gM - Envelope glycoprotein M - Human herpesvirus 1 (strain 17) (HHV-1)

Functionⁱ

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.UniRule annotation1 Publication

Protein family/group databases

TCDBⁱ	9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

TCDBⁱ

9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Envelope glycoprotein MUniRule annotation Short name: gMUniRule annotation
Gene namesⁱ	Name:gMUniRule annotation ORF Names:UL10
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome UP000180652 Componentⁱ: Genome

Subcellular locationⁱ

Virion membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
; Multi-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
host trans-Golgi network
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "Subcellular trafficking and functional relationship of the HSV-1 glycoproteins N and M."
  Striebinger H., Funk C., Raschbichler V., Bailer S.M.
  Viruses 8:83-83(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH GN, SUBCELLULAR LOCATION, FUNCTION.
Host endosome membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
; Multi-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
Host nucleus inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."
  Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.
  J. Virol. 81:800-812(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04035

Note:

During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.UniRule annotation1 Publication

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 32	IntravirionUniRule annotationAdd BLAST	32
Transmembraneⁱ	33 – 53	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	54 – 90	Virion surfaceUniRule annotationAdd BLAST	37
Transmembraneⁱ	91 – 111	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	112 – 137	IntravirionUniRule annotationAdd BLAST	26
Transmembraneⁱ	138 – 158	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	159 – 163	Virion surfaceUniRule annotation	5
Transmembraneⁱ	164 – 184	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	185 – 216	IntravirionUniRule annotationAdd BLAST	32
Transmembraneⁱ	217 – 237	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	238 – 250	Virion surfaceUniRule annotationAdd BLAST	13
Transmembraneⁱ	251 – 271	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	272 – 280	IntravirionUniRule annotation	9
Transmembraneⁱ	281 – 301	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	302 – 318	Virion surfaceUniRule annotationAdd BLAST	17
Transmembraneⁱ	319 – 339	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	340 – 473	IntravirionUniRule annotationAdd BLAST	134

GO - Cellular componentⁱ

host cell endosome membrane Source: UniProtKB-SubCell
host cell Golgi membrane Source: UniProtKB-UniRule
host cell nuclear inner membrane Source: UniProtKB-SubCell
host cell perinuclear region of cytoplasm
Source: CAFA
Inferred from direct assayⁱ
- 25609143
integral component of membrane Source: UniProtKB-UniRule
viral envelope Source: UniProtKB-UniRule
virion membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000115775	1 – 473	Envelope glycoprotein MAdd BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	59	Interchain (with gN)UniRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEⁱ	P04288

PRIDEⁱ

P04288

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridⁱ	971418, 1 interactor

BioGridⁱ

971418, 1 interactor

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the herpesviridae glycoprotein M family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000D2

OrthoDBⁱ

VOG090000D2

Family and domain databases

HAMAPⁱ	MF_04035 HSV_GM, 1 hit
InterProⁱ	View protein in InterPro IPR000785 Herpes_glycop_M
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01528 Herpes_glycop, 1 hit
PRINTSⁱ	PR00333 HSVINTEGRLMP

Sequenceⁱ

Sequence statusⁱ: Complete.

P04288-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA 
        60         70         80         90        100
SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV 
       110        120        130        140        150
LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL 
       160        170        180        190        200
QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL 
       210        220        230        240        250
MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP 
       260        270        280        290        300
GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC 
       310        320        330        340        350
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR 
       360        370        380        390        400
HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE 
       410        420        430        440        450
DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI 
       460        470 
YDTVGGYDPE PAEDPVYSTV RRW

Length:473

Mass (Da):51,393

Last modified:March 20, 1987 - v1

Checksum:ⁱE08FD792409A81E6

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	77	R → C in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	105	V → A in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	279	V → M in STRAIN: 17 syn+.	1
Natural variantⁱ	448	D → E in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	462	A → T in strain: Nonneuroinvasive mutant HF10.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32346.1 X03839 Genomic DNA Translation: CAA27451.1 DQ889502 Genomic DNA Translation: ABI63472.1 FJ593289 Genomic DNA Translation: ACM62232.1 M19120 Genomic DNA Translation: AAA45821.2
PIRⁱ	A03736 WMBE51
NCBI Reference Sequences More...RefSeqⁱ	YP_009137084.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	2703379
KEGGⁱ	vg:2703379

Protein	Similar proteins		Species	Score	Length	Source
P04288	Envelope glycoprotein M		HHV1		473	UniRef100_P04288

Protein	Similar proteins		Species	Score	Length	Source
P04288	Envelope glycoprotein M		HHV1		473	UniRef90_P04288
Envelope glycoprotein M		HHV11		455
Envelope glycoprotein M		Human alphaherpesvirus 1 strain RH2		473
Envelope glycoprotein M		HHV1		473
Envelope glycoprotein M		HHV1		455
+58

Protein	Similar proteins		Species	Score	Length	Source
P04288	Envelope glycoprotein M		HHV1		473	UniRef50_P04288
Envelope glycoprotein M		Human alphaherpesvirus 1 strain RH2		473
Envelope glycoprotein M		HHV11		455
Envelope glycoprotein M		HHV2		491
Envelope glycoprotein M		CHV16		455
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32346.1 X03839 Genomic DNA Translation: CAA27451.1 DQ889502 Genomic DNA Translation: ABI63472.1 FJ593289 Genomic DNA Translation: ACM62232.1 M19120 Genomic DNA Translation: AAA45821.2
PIRⁱ	A03736 WMBE51
RefSeqⁱ	YP_009137084.1, NC_001806.2

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	971418, 1 interactor

BioGridⁱ

971418, 1 interactor

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

Protein family/group databases

TCDBⁱ	9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

TCDBⁱ

9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

Proteomic databases

PRIDEⁱ	P04288

PRIDEⁱ

P04288

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2703379
KEGGⁱ	vg:2703379

Phylogenomic databases

OrthoDBⁱ	VOG090000D2

OrthoDBⁱ

VOG090000D2

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P04288

PROⁱ

PR:P04288

Family and domain databases

HAMAPⁱ	MF_04035 HSV_GM, 1 hit
InterProⁱ	View protein in InterPro IPR000785 Herpes_glycop_M
Pfamⁱ	View protein in Pfam PF01528 Herpes_glycop, 1 hit
PRINTSⁱ	PR00333 HSVINTEGRLMP
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GM_HHV11
Accessionⁱ	P04288Primary (citable) accession number: P04288 Secondary accession number(s): B9VQD7, Q09IC3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	March 20, 1987
	Last modified:	October 10, 2018
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04288 (GM_HHV11)

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Envelope glycoprotein M

gM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