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UniProtKB - P04417 (PA2B_GLOBL)
Protein
Basic phospholipase A2
Gene
N/A
Organism
Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)
Status
Functioni
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
By similarityCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 29 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 31 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 47 | By similarity | 1 | |
Metal bindingi | 48 | CalciumBy similarity | 1 | |
Active sitei | 89 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Neurotoxin, Presynaptic neurotoxin, Toxin |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 (EC:3.1.1.4)Short name: PA2-I Short name: svPLA2 Alternative name(s): Phosphatidylcholine 2-acylhydrolase |
Organismi | Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi) |
Taxonomic identifieri | 242054 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Gloydius |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161595 | 1 – 122 | Basic phospholipase A2Add BLAST | 122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 115 | By similarity | ||
Disulfide bondi | 28 ↔ 44 | By similarity | ||
Disulfide bondi | 43 ↔ 95 | By similarity | ||
Disulfide bondi | 49 ↔ 122 | By similarity | ||
Disulfide bondi | 50 ↔ 88 | By similarity | ||
Disulfide bondi | 57 ↔ 81 | By similarity | ||
Disulfide bondi | 75 ↔ 86 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | P04417 |
Expressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Homodimer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P04417-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
HLLQFRKMIK KMTGKEPVIS YAFYGCYCGS GGRGKPKDAT DRCCFVHDCC
60 70 80 90 100
YEKVTGCKPK WDDYTYSWKN GDIVCGGDDP CKKEICECDR AAAICFRDNL
110 120
KTYKKRYMAY PDILCSSKSE KC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence uncertaintyi | 74 | 1 |
Sequence databases
PIRi | A00766, PSABA |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A00766, PSABA |
3D structure databases
SMRi | P04417 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P04417 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2B_GLOBL | |
Accessioni | P04417Primary (citable) accession number: P04417 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families