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UniProtKB - P04518 (RDRP_CARMV)
Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Carnation mottle virus (CarMV)
Status
Functioni
RNA-dependent RNA polymerase that plays an essential role in the virus replication.
CuratedMiscellaneous
Readthrough of the terminator UAG occurs at position 246.
Catalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-KW
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-directed RNA polymerase (EC:2.7.7.48)Alternative name(s): Protein p88 Cleaved into the following chain: |
Gene namesi | ORF Names:ORF1 |
Organismi | Carnation mottle virus (CarMV) |
Taxonomic identifieri | 11986 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Tolucaviricetes › Tolivirales › Tombusviridae › Procedovirinae › Alphacarmovirus |
Virus hosti | Begonia [TaxID: 3681] Dianthus barbatus [TaxID: 278075] Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570] Dianthus chinensis [TaxID: 118431] Dianthus superbus [TaxID: 288950] Malus domestica (Apple) (Pyrus malus) [TaxID: 3750] Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000222895 | 1 – 763 | RNA-directed RNA polymeraseAdd BLAST | 763 | |
ChainiPRO_0000398299 | 1 – 245 | Protein p28Add BLAST | 245 |
Proteomic databases
PRIDEi | P04518 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 466 – 579 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 114 |
Family and domain databases
Gene3Di | 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV |
Pfami | View protein in Pfam PF00998, RdRP_3, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50507, RDRP_SSRNA_POS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04518-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI
60 70 80 90 100
VSSGGRCLVV QSPYGNPNQG LIRGEDEEID NVEESTPVEL TPLIEVKAEV
110 120 130 140 150
DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF
160 170 180 190 200
LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYGIKI
210 220 230 240 250
AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF
260 270 280 290 300
YLNGVETKIR RGGHPSVIEV DGQCPLKERK LYVQNAITTG YEYRVHNHSY
310 320 330 340 350
ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR
360 370 380 390 400
ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL
410 420 430 440 450
KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT
460 470 480 490 500
EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD
510 520 530 540 550
AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMSGDMNTA LGNCLLACLI
560 570 580 590 600
TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP
610 620 630 640 650
VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW
660 670 680 690 700
LKSVGMCGLR IAGGVPVVQE FYQKYVETAG NVRENKNITE KSSSGFFMMA
710 720 730 740 750
DRAKRGYSAV SEVCRFSFYQ AFGITPDQQI ALEGEIRSLT INTNVGPQCE
760
AADSLWILNR KYQ
Sequence cautioni
The sequence CAA26726 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02986 Genomic RNA Translation: CAA26726.1 Sequence problems. |
PIRi | A04208, RRVECV |
RefSeqi | YP_009032645.1, NC_001265.2 YP_009032646.1, NC_001265.2 |
Genome annotation databases
GeneIDi | 1724754 1724755 |
KEGGi | vg:1724754 vg:1724755 |
Keywords - Coding sequence diversityi
RNA suppression of terminationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02986 Genomic RNA Translation: CAA26726.1 Sequence problems. |
PIRi | A04208, RRVECV |
RefSeqi | YP_009032645.1, NC_001265.2 YP_009032646.1, NC_001265.2 |
3D structure databases
ModBasei | Search... |
Proteomic databases
PRIDEi | P04518 |
Genome annotation databases
GeneIDi | 1724754 1724755 |
KEGGi | vg:1724754 vg:1724755 |
Family and domain databases
Gene3Di | 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV |
Pfami | View protein in Pfam PF00998, RdRP_3, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50507, RDRP_SSRNA_POS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_CARMV | |
Accessioni | P04518Primary (citable) accession number: P04518 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | October 5, 2010 | |
Last modified: | September 29, 2021 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |