UniProtKB - P04440 (DPB1_HUMAN)
HLA class II histocompatibility antigen, DP beta 1 chain
HLA-DPB1
Functioni
GO - Molecular functioni
- peptide antigen binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: Reactome
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of T cell activation Source: UniProtKB
- positive regulation of T cell proliferation Source: UniProtKB
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P04440 |
Reactomei | R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-2132295, MHC class II antigen presentation R-HSA-389948, PD-1 signaling R-HSA-877300, Interferon gamma signaling |
SIGNORi | P04440 |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class II histocompatibility antigen, DP beta 1 chainAlternative name(s): HLA class II histocompatibility antigen, DP(W4) beta chain MHC class II antigen DPB1 |
Gene namesi | Name:HLA-DPB1 Synonyms:HLA-DP1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000223865.10 |
HGNCi | HGNC:4940, HLA-DPB1 |
MIMi | 142858, gene |
neXtProti | NX_P04440 |
Subcellular locationi
Endoplasmic reticulum
Plasma membrane
Golgi apparatus
Lysosome
Endosome
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Endoplasmic reticulum
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
Endosome
- endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: Reactome
- trans-Golgi network membrane Source: Reactome
Lysosome
- lysosomal membrane Source: Reactome
Plasma Membrane
- MHC class II protein complex Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- clathrin-coated endocytic vesicle membrane Source: Reactome
- endocytic vesicle membrane Source: Reactome
- ER to Golgi transport vesicle membrane Source: Reactome
- membrane Source: UniProtKB
- transport vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 225 | ExtracellularSequence analysisAdd BLAST | 196 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 247 – 258 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC IIPathology & Biotechi
Organism-specific databases
DisGeNETi | 3115 |
MalaCardsi | HLA-DPB1 |
OpenTargetsi | ENSG00000223865 |
Orphaneti | 133, Chronic beryllium disease 900, Granulomatosis with polyangiitis |
PharmGKBi | PA35064 |
Miscellaneous databases
Pharosi | P04440, Tbio |
Polymorphism and mutation databases
BioMutai | HLA-DPB1 |
DMDMi | 122263 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Add BLAST | 29 | |
ChainiPRO_0000018984 | 30 – 258 | HLA class II histocompatibility antigen, DP beta 1 chainAdd BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 200 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P04440 |
MassIVEi | P04440 |
MaxQBi | P04440 |
PaxDbi | P04440 |
PeptideAtlasi | P04440 |
PRIDEi | P04440 |
ProteomicsDBi | 51715 |
PTM databases
GlyConnecti | 1366, 7 N-Linked glycans (1 site) |
GlyGeni | P04440, 1 site |
iPTMneti | P04440 |
PhosphoSitePlusi | P04440 |
SwissPalmi | P04440 |
Expressioni
Gene expression databases
Bgeei | ENSG00000223865, Expressed in spleen and 135 other tissues |
ExpressionAtlasi | P04440, baseline and differential |
Genevisiblei | P04440, HS |
Organism-specific databases
HPAi | ENSG00000223865, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Binary interactionsi
P04440
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-2802503,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 109360, 41 interactors |
IntActi | P04440, 24 interactors |
MINTi | P04440 |
STRINGi | 9606.ENSP00000408146 |
Miscellaneous databases
RNActi | P04440, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P04440 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04440 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 212 | Ig-like C1-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 121 | Beta-1Add BLAST | 92 | |
Regioni | 122 – 215 | Beta-2Add BLAST | 94 | |
Regioni | 216 – 225 | Connecting peptide | 10 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYNI, Eukaryota |
GeneTreei | ENSGT00940000162390 |
InParanoidi | P04440 |
OMAi | ICQVEHT |
OrthoDBi | 1249505at2759 |
PhylomeDBi | P04440 |
TreeFami | TF336626 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 23 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT
60 70 80 90 100
QRFLERYIYN REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA
110 120 130 140 150
VPDRMCRHNY ELGGPMTLQR RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY
160 170 180 190 200
PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYTC
210 220 230 240 250
QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC GVGIFMHRRS
KKVQRGSA
Computationally mapped potential isoform sequencesi
There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5EP54 | Q5EP54_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 DPB1 | 258 | Annotation score: | ||
A0A182DWE9 | A0A182DWE9_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 DPB1 | 258 | Annotation score: | ||
A0A140T8Z3 | A0A140T8Z3_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 228 | Annotation score: | ||
A0A140T9T6 | A0A140T9T6_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 228 | Annotation score: | ||
A0A182DWF4 | A0A182DWF4_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 228 | Annotation score: | ||
A0A0G2JII1 | A0A0G2JII1_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 228 | Annotation score: | ||
A0A0G2JJV3 | A0A0G2JJV3_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 228 | Annotation score: | ||
H0Y5P2 | H0Y5P2_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 235 | Annotation score: | ||
H0Y7G7 | H0Y7G7_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 229 | Annotation score: | ||
A0A140T976 | A0A140T976_HUMAN | HLA class II histocompatibility ant... | HLA-DPB1 | 229 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060627 | 16 | T → M in allele DPB1*09:02. Corresponds to variant dbSNP:rs41558014EnsemblClinVar. | 1 | |
Natural variantiVAR_060628 | 24 | T → I. Corresponds to variant dbSNP:rs11551416Ensembl. | 1 | |
Natural variantiVAR_060629 | 30 | R → P in allele DPB1*75:01. | 1 | |
Natural variantiVAR_060630 | 31 | A → L in allele DPB1*75:01; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060631 | 32 | T → P in allele DPB1*75:01. | 1 | |
Natural variantiVAR_060632 | 33 | P → A in allele DPB1*75:01. | 1 | |
Natural variantiVAR_060633 | 37 | L → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1126504Ensembl. | 1 | |
Natural variantiVAR_060635 | 38 | F → D in allele DPB1*70:01; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060634 | 38 | F → H in allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*22:02, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*45:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*76:01, allele DPB1*86:01, allele DPB1*91:01 and allele DPB1*98:01; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060636 | 38 | F → L. Corresponds to variant dbSNP:rs12722013Ensembl. | 1 | |
Natural variantiVAR_033433 | 38 | F → Y in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*69:01, allele DPB1*74:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*92:01 and allele DPB1*93:01. Corresponds to variant dbSNP:rs1126509Ensembl. | 1 | |
Natural variantiVAR_060637 | 40 | G → L in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01; requires 2 nucleotide substitutions. Corresponds to variant dbSNP:rs386699869Ensembl. | 1 | |
Natural variantiVAR_033434 | 40 | G → V. Corresponds to variant dbSNP:rs1126513Ensembl. | 1 | |
Natural variantiVAR_060638 | 41 | R → L in allele DPB1*77:01. Corresponds to variant dbSNP:rs41540313Ensembl. | 1 | |
Natural variantiVAR_060639 | 44 | C → G in allele DPB1*26:02. Corresponds to variant dbSNP:rs1424116907Ensembl. | 1 | |
Natural variantiVAR_060640 | 46 | A → P in allele DPB1*38:01. Corresponds to variant dbSNP:rs41555313Ensembl. | 1 | |
Natural variantiVAR_060641 | 46 | A → T in allele DPB1*18:02. Corresponds to variant dbSNP:rs41555313Ensembl. | 1 | |
