UniProtKB - P04440 (DPB1_HUMAN)

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History
Entry version 169 (18 Jul 2018)
Sequence version 1 (13 Aug 1987)
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Protein

HLA class II histocompatibility antigen, DP beta 1 chain

Gene

HLA-DPB1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functionⁱ

peptide antigen binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20356827

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20356827
interferon-gamma-mediated signaling pathway Source: Reactome
positive regulation of interferon-gamma production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20356827
positive regulation of T cell activation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20356827
positive regulation of T cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20356827
T cell receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202424 Downstream TCR signaling R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-202430 Translocation of ZAP-70 to Immunological synapse R-HSA-202433 Generation of second messenger molecules R-HSA-2132295 MHC class II antigen presentation R-HSA-389948 PD-1 signaling R-HSA-877300 Interferon gamma signaling
SIGNORⁱ	P04440

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class II histocompatibility antigen, DP beta 1 chain Alternative name(s): HLA class II histocompatibility antigen, DP(W4) beta chain MHC class II antigen DPB1
Gene namesⁱ	Name:HLA-DPB1 Synonyms:HLA-DP1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000223865.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4940 HLA-DPB1
MIMⁱ	142858 gene
neXtProtⁱ	NX_P04440

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 225	ExtracellularSequence analysisAdd BLAST	196
Transmembraneⁱ	226 – 246	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	247 – 258	CytoplasmicSequence analysisAdd BLAST	12

Keywords - Cellular componentⁱ

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3115
MalaCards human disease database More...MalaCardsⁱ	HLA-DPB1
Open Targets More...OpenTargetsⁱ	ENSG00000223865
Orphanetⁱ	133 Chronic berylliosis 900 Granulomatosis with polyangiitis
PharmGKBⁱ	PA35064

Polymorphism and mutation databases

BioMutaⁱ	HLA-DPB1
DMDMⁱ	122263

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	Add BLAST		29
ChainⁱPRO_0000018984	30 – 258	HLA class II histocompatibility antigen, DP beta 1 chainAdd BLAST		229

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	44 ↔ 106	PROSITE-ProRule annotation
Glycosylationⁱ	48	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	144 ↔ 200	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04440
PaxDbⁱ	P04440
PeptideAtlas More...PeptideAtlasⁱ	P04440
PRIDEⁱ	P04440
ProteomicsDBⁱ	51715

PTM databases

iPTMnetⁱ	P04440
PhosphoSitePlusⁱ	P04440
SwissPalmⁱ	P04440

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000223865
CleanExⁱ	HS_HLA-DPB1
ExpressionAtlasⁱ	P04440 baseline and differential
Genevisibleⁱ	P04440 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011078 HPA058509

HPAⁱ

HPA011078
HPA058509

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

BioGridⁱ	109360, 40 interactors
IntActⁱ	P04440, 10 interactors
Molecular INTeraction database More...MINTⁱ	P04440
STRINGⁱ	9606.ENSP00000408146

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 47	Combined sources	11
Beta strandⁱ	50 – 59	Combined sources	10
Beta strandⁱ	62 – 68	Combined sources	7
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	73 – 78	Combined sources	6
Helixⁱ	79 – 81	Combined sources	3
Helixⁱ	82 – 89	Combined sources	8
Helixⁱ	92 – 99	Combined sources	8
Turnⁱ	100 – 104	Combined sources	5
Helixⁱ	105 – 112	Combined sources	8
Helixⁱ	114 – 118	Combined sources	5
Beta strandⁱ	125 – 130	Combined sources	6
Helixⁱ	134 – 137	Combined sources	4
Beta strandⁱ	141 – 152	Combined sources	12
Beta strandⁱ	155 – 160	Combined sources	6
Beta strandⁱ	163 – 165	Combined sources	3
Beta strandⁱ	167 – 171	Combined sources	5
Beta strandⁱ	178 – 180	Combined sources	3
Beta strandⁱ	182 – 189	Combined sources	8
Beta strandⁱ	197 – 203	Combined sources	7
Beta strandⁱ	211 – 216	Combined sources	6

3D structure databases

ProteinModelPortalⁱ	P04440
SMRⁱ	P04440
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04440

EvolutionaryTraceⁱ

P04440

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	124 – 212	Ig-like C1-typeAdd BLAST		89

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	30 – 121	Beta-1Add BLAST	92
Regionⁱ	122 – 215	Beta-2Add BLAST	94
Regionⁱ	216 – 225	Connecting peptide	10

Sequence similaritiesⁱ

Belongs to the MHC class II family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3 Eukaryota ENOG410YI0S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140849
HOVERGENⁱ	HBG012730
InParanoidⁱ	P04440
KEGG Orthology (KO) More...KOⁱ	K06752
OMAⁱ	ICQVEHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W5S
PhylomeDBⁱ	P04440
TreeFamⁱ	TF336626

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR000353 MHC_II_b_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00969 MHC_II_beta, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000328 MHC_II_b_N, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00921 MHC_II_beta, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04440-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT 
        60         70         80         90        100
QRFLERYIYN REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA 
       110        120        130        140        150
VPDRMCRHNY ELGGPMTLQR RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY 
       160        170        180        190        200
PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYTC 
       210        220        230        240        250
QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC GVGIFMHRRS 

KKVQRGSA

Length:258

Mass (Da):29,159

Last modified:August 13, 1987 - v1

Checksum:ⁱE74777D438DE9C41

Sequence cautionⁱ

The sequence AAQ12564 differs from that shown. Reason: Frameshift at position 39.Curated

Polymorphismⁱ

The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_060627	16	T → M in allele DPB1*09:02. Corresponds to variant dbSNP:rs41558014Ensembl.	1
Natural variantⁱVAR_060628	24	T → I. Corresponds to variant dbSNP:rs11551416Ensembl.	1
Natural variantⁱVAR_060629	30	R → P in allele DPB1*75:01.	1
Natural variantⁱVAR_060630	31	A → L in allele DPB1*75:01; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060631	32	T → P in allele DPB1*75:01.	1
Natural variantⁱVAR_060632	33	P → A in allele DPB1*75:01.	1
Natural variantⁱVAR_060633	37	L → V in allele DPB101:01, allele DPB103:01, allele DPB105:02, allele DPB106:01, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB111:02, allele DPB113:01, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB115:01, allele DPB116:02, allele DPB117:01, allele DPB117:02, allele DPB118:01, allele DPB120:02, allele DPB121:01, allele DPB121:02, allele DPB120:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB158:01, allele DPB166:01, allele DPB167:01, allele DPB169:01, allele DPB170:01, allele DPB174:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB185:01, allele DPB186:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB191:01, allele DPB192:01, allele DPB193:01 and allele DPB198:01. Corresponds to variant dbSNP:rs1126504Ensembl.	1
Natural variantⁱVAR_060635	38	F → D in allele DPB1*70:01; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060634	38	F → H in allele DPB109:01, allele DPB110:01, allele DPB114:01, allele DPB116:02, allele DPB117:01, allele DPB122:02, allele DPB130:01, allele DPB135:01, allele DPB145:01, allele DPB154:01, allele DPB155:01, allele DPB158:01, allele DPB166:01, allele DPB167:01, allele DPB176:01, allele DPB186:01, allele DPB191:01 and allele DPB198:01; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060636	38	F → L. Corresponds to variant dbSNP:rs12722013Ensembl.	1
Natural variantⁱVAR_033433	38	F → Y in allele DPB101:01, allele DPB103:01, allele DPB105:02, allele DPB106:01, allele DPB109:02, allele DPB111:01, allele DPB111:02, allele DPB113:01, allele DPB113:02, allele DPB114:02, allele DPB115:01, allele DPB117:02, allele DPB118:01, allele DPB120:02, allele DPB121:01, allele DPB121:02, allele DPB120:01, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB136:01, allele DPB137:01, allele DPB144:01, allele DPB150:01, allele DPB152:01, allele DPB156:01, allele DPB169:01, allele DPB174:01, allele DPB178:01, allele DPB179:01, allele DPB185:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB192:01 and allele DPB1*93:01. Corresponds to variant dbSNP:rs1126509Ensembl.	1
Natural variantⁱVAR_060637	40	G → L in allele DPB103:01, allele DPB105:02, allele DPB106:01, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB111:02, allele DPB113:01, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB116:02, allele DPB117:01, allele DPB117:02, allele DPB120:02, allele DPB121:01, allele DPB120:01, allele DPB122:02, allele DPB125:01, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB144:01, allele DPB145:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB158:01, allele DPB166:01, allele DPB167:01, allele DPB169:01, allele DPB170:01, allele DPB174:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB185:01, allele DPB186:01, allele DPB187:01, allele DPB188:01, allele DPB191:01, allele DPB192:01, allele DPB193:01 and allele DPB198:01; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs386699869Ensembl.	1
Natural variantⁱVAR_033434	40	G → V. Corresponds to variant dbSNP:rs1126513Ensembl.	1
Natural variantⁱVAR_060638	41	R → L in allele DPB1*77:01. Corresponds to variant dbSNP:rs41540313Ensembl.	1
Natural variantⁱVAR_060639	44	C → G in allele DPB1*26:02.	1
Natural variantⁱVAR_060640	46	A → P in allele DPB1*38:01. Corresponds to variant dbSNP:rs41555313Ensembl.	1
Natural variantⁱVAR_060641	46	A → T in allele DPB1*18:02. Corresponds to variant dbSNP:rs41555313Ensembl.	1
Natural variantⁱVAR_060642	57	Y → D in allele DPB1*99:01. Corresponds to variant dbSNP:rs41553416Ensembl.	1
Natural variantⁱVAR_060643	61	R → P in allele DPB114:02 and allele DPB121:02. Corresponds to variant dbSNP:rs41561114Ensembl.	1
Natural variantⁱVAR_033435	62	E → Q Ind allele DPB111:01, allele DPB115:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs12722018Ensembl.	1
Natural variantⁱVAR_060644	64	F → L in allele DPB102:02, allele DPB102:03, allele DPB105:01, allele DPB115:02, allele DPB117:02, allele DPB119:02, allele DPB121:01, allele DPB121:01, allele DPB122:01, allele DPB134:01, allele DPB136:01, allele DPB138:01, allele DPB144:01, allele DPB148:01, allele DPB158:01, allele DPB162:01, allele DPB163:01, allele DPB195:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs9277348Ensembl.	1
Natural variantⁱVAR_033436	64	F → Y in allele DPB101:01, allele DPB101:02, allele DPB109:02, allele DPB111:01, allele DPB113:01, allele DPB115:01, allele DPB120:02, allele DPB121:02, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB139:01, allele DPB140:01, allele DPB149:01, allele DPB153:01, allele DPB165:01, allele DPB174:01, allele DPB185:01, allele DPB189:01 and allele DPB196:01. Corresponds to variant dbSNP:rs1042117Ensembl.	1
Natural variantⁱVAR_033437	65	A → V in allele DPB101:02, allele DPB102:01, allele DPB102:02, allele DPB102:03, allele DPB103:01, allele DPB104:02, allele DPB104:03, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB106:02, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB110:01, allele DPB110:02, allele DPB111:02, allele DPB114:01, allele DPB114:02, allele DPB115:02, allele DPB116:01, allele DPB116:02, allele DPB117:01, allele DPB117:02, allele DPB118:01, allele DPB118:02, allele DPB119:01, allele DPB119:02, allele DPB121:01, allele DPB120:01, allele DPB122:01, allele DPB122:02, allele DPB123:01, allele DPB125:01, allele DPB126:02, allele DPB129:01, allele DPB130:01, allele DPB132:01, allele DPB134:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB138:01, allele DPB141:01, allele DPB144:01, allele DPB145:01, allele DPB146:01, allele DPB147:01, allele DPB148:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB157:01, allele DPB158:01, allele DPB159:01, allele DPB160:01, allele DPB162:01, allele DPB163:01, allele DPB167:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB171:01, allele DPB173:01, allele DPB175:01, allele DPB177:01, allele DPB178:01, allele DPB179:01, allele DPB180:01, allele DPB182:01, allele DPB183:01, allele DPB184:01, allele DPB186:01, allele DPB187:01, allele DPB188:01, allele DPB191:01, allele DPB193:01, allele DPB194:01, allele DPB195:01, allele DPB197:01 and allele DPB198:01. Corresponds to variant dbSNP:rs1042121Ensembl.	1
Natural variantⁱVAR_060645	68	D → Y in allele DPB1*24:02. Corresponds to variant dbSNP:rs77062860Ensembl.	1
Natural variantⁱVAR_060646	72	G → W in allele DPB1*97:01. Corresponds to variant dbSNP:rs41552915Ensembl.	1
Natural variantⁱVAR_054662	84	A → D in allele DPB102:01, allele DPB103:01, allele DPB104:02, allele DPB105:02, allele DPB106:01, allele DPB106:02, allele DPB108:01, allele DPB109:01, allele DPB110:01, allele DPB110:02, allele DPB111:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB116:02, allele DPB117:01, allele DPB118:01, allele DPB118:01, allele DPB118:02, allele DPB119:02, allele DPB120:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:02, allele DPB128:01, allele DPB129:01, allele DPB132:01, allele DPB135:01, allele DPB137:01, allele DPB141:01, allele DPB144:01, allele DPB145:01, allele DPB146:01, allele DPB148:01, allele DPB149:01, allele DPB150:01, allele DPB151:01, allele DPB153:01, allele DPB157:01, allele DPB159:01, allele DPB160:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB173:01, allele DPB175:01, allele DPB176:01, allele DPB177:01, allele DPB178:01, allele DPB179:01, allele DPB180:01, allele DPB181:01, allele DPB182:01, allele DPB183:01, allele DPB186:01, allele DPB188:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB194:01 and allele DPB198:01. Corresponds to variant dbSNP:rs707958Ensembl.	1
Natural variantⁱVAR_060647	84	A → E in allele DPB101:02, allele DPB102:02, allele DPB102:03, allele DPB105:01, allele DPB108:02, allele DPB117:02, allele DPB119:01, allele DPB121:01, allele DPB122:01, allele DPB124:01, allele DPB130:01, allele DPB136:01, allele DPB138:01, allele DPB147:01, allele DPB154:01, allele DPB184:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs386699870Ensembl.	1
Natural variantⁱVAR_059511	84	A → V. Corresponds to variant dbSNP:rs707958Ensembl.	1
Natural variantⁱVAR_033438	85	A → E in allele DPB102:01, allele DPB103:01, allele DPB104:02, allele DPB105:02, allele DPB106:01, allele DPB106:02, allele DPB108:01, allele DPB109:01, allele DPB110:01, allele DPB110:02, allele DPB111:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB116:02, allele DPB117:01, allele DPB118:01, allele DPB118:02, allele DPB119:02, allele DPB120:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:02, allele DPB128:01, allele DPB129:01, allele DPB132:01, allele DPB135:01, allele DPB137:01, allele DPB141:01, allele DPB144:01, allele DPB145:01, allele DPB146:01, allele DPB148:01, allele DPB149:01, allele DPB150:01, allele DPB151:01, allele DPB153:01, allele DPB157:01, allele DPB159:01, allele DPB160:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB173:01, allele DPB175:01, allele DPB176:01, allele DPB177:01, allele DPB178:01, allele DPB179:01, allele DPB180:01, allele DPB181:01, allele DPB182:01, allele DPB183:01, allele DPB184:01, allele DPB186:01, allele DPB188:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB194:01 and allele DPB198:01. Corresponds to variant dbSNP:rs1042131Ensembl.	1
Natural variantⁱVAR_033439	86	E → D in allele DPB103:01, allele DPB105:02, allele DPB106:01, allele DPB109:01, allele DPB110:02, allele DPB114:01, allele DPB114:02, allele DPB117:01, allele DPB120:01, allele DPB122:02, allele DPB129:01, allele DPB135:01, allele DPB144:01, allele DPB146:01, allele DPB150:01, allele DPB157:01, allele DPB169:01, allele DPB170:01, allele DPB176:01, allele DPB178:01, allele DPB180:01, allele DPB186:01, allele DPB188:01, allele DPB191:01, allele DPB192:01 and allele DPB198:01. Corresponds to variant dbSNP:rs1042133Ensembl.	1
Natural variantⁱVAR_060648	86	E → V in allele DPB1*32:01. Corresponds to variant dbSNP:rs41545212Ensembl.	1
Natural variantⁱVAR_060649	89	N → H in allele DPB1*02:03. Corresponds to variant dbSNP:rs41550319Ensembl.	1
Natural variantⁱVAR_060650	93	D → H in allele DPB1*96:01. Corresponds to variant dbSNP:rs41560812Ensembl.	1
Natural variantⁱVAR_059512	94	I → F Allele DPB141:01 and allele DPB183:01. Corresponds to variant dbSNP:rs1042136Ensembl.	1
Natural variantⁱVAR_059513	94	I → L in allele DPB103:01, allele DPB103:02, allele DPB105:02, allele DPB106:01, allele DPB110:02, allele DPB111:01, allele DPB114:01, allele DPB114:02, allele DPB115:01, allele DPB117:02, allele DPB120:01, allele DPB122:02, allele DPB125:01, allele DPB128:01, allele DPB129:01, allele DPB131:01, allele DPB134:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB156:01, allele DPB157:01, allele DPB159:01, allele DPB167:01, allele DPB169:01, allele DPB170:01, allele DPB172:01, allele DPB173:01, allele DPB174:01, allele DPB176:01, allele DPB178:01, allele DPB187:01, allele DPB191:01, allele DPB192:01 and allele DPB195:01. 1 PublicationCorresponds to variant dbSNP:rs1042136Ensembl.	1
Natural variantⁱVAR_060651	94	I → N in allele DPB1*60:01. Corresponds to variant dbSNP:rs41547212Ensembl.	1
Natural variantⁱVAR_033440	98	K → E in allele DPB102:01, allele DPB102:02, allele DPB102:03, allele DPB104:03, allele DPB106:01, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:02, allele DPB113:01, allele DPB113:02, allele DPB116:01, allele DPB116:02, allele DPB117:01, allele DPB118:02, allele DPB119:01, allele DPB120:02, allele DPB121:01, allele DPB122:01, allele DPB126:02, allele DPB129:01, allele DPB130:01, allele DPB132:01, allele DPB133:01, allele DPB137:01, allele DPB141:01, allele DPB144:01, allele DPB146:01, allele DPB147:01, allele DPB148:01, allele DPB154:01, allele DPB155:01, allele DPB158:01, allele DPB171:01, allele DPB181:01, allele DPB186:01, allele DPB188:01, allele DPB193:01 and allele DPB1*95:01. Corresponds to variant dbSNP:rs1042140EnsemblClinVar.	1
Natural variantⁱVAR_033441	98	K → R in allele DPB111:01, allele DPB115:01, allele DPB169:01 and allele DPB174:01. Corresponds to variant dbSNP:rs12722027Ensembl.	1
