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Protein

Argininosuccinate lyase

Gene

ASL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Enzyme activity is regulated by acetylation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (ASS1)
  3. Argininosuccinate lyase (ASL)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-arginine and fumarate from (N(omega)-L-arginino)succinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Argininosuccinate lyase (ASL)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine and fumarate from (N(omega)-L-arginino)succinate, the pathway urea cycle and in Nitrogen metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • argininosuccinate lyase activity Source: Reactome
  • identical protein binding Source: IntAct

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS10034-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.3.2.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-70635 Urea cycle

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P04424

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00068;UER00114

UPA00158;UER00273

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Argininosuccinate lyase (EC:4.3.2.1)
Short name:
ASAL
Alternative name(s):
Arginosuccinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126522.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:746 ASL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608310 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04424

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Argininosuccinic aciduria (ARGINSA)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of the urea cycle. The disease is characterized by mental and physical retardation, liver enlargement, skin lesions, dry and brittle hair showing trichorrhexis nodosa microscopically and fluorescing red, convulsions, and episodic unconsciousness.
See also OMIM:207900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04310631D → N in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs754995756EnsemblClinVar.1
Natural variantiVAR_07218670V → A in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1027739421Ensembl.1
Natural variantiVAR_07555173E → K in ARGINSA; complete loss of argininosuccinate lyase activity; abolishes protein expression. 1 Publication1
Natural variantiVAR_07218794R → C in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs374304304EnsemblClinVar.1
Natural variantiVAR_07218894R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs777437569EnsemblClinVar.1
Natural variantiVAR_00067695R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940585EnsemblClinVar.1
Natural variantiVAR_07218995R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs150244667EnsemblClinVar.1
Natural variantiVAR_072190104A → V in ARGINSA. 1 Publication1
Natural variantiVAR_000677111R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs138310841Ensembl.1
Natural variantiVAR_043107113R → Q in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs752783461EnsemblClinVar.1
Natural variantiVAR_072191120D → E in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072192121L → H in ARGINSA. 1 Publication1
Natural variantiVAR_072193126R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs201962738Ensembl.1
Natural variantiVAR_072194146R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs199938613Ensembl.1
Natural variantiVAR_072195156P → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs769017508Ensembl.1
Natural variantiVAR_072196160H → N in ARGINSA. 1 Publication1
Natural variantiVAR_072197166P → H in ARGINSA. 1 Publication1
Natural variantiVAR_072198168R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs727503811EnsemblClinVar.1
Natural variantiVAR_072199170S → N in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1180650883Ensembl.1
Natural variantiVAR_017572178V → M in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 3 PublicationsCorresponds to variant dbSNP:rs28941473EnsemblClinVar.1
Natural variantiVAR_072200180L → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1057141162Ensembl.1
Natural variantiVAR_072201182R → Q in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs751590073EnsemblClinVar.1
Natural variantiVAR_043108186R → Q in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs752397242Ensembl.1
Natural variantiVAR_072202191R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs143508372EnsemblClinVar.1
Natural variantiVAR_000678193R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs373697663EnsemblClinVar.1
Natural variantiVAR_072203193R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1428029508Ensembl.1
Natural variantiVAR_072204205A → V in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs796051925EnsemblClinVar.1
Natural variantiVAR_072205213R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1449589636Ensembl.1
Natural variantiVAR_072206227L → P in ARGINSA. 1 Publication1
Natural variantiVAR_072207229S → R in ARGINSA. 1 Publication1
Natural variantiVAR_072208229S → T in ARGINSA. 1 Publication1
Natural variantiVAR_072209231D → E in ARGINSA. 1 Publication1
Natural variantiVAR_043109236R → W in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs761268464Ensembl.1
Natural variantiVAR_072210237D → N in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs552951774Ensembl.1
Natural variantiVAR_072211256M → T in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs149057077Ensembl.1
Natural variantiVAR_072212262L → P in ARGINSA. 1 Publication1
Natural variantiVAR_000679286Q → R in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 4 PublicationsCorresponds to variant dbSNP:rs28941472EnsemblClinVar.1
Natural variantiVAR_072213295L → P in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1369337876Ensembl.1
Natural variantiVAR_075552297R → Q in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 1 PublicationCorresponds to variant dbSNP:rs750431938EnsemblClinVar.1
Natural variantiVAR_072214301G → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1161412459Ensembl.1
Natural variantiVAR_072215306R → W in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs868834862EnsemblClinVar.1
Natural variantiVAR_072216324D → A in ARGINSA. 1 Publication1
Natural variantiVAR_072217326Q → L in ARGINSA; severe. 1 Publication1
Natural variantiVAR_043110335V → L in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 2 Publications1
Natural variantiVAR_072218343L → F in ARGINSA. 1 Publication1
Natural variantiVAR_072219343L → P in ARGINSA. 1 Publication1
Natural variantiVAR_072220368M → V in ARGINSA. 1 Publication1
Natural variantiVAR_017573379R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940287EnsemblClinVar.1
Natural variantiVAR_072221380K → E in ARGINSA. 1 Publication1
Natural variantiVAR_043111382M → R in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 Publications1
Natural variantiVAR_017574385R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940286EnsemblClinVar.1
Natural variantiVAR_072222385R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs746120802EnsemblClinVar.1
Natural variantiVAR_072223385R → L in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072224388H → Q in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072225433S → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs796051928EnsemblClinVar.1
Natural variantiVAR_072226434V → L in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs773071023EnsemblClinVar.1
Natural variantiVAR_072227447S → N in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs373519615Ensembl.1
Natural variantiVAR_072228456R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs767271619EnsemblClinVar.1
Natural variantiVAR_043112456R → W in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs759396688Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51K → N: 2-fold reduction in activity. 1 Publication1
Mutagenesisi89H → Q: 10-fold reduction in activity. 1 Publication1
Mutagenesisi288K → R: Refractory to inhibition by TSA and NAM and by addition of extra amino acids. No effect on protein structure. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
435

