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Protein

Sarcoplasmic calcium-binding protein

Gene
N/A
Organism
Hediste diversicolor (Sandworm) (Nereis diversicolor)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

Miscellaneous

The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
This protein has three functional calcium-binding sites; potential site 2 has lost affinity for calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi16 – 271Add BLAST12
Calcium bindingi104 – 1152Add BLAST12
Calcium bindingi138 – 1493Add BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoplasmic calcium-binding protein
Short name:
SCP
OrganismiHediste diversicolor (Sandworm) (Nereis diversicolor)
Taxonomic identifieri126592 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaPalpataAciculataPhyllodocidaNereididaeHedisteHediste diversicolor species group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000736281 – 174Sarcoplasmic calcium-binding proteinAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP04571

Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04571
SMRiP04571
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04571

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 38EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini55 – 90EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 160EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat

Family and domain databases

CDDicd00052 EH, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

P04571-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SDLWVQKMKT YFNRIDFDKD GAITRMDFES MAERFAKESE MKAEHAKVLM
60 70 80 90 100
DSLTGVWDNF LTAVAGGKGI DETTFINSMK EMVKNPEAKS VVEGPLPLFF
110 120 130 140 150
RAVDTNEDNN ISRDEYGIFF GMLGLDKTMA PASFDAIDTN NDGLLSLEEF
160 170
VIAGSDFFMN DGDSTNKVFW GPLV
Length:174
Mass (Da):19,486
Last modified:August 13, 1987 - v1
Checksum:i9569B2FD57AC449B
GO

Sequence databases

PIRiA31989

Cross-referencesi

Sequence databases

PIRiA31989

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q80NMR-A1-174[»]
2SCPX-ray2.00A/B1-174[»]
ProteinModelPortaliP04571
SMRiP04571
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP04571

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP04571

Family and domain databases

CDDicd00052 EH, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSCP_HEDDI
AccessioniPrimary (citable) accession number: P04571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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