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Protein

Gamma-crystallin A

Gene

Cryga

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

GO - Molecular functioni

GO - Biological processi

  • eye development Source: MGI
  • lens development in camera-type eye Source: MGI

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin A
Alternative name(s):
Gamma-A-crystallin
Gamma-crystallin 4
Gene namesi
Name:Cryga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88521 Cryga

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575951 – 174Gamma-crystallin AAdd BLAST174

Proteomic databases

PaxDbiP04345
PRIDEiP04345

Expressioni

Gene expression databases

BgeeiENSMUSG00000044429 Expressed in 8 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYGA
GenevisibleiP04345 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058548

Structurei

3D structure databases

ProteinModelPortaliP04345
SMRiP04345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP04345
OMAiSCRAIPY
OrthoDBiEOG091G0L2P
PhylomeDBiP04345

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

P04345-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN
60 70 80 90 100
YQGYQYFLRR GDYPDYQQWM GFSDSIRSCR SIPYTSSHRI RLYERDDYRG
110 120 130 140 150
LVSELMDDCS CIHDRFRLHE IYSMHVLEGC WVLYEMPNYR GRQYLLRPGD
160 170
YRRYHDWGAM DAKVGSLRRV MDLY
Length:174
Mass (Da):21,149
Last modified:January 23, 2007 - v2
Checksum:i169758B24919D632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00635 Genomic DNA Translation: CAA25266.1
X00654 Genomic DNA Translation: CAA25275.1
BC056430 mRNA Translation: AAH56430.1
CCDSiCCDS15014.1
PIRiA02935 CYMSG4
I48353
RefSeqiNP_031800.1, NM_007774.3
UniGeneiMm.26904

Genome annotation databases

EnsembliENSMUST00000061497; ENSMUSP00000058548; ENSMUSG00000044429
GeneIDi12964
KEGGimmu:12964
UCSCiuc007bhk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00635 Genomic DNA Translation: CAA25266.1
X00654 Genomic DNA Translation: CAA25275.1
BC056430 mRNA Translation: AAH56430.1
CCDSiCCDS15014.1
PIRiA02935 CYMSG4
I48353
RefSeqiNP_031800.1, NM_007774.3
UniGeneiMm.26904

3D structure databases

ProteinModelPortaliP04345
SMRiP04345
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058548

Proteomic databases

PaxDbiP04345
PRIDEiP04345

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061497; ENSMUSP00000058548; ENSMUSG00000044429
GeneIDi12964
KEGGimmu:12964
UCSCiuc007bhk.1 mouse

Organism-specific databases

CTDi1418
MGIiMGI:88521 Cryga

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP04345
OMAiSCRAIPY
OrthoDBiEOG091G0L2P
PhylomeDBiP04345

Miscellaneous databases

ChiTaRSiCryga mouse
PROiPR:P04345
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044429 Expressed in 8 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYGA
GenevisibleiP04345 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRGA_MOUSE
AccessioniPrimary (citable) accession number: P04345
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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