UniProtKB - P04289 (CEP3_HHV11)
Protein
Cytoplasmic envelopment protein 3
Gene
UL11
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation4 Publications
GO - Biological processi
- anatomical structure morphogenesis Source: UniProtKB-UniRule
- viral budding from Golgi membrane Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Cytoplasmic envelopment protein 3UniRule annotation |
Gene namesi | ORF Names:UL11 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion tegument UniRule annotation2 Publications
- Virion membrane UniRule annotation; Lipid-anchor UniRule annotation
- Host cell membrane UniRule annotation1 Publication; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication
- Host Golgi apparatus membrane UniRule annotation2 Publications; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- host cell plasma membrane Source: UniProtKB-SubCell
- viral tegument Source: UniProtKB-SubCell
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegumentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed; by hostUniRule annotation | |||
ChainiPRO_0000115925 | 2 – 96 | Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine; by hostUniRule annotation1 Publication | 1 | |
Modified residuei | 40 | PhosphoserineUniRule annotation1 Publication | 1 |
Post-translational modificationi
Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation2 Publications
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation1 Publication
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, PhosphoproteinProteomic databases
PRIDEi | P04289 |
PTM databases
iPTMneti | P04289 |
Interactioni
Subunit structurei
Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus (By similarity).
Interacts with gE (via C-terminus).
Interacts with gD (via C-terminus).
Interacts with UL56.
UniRule annotationBy similarity2 PublicationsBinary interactionsi
P04289
With | #Exp. | IntAct |
---|---|---|
UL16 [P10200] | 3 | EBI-7044930,EBI-7044955 |
Protein-protein interaction databases
IntActi | P04289, 1 interactor |
MINTi | P04289 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 43 | Asp/Glu-rich (acidic)UniRule annotation | 7 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 18 – 19 | Di-leucine-like internalization motifUniRule annotation | 2 |
Domaini
The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication
Sequence similaritiesi
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation
Family and domain databases
HAMAPi | MF_04040, HSV_CEP3_alphahv, 1 hit |
InterProi | View protein in InterPro IPR024351, Tegument_UL11_Herpesvir IPR016395, UL11_simplexvir-type |
Pfami | View protein in Pfam PF11094, UL11, 1 hit |
PIRSFi | PIRSF003496, Myristoylat_tegument_UL11, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04289-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP
60 70 80 90
DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 39 | E → K in strain: 17 syn+. | 1 | |
Natural varianti | 54 | G → V in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 65 | R → C in strain: Nonneuroinvasive mutant HF10. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32347.1 X03839 Genomic DNA Translation: CAA27452.1 DQ889502 Genomic DNA Translation: ABI63473.1 FJ593289 Genomic DNA Translation: ACM62233.1 |
PIRi | A03737, WMBE11 |
RefSeqi | YP_009137085.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 24271464 |
KEGGi | vg:24271464 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32347.1 X03839 Genomic DNA Translation: CAA27452.1 DQ889502 Genomic DNA Translation: ABI63473.1 FJ593289 Genomic DNA Translation: ACM62233.1 |
PIRi | A03737, WMBE11 |
RefSeqi | YP_009137085.1, NC_001806.2 |
3D structure databases
SASBDBi | P04289 |
SMRi | P04289 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P04289, 1 interactor |
MINTi | P04289 |
PTM databases
iPTMneti | P04289 |
Proteomic databases
PRIDEi | P04289 |
Genome annotation databases
GeneIDi | 24271464 |
KEGGi | vg:24271464 |
Family and domain databases
HAMAPi | MF_04040, HSV_CEP3_alphahv, 1 hit |
InterProi | View protein in InterPro IPR024351, Tegument_UL11_Herpesvir IPR016395, UL11_simplexvir-type |
Pfami | View protein in Pfam PF11094, UL11, 1 hit |
PIRSFi | PIRSF003496, Myristoylat_tegument_UL11, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEP3_HHV11 | |
Accessioni | P04289Primary (citable) accession number: P04289 Secondary accession number(s): B9VQD8, Q09IC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families