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Protein

Metallothionein-1

Gene

MtnA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Mercury, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
ORF Names:CG9470
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002868 MtnA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973531 – 40Metallothionein-1Add BLAST40

Proteomic databases

PaxDbiP04357
PRIDEiP04357

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Gene expression databases

BgeeiFBgn0002868 Expressed in 31 organ(s), highest expression level in Malpighian tubule
ExpressionAtlasiP04357 baseline and differential
GenevisibleiP04357 DM

Interactioni

Protein-protein interaction databases

BioGridi66359, 9 interactors
DIPiDIP-19543N
IntActiP04357, 1 interactor
STRINGi7227.FBpp0081636

Structurei

3D structure databases

ProteinModelPortaliP04357
SMRiP04357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
InParanoidiP04357
OrthoDBiEOG091G1A2R
PhylomeDBiP04357

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04357-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSE
Length:40
Mass (Da):3,853
Last modified:March 20, 1987 - v1
Checksum:i99A2A53CCCAE634A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KFM8A0A0B4KFM8_DROME
Metallothionein A, isoform B
MtnA anon-WO0153538.42, anon-WO0153538.44, anon-WO0153538.49, BcDNA:GH18460, Dmel\CG9470
40Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti40E → K in allele MtnA-3 and strain: AF6, Highgrove, Indiana, LA20, Taiwan, ZH18, ZH21, ZH27, ZS11, ZS30 and ZS56. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02314 mRNA Translation: AAA28681.1
M27708 Genomic DNA Translation: AAA28684.1
X03758 Genomic DNA Translation: CAA27391.1
M69015 Genomic DNA Translation: AAB41334.1
EU744337 Genomic DNA Translation: ACH73302.1
EU744338 Genomic DNA Translation: ACH73303.1
EU744339 Genomic DNA Translation: ACH73304.1
EU744340 Genomic DNA Translation: ACH73305.1
EU744341 Genomic DNA Translation: ACH73306.1
EU744342 Genomic DNA Translation: ACH73307.1
EU744343 Genomic DNA Translation: ACH73308.1
EU744344 Genomic DNA Translation: ACH73309.1
EU744345 Genomic DNA Translation: ACH73310.1
EU744346 Genomic DNA Translation: ACH73311.1
EU744347 Genomic DNA Translation: ACH73312.1
EU744348 Genomic DNA Translation: ACH73313.1
EU744349 Genomic DNA Translation: ACH73314.1
EU744350 Genomic DNA Translation: ACH73315.1
AE014297 Genomic DNA Translation: AAF54452.1
BT001431 mRNA Translation: AAN71186.1
PIRiA25294 SMFF
RefSeqiNP_001262438.1, NM_001275509.1
NP_524299.1, NM_079575.2
UniGeneiDm.1134

Genome annotation databases

EnsemblMetazoaiFBtr0082158; FBpp0081636; FBgn0002868
FBtr0334686; FBpp0306744; FBgn0002868
GeneIDi41202
KEGGidme:Dmel_CG9470

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02314 mRNA Translation: AAA28681.1
M27708 Genomic DNA Translation: AAA28684.1
X03758 Genomic DNA Translation: CAA27391.1
M69015 Genomic DNA Translation: AAB41334.1
EU744337 Genomic DNA Translation: ACH73302.1
EU744338 Genomic DNA Translation: ACH73303.1
EU744339 Genomic DNA Translation: ACH73304.1
EU744340 Genomic DNA Translation: ACH73305.1
EU744341 Genomic DNA Translation: ACH73306.1
EU744342 Genomic DNA Translation: ACH73307.1
EU744343 Genomic DNA Translation: ACH73308.1
EU744344 Genomic DNA Translation: ACH73309.1
EU744345 Genomic DNA Translation: ACH73310.1
EU744346 Genomic DNA Translation: ACH73311.1
EU744347 Genomic DNA Translation: ACH73312.1
EU744348 Genomic DNA Translation: ACH73313.1
EU744349 Genomic DNA Translation: ACH73314.1
EU744350 Genomic DNA Translation: ACH73315.1
AE014297 Genomic DNA Translation: AAF54452.1
BT001431 mRNA Translation: AAN71186.1
PIRiA25294 SMFF
RefSeqiNP_001262438.1, NM_001275509.1
NP_524299.1, NM_079575.2
UniGeneiDm.1134

3D structure databases

ProteinModelPortaliP04357
SMRiP04357
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66359, 9 interactors
DIPiDIP-19543N
IntActiP04357, 1 interactor
STRINGi7227.FBpp0081636

Proteomic databases

PaxDbiP04357
PRIDEiP04357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082158; FBpp0081636; FBgn0002868
FBtr0334686; FBpp0306744; FBgn0002868
GeneIDi41202
KEGGidme:Dmel_CG9470

Organism-specific databases

CTDi41202
FlyBaseiFBgn0002868 MtnA

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
InParanoidiP04357
OrthoDBiEOG091G1A2R
PhylomeDBiP04357

Miscellaneous databases

ChiTaRSiMtnA fly
GenomeRNAii41202
PROiPR:P04357

Gene expression databases

BgeeiFBgn0002868 Expressed in 31 organ(s), highest expression level in Malpighian tubule
ExpressionAtlasiP04357 baseline and differential
GenevisibleiP04357 DM

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_DROME
AccessioniPrimary (citable) accession number: P04357
Secondary accession number(s): B5T1U3, B5T1U5, Q9VH67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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