alc

Functionⁱ

Participates in the host transcription shutoff by causing premature termination of transcription from host DNA. Acts as a site-specific termination factor that abolishes transcript elongation on cytosine-containing DNA but not on the 5-hydroxymethyl cytosine present in the viral DNA. Therefore inhibits as well transcription from other phages that contain cytosine in their DNA.2 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

suppression by virus of host transcription Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Bacterial host gene expression shutoff by virus, Bacterial host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein alc Alternative name(s): Protein unf
Gene namesⁱ	Name:alc Synonyms:unf
Organismⁱ	Enterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifierⁱ	10665 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Tevenvirinae › T4virus
Virus hostⁱ	Escherichia coli [TaxID: 562]
Proteomesⁱ	UP000009087 Componentⁱ: Genome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000164915	1 – 167	Protein alcAdd BLAST		167

Proteomic databases

PRIDEⁱ	P04546

PRIDEⁱ

P04546

Family & Domainsⁱ

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000VL

OrthoDBⁱ

VOG090000VL

Family and domain databases

InterProⁱ	View protein in InterPro IPR020367 Host_transcript_inhib_Alc
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17527 ALP, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD097382 Inhib_host_tscrpt_prot_Alc, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P04546-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLQLITTEM VVEAYGDTTD GISVFKGNRR VGYITGLKKD LAKQVKRKTT 
        60         70         80         90        100
IKEYRNRRLE QARDMLPDAV EEMKVFLENQ LAKYDCEVFI NQTQPNVHIN 
       110        120        130        140        150
SCKCYIIVNP LTGKHRLGIS NPNRSASDMA EDVEACFKIS KSPAEHHILI 
       160 
NGLSQDDIVE VIKTLCM

Length:167

Mass (Da):18,961

Last modified:February 1, 1995 - v2

Checksum:ⁱDCF76AD627598F06

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	104	C → Y in CAA26950 (PubMed:6389256).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03193 Genomic DNA Translation: CAA26950.1 AF158101 Genomic DNA Translation: AAD42532.1 M14731 Genomic DNA No translation available.
PIRⁱ	A04337 ZXBPAL
NCBI Reference Sequences More...RefSeqⁱ	NP_049838.1, NC_000866.4

Genome annotation databases

GeneIDⁱ	1258715
KEGGⁱ	vg:1258715

Protein	Similar proteins		Species	Score	Length	Source
P04546	Inhibitor of host transcription		Escherichia phage vB_EcoM-fHoEco02		168	UniRef90_P04546
Inhibitor of host transcription		Escherichia phage vB_EcoM-fFiEco06		167
Uncharacterized protein		Escherichia phage slur04		168
Inhibitor of host transcription [Escherichia phage e11/2]		Escherichia phage slur02		168
Uncharacterized protein		Escherichia phage slur13		168
+57

Protein	Similar proteins		Species	Score	Length	Source
P04546	Uncharacterized protein		Escherichia phage slur04		168	UniRef50_P04546
Inhibitor of host transcription [Escherichia phage e11/2]		Escherichia phage slur02		168
Uncharacterized protein		Escherichia phage slur13		168
Uncharacterized protein		Escherichia phage slur11		168
Inhibitor of host transcription		Escherichia phage PE37		167
+80

Entry informationⁱ

Entry nameⁱ	ALC_BPT4
Accessionⁱ	P04546Primary (citable) accession number: P04546
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	February 1, 1995
	Last modified:	May 23, 2018
	This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - P04546 (ALC_BPT4)

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Protein alc

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

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Supporting data

UniProtKB - P04546 (ALC_BPT4)

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Protein alc

alc

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Molecule processing

Proteomic databases

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Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