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Protein

Gamma-crystallin D

Gene

Crygd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin D
Alternative name(s):
Gamma-D-crystallin
Gamma-crystallin 1
Gene namesi
Name:Crygd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88524 Crygd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575981 – 174Gamma-crystallin DAdd BLAST174

Proteomic databases

PaxDbiP04342
PRIDEiP04342

PTM databases

PhosphoSitePlusiP04342

Expressioni

Tissue specificityi

Detected in the superior olivary complex of the auditory hindbrain.1 Publication

Gene expression databases

BgeeiENSMUSG00000067299 Expressed in 54 organ(s), highest expression level in epithelium of lens
CleanExiMM_CRYGD
ExpressionAtlasiP04342 differential
GenevisibleiP04342 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045327

Structurei

3D structure databases

ProteinModelPortaliP04342
SMRiP04342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP04342
OMAiQMIEITE
OrthoDBiEOG091G0L2P

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITFYEDR GFQGRHYECS TDHSNLQPYF SRCNSVRVDS GCWMLYEQPN
60 70 80 90 100
FTGCQYFLRR GDYPDYQQWM GFSDSVRSCR LIPHAGSHRI RLYEREEYRG
110 120 130 140 150
QMIEFTEDCP SLQDRFHFNE IYSLNVLEGC WVLYDMTNYR GRQYLLRPGE
160 170
YRRYHDWGAM NARVGSLRRV MDFY
Length:174
Mass (Da):21,118
Last modified:October 3, 2012 - v3
Checksum:i1AFC29C0269B35A1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CUK9F7CUK9_MOUSE
Gamma-crystallin D
Crygd
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → H in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti52T → A in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti52T → A in CAA11908 (PubMed:9782080).Curated1
Sequence conflicti102M → V in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti102M → V in CAA11908 (PubMed:9782080).Curated1
Sequence conflicti163R → K in AAA37475 (PubMed:6096855).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02583 mRNA Translation: AAA37475.1
AK136286 mRNA Translation: BAE22915.1
AC158958 Genomic DNA No translation available.
BC057013 mRNA Translation: AAH57013.1
BC132116 mRNA Translation: AAI32117.1
BC132118 mRNA Translation: AAI32119.1
AJ224342 Genomic DNA Translation: CAA11908.1
CCDSiCCDS35599.1
PIRiA02932 CYMSG1
RefSeqiNP_031802.2, NM_007776.2
UniGeneiMm.425031

Genome annotation databases

EnsembliENSMUST00000045028; ENSMUSP00000045327; ENSMUSG00000067299
GeneIDi12967
KEGGimmu:12967
UCSCiuc007bhg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02583 mRNA Translation: AAA37475.1
AK136286 mRNA Translation: BAE22915.1
AC158958 Genomic DNA No translation available.
BC057013 mRNA Translation: AAH57013.1
BC132116 mRNA Translation: AAI32117.1
BC132118 mRNA Translation: AAI32119.1
AJ224342 Genomic DNA Translation: CAA11908.1
CCDSiCCDS35599.1
PIRiA02932 CYMSG1
RefSeqiNP_031802.2, NM_007776.2
UniGeneiMm.425031

3D structure databases

ProteinModelPortaliP04342
SMRiP04342
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045327

PTM databases

PhosphoSitePlusiP04342

Proteomic databases

PaxDbiP04342
PRIDEiP04342

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045028; ENSMUSP00000045327; ENSMUSG00000067299
GeneIDi12967
KEGGimmu:12967
UCSCiuc007bhg.2 mouse

Organism-specific databases

CTDi1421
MGIiMGI:88524 Crygd

Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP04342
OMAiQMIEITE
OrthoDBiEOG091G0L2P

Miscellaneous databases

ChiTaRSiCrygd mouse
PROiPR:P04342
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067299 Expressed in 54 organ(s), highest expression level in epithelium of lens
CleanExiMM_CRYGD
ExpressionAtlasiP04342 differential
GenevisibleiP04342 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRGD_MOUSE
AccessioniPrimary (citable) accession number: P04342
Secondary accession number(s): O89027, Q6PGI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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