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Protein

Hemoglobin subunit beta-H1

Gene

Hbb-bh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is an embryonic beta-type chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)1
Metal bindingi93Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: MGI
  • hemoglobin alpha binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • organic acid binding Source: GO_Central
  • oxygen binding Source: GO_Central
  • oxygen carrier activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-H1
Alternative name(s):
Beta-H1-globin
Hemoglobin beta-H1 chain
Protein Z
Gene namesi
Name:Hbb-bh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96024 Hbb-bh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000530231 – 147Hemoglobin subunit beta-H1Add BLAST147

Proteomic databases

PaxDbiP04444
PeptideAtlasiP04444
PRIDEiP04444

PTM databases

PhosphoSitePlusiP04444

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSMUSG00000052217 Expressed in 108 organ(s), highest expression level in forebrain
ExpressionAtlasiP04444 baseline and differential
GenevisibleiP04444 MM

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-2938 Early embryonic hemoglobin complex
STRINGi10090.ENSMUSP00000064865

Structurei

3D structure databases

ProteinModelPortaliP04444
SMRiP04444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOVERGENiHBG009709
InParanoidiP04444
KOiK13825
OMAiTLWSNID
OrthoDBiEOG091G0R7W
TreeFamiTF333268

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P04444-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHFTAEEKA AITSIWDKVD LEKVGGETLG RLLIVYPWTQ RFFDKFGNLS
60 70 80 90 100
SALAIMGNPR IRAHGKKVLT SLGLGVKNMD NLKETFAHLS ELHCDKLHVD
110 120 130 140
PENFKLLGNM LVIVLSTHFA KEFTPEVQAA WQKLVIGVAN ALSHKYH
Length:147
Mass (Da):16,494
Last modified:January 23, 2007 - v3
Checksum:i158D57A33F002DAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32221.1
J00417 Genomic DNA Translation: AAB59638.1
AK028208 mRNA Translation: BAC25815.1
BC052008 mRNA Translation: AAH52008.1
V00724 Genomic DNA Translation: CAA24103.1
CCDSiCCDS21592.1
PIRiA02419 HBMSH1
RefSeqiNP_032245.1, NM_008219.3
UniGeneiMm.440281

Genome annotation databases

EnsembliENSMUST00000063957; ENSMUSP00000064865; ENSMUSG00000052217
GeneIDi15132
KEGGimmu:15132
UCSCiuc009iur.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA Translation: CAA32221.1
J00417 Genomic DNA Translation: AAB59638.1
AK028208 mRNA Translation: BAC25815.1
BC052008 mRNA Translation: AAH52008.1
V00724 Genomic DNA Translation: CAA24103.1
CCDSiCCDS21592.1
PIRiA02419 HBMSH1
RefSeqiNP_032245.1, NM_008219.3
UniGeneiMm.440281

3D structure databases

ProteinModelPortaliP04444
SMRiP04444
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2938 Early embryonic hemoglobin complex
STRINGi10090.ENSMUSP00000064865

PTM databases

PhosphoSitePlusiP04444

Proteomic databases

PaxDbiP04444
PeptideAtlasiP04444
PRIDEiP04444

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063957; ENSMUSP00000064865; ENSMUSG00000052217
GeneIDi15132
KEGGimmu:15132
UCSCiuc009iur.1 mouse

Organism-specific databases

CTDi15132
MGIiMGI:96024 Hbb-bh1

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOVERGENiHBG009709
InParanoidiP04444
KOiK13825
OMAiTLWSNID
OrthoDBiEOG091G0R7W
TreeFamiTF333268

Miscellaneous databases

PROiPR:P04444
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052217 Expressed in 108 organ(s), highest expression level in forebrain
ExpressionAtlasiP04444 baseline and differential
GenevisibleiP04444 MM

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBBZ_MOUSE
AccessioniPrimary (citable) accession number: P04444
Secondary accession number(s): Q61347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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