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UniProtKB - P04440 (DPB1_HUMAN)

Protein

HLA class II histocompatibility antigen, DP beta 1 chain

Gene

HLA-DPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP04440

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DP beta 1 chain
Alternative name(s):
HLA class II histocompatibility antigen, DP(W4) beta chain
MHC class II antigen DPB1
Gene namesi
Name:HLA-DPB1
Synonyms:HLA-DP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000223865.10
HGNCiHGNC:4940 HLA-DPB1
MIMi142858 gene
neXtProtiNX_P04440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 225ExtracellularSequence analysisAdd BLAST196
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 258CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3115
MalaCardsiHLA-DPB1
OpenTargetsiENSG00000223865
Orphaneti133 Chronic berylliosis
900 Granulomatosis with polyangiitis
PharmGKBiPA35064

Polymorphism and mutation databases

BioMutaiHLA-DPB1
DMDMi122263

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000001898430 – 258HLA class II histocompatibility antigen, DP beta 1 chainAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 106PROSITE-ProRule annotation
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 200PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP04440
PaxDbiP04440
PeptideAtlasiP04440
PRIDEiP04440
ProteomicsDBi51715

PTM databases

GlyConnecti1366
iPTMnetiP04440
PhosphoSitePlusiP04440
SwissPalmiP04440

Expressioni

Gene expression databases

BgeeiENSG00000223865 Expressed in 112 organ(s), highest expression level in lung
CleanExiHS_HLA-DPB1
ExpressionAtlasiP04440 baseline and differential
GenevisibleiP04440 HS

Organism-specific databases

HPAiHPA011078
HPA058509

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

BioGridi109360, 40 interactors
IntActiP04440, 10 interactors
MINTiP04440
STRINGi9606.ENSP00000408146

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04440
SMRiP04440
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04440

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 212Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 121Beta-1Add BLAST92
Regioni122 – 215Beta-2Add BLAST94
Regioni216 – 225Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
GeneTreeiENSGT00900000140849
HOVERGENiHBG012730
InParanoidiP04440
KOiK06752
OMAiICQVEHT
OrthoDBiEOG091G0W5S
PhylomeDBiP04440
TreeFamiTF336626

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 23 potential isoforms that are computationally mapped.Show allAlign All

P04440-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT 
        60         70         80         90        100
QRFLERYIYN REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA 
       110        120        130        140        150
VPDRMCRHNY ELGGPMTLQR RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY 
       160        170        180        190        200
PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYTC 
       210        220        230        240        250
QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC GVGIFMHRRS 

KKVQRGSA
Length:258
Mass (Da):29,159
Last modified:August 13, 1987 - v1
Checksum:iE74777D438DE9C41
GO

Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5EP54Q5EP54_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
258Annotation score:
A0A182DWE9A0A182DWE9_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
258Annotation score:
A0A0G2JJV3A0A0G2JJV3_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
228Annotation score:
A0A140T8Z3A0A140T8Z3_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
228Annotation score:
A0A182DWF4A0A182DWF4_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
228Annotation score:
A0A140T9T6A0A140T9T6_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
228Annotation score:
A0A0G2JII1A0A0G2JII1_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
228Annotation score:
H0Y7G7H0Y7G7_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
229Annotation score:
H0Y5P2H0Y5P2_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
235Annotation score:
A0A140T976A0A140T976_HUMAN
HLA class II histocompatibility ant...
HLA-DPB1
229Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAQ12564 differs from that shown. Reason: Frameshift at position 39.Curated

Polymorphismi

The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06062716T → M in allele DPB1*09:02. Corresponds to variant dbSNP:rs41558014Ensembl.1
Natural variantiVAR_06062824T → I. Corresponds to variant dbSNP:rs11551416Ensembl.1
Natural variantiVAR_06062930R → P in allele DPB1*75:01. 1
Natural variantiVAR_06063031A → L in allele DPB1*75:01; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06063132T → P in allele DPB1*75:01. 1
Natural variantiVAR_06063233P → A in allele DPB1*75:01. 1
Natural variantiVAR_06063337L → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1126504Ensembl.1
Natural variantiVAR_06063538F → D in allele DPB1*70:01; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06063438F → H in allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*22:02, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*45:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*76:01, allele DPB1*86:01, allele DPB1*91:01 and allele DPB1*98:01; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06063638F → L. Corresponds to variant dbSNP:rs12722013Ensembl.1
Natural variantiVAR_03343338F → Y in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*69:01, allele DPB1*74:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*92:01 and allele DPB1*93:01. Corresponds to variant dbSNP:rs1126509Ensembl.1
Natural variantiVAR_06063740G → L in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs386699869Ensembl.1
Natural variantiVAR_03343440G → V. Corresponds to variant dbSNP:rs1126513Ensembl.1
Natural variantiVAR_06063841R → L in allele DPB1*77:01. Corresponds to variant dbSNP:rs41540313Ensembl.1
Natural variantiVAR_06063944C → G in allele DPB1*26:02. 1
Natural variantiVAR_06064046A → P in allele DPB1*38:01. Corresponds to variant dbSNP:rs41555313Ensembl.1
Natural variantiVAR_06064146A → T in allele DPB1*18:02. Corresponds to variant dbSNP:rs41555313Ensembl.1
Natural variantiVAR_06064257Y → D in allele DPB1*99:01. Corresponds to variant dbSNP:rs41553416Ensembl.1
Natural variantiVAR_06064361R → P in allele DPB1*14:02 and allele DPB1*21:02. Corresponds to variant dbSNP:rs41561114Ensembl.1
Natural variantiVAR_03343562E → Q Ind allele DPB1*11:01, allele DPB1*15:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs12722018Ensembl.1
Natural variantiVAR_06064464F → L in allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*15:02, allele DPB1*17:02, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*34:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*48:01, allele DPB1*58:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*95:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs9277348Ensembl.1
Natural variantiVAR_03343664F → Y in allele DPB1*01:01, allele DPB1*01:02, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*15:01, allele DPB1*20:02, allele DPB1*21:02, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*39:01, allele DPB1*40:01, allele DPB1*49:01, allele DPB1*53:01, allele DPB1*65:01, allele DPB1*74:01, allele DPB1*85:01, allele DPB1*89:01 and allele DPB1*96:01. Corresponds to variant dbSNP:rs1042117Ensembl.1
Natural variantiVAR_03343765A → V in allele DPB1*01:02, allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*23:01, allele DPB1*25:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*34:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*71:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*93:01, allele DPB1*94:01, allele DPB1*95:01, allele DPB1*97:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042121Ensembl.1
Natural variantiVAR_06064568D → Y in allele DPB1*24:02. Corresponds to variant dbSNP:rs77062860Ensembl.1
Natural variantiVAR_06064672G → W in allele DPB1*97:01. Corresponds to variant dbSNP:rs41552915Ensembl.1
Natural variantiVAR_05466284A → D in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs707958Ensembl.1
Natural variantiVAR_06064784A → E in allele DPB1*01:02, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*08:02, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*24:01, allele DPB1*30:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*47:01, allele DPB1*54:01, allele DPB1*84:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs386699870Ensembl.1
Natural variantiVAR_05951184A → V. Corresponds to variant dbSNP:rs707958Ensembl.1
Natural variantiVAR_03343885A → E in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042131Ensembl.1
Natural variantiVAR_03343986E → D in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*10:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*50:01, allele DPB1*57:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*80:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042133Ensembl.1
Natural variantiVAR_06064886E → V in allele DPB1*32:01. Corresponds to variant dbSNP:rs41545212Ensembl.1
Natural variantiVAR_06064989N → H in allele DPB1*02:03. Corresponds to variant dbSNP:rs41550319Ensembl.1
Natural variantiVAR_06065093D → H in allele DPB1*96:01. Corresponds to variant dbSNP:rs41560812Ensembl.1
Natural variantiVAR_05951294I → F Allele DPB1*41:01 and allele DPB1*83:01. Corresponds to variant dbSNP:rs1042136Ensembl.1
Natural variantiVAR_05951394I → L in allele DPB1*03:01, allele DPB1*03:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*10:02, allele DPB1*11:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*31:01, allele DPB1*34:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*72:01, allele DPB1*73:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*87:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*95:01. 1 PublicationCorresponds to variant dbSNP:rs1042136Ensembl.1
Natural variantiVAR_06065194I → N in allele DPB1*60:01. Corresponds to variant dbSNP:rs41547212Ensembl.1
Natural variantiVAR_03344098K → E in allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*04:03, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*33:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*71:01, allele DPB1*81:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*93:01 and allele DPB1*95:01. Corresponds to variant dbSNP:rs1042140EnsemblClinVar.1
Natural variantiVAR_03344198K → R in allele DPB1*11:01, allele DPB1*15:01, allele DPB1*69:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs12722027Ensembl.1
Natural variantiVAR_06065299R → W in allele DPB1*94:01. Corresponds to variant dbSNP:rs41554314Ensembl.1
Natural variantiVAR_060653101V → L in allele DPB1*31:01 and allele DPB1*34:01. Corresponds to variant dbSNP:rs41546618Ensembl.1
Natural variantiVAR_060654102P → L in allele DPB1*78:01. Corresponds to variant dbSNP:rs41551920Ensembl.1
Natural variantiVAR_033443105M → I in allele DPB1*08:02, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*13:02 and allele DPB1*19:01. Corresponds to variant dbSNP:rs1042153Ensembl.1
Natural variantiVAR_033442105M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:02, allele DPB1*21:02, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*88:01, allele DPB1*90:01 and allele DPB1*92:01. 1 PublicationCorresponds to variant dbSNP:rs1042151Ensembl.1
Natural variantiVAR_060657113G → D in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs1042169Ensembl.1
Natural variantiVAR_060655113G → N in allele DPB1*22:02; requires 2 nucleotide substitutions. 1
Natural variantiVAR_060656113G → V in allele DPB1*15:01, allele DPB1*18:01, allele DPB1*28:01, allele DPB1*34:01, allele DPB1*40:01, allele DPB1*53:01, allele DPB1*62:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs1042169Ensembl.1
Natural variantiVAR_033444114G → E in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277354Ensembl.1
Natural variantiVAR_033445115P → A in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277355Ensembl.1
