UniProtKB - P04546 (ALC_BPT4)
Protein
Protein alc
Gene
alc
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Functioni
Participates in the host transcription shutoff by causing premature termination of transcription from host DNA. Acts as a site-specific termination factor that abolishes transcript elongation on cytosine-containing DNA but not on the 5-hydroxymethyl cytosine present in the viral DNA. Therefore inhibits as well transcription from other phages that contain cytosine in their DNA.2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- suppression by virus of host transcription Source: CACAO
Keywordsi
Molecular function | DNA-binding |
Biological process | Bacterial host gene expression shutoff by virus, Bacterial host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction |
Names & Taxonomyi
Protein namesi | Recommended name: Protein alcAlternative name(s): Protein unf |
Gene namesi | Name:alc Synonyms:unf |
Organismi | Enterobacteria phage T4 (Bacteriophage T4) |
Taxonomic identifieri | 10665 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Myoviridae › Tevenvirinae › Tequatrovirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164915 | 1 – 167 | Protein alcAdd BLAST | 167 |
Family & Domainsi
Family and domain databases
InterProi | View protein in InterPro IPR020367, Host_transcript_inhib_Alc |
Pfami | View protein in Pfam PF17527, ALC, 1 hit |
i Sequence
Sequence statusi: Complete.
P04546-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLQLITTEM VVEAYGDTTD GISVFKGNRR VGYITGLKKD LAKQVKRKTT
60 70 80 90 100
IKEYRNRRLE QARDMLPDAV EEMKVFLENQ LAKYDCEVFI NQTQPNVHIN
110 120 130 140 150
SCKCYIIVNP LTGKHRLGIS NPNRSASDMA EDVEACFKIS KSPAEHHILI
160
NGLSQDDIVE VIKTLCM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | C → Y in CAA26950 (PubMed:6389256).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03193 Genomic DNA Translation: CAA26950.1 AF158101 Genomic DNA Translation: AAD42532.1 M14731 Genomic DNA No translation available. |
PIRi | A04337, ZXBPAL |
RefSeqi | NP_049838.1, NC_000866.4 |
Genome annotation databases
GeneIDi | 1258715 |
KEGGi | vg:1258715 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03193 Genomic DNA Translation: CAA26950.1 AF158101 Genomic DNA Translation: AAD42532.1 M14731 Genomic DNA No translation available. |
PIRi | A04337, ZXBPAL |
RefSeqi | NP_049838.1, NC_000866.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 1258715 |
KEGGi | vg:1258715 |
Family and domain databases
InterProi | View protein in InterPro IPR020367, Host_transcript_inhib_Alc |
Pfami | View protein in Pfam PF17527, ALC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALC_BPT4 | |
Accessioni | P04546Primary (citable) accession number: P04546 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | February 1, 1995 | |
Last modified: | October 7, 2020 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |