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Protein

Envelope glycoprotein M

Gene

gM

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.UniRule annotation1 Publication

Protein family/group databases

TCDBi9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein MUniRule annotation
Short name:
gMUniRule annotation
Gene namesi
Name:gMUniRule annotation
ORF Names:UL10
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32IntravirionUniRule annotationAdd BLAST32
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Topological domaini54 – 90Virion surfaceUniRule annotationAdd BLAST37
Transmembranei91 – 111HelicalUniRule annotationAdd BLAST21
Topological domaini112 – 137IntravirionUniRule annotationAdd BLAST26
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Topological domaini159 – 163Virion surfaceUniRule annotation5
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Topological domaini185 – 216IntravirionUniRule annotationAdd BLAST32
Transmembranei217 – 237HelicalUniRule annotationAdd BLAST21
Topological domaini238 – 250Virion surfaceUniRule annotationAdd BLAST13
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Topological domaini272 – 280IntravirionUniRule annotation9
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Topological domaini302 – 318Virion surfaceUniRule annotationAdd BLAST17
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Topological domaini340 – 473IntravirionUniRule annotationAdd BLAST134

GO - Cellular componenti

Keywords - Cellular componenti

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157751 – 473Envelope glycoprotein MAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59Interchain (with gN)UniRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP04288

Interactioni

Subunit structurei

Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi971418, 1 interactor

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein M family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000D2

Family and domain databases

HAMAPiMF_04035 HSV_GM, 1 hit
InterProiView protein in InterPro
IPR000785 Herpes_glycop_M
PfamiView protein in Pfam
PF01528 Herpes_glycop, 1 hit
PRINTSiPR00333 HSVINTEGRLMP

Sequencei

Sequence statusi: Complete.

P04288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA
60 70 80 90 100
SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV
110 120 130 140 150
LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL
160 170 180 190 200
QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL
210 220 230 240 250
MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP
260 270 280 290 300
GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC
310 320 330 340 350
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR
360 370 380 390 400
HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE
410 420 430 440 450
DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI
460 470
YDTVGGYDPE PAEDPVYSTV RRW
Length:473
Mass (Da):51,393
Last modified:March 20, 1987 - v1
Checksum:iE08FD792409A81E6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77R → C in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti105V → A in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti279V → M in STRAIN: 17 syn+. 1
Natural varianti448D → E in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti462A → T in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32346.1
X03839 Genomic DNA Translation: CAA27451.1
DQ889502 Genomic DNA Translation: ABI63472.1
FJ593289 Genomic DNA Translation: ACM62232.1
M19120 Genomic DNA Translation: AAA45821.2
PIRiA03736 WMBE51
RefSeqiYP_009137084.1, NC_001806.2

Genome annotation databases

GeneIDi2703379
KEGGivg:2703379

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32346.1
X03839 Genomic DNA Translation: CAA27451.1
DQ889502 Genomic DNA Translation: ABI63472.1
FJ593289 Genomic DNA Translation: ACM62232.1
M19120 Genomic DNA Translation: AAA45821.2
PIRiA03736 WMBE51
RefSeqiYP_009137084.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971418, 1 interactor

Chemistry databases

ChEMBLiCHEMBL2364696

Protein family/group databases

TCDBi9.B.212.1.1 the human simplex virus-1 gm protein (hsv-gm) family

Proteomic databases

PRIDEiP04288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703379
KEGGivg:2703379

Phylogenomic databases

OrthoDBiVOG090000D2

Miscellaneous databases

PROiPR:P04288

Family and domain databases

HAMAPiMF_04035 HSV_GM, 1 hit
InterProiView protein in InterPro
IPR000785 Herpes_glycop_M
PfamiView protein in Pfam
PF01528 Herpes_glycop, 1 hit
PRINTSiPR00333 HSVINTEGRLMP
ProtoNetiSearch...

Entry informationi

Entry nameiGM_HHV11
AccessioniPrimary (citable) accession number: P04288
Secondary accession number(s): B9VQD7, Q09IC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: October 10, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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