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Protein

Ras-like protein 2

Gene

Ras64B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in endocytic processes and/or other transport pathways mediated by vesicle trafficking. May interact functionally with ROP protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-442742 CREB phosphorylation through the activation of Ras

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein 2
Gene namesi
Name:Ras64B
Synonyms:ras2
ORF Names:CG1167
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003206 Ras64B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14G → V: Causes developmental abnormalities. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826681 – 189Ras-like protein 2Add BLAST189
PropeptideiPRO_0000281316190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP04388
PRIDEiP04388

Expressioni

Developmental stagei

A uniform expression is seen in unfertilized eggs, embryos, larvae, pupae and adult flies. Expression during embryogenesis is restricted to the CNS and the Garland cells, a small group of nephrocytes that takes up waste materials from the hemolymph by endocytosis. In post-embryonic stages, expression is seen in the larval salivary glands and the CNS, and in the adult CNS and reproductive systems.

Gene expression databases

BgeeiFBgn0003206
GenevisibleiP04388 DM

Interactioni

Protein-protein interaction databases

BioGridi63974, 19 interactors
IntActiP04388, 1 interactor
STRINGi7227.FBpp0073068

Structurei

3D structure databases

ProteinModelPortaliP04388
SMRiP04388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiP04388
KOiK07830
OMAiYAQTYKL
OrthoDBiEOG091G0UAU
PhylomeDBiP04388

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMQTYKLVV VGGGGVGKSA ITIQFIQSYF VTDYDPTIED SYTKQCNIDD
60 70 80 90 100
VPAKLDILDT AGQEEFSAMR EQYMRSGEGF LLVFALNDHS SFDEIPKFQR
110 120 130 140 150
QILRVKDRDE FPMLMVGNKC DLKHQQQVSL EEAQNTSRNL MIPYIECSAK
160 170 180 190
LRVNVDQAFH ELVRIVRKFQ IAERPFIEQD YKKKGKRKCC LM
Length:192
Mass (Da):22,236
Last modified:August 1, 1992 - v2
Checksum:i3F58A3A33E8FDEBC
GO

Sequence cautioni

The sequence CAA31071 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29SY → VS in CAA30242 (PubMed:3412773).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10804, M10759, M10803 Genomic DNA Translation: AAA99202.1 Sequence problems.
M16431, M16124, M16430 Genomic DNA Translation: AAA28849.1
U15967 Genomic DNA Translation: AAB60243.1
AE014296 Genomic DNA Translation: AAF47845.2
AY119135 mRNA Translation: AAM50995.1
K01962, K01961 Genomic DNA Translation: AAA28848.1 Sequence problems.
AF186651 Genomic DNA Translation: AAF15517.1
X12559 Genomic DNA Translation: CAA31072.1
X12558 Genomic DNA Translation: CAA31071.1 Different initiation.
X07255 Genomic DNA Translation: CAA30242.1
PIRiA01370 TVFFR
S55022
RefSeqiNP_523917.2, NM_079193.4
UniGeneiDm.31139

Genome annotation databases

EnsemblMetazoaiFBtr0073212; FBpp0073068; FBgn0003206
GeneIDi38494
KEGGidme:Dmel_CG1167

Similar proteinsi

Entry informationi

Entry nameiRAS2_DROME
AccessioniPrimary (citable) accession number: P04388
Secondary accession number(s): Q9VZH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 1, 1992
Last modified: July 18, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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