-thyronineBy similarity | 1 | |
Binding sitei | 275 | 3,3',5-triiodo-L-thyronine; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 51 – 125 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 51 – 71 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 89 – 113 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- nuclear receptor activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: AgBase
- thyroid hormone binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- hormone-mediated signaling pathway Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- thyroid hormone mediated signaling pathway Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Thyroid hormone receptor alphaAlternative name(s): Nuclear receptor subfamily 1 group A member 1 |
Gene namesi | Name:THRA Synonyms:NR1A1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053431 | 1 – 408 | Thyroid hormone receptor alphaAdd BLAST | 408 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 28 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P04625 |
PTM databases
iPTMneti | P04625 |
Interactioni
Subunit structurei
Probably interacts with SFPQ.
1 PublicationBinary interactionsi
P04625
With | #Exp. | IntAct |
---|---|---|
RXRA [P19793] from Homo sapiens. | 4 | EBI-286261,EBI-78598 |
SFPQ - isoform Long [P23246-1] from Homo sapiens. | 2 | EBI-286261,EBI-355463 |
Protein-protein interaction databases
ComplexPortali | CPX-704, RXRalpha-TRalpha nuclear hormone receptor complex |
DIPi | DIP-32625N |
IntActi | P04625, 5 interactors |
STRINGi | 9031.ENSGALP00000000351 |
Chemistry databases
BindingDBi | P04625 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04625 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 161 – 405 | NR LBDPROSITE-ProRule annotationAdd BLAST | 245 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | ModulatingAdd BLAST | 50 | |
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Domaini
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 51 – 71 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 89 – 113 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157917 |
InParanoidi | P04625 |
OMAi | VAEWDLI |
PhylomeDBi | P04625 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50252 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P04625-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQKPSTLDP LSEPEDTRWL DGKRKRKSSQ CLVKSSMSGY IPSYLDKDEQ
60 70 80 90 100
CVVCGDKATG YHYRCITCEG CKGFFRRTIQ KNLHPTYSCK YDGCCVIDKI
110 120 130 140 150
TRNQCQLCRF KKCISVGMAM DLVLDDSKRV AKRKLIEENR ERRRKEEMIK
160 170 180 190 200
SLQHRPSPSA EEWELIHVVT EAHRSTNAQG SHWKQKRKFL PEDIGQSPMA
210 220 230 240 250
SMPDGDKVDL EAFSEFTKII TPAITRVVDF AKKLPMFSEL PCEDQIILLK
260 270 280 290 300
GCCMEIMSLR AAVRYDPESE TLTLSGEMAV KREQLKNGGL GVVSDAIFDL
310 320 330 340 350
GKSLSAFNLD DTEVALLQAV LLMSSDRTGL ICVDKIEKCQ ETYLLAFEHY
360 370 380 390 400
INYRKHNIPH FWPKLLMKVT DLRMIGACHA SRFLHMKVEC PTELFPPLFL
EVFEDQEV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2U6Z5 | A0A3Q2U6Z5_CHICK | Thyroid hormone receptor alpha | THRA | 441 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04854 Genomic DNA Translation: CAA28545.1 Y00987 mRNA Translation: CAA68792.1 |
PIRi | A25236, TVCHVR |
RefSeqi | NP_990644.1, NM_205313.1 |
Genome annotation databases
Ensembli | ENSGALT00000052263; ENSGALP00000052375; ENSGALG00000040017 ENSGALT00000058539; ENSGALP00000050455; ENSGALG00000040017 |
GeneIDi | 396251 |
KEGGi | gga:396251 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04854 Genomic DNA Translation: CAA28545.1 Y00987 mRNA Translation: CAA68792.1 |
PIRi | A25236, TVCHVR |
RefSeqi | NP_990644.1, NM_205313.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UVV | X-ray | 2.95 | A | 148-408 | [»] | |
SMRi | P04625 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-704, RXRalpha-TRalpha nuclear hormone receptor complex |
DIPi | DIP-32625N |
IntActi | P04625, 5 interactors |
STRINGi | 9031.ENSGALP00000000351 |
Chemistry databases
BindingDBi | P04625 |
PTM databases
iPTMneti | P04625 |
Proteomic databases
PaxDbi | P04625 |
Genome annotation databases
Ensembli | ENSGALT00000052263; ENSGALP00000052375; ENSGALG00000040017 ENSGALT00000058539; ENSGALP00000050455; ENSGALG00000040017 |
GeneIDi | 396251 |
KEGGi | gga:396251 |
Organism-specific databases
CTDi | 7067 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157917 |
InParanoidi | P04625 |
OMAi | VAEWDLI |
PhylomeDBi | P04625 |
Miscellaneous databases
PROi | PR:P04625 |
Gene expression databases
ExpressionAtlasi | P04625, baseline |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50252 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THA_CHICK | |
Accessioni | P04625Primary (citable) accession number: P04625 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | September 29, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families