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Protein

Interleukin-2

Gene

Il2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-9020558 Interleukin-2 signaling
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96548 Il2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001549321 – 169Interleukin-2Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi92 ↔ 140By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04351
PRIDEiP04351

PTM databases

PhosphoSitePlusiP04351

Expressioni

Gene expression databases

BgeeiENSMUSG00000027720
CleanExiMM_IL2
GenevisibleiP04351 MM

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: MGI
  • kappa-type opioid receptor binding Source: MGI

Protein-protein interaction databases

IntActiP04351, 1 interactor
STRINGi10090.ENSMUSP00000029275

Chemistry databases

BindingDBiP04351

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 60Combined sources14
Helixi70 – 73Combined sources4
Beta strandi75 – 79Combined sources5
Helixi87 – 90Combined sources4
Helixi91 – 94Combined sources4
Helixi97 – 103Combined sources7
Helixi118 – 132Combined sources15
Beta strandi134 – 136Combined sources3
Beta strandi144 – 148Combined sources5
Helixi149 – 164Combined sources16

3D structure databases

ProteinModelPortaliP04351
SMRiP04351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 46Poly-GlnAdd BLAST12

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOGENOMiHOG000048727
HOVERGENiHBG007496
InParanoidiP04351
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ
PhylomeDBiP04351
TreeFamiTF338200

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMQLASCV TLTLVLLVNS APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ
60 70 80 90 100
LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL
110 120 130 140 150
RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV
160
DFLRRWIAFC QSIISTSPQ
Length:169
Mass (Da):19,400
Last modified:March 20, 1987 - v1
Checksum:iB3B17644F6EF83CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → E in AAA39281 (PubMed:3003564).Curated1

Polymorphismi

The poly-Gln region is highly polymorphic.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26S → P in strain: RF/J and CAST/Ei. 1
Natural varianti30S → P in strain: RF/J. 1
Natural varianti32 – 39AEAQQQQQ → SSSTAEA in strain: CAST/Ei. 8
Natural varianti32 – 38AEAQQQQ → SSSTAEA in strain: RF/J. 7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01663 Genomic DNA Translation: CAA25823.1
X01664 Genomic DNA Translation: CAA25824.1
X01665 Genomic DNA Translation: CAA25825.1
X01772 mRNA Translation: CAA25909.1
K02292 mRNA Translation: AAA39289.1
M16762, M16760, M16761 Genomic DNA Translation: AAA39281.1
AF195956 Genomic DNA Translation: AAF32272.1
AF065914 mRNA Translation: AAD25890.1
AL662823 Genomic DNA Translation: CAM18418.1
X66058 mRNA Translation: CAA46854.1
L07574 Genomic DNA Translation: AAA39326.1
L07576 Genomic DNA Translation: AAA39328.1
CCDSiCCDS17316.1
PIRiA93550 ICMS2
I54512
I68871
RefSeqiNP_032392.1, NM_008366.3
UniGeneiMm.14190

Genome annotation databases

EnsembliENSMUST00000029275; ENSMUSP00000029275; ENSMUSG00000027720
GeneIDi16183
KEGGimmu:16183
UCSCiuc008pai.3 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL2_MOUSE
AccessioniPrimary (citable) accession number: P04351
Secondary accession number(s): P97945, Q791T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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