Natural variantiVAR_060642 | 57 | Y → D in allele DPB1*99:01. Corresponds to variant dbSNP:rs41553416Ensembl. | 1 | |
Natural variantiVAR_060643 | 61 | R → P in allele DPB1*14:02 and allele DPB1*21:02. Corresponds to variant dbSNP:rs41561114Ensembl. | 1 | |
Natural variantiVAR_033435 | 62 | E → Q Ind allele DPB1*11:01, allele DPB1*15:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs12722018Ensembl. | 1 | |
Natural variantiVAR_060644 | 64 | F → L in allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*15:02, allele DPB1*17:02, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*34:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*48:01, allele DPB1*58:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*95:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs9277348Ensembl. | 1 | |
Natural variantiVAR_033436 | 64 | F → Y in allele DPB1*01:01, allele DPB1*01:02, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*15:01, allele DPB1*20:02, allele DPB1*21:02, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*39:01, allele DPB1*40:01, allele DPB1*49:01, allele DPB1*53:01, allele DPB1*65:01, allele DPB1*74:01, allele DPB1*85:01, allele DPB1*89:01 and allele DPB1*96:01. Corresponds to variant dbSNP:rs1042117Ensembl. | 1 | |
Natural variantiVAR_033437 | 65 | A → V in allele DPB1*01:02, allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*23:01, allele DPB1*25:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*34:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*71:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*93:01, allele DPB1*94:01, allele DPB1*95:01, allele DPB1*97:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042121Ensembl. | 1 | |
Natural variantiVAR_060645 | 68 | D → Y in allele DPB1*24:02. Corresponds to variant dbSNP:rs77062860Ensembl. | 1 | |
Natural variantiVAR_060646 | 72 | G → W in allele DPB1*97:01. Corresponds to variant dbSNP:rs41552915Ensembl. | 1 | |
Natural variantiVAR_054662 | 84 | A → D in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs707958Ensembl. | 1 | |
Natural variantiVAR_060647 | 84 | A → E in allele DPB1*01:02, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*08:02, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*24:01, allele DPB1*30:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*47:01, allele DPB1*54:01, allele DPB1*84:01 and allele DPB1*97:01. Corresponds to variant dbSNP:rs386699870Ensembl. | 1 | |
Natural variantiVAR_059511 | 84 | A → V. Corresponds to variant dbSNP:rs707958Ensembl. | 1 | |
Natural variantiVAR_033438 | 85 | A → E in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042131Ensembl. | 1 | |
Natural variantiVAR_033439 | 86 | E → D in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*10:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*50:01, allele DPB1*57:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*80:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*98:01. Corresponds to variant dbSNP:rs1042133Ensembl. | 1 | |
Natural variantiVAR_060648 | 86 | E → V in allele DPB1*32:01. Corresponds to variant dbSNP:rs41545212Ensembl. | 1 | |
Natural variantiVAR_060649 | 89 | N → H in allele DPB1*02:03. Corresponds to variant dbSNP:rs41550319Ensembl. | 1 | |
Natural variantiVAR_060650 | 93 | D → H in allele DPB1*96:01. Corresponds to variant dbSNP:rs41560812Ensembl. | 1 | |
Natural variantiVAR_059512 | 94 | I → F Allele DPB1*41:01 and allele DPB1*83:01. Corresponds to variant dbSNP:rs1042136Ensembl. | 1 | |
Natural variantiVAR_059513 | 94 | I → L in allele DPB1*03:01, allele DPB1*03:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*10:02, allele DPB1*11:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*31:01, allele DPB1*34:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*72:01, allele DPB1*73:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*87:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*95:01. 1 PublicationCorresponds to variant dbSNP:rs1042136Ensembl. | 1 | |
Natural variantiVAR_060651 | 94 | I → N in allele DPB1*60:01. Corresponds to variant dbSNP:rs41547212Ensembl. | 1 | |
Natural variantiVAR_033440 | 98 | K → E in allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*04:03, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*33:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*71:01, allele DPB1*81:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*93:01 and allele DPB1*95:01. Corresponds to variant dbSNP:rs1042140EnsemblClinVar. | 1 | |
Natural variantiVAR_033441 | 98 | K → R in allele DPB1*11:01, allele DPB1*15:01, allele DPB1*69:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs12722027Ensembl. | 1 | |
Natural variantiVAR_060652 | 99 | R → W in allele DPB1*94:01. Corresponds to variant dbSNP:rs41554314Ensembl. | 1 | |
Natural variantiVAR_060653 | 101 | V → L in allele DPB1*31:01 and allele DPB1*34:01. Corresponds to variant dbSNP:rs41546618Ensembl. | 1 | |
Natural variantiVAR_060654 | 102 | P → L in allele DPB1*78:01. Corresponds to variant dbSNP:rs41551920Ensembl. | 1 | |
Natural variantiVAR_033443 | 105 | M → I in allele DPB1*08:02, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*13:02 and allele DPB1*19:01. Corresponds to variant dbSNP:rs1042153Ensembl. | 1 | |
Natural variantiVAR_033442 | 105 | M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:02, allele DPB1*21:02, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*88:01, allele DPB1*90:01 and allele DPB1*92:01. 1 PublicationCorresponds to variant dbSNP:rs1042151Ensembl. | 1 | |
Natural variantiVAR_060657 | 113 | G → D in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs1042169Ensembl. | 1 | |
Natural variantiVAR_060655 | 113 | G → N in allele DPB1*22:02; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060656 | 113 | G → V in allele DPB1*15:01, allele DPB1*18:01, allele DPB1*28:01, allele DPB1*34:01, allele DPB1*40:01, allele DPB1*53:01, allele DPB1*62:01 and allele DPB1*74:01. Corresponds to variant dbSNP:rs1042169Ensembl. | 1 | |
Natural variantiVAR_033444 | 114 | G → E in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277354Ensembl. | 1 | |
Natural variantiVAR_033445 | 115 | P → A in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277355Ensembl. | 1 | |
Natural variantiVAR_033446 | 116 | M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 PublicationCorresponds to variant dbSNP:rs9277356Ensembl. | 1 | |
Natural variantiVAR_060658 | 120 | R → H in allele DPB1*82:01 and allele DPB1*85:01. Corresponds to variant dbSNP:rs41541915Ensembl. | 1 | |
Natural variantiVAR_060659 | 125 | R → K in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 PublicationCorresponds to variant dbSNP:rs1126537Ensembl. | 1 | |
Natural variantiVAR_060660 | 199 | T → I in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 PublicationCorresponds to variant dbSNP:rs1042335Ensembl. | 1 | |
Natural variantiVAR_033447 | 207 | L → M in allele DPB1*04:02. Corresponds to variant dbSNP:rs14362Ensembl. | 1 | |
Natural variantiVAR_050393 | 223 | R → Q in allele DPB1*01:01. Corresponds to variant dbSNP:rs9276Ensembl. | 1 | |
Natural variantiVAR_050394 | 234 | V → M in allele DPB1*05:01 and allele DPB1*19:01. Corresponds to variant dbSNP:rs11551421Ensembl. | 1 | |
