HLA-A

Functionⁱ

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functionⁱ

beta-2-microglobulin binding Source: UniProtKB
peptide antigen binding Source: UniProtKB
TAP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8617941

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 6609814
interferon-gamma-mediated signaling pathway Source: Reactome
protein ubiquitination Source: Reactome
regulation of immune response Source: Reactome
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300 Interferon gamma signaling R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class I histocompatibility antigen, A-3 alpha chain Alternative name(s): MHC class I antigen A*3
Gene namesⁱ	Name:HLA-A Synonyms:HLAA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000206503.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4931 HLA-A
MIMⁱ	142800 gene
neXtProtⁱ	NX_P04439

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 308	ExtracellularSequence analysisAdd BLAST	284
Transmembraneⁱ	309 – 332	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	333 – 365	CytoplasmicSequence analysisAdd BLAST	33

Keywords - Cellular componentⁱ

Membrane, MHC I

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3105
MalaCards human disease database More...MalaCardsⁱ	HLA-A
Open Targets More...OpenTargetsⁱ	ENSG00000206503
PharmGKBⁱ	PA35055

Chemistry databases

ChEMBLⁱ	CHEMBL2632

ChEMBLⁱ

CHEMBL2632

Polymorphism and mutation databases

BioMutaⁱ	PIKFYVE
DMDMⁱ	34223717

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000018815	25 – 365	HLA class I histocompatibility antigen, A-3 alpha chainAdd BLAST		341

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	125 ↔ 188	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	227 ↔ 283	PROSITE-ProRule annotation1 Publication
Modified residueⁱ	343	PhosphoserineBy similarity	1
Modified residueⁱ	344	PhosphotyrosineBy similarity	1
Modified residueⁱ	349	PhosphoserineBy similarity	1
Modified residueⁱ	350	PhosphoserineBy similarity	1
Modified residueⁱ	352	PhosphoserineCombined sources	1
Modified residueⁱ	356	PhosphoserineCombined sources	1
Modified residueⁱ	359	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P04439
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04439
PaxDbⁱ	P04439
PeptideAtlas More...PeptideAtlasⁱ	P04439
PRIDEⁱ	P04439

PTM databases

GlyConnectⁱ	1324
iPTMnetⁱ	P04439
SwissPalmⁱ	P04439

Miscellaneous databases

PMAP-CutDBⁱ	P04439

PMAP-CutDBⁱ

P04439

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_HLA-A
ExpressionAtlasⁱ	P04439 baseline and differential
Genevisibleⁱ	P04439 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB078470

HPAⁱ

CAB078470

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

GO - Molecular functionⁱ

beta-2-microglobulin binding Source: UniProtKB
TAP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8617941

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109350, 90 interactors
IntActⁱ	P04439, 15 interactors
STRINGⁱ	9606.ENSP00000366005

Chemistry databases

BindingDBⁱ

P04439

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 36	Combined sources	10
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 61	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	74 – 76	Combined sources	3
Helixⁱ	81 – 108	Combined sources	28
Beta strandⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 127	Combined sources	10
Beta strandⁱ	133 – 142	Combined sources	10
Beta strandⁱ	145 – 150	Combined sources	6
Beta strandⁱ	157 – 161	Combined sources	5
Helixⁱ	162 – 173	Combined sources	12
Helixⁱ	176 – 184	Combined sources	9
Helixⁱ	187 – 198	Combined sources	12
Helixⁱ	200 – 203	Combined sources	4
Beta strandⁱ	210 – 217	Combined sources	8
Beta strandⁱ	219 – 235	Combined sources	17
Beta strandⁱ	238 – 243	Combined sources	6
Beta strandⁱ	251 – 254	Combined sources	4
Beta strandⁱ	261 – 263	Combined sources	3
Beta strandⁱ	265 – 274	Combined sources	10
Helixⁱ	278 – 280	Combined sources	3
Beta strandⁱ	281 – 286	Combined sources	6
Beta strandⁱ	290 – 292	Combined sources	3
Beta strandⁱ	294 – 297	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P04439
SMRⁱ	P04439
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	209 – 295	Ig-like C1-typeAdd BLAST		87

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	25 – 114	Alpha-1Add BLAST	90
Regionⁱ	115 – 206	Alpha-2Add BLAST	92
Regionⁱ	207 – 298	Alpha-3Add BLAST	92
Regionⁱ	299 – 308	Connecting peptide	10

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
PhylomeDBⁱ	P04439

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 47 potential isoforms that are computationally mapped.Show all Align All

P04439-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG 
        60         70         80         90        100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV 
       110        120        130        140        150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL 
       160        170        180        190        200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK 
       210        220        230        240        250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 
       260        270        280        290        300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 
       310        320        330        340        350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS 
       360 
DSAQGSDVSL TACKV