Natural variantiVAR_033446116M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277356Ensembl.1
Natural variantiVAR_060658120R → H in allele DPB1*82:01 and allele DPB1*85:01. Corresponds to variant dbSNP:rs41541915Ensembl.1
Natural variantiVAR_060659125R → K in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 PublicationCorresponds to variant dbSNP:rs1126537Ensembl.1
Natural variantiVAR_060660199T → I in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 PublicationCorresponds to variant dbSNP:rs1042335Ensembl.1
Natural variantiVAR_033447207L → M in allele DPB1*04:02. Corresponds to variant dbSNP:rs14362Ensembl.1
Natural variantiVAR_050393223R → Q in allele DPB1*01:01. Corresponds to variant dbSNP:rs9276Ensembl.1
Natural variantiVAR_050394234V → M in allele DPB1*05:01 and allele DPB1*19:01. Corresponds to variant dbSNP:rs11551421Ensembl.1
Natural variantiVAR_033448244I → T in allele DPB1*15:01. Corresponds to variant dbSNP:rs3097675Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01426 mRNA Translation: CAA25672.1
X02964 Genomic DNA No translation available.
X03023 Genomic DNA Translation: CAE82008.1
X03024 Genomic DNA Translation: CAE82007.1
X03022 Genomic DNA Translation: CAA26823.1
X03025 Genomic DNA Translation: CAE82037.1
X03026 Genomic DNA Translation: CAE82042.1
X03028 Genomic DNA Translation: CAE82073.1
X03027 Genomic DNA Translation: CAE82043.1
X03067 mRNA Translation: CAA26871.1
X02228 Genomic DNA Translation: CAA26147.1
J03041 mRNA Translation: AAA35993.1
M83664 mRNA Translation: AAA59837.1
AY804132 mRNA Translation: AAW78737.1
AY804133 mRNA Translation: AAW78738.1
AY804135 mRNA Translation: AAW78740.1
AY804136 mRNA Translation: AAW78741.1
AY804137 mRNA Translation: AAW78742.1
AY804138 mRNA Translation: AAW78743.1
AY804139 mRNA Translation: AAW78744.1
AY804141 mRNA Translation: AAW78746.1
AY804142 mRNA Translation: AAW78747.1
AY804143 mRNA Translation: AAW78748.1
AY831401 mRNA Translation: AAW80919.1
AY831402 mRNA Translation: AAW80920.1
AY831403 mRNA Translation: AAW80921.1
AY831404 mRNA Translation: AAW80922.1
AY656678 mRNA Translation: AAV71025.1
AY656679 mRNA Translation: AAV71026.1
AY656680 mRNA Translation: AAV71027.1
AK313305 mRNA Translation: BAG36110.1
BT019780 mRNA Translation: AAV38583.1
AL645931 Genomic DNA No translation available.
AL662824 Genomic DNA No translation available.
AL805913 Genomic DNA No translation available.
AL845446 Genomic DNA No translation available.
BX120009 Genomic DNA No translation available.
CR759795 Genomic DNA No translation available.
CR759904 Genomic DNA No translation available.
CR762479 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03674.1
BC007963 mRNA Translation: AAH07963.1
BC013184 mRNA Translation: AAH13184.1
M28202 mRNA Translation: AAA53197.1
Y09327 Genomic DNA Translation: CAA70507.1
L31816 Genomic DNA No translation available.
M97686 Genomic DNA No translation available.
X96985 Genomic DNA No translation available.
Y13900 Genomic DNA Translation: CAA74199.1
Y14230 Genomic DNA Translation: CAA74608.1
Y16095 Genomic DNA Translation: CAA76060.1
AY823995 Genomic DNA Translation: AAW79272.1
AJ563603 Genomic DNA Translation: CAD91639.1
AM039828 Genomic DNA Translation: CAJ01690.1
AM408787 Genomic DNA Translation: CAL64063.1
AM698036 Genomic DNA Translation: CAM91695.1
M84619 Genomic DNA No translation available.
M84620 Genomic DNA No translation available.
M84622 Genomic DNA No translation available.
M84623 Genomic DNA No translation available.
M84624 Genomic DNA No translation available.
M84626 Genomic DNA No translation available.
X82123 Genomic DNA Translation: CAA57635.1
U22311 Genomic DNA Translation: AAB60413.1
U22313 Genomic DNA Translation: AAB17108.1
K01615 mRNA Translation: AAA36313.1
FM883600 Genomic DNA Translation: CAT04585.2
FM882212 Genomic DNA Translation: CAT03206.1
FM956650 Genomic DNA Translation: CAX11690.1
FM991729 Genomic DNA Translation: CAX20314.1
FM992080 Genomic DNA Translation: CAX21583.2
FM992366 Genomic DNA Translation: CAX30407.1
FM992364 Genomic DNA Translation: CAX30405.1
FN252853 Genomic DNA Translation: CAX53275.1
FN256250 Genomic DNA Translation: CAX53717.1
FN256251 Genomic DNA Translation: CAX53721.1
FN256254 Genomic DNA Translation: CAX53718.1
FN256253 Genomic DNA Translation: CAX53726.1
FN256255 Genomic DNA Translation: CAX53722.1
FN393829 Genomic DNA Translation: CAY85528.1
M23675 Genomic DNA Translation: AAA59740.1
M62326 Genomic DNA Translation: AAA59719.1
M62331 Genomic DNA Translation: AAA59724.1
L07768 Genomic DNA Translation: AAA59690.1
D13174 Genomic DNA Translation: BAA02465.1
D10834 Genomic DNA Translation: BAA01614.1
D28809 Genomic DNA Translation: BAA05970.1
X96986 Genomic DNA Translation: CAA65710.2
X91886 Genomic DNA No translation available.
Y18498 Genomic DNA Translation: CAC12860.1
AJ238005 Genomic DNA Translation: CAC12865.1
AJ271373 Genomic DNA Translation: CAB70605.2
AF288354 Genomic DNA Translation: AAG30143.1
AJ292074 Genomic DNA Translation: CAC27995.1
AF536241 Genomic DNA Translation: AAN33050.1
AF549409 Genomic DNA Translation: AAQ12563.1
AF549410 Genomic DNA Translation: AAQ12564.1 Frameshift.
AJ514871 Genomic DNA Translation: CAD55852.1
AY374100 Genomic DNA Translation: AAR21105.1
DQ206450 Genomic DNA Translation: ABB17974.1
M83914 Genomic DNA Translation: AAA36264.1
M83915 Genomic DNA Translation: AAA36259.1
M83916 Genomic DNA Translation: AAA36260.1
M83917 Genomic DNA Translation: AAA36261.1
M83918 Genomic DNA Translation: AAA36262.1
M83919 Genomic DNA Translation: AAA36263.1
AJ297820 Genomic DNA Translation: CAC14048.1
AY029777 Genomic DNA Translation: AAK40344.1
AF489518 Genomic DNA Translation: AAL92172.1
AF492640 Genomic DNA Translation: AAO84765.1
AY425707 Genomic DNA Translation: AAR29060.1
AY572830 Genomic DNA Translation: AAS77869.1
AY855160 Genomic DNA Translation: AAW33682.1
AY855161 Genomic DNA Translation: AAW33683.1
DQ089022 Genomic DNA Translation: AAY98352.1
AB247517 Genomic DNA Translation: BAE78492.1
DQ386161 Genomic DNA Translation: ABD36812.1
DQ485789 Genomic DNA Translation: ABF47047.1
AM887530 Genomic DNA Translation: CAP08783.1
FM211032 Genomic DNA Translation: CAR66500.1
FJ976693 Genomic DNA Translation: ACS12738.1
L17310 Genomic DNA Translation: AAA53479.1
L17311 Genomic DNA Translation: AAA53480.1
L17313 Genomic DNA Translation: AAA53481.1
L17314 Genomic DNA Translation: AAA53482.1
L22076 Genomic DNA Translation: AAA53476.1
L22077 Genomic DNA Translation: AAA53477.1
L23400 Genomic DNA Translation: AAA58441.1
U59437 Genomic DNA Translation: AAD09481.1
U59438 Genomic DNA Translation: AAD09482.1
U59439 Genomic DNA Translation: AAD09483.1
U59440 Genomic DNA Translation: AAD09484.1
U59441 Genomic DNA Translation: AAD09485.1
U59442 Genomic DNA Translation: AAD09486.1
AF074845 Genomic DNA Translation: AAD39682.1
AF074846 Genomic DNA Translation: AAD39683.1
AY033075 Genomic DNA Translation: AAK51161.1
U34033 Genomic DNA Translation: AAA81335.1
Z92523 Genomic DNA Translation: CAB06822.1
X78042 Genomic DNA No translation available.
U29534 Genomic DNA Translation: AAB52511.1
AY618897 Genomic DNA Translation: AAT40308.1
X97406 Genomic DNA Translation: CAA66059.1
L01466 Genomic DNA No translation available.
M87046 Genomic DNA No translation available.
D10478 Genomic DNA Translation: BAA01281.1
D10882 Genomic DNA Translation: BAA01704.1
U94839 Genomic DNA Translation: AAC64232.1
X80752 Genomic DNA Translation: CAA56728.1
AF077015 Genomic DNA Translation: AAC26835.1
K00409 mRNA Translation: AAA36312.1
CCDSiCCDS4765.1
PIRiA02228 HLHUS1
A02229 HLHUPB
D30536
D30537
E30536
I37298
I37541 S49382
I38195 HLHUS2
I38197
I59621
I59637
I59641
I81234
I81235
I81236
I81237
I81238
RefSeqiNP_002112.3, NM_002121.5
UniGeneiHs.485130

