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Protein

Interleukin-5

Gene

Il5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB-KW
  • interleukin-5 receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell growth factor II
Short name:
BCGF-II
Cytotoxic T-lymphocyte inducer
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:Il5
Synonyms:Il-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96557 Il5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1163111

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001556421 – 133Interleukin-5Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi62Interchain (with C-104)By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104Interchain (with C-62)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04401
PRIDEiP04401

PTM databases

iPTMnetiP04401
PhosphoSitePlusiP04401

Expressioni

Gene expression databases

BgeeiENSMUSG00000036117 Expressed in 21 organ(s), highest expression level in retina
CleanExiMM_IL5
ExpressionAtlasiP04401 baseline and differential
GenevisibleiP04401 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043369

Chemistry databases

BindingDBiP04401

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04401
SMRiP04401
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04401

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP04401
KOiK05428
OMAiGVINTEW
OrthoDBiEOG091G0XPD
PhylomeDBiP04401
TreeFamiTF338422

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04401-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR
60 70 80 90 100
LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ
110 120 130
KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Length:133
Mass (Da):15,410
Last modified:November 1, 1988 - v1
Checksum:iC6DC091682452AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06270 mRNA Translation: CAA29606.1
X06271 Genomic DNA Translation: CAA29607.1
X04601 mRNA Translation: CAA28266.1
CCDSiCCDS24685.1
PIRiS00807 ICMS5
RefSeqiNP_034688.1, NM_010558.1
UniGeneiMm.4461

Genome annotation databases

EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117
GeneIDi16191
KEGGimmu:16191
UCSCiuc007iwv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06270 mRNA Translation: CAA29606.1
X06271 Genomic DNA Translation: CAA29607.1
X04601 mRNA Translation: CAA28266.1
CCDSiCCDS24685.1
PIRiS00807 ICMS5
RefSeqiNP_034688.1, NM_010558.1
UniGeneiMm.4461

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5KX-ray2.50A/B21-133[»]
ProteinModelPortaliP04401
SMRiP04401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043369

Chemistry databases

BindingDBiP04401
ChEMBLiCHEMBL1163111

PTM databases

iPTMnetiP04401
PhosphoSitePlusiP04401

Proteomic databases

PaxDbiP04401
PRIDEiP04401

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117
GeneIDi16191
KEGGimmu:16191
UCSCiuc007iwv.1 mouse

Organism-specific databases

CTDi3567
MGIiMGI:96557 Il5

Phylogenomic databases

eggNOGiENOG410IYJN Eukaryota
ENOG41117ER LUCA
GeneTreeiENSGT00390000016991
HOGENOMiHOG000074049
HOVERGENiHBG003865
InParanoidiP04401
KOiK05428
OMAiGVINTEW
OrthoDBiEOG091G0XPD
PhylomeDBiP04401
TreeFamiTF338422

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

EvolutionaryTraceiP04401
PROiPR:P04401
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036117 Expressed in 21 organ(s), highest expression level in retina
CleanExiMM_IL5
ExpressionAtlasiP04401 baseline and differential
GenevisibleiP04401 MM

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000186 IL-5
PANTHERiPTHR45421 PTHR45421, 1 hit
PfamiView protein in Pfam
PF02025 IL5, 1 hit
PRINTSiPR00432 INTERLEUKIN5
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721 Interleukin_5, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL5_MOUSE
AccessioniPrimary (citable) accession number: P04401
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1988
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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