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ASL

MalaCards human disease database

More...
MalaCardsi
ASL
MIMi207900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000126522

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
23 Argininosuccinic aciduria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25046

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB02267 Argininosuccinate
DB00125 L-Arginine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001377122 – 464Argininosuccinate lyaseAdd BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysine1 Publication1
Modified residuei288N6-acetyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P04424

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P04424

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04424

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P04424

PeptideAtlas

More...
PeptideAtlasi
P04424

PRoteomics IDEntifications database

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PRIDEi
P04424

ProteomicsDB human proteome resource

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ProteomicsDBi
51704

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04424

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P04424

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126522 Expressed in 92 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

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CleanExi
HS_ASL

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P04424 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P04424 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB003696
HPA016646

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106927, 17 interactors

Protein interaction database and analysis system

More...
IntActi
P04424, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307188

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOSX-ray4.20A/B1-464[»]
1K62X-ray2.65A/B1-464[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04424

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04424

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04424

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1316 Eukaryota
COG0165 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153479

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000242744

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004281

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P04424

KEGG Orthology (KO)

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KOi
K01755

Identification of Orthologs from Complete Genome Data

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OMAi
KKNPDVF

Database of Orthologous Groups

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OrthoDBi
580544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04424

TreeFam database of animal gene trees

More...
TreeFami
TF300656

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01359 Argininosuccinate_lyase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.275.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00006 Arg_succ_lyase, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like

The PANTHER Classification System

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PANTHERi
PTHR43814 PTHR43814, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00149 FUMRATELYASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48557 SSF48557, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00838 argH, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P04424-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE
60 70 80 90 100
KAGLLTKAEM DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI
110 120 130 140 150
GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE
160 170 180 190 200
RDVLFPGYTH LQRAQPIRWS HWILSHAVAL TRDSERLLEV RKRINVLPLG
210 220 230 240 250
SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA EFLFWASLCM
260 270 280 290 300
THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA
310 320 330 340 350
GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI
360 370 380 390 400
STLQIHQENM GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET
410 420 430 440 450
KGVALNQLSL QELQTISPLF SGDVICVWDY GHSVEQYGAL GGTARSSVDW
460
QIRQVRALLQ AQQA
Length:464
Mass (Da):51,658
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF751625C1A581883
GO
Isoform 2 (identifier: P04424-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-326: Missing.

Note: Gene prediction based on EST data.
Show »
Length:444
Mass (Da):49,509
Checksum:i07114189995B2342
GO
Isoform 3 (identifier: P04424-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-201: Missing.

Note: Gene prediction based on EST data.
Show »
Length:438
Mass (Da):48,733
Checksum:iC05AA06470444AA4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W943F8W943_HUMAN
Argininosuccinate lyase
ASL
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51786 differs from that shown. Reason: Frameshift at positions 387 and 452.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246A → R in CAA68722 (PubMed:3391281).Curated1
Sequence conflicti246A → R in AAA51786 (PubMed:3463959).Curated1
Sequence conflicti246A → R in AAA51787 (PubMed:2644168).Curated1
Sequence conflicti246A → R in AAA51788 (Ref. 4) Curated1
Sequence conflicti246A → R in AAL57276 (Ref. 5) Curated1
Sequence conflicti431G → R in CAA68722 (PubMed:3391281).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04310631D → N in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs754995756EnsemblClinVar.1
Natural variantiVAR_07218670V → A in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1027739421Ensembl.1
Natural variantiVAR_07555173E → K in ARGINSA; complete loss of argininosuccinate lyase activity; abolishes protein expression. 1 Publication1
Natural variantiVAR_07218794R → C in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs374304304EnsemblClinVar.1
Natural variantiVAR_07218894R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs777437569EnsemblClinVar.1
Natural variantiVAR_00067695R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940585EnsemblClinVar.1
Natural variantiVAR_07218995R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs150244667EnsemblClinVar.1
Natural variantiVAR_072190104A → V in ARGINSA. 1 Publication1
Natural variantiVAR_000677111R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs138310841Ensembl.1
Natural variantiVAR_043107113R → Q in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs752783461EnsemblClinVar.1
Natural variantiVAR_072191120D → E in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072192121L → H in ARGINSA. 1 Publication1
Natural variantiVAR_072193126R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs201962738Ensembl.1
Natural variantiVAR_072194146R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs199938613Ensembl.1
Natural variantiVAR_072195156P → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs769017508Ensembl.1
Natural variantiVAR_072196160H → N in ARGINSA. 1 Publication1
Natural variantiVAR_072197166P → H in ARGINSA. 1 Publication1
Natural variantiVAR_072198168R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs727503811EnsemblClinVar.1
Natural variantiVAR_072199170S → N in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1180650883Ensembl.1
Natural variantiVAR_017572178V → M in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 3 PublicationsCorresponds to variant dbSNP:rs28941473EnsemblClinVar.1
Natural variantiVAR_072200180L → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1057141162Ensembl.1
Natural variantiVAR_036281181T → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_072201182R → Q in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs751590073EnsemblClinVar.1
Natural variantiVAR_043108186R → Q in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs752397242Ensembl.1
Natural variantiVAR_072202191R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs143508372EnsemblClinVar.1
Natural variantiVAR_000678193R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs373697663EnsemblClinVar.1
Natural variantiVAR_072203193R → W in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1428029508Ensembl.1
Natural variantiVAR_036282200G → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_072204205A → V in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs796051925EnsemblClinVar.1
Natural variantiVAR_072205213R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1449589636Ensembl.1
Natural variantiVAR_072206227L → P in ARGINSA. 1 Publication1