Natural variantⁱVAR_060652	99	R → W in allele DPB1*94:01. Corresponds to variant dbSNP:rs41554314Ensembl.	1
Natural variantⁱVAR_060653	101	V → L in allele DPB131:01 and allele DPB134:01. Corresponds to variant dbSNP:rs41546618Ensembl.	1
Natural variantⁱVAR_060654	102	P → L in allele DPB1*78:01. Corresponds to variant dbSNP:rs41551920Ensembl.	1
Natural variantⁱVAR_033443	105	M → I in allele DPB108:02, allele DPB109:02, allele DPB113:01, allele DPB113:02 and allele DPB1*19:01. Corresponds to variant dbSNP:rs1042153Ensembl.	1
Natural variantⁱVAR_033442	105	M → V in allele DPB101:01, allele DPB103:01, allele DPB105:02, allele DPB108:01, allele DPB109:01, allele DPB110:01, allele DPB114:01, allele DPB114:02, allele DPB117:02, allele DPB121:02, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB129:01, allele DPB135:01, allele DPB137:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB156:01, allele DPB157:01, allele DPB165:01, allele DPB167:01, allele DPB168:01, allele DPB170:01, allele DPB173:01, allele DPB175:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB184:01, allele DPB188:01, allele DPB190:01 and allele DPB1*92:01. 1 PublicationCorresponds to variant dbSNP:rs1042151Ensembl.	1
Natural variantⁱVAR_060657	113	G → D in allele DPB101:01, allele DPB103:01, allele DPB103:02, allele DPB104:03, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB111:01, allele DPB113:01, allele DPB113:02, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB117:01, allele DPB117:02, allele DPB119:01, allele DPB121:01, allele DPB121:01, allele DPB121:02, allele DPB121:02, allele DPB120:01, allele DPB122:01, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB131:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB138:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB157:01, allele DPB158:01, allele DPB163:01, allele DPB165:01, allele DPB167:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB184:01, allele DPB185:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB197:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs1042169Ensembl.	1
Natural variantⁱVAR_060655	113	G → N in allele DPB1*22:02; requires 2 nucleotide substitutions.	1
Natural variantⁱVAR_060656	113	G → V in allele DPB115:01, allele DPB118:01, allele DPB128:01, allele DPB134:01, allele DPB140:01, allele DPB153:01, allele DPB162:01 and allele DPB174:01. Corresponds to variant dbSNP:rs1042169Ensembl.	1
Natural variantⁱVAR_033444	114	G → E in allele DPB101:01, allele DPB103:01, allele DPB103:02, allele DPB104:03, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB113:01, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB117:01, allele DPB117:02, allele DPB119:01, allele DPB121:01, allele DPB121:02, allele DPB120:01, allele DPB122:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB131:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB138:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB157:01, allele DPB158:01, allele DPB163:01, allele DPB165:01, allele DPB167:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB184:01, allele DPB185:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB197:01 and allele DPB198:01. 1 PublicationCorresponds to variant dbSNP:rs9277354Ensembl.	1
Natural variantⁱVAR_033445	115	P → A in allele DPB101:01, allele DPB103:01, allele DPB103:02, allele DPB104:03, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB113:01, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB117:01, allele DPB117:02, allele DPB119:01, allele DPB121:01, allele DPB121:02, allele DPB120:01, allele DPB122:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB131:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB138:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB157:01, allele DPB158:01, allele DPB163:01, allele DPB165:01, allele DPB167:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB184:01, allele DPB185:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB197:01 and allele DPB198:01. 1 PublicationCorresponds to variant dbSNP:rs9277355Ensembl.	1
Natural variantⁱVAR_033446	116	M → V in allele DPB101:01, allele DPB103:01, allele DPB103:02, allele DPB104:03, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB108:01, allele DPB108:02, allele DPB109:01, allele DPB109:02, allele DPB110:01, allele DPB111:01, allele DPB113:01, allele DPB113:02, allele DPB114:01, allele DPB114:02, allele DPB116:01, allele DPB117:01, allele DPB117:02, allele DPB119:01, allele DPB121:01, allele DPB121:02, allele DPB120:01, allele DPB122:01, allele DPB122:02, allele DPB125:01, allele DPB125:02, allele DPB126:01, allele DPB127:01, allele DPB129:01, allele DPB130:01, allele DPB131:01, allele DPB135:01, allele DPB136:01, allele DPB137:01, allele DPB138:01, allele DPB144:01, allele DPB145:01, allele DPB150:01, allele DPB152:01, allele DPB154:01, allele DPB155:01, allele DPB156:01, allele DPB158:01, allele DPB163:01, allele DPB165:01, allele DPB167:01, allele DPB168:01, allele DPB169:01, allele DPB170:01, allele DPB176:01, allele DPB178:01, allele DPB179:01, allele DPB184:01, allele DPB185:01, allele DPB187:01, allele DPB188:01, allele DPB189:01, allele DPB190:01, allele DPB191:01, allele DPB192:01, allele DPB193:01, allele DPB197:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277356Ensembl.	1
Natural variantⁱVAR_060658	120	R → H in allele DPB182:01 and allele DPB185:01. Corresponds to variant dbSNP:rs41541915Ensembl.	1
Natural variantⁱVAR_060659	125	R → K in allele DPB101:01, allele DPB103:01, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB109:01, allele DPB109:02, allele DPB113:01, allele DPB114:01, allele DPB115:01, allele DPB118:01, allele DPB119:01, allele DPB120:01, allele DPB126:01, allele DPB145:01 and allele DPB185:01. 1 PublicationCorresponds to variant dbSNP:rs1126537Ensembl.	1
Natural variantⁱVAR_060660	199	T → I in allele DPB101:01, allele DPB103:01, allele DPB105:01, allele DPB105:02, allele DPB106:01, allele DPB109:01, allele DPB109:02, allele DPB113:01, allele DPB114:01, allele DPB115:01, allele DPB118:01, allele DPB119:01, allele DPB120:01, allele DPB126:01, allele DPB145:01 and allele DPB185:01. 1 PublicationCorresponds to variant dbSNP:rs1042335Ensembl.	1
Natural variantⁱVAR_033447	207	L → M in allele DPB1*04:02. Corresponds to variant dbSNP:rs14362Ensembl.	1
Natural variantⁱVAR_050393	223	R → Q in allele DPB1*01:01. Corresponds to variant dbSNP:rs9276Ensembl.	1
Natural variantⁱVAR_050394	234	V → M in allele DPB105:01 and allele DPB119:01. Corresponds to variant dbSNP:rs11551421Ensembl.	1
Natural variantⁱVAR_033448	244	I → T in allele DPB1*15:01. Corresponds to variant dbSNP:rs3097675Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X01426 mRNA Translation: CAA25672.1 X02964 Genomic DNA No translation available. X03023 Genomic DNA Translation: CAE82008.1 X03024 Genomic DNA Translation: CAE82007.1 X03022 Genomic DNA Translation: CAA26823.1 X03025 Genomic DNA Translation: CAE82037.1 X03026 Genomic DNA Translation: CAE82042.1 X03028 Genomic DNA Translation: CAE82073.1 X03027 Genomic DNA Translation: CAE82043.1 X03067 mRNA Translation: CAA26871.1 X02228 Genomic DNA Translation: CAA26147.1 J03041 mRNA Translation: AAA35993.1 M83664 mRNA Translation: AAA59837.1 AY804132 mRNA Translation: AAW78737.1 AY804133 mRNA Translation: AAW78738.1 AY804135 mRNA Translation: AAW78740.1 AY804136 mRNA Translation: AAW78741.1 AY804137 mRNA Translation: AAW78742.1 AY804138 mRNA Translation: AAW78743.1 AY804139 mRNA Translation: AAW78744.1 AY804141 mRNA Translation: AAW78746.1 AY804142 mRNA Translation: AAW78747.1 AY804143 mRNA Translation: AAW78748.1 AY831401 mRNA Translation: AAW80919.1 AY831402 mRNA Translation: AAW80920.1 AY831403 mRNA Translation: AAW80921.1 AY831404 mRNA Translation: AAW80922.1 AY656678 mRNA Translation: AAV71025.1 AY656679 mRNA Translation: AAV71026.1 AY656680 mRNA Translation: AAV71027.1 AK313305 mRNA Translation: BAG36110.1 BT019780 mRNA Translation: AAV38583.1 AL645931 Genomic DNA No translation available. AL662824 Genomic DNA No translation available. AL805913 Genomic DNA No translation available. AL845446 Genomic DNA No translation available. BX120009 Genomic DNA No translation available. CR759795 Genomic DNA No translation available. CR759904 Genomic DNA No translation available. CR762479 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03674.1 BC007963 mRNA Translation: AAH07963.1 BC013184 mRNA Translation: AAH13184.1 M28202 mRNA Translation: AAA53197.1 Y09327 Genomic DNA Translation: CAA70507.1 L31816 Genomic DNA No translation available. M97686 Genomic DNA No translation available. X96985 Genomic DNA No translation available. Y13900 Genomic DNA Translation: CAA74199.1 Y14230 Genomic DNA Translation: CAA74608.1 Y16095 Genomic DNA Translation: CAA76060.1 AY823995 Genomic DNA Translation: AAW79272.1 AJ563603 Genomic DNA Translation: CAD91639.1 AM039828 Genomic DNA Translation: CAJ01690.1 AM408787 Genomic DNA Translation: CAL64063.1 AM698036 Genomic DNA Translation: CAM91695.1 M84619 Genomic DNA No translation available. M84620 Genomic DNA No translation available. M84622 Genomic DNA No translation available. M84623 Genomic DNA No translation available. M84624 Genomic DNA No translation available. M84626 Genomic DNA No translation available. X82123 Genomic DNA Translation: CAA57635.1 U22311 Genomic DNA Translation: AAB60413.1 U22313 Genomic DNA Translation: AAB17108.1 K01615 mRNA Translation: AAA36313.1 FM883600 Genomic DNA Translation: CAT04585.2 FM882212 Genomic DNA Translation: CAT03206.1 FM956650 Genomic DNA Translation: CAX11690.1 FM991729 Genomic DNA Translation: CAX20314.1 FM992080 Genomic DNA Translation: CAX21583.2 FM992366 Genomic DNA Translation: CAX30407.1 FM992364 Genomic DNA Translation: CAX30405.1 FN252853 Genomic DNA Translation: CAX53275.1 FN256250 Genomic DNA Translation: CAX53717.1 FN256251 Genomic DNA Translation: CAX53721.1 FN256254 Genomic DNA Translation: CAX53718.1 FN256253 Genomic DNA Translation: CAX53726.1 FN256255 Genomic DNA Translation: CAX53722.1 FN393829 Genomic DNA Translation: CAY85528.1 M23675 Genomic DNA Translation: AAA59740.1 M62326 Genomic DNA Translation: AAA59719.1 M62331 Genomic DNA Translation: AAA59724.1 L07768 Genomic DNA Translation: AAA59690.1 D13174 Genomic DNA Translation: BAA02465.1 D10834 Genomic DNA Translation: BAA01614.1 D28809 Genomic DNA Translation: BAA05970.1 X96986 Genomic DNA Translation: CAA65710.2 X91886 Genomic DNA No translation available. Y18498 Genomic DNA Translation: CAC12860.1 AJ238005 Genomic DNA Translation: CAC12865.1 AJ271373 Genomic DNA Translation: CAB70605.2 AF288354 Genomic DNA Translation: AAG30143.1 AJ292074 Genomic DNA Translation: CAC27995.1 AF536241 Genomic DNA Translation: AAN33050.1 AF549409 Genomic DNA Translation: AAQ12563.1 AF549410 Genomic DNA Translation: AAQ12564.1 Frameshift. AJ514871 Genomic DNA Translation: CAD55852.1 AY374100 Genomic DNA Translation: AAR21105.1 DQ206450 Genomic DNA Translation: ABB17974.1 M83914 Genomic DNA Translation: AAA36264.1 M83915 Genomic DNA Translation: AAA36259.1 M83916 Genomic DNA Translation: AAA36260.1 M83917 Genomic DNA Translation: AAA36261.1 M83918 Genomic DNA Translation: AAA36262.1 M83919 Genomic DNA Translation: AAA36263.1 AJ297820 Genomic DNA Translation: CAC14048.1 AY029777 Genomic DNA Translation: AAK40344.1 AF489518 Genomic DNA Translation: AAL92172.1 AF492640 Genomic DNA Translation: AAO84765.1 AY425707 Genomic DNA Translation: AAR29060.1 AY572830 Genomic DNA Translation: AAS77869.1 AY855160 Genomic DNA Translation: AAW33682.1 AY855161 Genomic DNA Translation: AAW33683.1 DQ089022 Genomic DNA Translation: AAY98352.1 AB247517 Genomic DNA Translation: BAE78492.1 DQ386161 Genomic DNA Translation: ABD36812.1 DQ485789 Genomic DNA Translation: ABF47047.1 AM887530 Genomic DNA Translation: CAP08783.1 FM211032 Genomic DNA Translation: CAR66500.1 FJ976693 Genomic DNA Translation: ACS12738.1 L17310 Genomic DNA Translation: AAA53479.1 L17311 Genomic DNA Translation: AAA53480.1 L17313 Genomic DNA Translation: AAA53481.1 L17314 Genomic DNA Translation: AAA53482.1 L22076 Genomic DNA Translation: AAA53476.1 L22077 Genomic DNA Translation: AAA53477.1 L23400 Genomic DNA Translation: AAA58441.1 U59437 Genomic DNA Translation: AAD09481.1 U59438 Genomic DNA Translation: AAD09482.1 U59439 Genomic DNA Translation: AAD09483.1 U59440 Genomic DNA Translation: AAD09484.1 U59441 Genomic DNA Translation: AAD09485.1 U59442 Genomic DNA Translation: AAD09486.1 AF074845 Genomic DNA Translation: AAD39682.1 AF074846 Genomic DNA Translation: AAD39683.1 AY033075 Genomic DNA Translation: AAK51161.1 U34033 Genomic DNA Translation: AAA81335.1 Z92523 Genomic DNA Translation: CAB06822.1 X78042 Genomic DNA No translation available. U29534 Genomic DNA Translation: AAB52511.1 AY618897 Genomic DNA Translation: AAT40308.1 X97406 Genomic DNA Translation: CAA66059.1 L01466 Genomic DNA No translation available. M87046 Genomic DNA No translation available. D10478 Genomic DNA Translation: BAA01281.1 D10882 Genomic DNA Translation: BAA01704.1 U94839 Genomic DNA Translation: AAC64232.1 X80752 Genomic DNA Translation: CAA56728.1 AF077015 Genomic DNA Translation: AAC26835.1 K00409 mRNA Translation: AAA36312.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4765.1
PIRⁱ	A02228 HLHUS1 A02229 HLHUPB D30536 D30537 E30536 I37298 I37541 S49382 I38195 HLHUS2 I38197 I59621 I59637 I59641 I81234 I81235 I81236 I81237 I81238
NCBI Reference Sequences More...RefSeqⁱ	NP_002112.3, NM_002121.5
UniGeneⁱ	Hs.485130

