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Protein

Tegument protein UL14

Gene

UL14

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids. The UL51-UL14 complex regulates final viral envelopment for efficient viral replication (PubMed:27440890).2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL14
Gene namesi
ORF Names:UL14
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159351 – 219Tegument protein UL14Add BLAST219

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP04291

Interactioni

Subunit structurei

Interacts with UL51.1 Publication

Protein-protein interaction databases

BioGridi971422, 1 interactor

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000ER

Family and domain databases

InterProiView protein in InterPro
IPR005207 Herpes_UL14
PfamiView protein in Pfam
PF03580 Herpes_UL14, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008302 Herpes_UL14, 1 hit

Sequencei

Sequence statusi: Complete.

P04291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA
60 70 80 90 100
KAAHLELEAR LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP
110 120 130 140 150
ALGERLDAVD DRLADQEEQL EEAATNASLW GDGDLAEGWM SPADSDLLVM
160 170 180 190 200
WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP PGAPAAPLSR TPPSPAPPTG
210
PATDPASASG FARDYPDGE
Length:219
Mass (Da):23,934
Last modified:August 15, 2003 - v2
Checksum:i58479A4B7255F3BA
GO

Sequence cautioni

The sequence CAA27455 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 18TH → RP (PubMed:3010237).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109V → M in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti178T → M in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti201P → A in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32327.1
X03839 Genomic DNA Translation: CAA27455.1 Sequence problems.
DQ889502 Genomic DNA Translation: ABI63476.1
FJ593289 Genomic DNA Translation: ACM62236.1
PIRiA03739 WMBE21
RefSeqiYP_009137088.1, NC_001806.2

Genome annotation databases

GeneIDi2703384
KEGGivg:2703384

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32327.1
X03839 Genomic DNA Translation: CAA27455.1 Sequence problems.
DQ889502 Genomic DNA Translation: ABI63476.1
FJ593289 Genomic DNA Translation: ACM62236.1
PIRiA03739 WMBE21
RefSeqiYP_009137088.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971422, 1 interactor

Proteomic databases

PRIDEiP04291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703384
KEGGivg:2703384

Phylogenomic databases

OrthoDBiVOG090000ER

Family and domain databases

InterProiView protein in InterPro
IPR005207 Herpes_UL14
PfamiView protein in Pfam
PF03580 Herpes_UL14, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008302 Herpes_UL14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEG3_HHV11
AccessioniPrimary (citable) accession number: P04291
Secondary accession number(s): B9VQE1, O09797, Q09IB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 15, 2003
Last modified: October 25, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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