Natural variantiVAR_072207229S → R in ARGINSA. 1 Publication1
Natural variantiVAR_072208229S → T in ARGINSA. 1 Publication1
Natural variantiVAR_072209231D → E in ARGINSA. 1 Publication1
Natural variantiVAR_043109236R → W in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 2 PublicationsCorresponds to variant dbSNP:rs761268464Ensembl.1
Natural variantiVAR_072210237D → N in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs552951774Ensembl.1
Natural variantiVAR_072211256M → T in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs149057077Ensembl.1
Natural variantiVAR_072212262L → P in ARGINSA. 1 Publication1
Natural variantiVAR_000679286Q → R in ARGINSA; complete loss of argininosuccinate lyase activity; no effect on protein expression. 4 PublicationsCorresponds to variant dbSNP:rs28941472EnsemblClinVar.1
Natural variantiVAR_072213295L → P in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1369337876Ensembl.1
Natural variantiVAR_075552297R → Q in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 1 PublicationCorresponds to variant dbSNP:rs750431938EnsemblClinVar.1
Natural variantiVAR_072214301G → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs1161412459Ensembl.1
Natural variantiVAR_072215306R → W in ARGINSA; severe. 1 PublicationCorresponds to variant dbSNP:rs868834862EnsemblClinVar.1
Natural variantiVAR_072216324D → A in ARGINSA. 1 Publication1
Natural variantiVAR_072217326Q → L in ARGINSA; severe. 1 Publication1
Natural variantiVAR_043110335V → L in ARGINSA; reduction of argininosuccinate lyase activity; no effect on protein expression. 2 Publications1
Natural variantiVAR_072218343L → F in ARGINSA. 1 Publication1
Natural variantiVAR_072219343L → P in ARGINSA. 1 Publication1
Natural variantiVAR_072220368M → V in ARGINSA. 1 Publication1
Natural variantiVAR_017573379R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940287EnsemblClinVar.1
Natural variantiVAR_072221380K → E in ARGINSA. 1 Publication1
Natural variantiVAR_043111382M → R in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 Publications1
Natural variantiVAR_017574385R → C in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs28940286EnsemblClinVar.1
Natural variantiVAR_072222385R → H in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs746120802EnsemblClinVar.1
Natural variantiVAR_072223385R → L in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072224388H → Q in ARGINSA; severe. 1 Publication1
Natural variantiVAR_072225433S → R in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs796051928EnsemblClinVar.1
Natural variantiVAR_072226434V → L in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs773071023EnsemblClinVar.1
Natural variantiVAR_072227447S → N in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs373519615Ensembl.1
Natural variantiVAR_072228456R → Q in ARGINSA. 1 PublicationCorresponds to variant dbSNP:rs767271619EnsemblClinVar.1
Natural variantiVAR_043112456R → W in ARGINSA; reduction of argininosuccinate lyase activity; reduces protein expression. 2 PublicationsCorresponds to variant dbSNP:rs759396688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047255176 – 201Missing in isoform 3. CuratedAdd BLAST26
Alternative sequenceiVSP_047256307 – 326Missing in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00753 mRNA Translation: CAA68722.1
M14218 mRNA Translation: AAA51786.1 Frameshift.
J03058 mRNA Translation: AAA51787.1
M57638 mRNA Translation: AAA51788.1
AF376770 Genomic DNA Translation: AAL57276.1
AC068533 Genomic DNA No translation available.
BC008195 mRNA Translation: AAH08195.1
BC033146 mRNA Translation: AAH33146.1
M21007, M21006 Genomic DNA Translation: AAA35566.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47597.1 [P04424-2]
CCDS47598.1 [P04424-3]
CCDS5531.1 [P04424-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31658 WZHURS

NCBI Reference Sequences

More...
RefSeqi
NP_000039.2, NM_000048.3 [P04424-1]
NP_001020114.1, NM_001024943.1 [P04424-1]
NP_001020115.1, NM_001024944.1 [P04424-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632015

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304874; ENSP00000307188; ENSG00000126522 [P04424-1]
ENST00000380839; ENSP00000370219; ENSG00000126522 [P04424-3]
ENST00000395331; ENSP00000378740; ENSG00000126522 [P04424-2]
ENST00000395332; ENSP00000378741; ENSG00000126522 [P04424-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
435

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:435

UCSC genome browser

More...
UCSCi
uc003tuo.4 human [P04424-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00753 mRNA Translation: CAA68722.1
M14218 mRNA Translation: AAA51786.1 Frameshift.
J03058 mRNA Translation: AAA51787.1
M57638 mRNA Translation: AAA51788.1
AF376770 Genomic DNA Translation: AAL57276.1
AC068533 Genomic DNA No translation available.
BC008195 mRNA Translation: AAH08195.1
BC033146 mRNA Translation: AAH33146.1
M21007, M21006 Genomic DNA Translation: AAA35566.1
CCDSiCCDS47597.1 [P04424-2]
CCDS47598.1 [P04424-3]
CCDS5531.1 [P04424-1]
PIRiA31658 WZHURS
RefSeqiNP_000039.2, NM_000048.3 [P04424-1]
NP_001020114.1, NM_001024943.1 [P04424-1]
NP_001020115.1, NM_001024944.1 [P04424-2]
UniGeneiHs.632015

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOSX-ray4.20A/B1-464[»]
1K62X-ray2.65A/B1-464[»]
ProteinModelPortaliP04424
SMRiP04424
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106927, 17 interactors
IntActiP04424, 8 interactors
STRINGi9606.ENSP00000307188

Chemistry databases

DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB02267 Argininosuccinate
DB00125 L-Arginine

PTM databases

iPTMnetiP04424
PhosphoSitePlusiP04424

Polymorphism and mutation databases

BioMutaiASL

Proteomic databases

EPDiP04424
jPOSTiP04424
MaxQBiP04424
PaxDbiP04424
PeptideAtlasiP04424
PRIDEiP04424
ProteomicsDBi51704

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
435
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304874; ENSP00000307188; ENSG00000126522 [P04424-1]
ENST00000380839; ENSP00000370219; ENSG00000126522 [P04424-3]
ENST00000395331; ENSP00000378740; ENSG00000126522 [P04424-2]
ENST00000395332; ENSP00000378741; ENSG00000126522 [P04424-1]
GeneIDi435
KEGGihsa:435
UCSCiuc003tuo.4 human [P04424-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
435
DisGeNETi435
EuPathDBiHostDB:ENSG00000126522.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ASL
GeneReviewsiASL
HGNCiHGNC:746 ASL
HPAiCAB003696
HPA016646
MalaCardsiASL
MIMi207900 phenotype
608310 gene
neXtProtiNX_P04424
OpenTargetsiENSG00000126522
Orphaneti23 Argininosuccinic aciduria
PharmGKBiPA25046

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1316 Eukaryota
COG0165 LUCA
GeneTreeiENSGT00940000153479
HOGENOMiHOG000242744
HOVERGENiHBG004281
InParanoidiP04424
KOiK01755
OMAiKKNPDVF
OrthoDBi580544at2759
PhylomeDBiP04424
TreeFamiTF300656

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

UPA00158;UER00273

BioCyciMetaCyc:HS10034-MONOMER
BRENDAi4.3.2.1 2681
ReactomeiR-HSA-70635 Urea cycle
SABIO-RKiP04424

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ASL human
EvolutionaryTraceiP04424

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
435

Protein Ontology

More...
PROi
PR:P04424

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126522 Expressed in 92 organ(s), highest expression level in right lobe of liver
CleanExiHS_ASL
ExpressionAtlasiP04424 baseline and differential
GenevisibleiP04424 HS

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARLY_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04424
Secondary accession number(s): E7EMI0
, E9PE48, Q6LDS5, Q96HS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 212 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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