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Protein

RNA-binding protein

Gene

US11

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host DDX58 and IFIH1. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processHost-virus interaction, Inhibition of host autophagy by virus, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host PKR by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein
Alternative name(s):
Vmw21
Gene namesi
Name:US11
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • host nucleolus 1 Publication
  • Host cytoplasm 1 Publication
  • Note: Following infection, it is released into the cell cytoplasm.

GO - Cellular componenti

  • host cell cytoplasm Source: UniProtKB
  • host cell nucleolus Source: UniProtKB
  • host cell nucleus Source: UniProtKB

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157401 – 161RNA-binding proteinAdd BLAST161

Post-translational modificationi

May be phosphorylated on Ser residues by host kinases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP04487

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Associates with RNA derived from the 60S ribosomal subunits. Seems to form large heterogeneous polymers of up to 200 identical subunits in the cytoplasm. Interacts with host EIF2AK2. Interacts with host NCL. Interacts with host DDX58; this interaction prevents DDX58 binding to host MAVS. Interacts with host IFIH1; this interaction prevents host IFH1 binding to MAVS.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi971460, 2 interactors
IntActiP04487, 145 interactors
MINTiP04487

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 9016
Repeati91 – 9626
Repeati97 – 10236
Repeati103 – 10846
Repeati109 – 11456
Repeati115 – 12066
Repeati121 – 12676
Repeati127 – 13286
Repeati133 – 13896
Repeati139 – 144106
Repeati145 – 150116
Repeati151 – 156126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 15612 X 6 AA approximate tandem repeatsAdd BLAST72

Domaini

The N-terminal tetrapeptide may be responsible for virion incorporation.
The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure.

Sequence similaritiesi

Belongs to the simplex virus US11 protein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK19438
OrthoDBiVOG0900035F

Family and domain databases

InterProiView protein in InterPro
IPR020124 Herpes_US11_RNA-bd_N
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028529 Herpes_US11_RNA-bd_N, 1 hit

Sequencei

Sequence statusi: Complete.

P04487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTQPPAPV GPGDPDVYLK GVPSAGMHPR GVHAPRGHPR MISGPPQRGD
60 70 80 90 100
NDQAAGQCGD SGLLRVGADT TISKPSEAVR PPTIPRTPRV PREPRVPRPP
110 120 130 140 150
REPREPRVPR APRDPRVPRD PRDPRQPRSP REPRSPREPR SPREPRTPRT
160
PREPRTARGS V
Length:161
Mass (Da):17,757
Last modified:August 13, 1987 - v1
Checksum:i1CECA86CF1B9F2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96677.1
X14112 Genomic DNA Translation: CAA32276.1
X02138 Genomic DNA Translation: CAA26065.1
X00428 Genomic RNA Translation: CAA25125.1
PIRiA03728 DNBE17
RefSeqiYP_009137147.1, NC_001806.2

Genome annotation databases

GeneIDi2703439
KEGGivg:2703439

Similar proteinsi

Entry informationi

Entry nameiRNB_HHV11
AccessioniPrimary (citable) accession number: P04487
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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