Length:365

Mass (Da):40,841

Last modified:August 22, 2003 - v2

Checksum:ⁱDEDFCEC4450E0580

GO

Computationally mapped potential isoform sequencesⁱ

There are 47 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	P01892	1A02_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-2 alpha chain (MHC class I antigen A*2)	HLA-A HLAA	365	Annotation score:
	P30443	1A01_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-1 alpha chain (MHC class I antigen A*1)	HLA-A HLAA	365	Annotation score:
	P01891	1A68_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-68 alpha chain (Aw-68) (HLA class I histocompatibility antigen, A-28 alpha chain) (MHC class I antigen A*68)	HLA-A HLAA	365	Annotation score:
	P13746	1A11_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-11 alpha chain (MHC class I antigen A*11)	HLA-A HLAA	365	Annotation score:
	P05534	1A24_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-24 alpha chain (Aw-24) (HLA class I histocompatibility antigen, A-9 alpha chain) (MHC class I antigen A*24)	HLA-A HLAA	365	Annotation score:
	P16188	1A30_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-30 alpha chain (MHC class I antigen A*30)	HLA-A HLAA	365	Annotation score:
	P30450	1A26_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-26 alpha chain (MHC class I antigen A*26)	HLA-A HLAA	365	Annotation score:
	P10314	1A32_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-32 alpha chain (MHC class I antigen A*32)	HLA-A HLAA	365	Annotation score:
	P30453	1A34_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-34 alpha chain (Aw-34) (HLA class I histocompatibility antigen, A-10 alpha chain) (MHC class I antigen A*34)	HLA-A HLAA	365	Annotation score:
	P30459	1A74_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, A-74 alpha chain (Aw-19) (Aw-74) (MHC class I antigen A*74)	HLA-A HLAA	365	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	319	G → A in AAB66582 (PubMed:10079303).Curated		1

Polymorphismⁱ

The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is that of A*03:01.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050310	89	R → G. Corresponds to variant dbSNP:rs199474430Ensembl.	1
Natural variantⁱVAR_050311	94	Q → H. Corresponds to variant dbSNP:rs78306866Ensembl.	1
Natural variantⁱVAR_050312	101	D → N. Corresponds to variant dbSNP:rs1136688Ensembl.	1
Natural variantⁱVAR_050313	121	I → M. Corresponds to variant dbSNP:rs1136695Ensembl.	1
Natural variantⁱVAR_050314	129	S → P. Corresponds to variant dbSNP:rs1136700Ensembl.	1
Natural variantⁱVAR_050315	131	G → W. Corresponds to variant dbSNP:rs1136702Ensembl.	1
Natural variantⁱVAR_050316	133	F → L. Corresponds to variant dbSNP:rs1059488Ensembl.	1
Natural variantⁱVAR_050317	151	N → K. Corresponds to variant dbSNP:rs1059509Ensembl.	1
Natural variantⁱVAR_050318	166	I → TCombined sourcesCorresponds to variant dbSNP:rs1059516Ensembl.	1
Natural variantⁱVAR_050319	169	R → H. Corresponds to variant dbSNP:rs1059520Ensembl.	1
Natural variantⁱVAR_004351	176	E → V in allele A*03:02. Corresponds to variant dbSNP:rs9256983Ensembl.	1
Natural variantⁱVAR_004352	180	L → Q in allele A*03:02.	1
Natural variantⁱVAR_016604	185	D → E in allele A*03:05. Corresponds to variant dbSNP:rs1059542Ensembl.	1
Natural variantⁱVAR_033149	186	G → A in allele A*03:06. Corresponds to variant dbSNP:rs41545519Ensembl.	1
Natural variantⁱVAR_016605	199	G → R in allele A*03:04. Corresponds to variant dbSNP:rs41559916Ensembl.	1
Natural variantⁱVAR_050320	205	R → H. Corresponds to variant dbSNP:rs17185861Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00492 Genomic DNA Translation: CAA25162.1 Sequence problems. U32184 mRNA Translation: AAB63980.1 BA000025 Genomic DNA Translation: BAB63400.1 AF217561 mRNA Translation: AAF28734.1 AF015930 mRNA Translation: AAB66582.1 AH008295 Genomic DNA Translation: AAF03243.1 AJ401085 Genomic DNA Translation: CAC06086.1 AJ401086 Genomic DNA Translation: CAC06087.1 AJ401087 Genomic DNA Translation: CAC06088.1 AJ748743 Genomic DNA Translation: CAG38621.1 AL671277 Genomic DNA No translation available. AH009116 Genomic DNA Translation: AAF29557.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34373.1
PIRⁱ	A02192 HLHUA3
NCBI Reference Sequences More...RefSeqⁱ	NP_002107.3, NM_002116.7
UniGeneⁱ	Hs.181244 Hs.713441

Genome annotation databases

Ensemblⁱ	ENST00000376809; ENSP00000366005; ENSG00000206503 ENST00000396634; ENSP00000379873; ENSG00000206503
GeneIDⁱ	3105

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04439	MHC class I antigen		HUMAN		365	UniRef100_P04439
MHC class I antigen (Fragment)		HUMAN		364
MHC class I antigen (Fragment)		HUMAN		364
cDNA FLJ51110, highly similar to HLA class I histocompatibility antigen, A-3 alpha chain		HUMAN		244
UPI000C210325		HUMAN		341

Protein	Similar proteins		Species	Score	Length	Source
P04439	HLA class I histocompatibility antigen, A-1 alpha chain	)	HUMAN		365	UniRef90_P30443
Popy Class I histocompatibility antigen, A-1 alpha chain		PONPY		365
Patr class I histocompatibility antigen, A-2 alpha chain		PANTR		365
Class I histocompatibility antigen, Gogo-A*0401 alpha chain		GORGO		365
MHC class I antigen		PONAB		365
+1914

Protein	Similar proteins		Species	Score	Length	Source
P04439	HLA class I histocompatibility antigen, A-2 alpha chain	)	HUMAN		365	UniRef50_P01892
Class I histocompatibility antigen, Gogo-A*0201 alpha chain		GORGO		365
Patr class I histocompatibility antigen, A-108 alpha chain		PANTR		365
Popy Class I histocompatibility antigen, A-1 alpha chain		PONPY		365
MHC class I antigen		PONAB		365
+4209

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00492 Genomic DNA Translation: CAA25162.1 Sequence problems. U32184 mRNA Translation: AAB63980.1 BA000025 Genomic DNA Translation: BAB63400.1 AF217561 mRNA Translation: AAF28734.1 AF015930 mRNA Translation: AAB66582.1 AH008295 Genomic DNA Translation: AAF03243.1 AJ401085 Genomic DNA Translation: CAC06086.1 AJ401086 Genomic DNA Translation: CAC06087.1 AJ401087 Genomic DNA Translation: CAC06088.1 AJ748743 Genomic DNA Translation: CAG38621.1 AL671277 Genomic DNA No translation available. AH009116 Genomic DNA Translation: AAF29557.1
CCDSⁱ	CCDS34373.1
PIRⁱ	A02192 HLHUA3
RefSeqⁱ	NP_002107.3, NM_002116.7
UniGeneⁱ	Hs.181244 Hs.713441

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XPG	X-ray	2.60	A	25-298	[»]
	3RL1	X-ray	2.00	A	25-298	[»]
	3RL2	X-ray	2.39	A	25-298	[»]
	6ENY	electron microscopy	5.80	F	25-365	[»]
ProteinModelPortalⁱ	P04439
SMRⁱ	P04439
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109350, 90 interactors
IntActⁱ	P04439, 15 interactors
STRINGⁱ	9606.ENSP00000366005

Chemistry databases

BindingDBⁱ	P04439
ChEMBLⁱ	CHEMBL2632

PTM databases

GlyConnectⁱ	1324
iPTMnetⁱ	P04439
SwissPalmⁱ	P04439

Polymorphism and mutation databases

BioMutaⁱ	PIKFYVE
DMDMⁱ	34223717

Proteomic databases

EPDⁱ	P04439
MaxQBⁱ	P04439
PaxDbⁱ	P04439
PeptideAtlasⁱ	P04439
PRIDEⁱ	P04439

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3105
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376809; ENSP00000366005; ENSG00000206503 ENST00000396634; ENSP00000379873; ENSG00000206503
GeneIDⁱ	3105

Organism-specific databases

CTDⁱ	3105
DisGeNETⁱ	3105
EuPathDBⁱ	HostDB:ENSG00000206503.11
GeneCardsⁱ	HLA-A
HGNCⁱ	HGNC:4931 HLA-A
HPAⁱ	CAB078470
MalaCardsⁱ	HLA-A
MIMⁱ	142800 gene
neXtProtⁱ	NX_P04439
OpenTargetsⁱ	ENSG00000206503
PharmGKBⁱ	PA35055
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
PhylomeDBⁱ	P04439

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300 Interferon gamma signaling R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSⁱ	HLA-A human
GeneWikiⁱ	HLA-A
GenomeRNAiⁱ	3105
PMAP-CutDBⁱ	P04439
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_HLA-A
ExpressionAtlasⁱ	P04439 baseline and differential
Genevisibleⁱ	P04439 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 IPR010579 MHC_I_a_C
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit PF06623 MHC_I_C, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1A03_HUMAN
Accessionⁱ	P04439Primary (citable) accession number: P04439 Secondary accession number(s): O19546 Q9TPR8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	August 22, 2003
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P04439 (1A03_HUMAN)

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HLA class I histocompatibility antigen, A-3 alpha chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