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Protein

Myosin-6

Gene

MYH6

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-6 (MYO6).Curated

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-6
Alternative name(s):
Alpha isomyosin
Myosin heavy chain 6
Myosin heavy chain, cardiac muscle alpha isoform
Short name:
MyHC-alpha
Gene namesi
Name:MYH6
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000123405‹1 – ›465Myosin-6Add BLAST›465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei456PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP04460
SMRiP04460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 35Myosin motorAdd BLAST›35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – ›465Sequence analysisAdd BLAST›430

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000173959
InParanoidiP04460

Family and domain databases

Gene3Di4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR027401 Myosin_IQ_contain_sf
IPR002928 Myosin_tail
PfamiView protein in Pfam
PF01576 Myosin_tail_1, 1 hit

Sequencei

Sequence statusi: Fragment.

P04460-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ILERGDALLV VQWNIRAFTG VKKWPWMELY FEIEPLLKSA EAEKEMAAMK
60 70 80 90 100
EEFGRIKESL EKSEARRKEL EEKMVSLLQE KNDLQLQVQA EQDNLNDAEE
110 120 130 140 150
RCDQLIKNKI QLEAKVKEMN ERLEDEEEMN AELTAKKRKL EDECSELKKD
160 170 180 190 200
IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDEIIAKLT KEKKALQEAH
210 220 230 240 250
QQALDDLQAE EDKVNTLTKA KLKLEQQVDD LEGSLEQEKK VRMDLERAKR
260 270 280 290 300
KLEGDLKLTQ ESIMDLENDK QQLEERLKKK EFDISQLNSK IEDEQALVLQ
310 320 330 340 350
LQKKLKENQA RIEELEEELE AERTARAKVE KLRSDLSREL EEISERLEEA
360 370 380 390 400
GGATSVQIEM NKKREAEFQK MRRDLEEATL QHEATASALR RKHADSVAEL
410 420 430 440 450
GEQIDNLQRV KQKLEKEKSE FKLELDDVTS NMEQIIKAKA NLEKVSRTLE
460
DQANEYRRKL EEAQR
Length:465
Mass (Da):54,376
Last modified:August 13, 1987 - v1
Checksum:iBAC86AFF8CE8E29C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti271Q → L in AAA31410 (PubMed:6193509).Curated1
Non-terminal residuei4651

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02443 mRNA Translation: AAA31412.1
K01697 mRNA Translation: AAA31416.1
J00671 mRNA Translation: AAA31410.1
PIRiA02986
UniGeneiOcu.1933
Ocu.6920

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02443 mRNA Translation: AAA31412.1
K01697 mRNA Translation: AAA31416.1
J00671 mRNA Translation: AAA31410.1
PIRiA02986
UniGeneiOcu.1933
Ocu.6920

3D structure databases

ProteinModelPortaliP04460
SMRiP04460
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000173959
InParanoidiP04460

Family and domain databases

Gene3Di4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR027401 Myosin_IQ_contain_sf
IPR002928 Myosin_tail
PfamiView protein in Pfam
PF01576 Myosin_tail_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYH6_RABIT
AccessioniPrimary (citable) accession number: P04460
Secondary accession number(s): Q28712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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