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Protein

Retrovirus-related Pol polyprotein from transposon 17.6

Gene

pol

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The open reading frame is located in a copia-like transposable element called 17.6.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei30For protease activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A02.052

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon 17.6
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pol
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014453 17.6\pol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995571 – 1058Retrovirus-related Pol polyprotein from transposon 17.6Add BLAST1058

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
P04323

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P04323

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04323

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 415Reverse transcriptasePROSITE-ProRule annotationAdd BLAST185
Domaini810 – 967Integrase catalyticPROSITE-ProRule annotationAdd BLAST158

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001584 Integrase_cat-core
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630 SSF50630, 1 hit
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P04323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TGRKFSATSL GKPQYITIKY KENNLKCLID TGSTVNMTSK NIFDLPIQNT
60 70 80 90 100
STFIHTSNGP LIVNKSIIIP SKILFPTTNE FLLHPFSENY DLLLGRKLLA
110 120 130 140 150
EAKATISYRD QEVTLYNNKY KLIEGIATHE QSHFQNVNMI PDTMLRQPNK
160 170 180 190 200
ISPILESDLY RLEHLNNEEK QRLCALLQKY HDIQYHEGDK LTFTNQTKHT
210 220 230 240 250
INTKHNLPLY SKYSYPQAYE QEVESQIQDM LNQGIIRTSN SPYNSPIWVV
260 270 280 290 300
PKKQDASGKQ KFRIVIDYRK LNEITVGDRH PIPNMDEILG KLGRCNYFTT
310 320 330 340 350
IDLAKGFHQI EMDPESVSKT AFSTKHGHYE YLRMPFGLKN APATFQRCMN
360 370 380 390 400
DILRPLLNKH CLVYLDDIIV FSTSLDEHLQ SLGLVFEKLA KANLKLQLDK
410 420 430 440 450
CEFLKQETTF LGHVLTPDGI KPNPEKIEAI QKYPIPTKPK EIKAFLGLTG
460 470 480 490 500
YYRKFIPNFA DIAKPMTKCL KKNMKIDTTN PEYDSAFKKL KYLISEDPIL
510 520 530 540 550
KVPDFTKKFT LTTDASDVAL GAVLSQDGHP LSYISRTLNE HEINYSTIEK
560 570 580 590 600
ELLAIVWATK TFRHYLLGRH FEISSDHQPL SWLYRMKDPN SKLTRWRVKL
610 620 630 640 650
SEFDFDIKYI KGKENCVADA LSRIKLEETY LSEQTQHSAE EDNSDLIFIT
660 670 680 690 700
ERPLNTFNRQ VIFSKGPPDI KVTKYFKKHI TQIFYDIMTR EKAEQYLIDH
710 720 730 740 750
FCGKKSALYI ESDADFEVIQ AAHKLAINTK YTKILRSTIL LKNITTYAEF
760 770 780 790 800
KELILTAHEK LLHPGIQKTT KLFGETYYFP NSQLLIQNII NECSICNLAK
810 820 830 840 850
TEHRNTDMPT KTTPKPEHCR EKFMIDIYSS EGKHYVSCID IYSKFATLEE
860 870 880 890 900
IKTKDWIECK NALMRIFNQL GKPKLLKADR DGAFSSLALK RWLESEEVEL
910 920 930 940 950
QLNTTKTGVA DIERLHKTIN EKIRIIKTSD DEETKLSKME TVLNIYNHKT
960 970 980 990 1000
KHDTTGQTPA HIFLYAGQPI LDTQQNKENK INKINNDRVE YEVDTRYRKG
1010 1020 1030 1040 1050
PLQKGKLENP FKPTKNVEQT DSDHYKITNR NRITHYYKTQ FKKRKKNNQL

SISQAPGT
Length:1,058
Mass (Da):122,698
Last modified:March 20, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC893F5C4A7E1F091
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X01472 Genomic DNA Translation: CAA25702.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A03971 GNFF17

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01472 Genomic DNA Translation: CAA25702.1
PIRiA03971 GNFF17

3D structure databases

ProteinModelPortaliP04323
SMRiP04323
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.052

Proteomic databases

PRIDEiP04323

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0014453 17.6\pol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P04323

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom
PfamiView protein in Pfam
PF00078 RVT_1, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04323
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: December 5, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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