Genome annotation databases

EnsembliENST00000399500; ENSP00000382422; ENSG00000215048
ENST00000411749; ENSP00000414196; ENSG00000236693
ENST00000418931; ENSP00000408146; ENSG00000223865
ENST00000425130; ENSP00000396095; ENSG00000230763
ENST00000433800; ENSP00000407674; ENSG00000226826
ENST00000454006; ENSP00000389288; ENSG00000237710
GeneIDi3115
KEGGihsa:3115
UCSCiuc003ocu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01426 mRNA Translation: CAA25672.1
X02964 Genomic DNA No translation available.
X03023 Genomic DNA Translation: CAE82008.1
X03024 Genomic DNA Translation: CAE82007.1
X03022 Genomic DNA Translation: CAA26823.1
X03025 Genomic DNA Translation: CAE82037.1
X03026 Genomic DNA Translation: CAE82042.1
X03028 Genomic DNA Translation: CAE82073.1
X03027 Genomic DNA Translation: CAE82043.1
X03067 mRNA Translation: CAA26871.1
X02228 Genomic DNA Translation: CAA26147.1
J03041 mRNA Translation: AAA35993.1
M83664 mRNA Translation: AAA59837.1
AY804132 mRNA Translation: AAW78737.1
AY804133 mRNA Translation: AAW78738.1
AY804135 mRNA Translation: AAW78740.1
AY804136 mRNA Translation: AAW78741.1
AY804137 mRNA Translation: AAW78742.1
AY804138 mRNA Translation: AAW78743.1
AY804139 mRNA Translation: AAW78744.1
AY804141 mRNA Translation: AAW78746.1
AY804142 mRNA Translation: AAW78747.1
AY804143 mRNA Translation: AAW78748.1
AY831401 mRNA Translation: AAW80919.1
AY831402 mRNA Translation: AAW80920.1
AY831403 mRNA Translation: AAW80921.1
AY831404 mRNA Translation: AAW80922.1
AY656678 mRNA Translation: AAV71025.1
AY656679 mRNA Translation: AAV71026.1
AY656680 mRNA Translation: AAV71027.1
AK313305 mRNA Translation: BAG36110.1
BT019780 mRNA Translation: AAV38583.1
AL645931 Genomic DNA No translation available.
AL662824 Genomic DNA No translation available.
AL805913 Genomic DNA No translation available.
AL845446 Genomic DNA No translation available.
BX120009 Genomic DNA No translation available.
CR759795 Genomic DNA No translation available.
CR759904 Genomic DNA No translation available.
CR762479 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03674.1
BC007963 mRNA Translation: AAH07963.1
BC013184 mRNA Translation: AAH13184.1
M28202 mRNA Translation: AAA53197.1
Y09327 Genomic DNA Translation: CAA70507.1
L31816 Genomic DNA No translation available.
M97686 Genomic DNA No translation available.
X96985 Genomic DNA No translation available.
Y13900 Genomic DNA Translation: CAA74199.1
Y14230 Genomic DNA Translation: CAA74608.1
Y16095 Genomic DNA Translation: CAA76060.1
AY823995 Genomic DNA Translation: AAW79272.1
AJ563603 Genomic DNA Translation: CAD91639.1
AM039828 Genomic DNA Translation: CAJ01690.1
AM408787 Genomic DNA Translation: CAL64063.1
AM698036 Genomic DNA Translation: CAM91695.1
M84619 Genomic DNA No translation available.
M84620 Genomic DNA No translation available.
M84622 Genomic DNA No translation available.
M84623 Genomic DNA No translation available.
M84624 Genomic DNA No translation available.
M84626 Genomic DNA No translation available.
X82123 Genomic DNA Translation: CAA57635.1
U22311 Genomic DNA Translation: AAB60413.1
U22313 Genomic DNA Translation: AAB17108.1
K01615 mRNA Translation: AAA36313.1
FM883600 Genomic DNA Translation: CAT04585.2
FM882212 Genomic DNA Translation: CAT03206.1
FM956650 Genomic DNA Translation: CAX11690.1
FM991729 Genomic DNA Translation: CAX20314.1
FM992080 Genomic DNA Translation: CAX21583.2
FM992366 Genomic DNA Translation: CAX30407.1
FM992364 Genomic DNA Translation: CAX30405.1
FN252853 Genomic DNA Translation: CAX53275.1
FN256250 Genomic DNA Translation: CAX53717.1
