UL11

Functionⁱ

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation4 Publications

GO - Biological processⁱ

anatomical structure morphogenesis Source: UniProtKB-UniRule
viral budding from Golgi membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 16928743

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytoplasmic envelopment protein 3UniRule annotation
Gene namesⁱ	ORF Names:UL11
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome UP000180652 Componentⁱ: Genome

Subcellular locationⁱ

Note:

Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

GO - Cellular componentⁱ

host cell Golgi membrane Source: UniProtKB-SubCell
host cell plasma membrane Source: UniProtKB-SubCell
viral tegument Source: UniProtKB-SubCell
virion membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed; by hostUniRule annotation
ChainⁱPRO_0000115925	2 – 96	Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST		95

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine; by hostUniRule annotation1 Publication		1
Modified residueⁱ	40	PhosphoserineUniRule annotation1 Publication		1

Post-translational modificationⁱ

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation2 Publications

Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEⁱ	P04289

PRIDEⁱ

P04289

PTM databases

iPTMnetⁱ	P04289

iPTMnetⁱ

P04289

Interactionⁱ

Subunit structureⁱ

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus (By similarity). Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56.UniRule annotationBy similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
UL16	P10200	3	EBI-7044930,EBI-7044955

With

Entry

#Exp.

IntAct

Notes

UL16

P10200

3

EBI-7044930,EBI-7044955

Protein-protein interaction databases

IntActⁱ	P04289, 1 interactor
Molecular INTeraction database More...MINTⁱ	P04289

Structureⁱ

3D structure databases

SMRⁱ	P04289
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	37 – 43	Asp/Glu-rich (acidic)UniRule annotation		7

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	18 – 19	Di-leucine-like internalization motifUniRule annotation		2

Domainⁱ

The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication

Sequence similaritiesⁱ

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090002QO

OrthoDBⁱ

VOG090002QO

Family and domain databases

HAMAPⁱ	MF_04040 HSV_CEP3_alphahv, 1 hit
InterProⁱ	View protein in InterPro IPR024351 Tegument_UL11_Herpesvir IPR016395 UL11_simplexvir-type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11094 UL11, 1 hit
PIRSFⁱ	PIRSF003496 Myristoylat_tegument_UL11, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04289-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP 
        60         70         80         90 
DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE

Length:96

Mass (Da):10,487

Last modified:January 23, 2007 - v3

Checksum:ⁱ5D09A5B1F2034B09

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	39	E → K in strain: 17 syn+.	1
Natural variantⁱ	54	G → V in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	65	R → C in strain: Nonneuroinvasive mutant HF10.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32347.1 X03839 Genomic DNA Translation: CAA27452.1 DQ889502 Genomic DNA Translation: ABI63473.1 FJ593289 Genomic DNA Translation: ACM62233.1
PIRⁱ	A03737 WMBE11
NCBI Reference Sequences More...RefSeqⁱ	YP_009137085.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	24271464
KEGGⁱ	vg:24271464

Protein	Similar proteins		Species	Score	Length	Source
P04289	Cytoplasmic envelopment protein 3		HHV1		96	UniRef100_P04289

Protein	Similar proteins		Species	Score	Length	Source
P04289	Cytoplasmic envelopment protein 3		HHV1K		96	UniRef90_P04289
Cytoplasmic envelopment protein 3		HHV1		96
Cytoplasmic envelopment protein 3		HHV11		96
Cytoplasmic envelopment protein 3		Human alphaherpesvirus 1 strain RH2		96
Cytoplasmic envelopment protein 3		HHV1		96
+17

Protein	Similar proteins		Species	Score	Length	Source
P04289	Cytoplasmic envelopment protein 3		HHV1K		96	UniRef50_P04289
Cytoplasmic envelopment protein 3		HHV2H		96
Cytoplasmic envelopment protein 3		HHV1		96
Cytoplasmic envelopment protein 3		HHV11		96
Cytoplasmic envelopment protein 3		Human alphaherpesvirus 1 strain RH2		96
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32347.1 X03839 Genomic DNA Translation: CAA27452.1 DQ889502 Genomic DNA Translation: ABI63473.1 FJ593289 Genomic DNA Translation: ACM62233.1
PIRⁱ	A03737 WMBE11
RefSeqⁱ	YP_009137085.1, NC_001806.2

3D structure databases

SMRⁱ	P04289
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P04289, 1 interactor
MINTⁱ	P04289

PTM databases

iPTMnetⁱ	P04289

iPTMnetⁱ

P04289

Proteomic databases

PRIDEⁱ	P04289

PRIDEⁱ

P04289

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	24271464
KEGGⁱ	vg:24271464

Phylogenomic databases

OrthoDBⁱ	VOG090002QO

OrthoDBⁱ

VOG090002QO

Family and domain databases

HAMAPⁱ	MF_04040 HSV_CEP3_alphahv, 1 hit
InterProⁱ	View protein in InterPro IPR024351 Tegument_UL11_Herpesvir IPR016395 UL11_simplexvir-type
Pfamⁱ	View protein in Pfam PF11094 UL11, 1 hit
PIRSFⁱ	PIRSF003496 Myristoylat_tegument_UL11, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEP3_HHV11
Accessionⁱ	P04289Primary (citable) accession number: P04289 Secondary accession number(s): B9VQD8, Q09IC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - P04289 (CEP3_HHV11)

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Cytoplasmic envelopment protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