Natural variantiVAR_033448 | 244 | I → T in allele DPB1*15:01. Corresponds to variant dbSNP:rs3097675Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01426 mRNA Translation: CAA25672.1 X02964 Genomic DNA No translation available. X03023 Genomic DNA Translation: CAE82008.1 X03024 Genomic DNA Translation: CAE82007.1 X03022 Genomic DNA Translation: CAA26823.1 X03025 Genomic DNA Translation: CAE82037.1 X03026 Genomic DNA Translation: CAE82042.1 X03028 Genomic DNA Translation: CAE82073.1 X03027 Genomic DNA Translation: CAE82043.1 X03067 mRNA Translation: CAA26871.1 X02228 Genomic DNA Translation: CAA26147.1 J03041 mRNA Translation: AAA35993.1 M83664 mRNA Translation: AAA59837.1 AY804132 mRNA Translation: AAW78737.1 AY804133 mRNA Translation: AAW78738.1 AY804135 mRNA Translation: AAW78740.1 AY804136 mRNA Translation: AAW78741.1 AY804137 mRNA Translation: AAW78742.1 AY804138 mRNA Translation: AAW78743.1 AY804139 mRNA Translation: AAW78744.1 AY804141 mRNA Translation: AAW78746.1 AY804142 mRNA Translation: AAW78747.1 AY804143 mRNA Translation: AAW78748.1 AY831401 mRNA Translation: AAW80919.1 AY831402 mRNA Translation: AAW80920.1 AY831403 mRNA Translation: AAW80921.1 AY831404 mRNA Translation: AAW80922.1 AY656678 mRNA Translation: AAV71025.1 AY656679 mRNA Translation: AAV71026.1 AY656680 mRNA Translation: AAV71027.1 AK313305 mRNA Translation: BAG36110.1 BT019780 mRNA Translation: AAV38583.1 AL645931 Genomic DNA No translation available. AL662824 Genomic DNA No translation available. AL805913 Genomic DNA No translation available. AL845446 Genomic DNA No translation available. BX120009 Genomic DNA No translation available. CR759795 Genomic DNA No translation available. CR759904 Genomic DNA No translation available. CR762479 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03674.1 BC007963 mRNA Translation: AAH07963.1 BC013184 mRNA Translation: AAH13184.1 M28202 mRNA Translation: AAA53197.1 Y09327 Genomic DNA Translation: CAA70507.1 L31816 Genomic DNA No translation available. M97686 Genomic DNA No translation available. X96985 Genomic DNA No translation available. Y13900 Genomic DNA Translation: CAA74199.1 Y14230 Genomic DNA Translation: CAA74608.1 Y16095 Genomic DNA Translation: CAA76060.1 AY823995 Genomic DNA Translation: AAW79272.1 AJ563603 Genomic DNA Translation: CAD91639.1 AM039828 Genomic DNA Translation: CAJ01690.1 AM408787 Genomic DNA Translation: CAL64063.1 AM698036 Genomic DNA Translation: CAM91695.1 M84619 Genomic DNA No translation available. M84620 Genomic DNA No translation available. M84622 Genomic DNA No translation available. M84623 Genomic DNA No translation available. M84624 Genomic DNA No translation available. M84626 Genomic DNA No translation available. X82123 Genomic DNA Translation: CAA57635.1 U22311 Genomic DNA Translation: AAB60413.1 U22313 Genomic DNA Translation: AAB17108.1 K01615 mRNA Translation: AAA36313.1 FM883600 Genomic DNA Translation: CAT04585.2 FM882212 Genomic DNA Translation: CAT03206.1 FM956650 Genomic DNA Translation: CAX11690.1 FM991729 Genomic DNA Translation: CAX20314.1 FM992080 Genomic DNA Translation: CAX21583.2 FM992366 Genomic DNA Translation: CAX30407.1 FM992364 Genomic DNA Translation: CAX30405.1 FN252853 Genomic DNA Translation: CAX53275.1 FN256250 Genomic DNA Translation: CAX53717.1 FN256251 Genomic DNA Translation: CAX53721.1 FN256254 Genomic DNA Translation: CAX53718.1 FN256253 Genomic DNA Translation: CAX53726.1 FN256255 Genomic DNA Translation: CAX53722.1 FN393829 Genomic DNA Translation: CAY85528.1 M23675 Genomic DNA Translation: AAA59740.1 M62326 Genomic DNA Translation: AAA59719.1 M62331 Genomic DNA Translation: AAA59724.1 L07768 Genomic DNA Translation: AAA59690.1 D13174 Genomic DNA Translation: BAA02465.1 D10834 Genomic DNA Translation: BAA01614.1 D28809 Genomic DNA Translation: BAA05970.1 X96986 Genomic DNA Translation: CAA65710.2 X91886 Genomic DNA No translation available. Y18498 Genomic DNA Translation: CAC12860.1 AJ238005 Genomic DNA Translation: CAC12865.1 AJ271373 Genomic DNA Translation: CAB70605.2 AF288354 Genomic DNA Translation: AAG30143.1 AJ292074 Genomic DNA Translation: CAC27995.1 AF536241 Genomic DNA Translation: AAN33050.1 AF549409 Genomic DNA Translation: AAQ12563.1 AF549410 Genomic DNA Translation: AAQ12564.1 Frameshift. AJ514871 Genomic DNA Translation: CAD55852.1 AY374100 Genomic DNA Translation: AAR21105.1 DQ206450 Genomic DNA Translation: ABB17974.1 M83914 Genomic DNA Translation: AAA36264.1 M83915 Genomic DNA Translation: AAA36259.1 M83916 Genomic DNA Translation: AAA36260.1 M83917 Genomic DNA Translation: AAA36261.1 M83918 Genomic DNA Translation: AAA36262.1 M83919 Genomic DNA Translation: AAA36263.1 AJ297820 Genomic DNA Translation: CAC14048.1 AY029777 Genomic DNA Translation: AAK40344.1 AF489518 Genomic DNA Translation: AAL92172.1 AF492640 Genomic DNA Translation: AAO84765.1 AY425707 Genomic DNA Translation: AAR29060.1 AY572830 Genomic DNA Translation: AAS77869.1 AY855160 Genomic DNA Translation: AAW33682.1 AY855161 Genomic DNA Translation: AAW33683.1 DQ089022 Genomic DNA Translation: AAY98352.1 AB247517 Genomic DNA Translation: BAE78492.1 DQ386161 Genomic DNA Translation: ABD36812.1 DQ485789 Genomic DNA Translation: ABF47047.1 AM887530 Genomic DNA Translation: CAP08783.1 FM211032 Genomic DNA Translation: CAR66500.1 FJ976693 Genomic DNA Translation: ACS12738.1 L17310 Genomic DNA Translation: AAA53479.1 L17311 Genomic DNA Translation: AAA53480.1 L17313 Genomic DNA Translation: AAA53481.1 L17314 Genomic DNA Translation: AAA53482.1 L22076 Genomic DNA Translation: AAA53476.1 L22077 Genomic DNA Translation: AAA53477.1 L23400 Genomic DNA Translation: AAA58441.1 U59437 Genomic DNA Translation: AAD09481.1 U59438 Genomic DNA Translation: AAD09482.1 U59439 Genomic DNA Translation: AAD09483.1 U59440 Genomic DNA Translation: AAD09484.1 U59441 Genomic DNA Translation: AAD09485.1 U59442 Genomic DNA Translation: AAD09486.1 AF074845 Genomic DNA Translation: AAD39682.1 AF074846 Genomic DNA Translation: AAD39683.1 AY033075 Genomic DNA Translation: AAK51161.1 U34033 Genomic DNA Translation: AAA81335.1 Z92523 Genomic DNA Translation: CAB06822.1 X78042 Genomic DNA No translation available. U29534 Genomic DNA Translation: AAB52511.1 AY618897 Genomic DNA Translation: AAT40308.1 X97406 Genomic DNA Translation: CAA66059.1 L01466 Genomic DNA No translation available. M87046 Genomic DNA No translation available. D10478 Genomic DNA Translation: BAA01281.1 D10882 Genomic DNA Translation: BAA01704.1 U94839 Genomic DNA Translation: AAC64232.1 X80752 Genomic DNA Translation: CAA56728.1 AF077015 Genomic DNA Translation: AAC26835.1 K00409 mRNA Translation: AAA36312.1 |
CCDSi | CCDS4765.1 |
PIRi | A02228, HLHUS1 A02229, HLHUPB D30536 D30537 E30536 I37298 I37541, S49382 I38195, HLHUS2 I38197 I59621 I59637 I59641 I81234 I81235 I81236 I81237 I81238 |
RefSeqi | NP_002112.3, NM_002121.5 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01426 mRNA Translation: CAA25672.1 X02964 Genomic DNA No translation available. X03023 Genomic DNA Translation: CAE82008.1 X03024 Genomic DNA Translation: CAE82007.1 X03022 Genomic DNA Translation: CAA26823.1 X03025 Genomic DNA Translation: CAE82037.1 X03026 Genomic DNA Translation: CAE82042.1 X03028 Genomic DNA Translation: CAE82073.1 X03027 Genomic DNA Translation: CAE82043.1 X03067 mRNA Translation: CAA26871.1 X02228 Genomic DNA Translation: CAA26147.1 J03041 mRNA Translation: AAA35993.1 M83664 mRNA Translation: AAA59837.1 AY804132 mRNA Translation: AAW78737.1 AY804133 mRNA Translation: AAW78738.1 AY804135 mRNA Translation: AAW78740.1 AY804136 mRNA Translation: AAW78741.1 AY804137 mRNA Translation: AAW78742.1 AY804138 mRNA Translation: AAW78743.1 AY804139 mRNA Translation: AAW78744.1 AY804141 mRNA Translation: AAW78746.1 AY804142 mRNA Translation: AAW78747.1 AY804143 mRNA Translation: AAW78748.1 AY831401 mRNA Translation: AAW80919.1 AY831402 mRNA Translation: AAW80920.1 AY831403 mRNA Translation: AAW80921.1 AY831404 mRNA Translation: AAW80922.1 AY656678 mRNA Translation: AAV71025.1 AY656679 mRNA Translation: AAV71026.1 AY656680 mRNA Translation: AAV71027.1 AK313305 mRNA Translation: BAG36110.1 BT019780 mRNA Translation: AAV38583.1 AL645931 Genomic DNA No translation available. AL662824 Genomic DNA No translation available. AL805913 Genomic DNA No translation available. AL845446 Genomic DNA No translation available. BX120009 Genomic DNA No translation available. CR759795 