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Protein

Protein alc

Gene

alc

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Participates in the host transcription shutoff by causing premature termination of transcription from host DNA. Acts as a site-specific termination factor that abolishes transcript elongation on cytosine-containing DNA but not on the 5-hydroxymethyl cytosine present in the viral DNA. Therefore inhibits as well transcription from other phages that contain cytosine in their DNA.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processBacterial host gene expression shutoff by virus, Bacterial host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein alc
Alternative name(s):
Protein unf
Gene namesi
Name:alc
Synonyms:unf
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649151 – 167Protein alcAdd BLAST167

Proteomic databases

PRIDEiP04546

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090000VL

Family and domain databases

InterProiView protein in InterPro
IPR020367 Host_transcript_inhib_Alc
PfamiView protein in Pfam
PF17527 ALP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD097382 Inhib_host_tscrpt_prot_Alc, 1 hit

Sequencei

Sequence statusi: Complete.

P04546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLQLITTEM VVEAYGDTTD GISVFKGNRR VGYITGLKKD LAKQVKRKTT
60 70 80 90 100
IKEYRNRRLE QARDMLPDAV EEMKVFLENQ LAKYDCEVFI NQTQPNVHIN
110 120 130 140 150
SCKCYIIVNP LTGKHRLGIS NPNRSASDMA EDVEACFKIS KSPAEHHILI
160
NGLSQDDIVE VIKTLCM
Length:167
Mass (Da):18,961
Last modified:February 1, 1995 - v2
Checksum:iDCF76AD627598F06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104C → Y in CAA26950 (PubMed:6389256).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03193 Genomic DNA Translation: CAA26950.1
AF158101 Genomic DNA Translation: AAD42532.1
M14731 Genomic DNA No translation available.
PIRiA04337 ZXBPAL
RefSeqiNP_049838.1, NC_000866.4

Genome annotation databases

GeneIDi1258715
KEGGivg:1258715

Similar proteinsi

Entry informationi

Entry nameiALC_BPT4
AccessioniPrimary (citable) accession number: P04546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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