FN256251 Genomic DNA Translation: CAX53721.1
FN256254 Genomic DNA Translation: CAX53718.1
FN256253 Genomic DNA Translation: CAX53726.1
FN256255 Genomic DNA Translation: CAX53722.1
FN393829 Genomic DNA Translation: CAY85528.1
M23675 Genomic DNA Translation: AAA59740.1
M62326 Genomic DNA Translation: AAA59719.1
M62331 Genomic DNA Translation: AAA59724.1
L07768 Genomic DNA Translation: AAA59690.1
D13174 Genomic DNA Translation: BAA02465.1
D10834 Genomic DNA Translation: BAA01614.1
D28809 Genomic DNA Translation: BAA05970.1
X96986 Genomic DNA Translation: CAA65710.2
X91886 Genomic DNA No translation available.
Y18498 Genomic DNA Translation: CAC12860.1
AJ238005 Genomic DNA Translation: CAC12865.1
AJ271373 Genomic DNA Translation: CAB70605.2
AF288354 Genomic DNA Translation: AAG30143.1
AJ292074 Genomic DNA Translation: CAC27995.1
AF536241 Genomic DNA Translation: AAN33050.1
AF549409 Genomic DNA Translation: AAQ12563.1
AF549410 Genomic DNA Translation: AAQ12564.1 Frameshift.
AJ514871 Genomic DNA Translation: CAD55852.1
AY374100 Genomic DNA Translation: AAR21105.1
DQ206450 Genomic DNA Translation: ABB17974.1
M83914 Genomic DNA Translation: AAA36264.1
M83915 Genomic DNA Translation: AAA36259.1
M83916 Genomic DNA Translation: AAA36260.1
M83917 Genomic DNA Translation: AAA36261.1
M83918 Genomic DNA Translation: AAA36262.1
M83919 Genomic DNA Translation: AAA36263.1
AJ297820 Genomic DNA Translation: CAC14048.1
AY029777 Genomic DNA Translation: AAK40344.1
AF489518 Genomic DNA Translation: AAL92172.1
AF492640 Genomic DNA Translation: AAO84765.1
AY425707 Genomic DNA Translation: AAR29060.1
AY572830 Genomic DNA Translation: AAS77869.1
AY855160 Genomic DNA Translation: AAW33682.1
AY855161 Genomic DNA Translation: AAW33683.1
DQ089022 Genomic DNA Translation: AAY98352.1
AB247517 Genomic DNA Translation: BAE78492.1
DQ386161 Genomic DNA Translation: ABD36812.1
DQ485789 Genomic DNA Translation: ABF47047.1
AM887530 Genomic DNA Translation: CAP08783.1
FM211032 Genomic DNA Translation: CAR66500.1
FJ976693 Genomic DNA Translation: ACS12738.1
L17310 Genomic DNA Translation: AAA53479.1
L17311 Genomic DNA Translation: AAA53480.1
L17313 Genomic DNA Translation: AAA53481.1
L17314 Genomic DNA Translation: AAA53482.1
L22076 Genomic DNA Translation: AAA53476.1
L22077 Genomic DNA Translation: AAA53477.1
L23400 Genomic DNA Translation: AAA58441.1
U59437 Genomic DNA Translation: AAD09481.1
U59438 Genomic DNA Translation: AAD09482.1
U59439 Genomic DNA Translation: AAD09483.1
U59440 Genomic DNA Translation: AAD09484.1
U59441 Genomic DNA Translation: AAD09485.1
U59442 Genomic DNA Translation: AAD09486.1
AF074845 Genomic DNA Translation: AAD39682.1
AF074846 Genomic DNA Translation: AAD39683.1
AY033075 Genomic DNA Translation: AAK51161.1
U34033 Genomic DNA Translation: AAA81335.1
Z92523 Genomic DNA Translation: CAB06822.1
X78042 Genomic DNA No translation available.
U29534 Genomic DNA Translation: AAB52511.1
AY618897 Genomic DNA Translation: AAT40308.1
X97406 Genomic DNA Translation: CAA66059.1
L01466 Genomic DNA No translation available.
M87046 Genomic DNA No translation available.
D10478 Genomic DNA Translation: BAA01281.1
D10882 Genomic DNA Translation: BAA01704.1
U94839 Genomic DNA Translation: AAC64232.1
X80752 Genomic DNA Translation: CAA56728.1
AF077015 Genomic DNA Translation: AAC26835.1
K00409 mRNA Translation: AAA36312.1
CCDSiCCDS4765.1
PIRiA02228 HLHUS1
A02229 HLHUPB
D30536
D30537
E30536
I37298
I37541 S49382
I38195 HLHUS2
I38197
I59621
I59637
I59641
I81234
I81235
I81236
I81237
I81238
RefSeqiNP_002112.3, NM_002121.5
UniGeneiHs.485130