Genomic DNA No translation available. CR759904 Genomic DNA No translation available. CR762479 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03674.1 BC007963 mRNA Translation: AAH07963.1 BC013184 mRNA Translation: AAH13184.1 M28202 mRNA Translation: AAA53197.1 Y09327 Genomic DNA Translation: CAA70507.1 L31816 Genomic DNA No translation available. M97686 Genomic DNA No translation available. X96985 Genomic DNA No translation available. Y13900 Genomic DNA Translation: CAA74199.1 Y14230 Genomic DNA Translation: CAA74608.1 Y16095 Genomic DNA Translation: CAA76060.1 AY823995 Genomic DNA Translation: AAW79272.1 AJ563603 Genomic DNA Translation: CAD91639.1 AM039828 Genomic DNA Translation: CAJ01690.1 AM408787 Genomic DNA Translation: CAL64063.1 AM698036 Genomic DNA Translation: CAM91695.1 M84619 Genomic DNA No translation available. M84620 Genomic DNA No translation available. M84622 Genomic DNA No translation available. M84623 Genomic DNA No translation available. M84624 Genomic DNA No translation available. M84626 Genomic DNA No translation available. X82123 Genomic DNA Translation: CAA57635.1 U22311 Genomic DNA Translation: AAB60413.1 U22313 Genomic DNA Translation: AAB17108.1 K01615 mRNA Translation: AAA36313.1 FM883600 Genomic DNA Translation: CAT04585.2 FM882212 Genomic DNA Translation: CAT03206.1 FM956650 Genomic DNA Translation: CAX11690.1 FM991729 Genomic DNA Translation: CAX20314.1 FM992080 Genomic DNA Translation: CAX21583.2 FM992366 Genomic DNA Translation: CAX30407.1 FM992364 Genomic DNA Translation: CAX30405.1 FN252853 Genomic DNA Translation: CAX53275.1 FN256250 Genomic DNA Translation: CAX53717.1 FN256251 Genomic DNA Translation: CAX53721.1 FN256254 Genomic DNA Translation: CAX53718.1 FN256253 Genomic DNA Translation: CAX53726.1 FN256255 Genomic DNA Translation: CAX53722.1 FN393829 Genomic DNA Translation: CAY85528.1 M23675 Genomic DNA Translation: AAA59740.1 M62326 Genomic DNA Translation: AAA59719.1 M62331 Genomic DNA Translation: AAA59724.1 L07768 Genomic DNA Translation: AAA59690.1 D13174 Genomic DNA Translation: BAA02465.1 D10834 Genomic DNA Translation: BAA01614.1 D28809 Genomic DNA Translation: BAA05970.1 X96986 Genomic DNA Translation: CAA65710.2 X91886 Genomic DNA No translation available. Y18498 Genomic DNA Translation: CAC12860.1 AJ238005 Genomic DNA Translation: CAC12865.1 AJ271373 Genomic DNA Translation: CAB70605.2 AF288354 Genomic DNA Translation: AAG30143.1 AJ292074 Genomic DNA Translation: CAC27995.1 AF536241 Genomic DNA Translation: AAN33050.1 AF549409 Genomic DNA Translation: AAQ12563.1 AF549410 Genomic DNA Translation: AAQ12564.1 Frameshift. AJ514871 Genomic DNA Translation: CAD55852.1 AY374100 Genomic DNA Translation: AAR21105.1 DQ206450 Genomic DNA Translation: ABB17974.1 M83914 Genomic DNA Translation: AAA36264.1 M83915 Genomic DNA Translation: AAA36259.1 M83916 Genomic DNA Translation: AAA36260.1 M83917 Genomic DNA Translation: AAA36261.1 M83918 Genomic DNA Translation: AAA36262.1 M83919 Genomic DNA Translation: AAA36263.1 AJ297820 Genomic DNA Translation: CAC14048.1 AY029777 Genomic DNA Translation: AAK40344.1 AF489518 Genomic DNA Translation: AAL92172.1 AF492640 Genomic DNA Translation: AAO84765.1 AY425707 Genomic DNA Translation: AAR29060.1 AY572830 Genomic DNA Translation: AAS77869.1 AY855160 Genomic DNA Translation: AAW33682.1 AY855161 Genomic DNA Translation: AAW33683.1 DQ089022 Genomic DNA Translation: AAY98352.1 AB247517 Genomic DNA Translation: BAE78492.1 DQ386161 Genomic DNA Translation: ABD36812.1 DQ485789 Genomic DNA Translation: ABF47047.1 AM887530 Genomic DNA Translation: CAP08783.1 FM211032 Genomic DNA Translation: CAR66500.1 FJ976693 Genomic DNA Translation: ACS12738.1 L17310 Genomic DNA Translation: AAA53479.1 L17311 Genomic DNA Translation: AAA53480.1 L17313 Genomic DNA Translation: AAA53481.1 L17314 Genomic DNA Translation: AAA53482.1 L22076 Genomic DNA Translation: AAA53476.1 L22077 Genomic