Genome annotation databases

Ensemblⁱ	ENST00000399500; ENSP00000382422; ENSG00000215048 ENST00000411749; ENSP00000414196; ENSG00000236693 ENST00000418931; ENSP00000408146; ENSG00000223865 ENST00000425130; ENSP00000396095; ENSG00000230763 ENST00000433800; ENSP00000407674; ENSG00000226826 ENST00000454006; ENSP00000389288; ENSG00000237710
GeneIDⁱ	3115
KEGGⁱ	hsa:3115
UCSC genome browser More...UCSCⁱ	uc003ocu.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P04440	HLA class II antigen		HUMAN		258
MHC class II antigen (Fragment)		HUMAN		207
MHC class II antigen (Fragment)		HUMAN		207
MHC class II antigen (Fragment)		HUMAN		207
MHC class II antigen (Fragment)		HUMAN		207
+223

Protein	Similar proteins		Species	Score	Length
P04440	HLA class II antigen		HUMAN		258
HLA-DPB1 isoform 1		PANTR		258
MHC class II antigen		MACNE		258
Major histocompatibility complex class II (Fragment)		MACMU		87
MHC class II protein		MACFA		258
+1055

Protein	Similar proteins		Species	Score	Length
P04440	HLA class II antigen		HUMAN		258
MHC class II antigen		MACMU		258
MHC class II protein		MACFA		258
Major histocompatibility complex, class II, DP beta 1		NOMLE		258
MHC class II antigen		MACLI		258
+1904

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LQZ	X-ray	3.25	B	33-218	[»]
4P4K	X-ray	2.80	B/F	32-218	[»]
4P4R	X-ray	3.00	B/D	32-218	[»]
4P57	X-ray	2.60	B/D	33-218	[»]
4P5K	X-ray	2.59	B/E	33-218	[»]
4P5M	X-ray	1.70	B/D/F/H	33-218	[»]
ProteinModelPortalⁱ	P04440
SMRⁱ	P04440
ModBaseⁱ	Search...
MobiDBⁱ	Search...

The DNASU plasmid repository More...DNASUⁱ	3115
Structural Biology Knowledgebase	Search...

Ensemblⁱ	ENST00000399500; ENSP00000382422; ENSG00000215048 ENST00000411749; ENSP00000414196; ENSG00000236693 ENST00000418931; ENSP00000408146; ENSG00000223865 ENST00000425130; ENSP00000396095; ENSG00000230763 ENST00000433800; ENSP00000407674; ENSG00000226826 ENST00000454006; ENSP00000389288; ENSG00000237710
GeneIDⁱ	3115
KEGGⁱ	hsa:3115
UCSC genome browser More...UCSCⁱ	uc003ocu.3 human

CTDⁱ	3115
DisGeNET More...DisGeNETⁱ	3115
EuPathDBⁱ	HostDB:ENSG00000223865.10
GeneCardsⁱ	HLA-DPB1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4940 HLA-DPB1
Human Protein Atlas More...HPAⁱ	HPA011078 HPA058509
MalaCards human disease database More...MalaCardsⁱ	HLA-DPB1
MIMⁱ	142858 gene
neXtProtⁱ	NX_P04440
Open Targets More...OpenTargetsⁱ	ENSG00000223865
Orphanetⁱ	133 Chronic berylliosis 900 Granulomatosis with polyangiitis
PharmGKBⁱ	PA35064
GenAtlas: human gene database More...GenAtlasⁱ	Search...

ChiTaRSⁱ	HLA-DPB1 human
EvolutionaryTraceⁱ	P04440
GeneWikiⁱ	HLA-DPB1
GenomeRNAiⁱ	3115
Protein Ontology More...PROⁱ	PR:P04440
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DPB1_HUMAN
Accessionⁱ	P04440Primary (citable) accession number: P04440 Secondary accession number(s): A0PFJ7 Q9XS12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	August 13, 1987
	Last modified:	July 18, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P04440 (DPB1_HUMAN)

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HLA class II histocompatibility antigen, DP beta 1 chain

HLA-DPB1

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