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25B33-218[»]
4P4KX-ray2.80B/F32-218[»]
4P4RX-ray3.00B/D32-218[»]
4P57X-ray2.60B/D33-218[»]
4P5KX-ray2.59B/E33-218[»]
4P5MX-ray1.70B/D/F/H33-218[»]
ProteinModelPortaliP04440
SMRiP04440
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109360, 40 interactors
IntActiP04440, 10 interactors
MINTiP04440
STRINGi9606.ENSP00000408146

PTM databases

GlyConnecti1366
iPTMnetiP04440
PhosphoSitePlusiP04440
SwissPalmiP04440

Polymorphism and mutation databases

BioMutaiHLA-DPB1
DMDMi122263

Proteomic databases

MaxQBiP04440
PaxDbiP04440
PeptideAtlasiP04440
PRIDEiP04440
ProteomicsDBi51715

Protocols and materials databases

DNASUi3115
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399500; ENSP00000382422; ENSG00000215048
ENST00000411749; ENSP00000414196; ENSG00000236693
ENST00000418931; ENSP00000408146; ENSG00000223865
ENST00000425130; ENSP00000396095; ENSG00000230763
ENST00000433800; ENSP00000407674; ENSG00000226826
ENST00000454006; ENSP00000389288; ENSG00000237710
GeneIDi3115
KEGGihsa:3115
UCSCiuc003ocu.3 human

Organism-specific databases

CTDi3115
DisGeNETi3115
EuPathDBiHostDB:ENSG00000223865.10
GeneCardsiHLA-DPB1
HGNCiHGNC:4940 HLA-DPB1
HPAiHPA011078
HPA058509
MalaCardsiHLA-DPB1
MIMi142858 gene
neXtProtiNX_P04440
OpenTargetsiENSG00000223865
Orphaneti133 Chronic berylliosis
900 Granulomatosis with polyangiitis
PharmGKBiPA35064
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
GeneTreeiENSGT00900000140849
HOVERGENiHBG012730
InParanoidiP04440
KOiK06752
OMAiICQVEHT
OrthoDBiEOG091G0W5S
PhylomeDBiP04440
TreeFamiTF336626

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP04440

Miscellaneous databases

ChiTaRSiHLA-DPB1 human
EvolutionaryTraceiP04440
GeneWikiiHLA-DPB1
GenomeRNAii3115
PROiPR:P04440
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000223865 Expressed in 112 organ(s), highest expression level in lung
CleanExiHS_HLA-DPB1
ExpressionAtlasiP04440 baseline and differential
GenevisibleiP04440 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPB1_HUMAN
AccessioniPrimary (citable) accession number: P04440
Secondary accession number(s): A0PFJ7
, A5I886, A8YPB3, B5U8B4, B7VF80, B7VF87, B8ZX68, B8ZYT0, B9W5S8, B9W6F7, B9W6F9, C0MPP5, C0MPQ2, C0MPQ3, C0MPQ5, C0MPQ6, C0MPQ7, C4R9J5, C5IZL1, O00259, O19698, O19700, O19702, O19749, O46884, O77952, O98215, O98216, O98217, O98218, O98219, O98222, O98223, P01916, P04232, P13763, P79493, P79608, Q0P0L4, Q0ZFN3, Q14279, Q27S71, Q29682, Q29684, Q29698, Q29714, Q29775, Q29776, Q29778, Q29779, Q29781, Q29827, Q29828, Q29879, Q29880, Q29898, Q29977, Q2MGW3, Q30015, Q30031, Q30032, Q30033, Q30034, Q30050, Q30051, Q30052, Q30053, Q30054, Q30055, Q30174, Q4GY31, Q4JHD8, Q5ENE0, Q5ENE1, Q5ENW3, Q5EP46, Q5EP47, Q5EP49, Q5EP51, Q5EP52, Q5EP53, Q5EP56, Q5I4H8, Q5I4H9, Q5ISH4, Q5ISH5, Q5SQ73, Q5STP2, Q5YLA6, Q6IVX1, Q6LBX2, Q6LBX3, Q6LBX4, Q6LBX5, Q6LBX6, Q6LBX7, Q6PWX6, Q6TAS4, Q714U1, Q714U2, Q7YQ10, Q860Z7, Q8HWL7, Q8HWT5, Q8SNC4, Q95HC1, Q95IT7, Q95IT8, Q9BD13, Q9GIM2, Q9GIM4, Q9GIX6, Q9GJ41, Q9MY67, Q9TNT7, Q9TQE2, Q9XS11, Q9XS12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 10, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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