DNA Translation: AAA53477.1 L23400 Genomic DNA Translation: AAA58441.1 U59437 Genomic DNA Translation: AAD09481.1 U59438 Genomic DNA Translation: AAD09482.1 U59439 Genomic DNA Translation: AAD09483.1 U59440 Genomic DNA Translation: AAD09484.1 U59441 Genomic DNA Translation: AAD09485.1 U59442 Genomic DNA Translation: AAD09486.1 AF074845 Genomic DNA Translation: AAD39682.1 AF074846 Genomic DNA Translation: AAD39683.1 AY033075 Genomic DNA Translation: AAK51161.1 U34033 Genomic DNA Translation: AAA81335.1 Z92523 Genomic DNA Translation: CAB06822.1 X78042 Genomic DNA No translation available. U29534 Genomic DNA Translation: AAB52511.1 AY618897 Genomic DNA Translation: AAT40308.1 X97406 Genomic DNA Translation: CAA66059.1 L01466 Genomic DNA No translation available. M87046 Genomic DNA No translation available. D10478 Genomic DNA Translation: BAA01281.1 D10882 Genomic DNA Translation: BAA01704.1 U94839 Genomic DNA Translation: AAC64232.1 X80752 Genomic DNA Translation: CAA56728.1 AF077015 Genomic DNA Translation: AAC26835.1 K00409 mRNA Translation: AAA36312.1 |
CCDSi | CCDS4765.1 |
PIRi | A02228, HLHUS1 A02229, HLHUPB D30536 D30537 E30536 I37298 I37541, S49382 I38195, HLHUS2 I38197 I59621 I59637 I59641 I81234 I81235 I81236 I81237 I81238 |
RefSeqi | NP_002112.3, NM_002121.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LQZ | X-ray | 3.25 | B | 33-218 | [»] | |
4P4K | X-ray | 2.80 | B/F | 32-218 | [»] | |
4P4R | X-ray | 3.00 | B/D | 32-218 | [»] | |
4P57 | X-ray | 2.60 | B/D | 33-218 | [»] | |
4P5K | X-ray | 2.59 | B/E | 33-218 | [»] | |
4P5M | X-ray | 1.70 | B/D/F/H | 33-218 | [»] | |
SMRi | P04440 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109360, 41 interactors |
IntActi | P04440, 24 interactors |
MINTi | P04440 |
STRINGi | 9606.ENSP00000408146 |
PTM databases
GlyConnecti | 1366, 7 N-Linked glycans (1 site) |
GlyGeni | P04440, 1 site |
iPTMneti | P04440 |
PhosphoSitePlusi | P04440 |
SwissPalmi | P04440 |
Polymorphism and mutation databases
BioMutai | HLA-DPB1 |
DMDMi | 122263 |
Proteomic databases
jPOSTi | P04440 |
MassIVEi | P04440 |
MaxQBi | P04440 |
PaxDbi | P04440 |
PeptideAtlasi | P04440 |
PRIDEi | P04440 |
ProteomicsDBi | 51715 |
Protocols and materials databases
Antibodypediai | 28872, 565 antibodies |
DNASUi | 3115 |
Genome annotation databases
Organism-specific databases
CTDi | 3115 |
DisGeNETi | 3115 |
EuPathDBi | HostDB:ENSG00000223865.10 |
GeneCardsi | HLA-DPB1 |
HGNCi | HGNC:4940, HLA-DPB1 |
HPAi | ENSG00000223865, Tissue enhanced (lymphoid) |
MalaCardsi | HLA-DPB1 |
MIMi | 142858, gene |
neXtProti | NX_P04440 |
OpenTargetsi | ENSG00000223865 |
Orphaneti | 133, Chronic beryllium disease 900, Granulomatosis with polyangiitis |
PharmGKBi | PA35064 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYNI, Eukaryota |
GeneTreei | ENSGT00940000162390 |
InParanoidi | P04440 |
OMAi | ICQVEHT |
OrthoDBi | 1249505at2759 |
PhylomeDBi | P04440 |
TreeFami | TF336626 |
Enzyme and pathway databases
PathwayCommonsi | P04440 |
Reactomei | R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-2132295, MHC class II antigen presentation R-HSA-389948, PD-1 signaling R-HSA-877300, Interferon gamma signaling |
SIGNORi | P04440 |
Miscellaneous databases
BioGRID-ORCSi | 3115, 4 hits in 838 CRISPR screens |
ChiTaRSi | HLA-DPB1, human |
EvolutionaryTracei | P04440 |
GeneWikii | HLA-DPB1 |
GenomeRNAii | 3115 |
Pharosi | P04440, Tbio |
PROi | PR:P04440 |
RNActi | P04440, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000223865, Expressed in spleen and 135 other tissues |
ExpressionAtlasi | P04440, baseline and differential |
Genevisiblei | P04440, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPB1_HUMAN | |
Accessioni | P04440Primary (citable) accession number: P04440 Secondary accession number(s): A0PFJ7 Q9XS12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | December 2, 2020 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations