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Protein

Sperm protamine P1

Gene

PRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO - Molecular functioni

  • DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, DNA condensation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protamine P1
Alternative name(s):
Cysteine-rich protamine
Gene namesi
Name:PRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000175646.3
HGNCiHGNC:9447 PRM1
MIMi182880 gene
neXtProtiNX_P04553

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5619
OpenTargetsiENSG00000175646
PharmGKBiPA33792

Polymorphism and mutation databases

BioMutaiPRM1
DMDMi123691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001914822 – 51Sperm protamine P12 PublicationsAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6InterchainBy similarity
Disulfide bondi39Interchain (with C-39)By similarity
Disulfide bondi40 ↔ 48By similarity

Post-translational modificationi

Phosphorylated by SRPK1.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP04553
PRIDEiP04553
ProteomicsDBi51716

PTM databases

iPTMnetiP04553
PhosphoSitePlusiP04553

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000175646 Expressed in 85 organ(s), highest expression level in left testis
CleanExiHS_PRM1
ExpressionAtlasiP04553 baseline and differential
GenevisibleiP04553 HS

Organism-specific databases

HPAiHPA055150

Interactioni

Subunit structurei

Cross-linked by interchain disulfide bonds around the DNA-helix.

Protein-protein interaction databases

BioGridi111604, 1 interactor
IntActiP04553, 1 interactor
STRINGi9606.ENSP00000310515

Structurei

3D structure databases

ProteinModelPortaliP04553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protamine P1 family.Curated

Phylogenomic databases

HOVERGENiHBG081661
OMAiRYRLRCR

Family and domain databases

InterProiView protein in InterPro
IPR000221 Protamine_P1
PfamiView protein in Pfam
PF00260 Protamine_P1, 1 hit
PROSITEiView protein in PROSITE
PS00048 PROTAMINE_P1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR

H
Length:51
Mass (Da):6,823
Last modified:January 23, 2007 - v2
Checksum:i4A5C6A92C713C33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA Translation: CAA87065.1
M60331 Genomic DNA Translation: AAA63249.1
M29706 Genomic DNA Translation: AAA60191.1
Y00443 mRNA Translation: CAA68499.1
U15422 Genomic DNA Translation: AAC50486.1
S68144 Genomic DNA Translation: AAB29321.2
AF215707 Genomic DNA Translation: AAF34620.1
BT006746 mRNA Translation: AAP35392.1
BC003673 mRNA Translation: AAH03673.1
CCDSiCCDS10547.1
PIRiA38515 HSHUP1
RefSeqiNP_002752.1, NM_002761.2
UniGeneiHs.2909
Hs.60257

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646
GeneIDi5619
KEGGihsa:5619

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA Translation: CAA87065.1
M60331 Genomic DNA Translation: AAA63249.1
M29706 Genomic DNA Translation: AAA60191.1
Y00443 mRNA Translation: CAA68499.1
U15422 Genomic DNA Translation: AAC50486.1
S68144 Genomic DNA Translation: AAB29321.2
AF215707 Genomic DNA Translation: AAF34620.1
BT006746 mRNA Translation: AAP35392.1
BC003673 mRNA Translation: AAH03673.1
CCDSiCCDS10547.1
PIRiA38515 HSHUP1
RefSeqiNP_002752.1, NM_002761.2
UniGeneiHs.2909
Hs.60257

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortaliP04553
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111604, 1 interactor
IntActiP04553, 1 interactor
STRINGi9606.ENSP00000310515

PTM databases

iPTMnetiP04553
PhosphoSitePlusiP04553

Polymorphism and mutation databases

BioMutaiPRM1
DMDMi123691

Proteomic databases

PaxDbiP04553
PRIDEiP04553
ProteomicsDBi51716

Protocols and materials databases

DNASUi5619
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646
GeneIDi5619
KEGGihsa:5619

Organism-specific databases

CTDi5619
DisGeNETi5619
EuPathDBiHostDB:ENSG00000175646.3
GeneCardsiPRM1
H-InvDBiHIX0012816
HGNCiHGNC:9447 PRM1
HPAiHPA055150
MIMi182880 gene
neXtProtiNX_P04553
OpenTargetsiENSG00000175646
PharmGKBiPA33792
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081661
OMAiRYRLRCR

Miscellaneous databases

GenomeRNAii5619
PROiPR:P04553
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175646 Expressed in 85 organ(s), highest expression level in left testis
CleanExiHS_PRM1
ExpressionAtlasiP04553 baseline and differential
GenevisibleiP04553 HS

Family and domain databases

InterProiView protein in InterPro
IPR000221 Protamine_P1
PfamiView protein in Pfam
PF00260 Protamine_P1, 1 hit
PROSITEiView protein in PROSITE
PS00048 PROTAMINE_P1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP1_HUMAN
AccessioniPrimary (citable) accession number: P04553
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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