UniProtKB - P04288 (GM_HHV11)
Protein
Envelope glycoprotein M
Gene
gM
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.UniRule annotation1 Publication
Protein family/group databases
TCDBi | 9.B.212.1.1, the human simplex virus-1 gm protein (hsv-gm) family |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope glycoprotein MUniRule annotationShort name: gMUniRule annotation |
Gene namesi | Name:gMUniRule annotation ORF Names:UL10 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- host trans-Golgi network UniRule annotation1 Publication
- Host endosome membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Host nucleus inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation Note: During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.UniRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | IntravirionUniRule annotationAdd BLAST | 32 | |
Transmembranei | 33 – 53 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 54 – 90 | Virion surfaceUniRule annotationAdd BLAST | 37 | |
Transmembranei | 91 – 111 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 112 – 137 | IntravirionUniRule annotationAdd BLAST | 26 | |
Transmembranei | 138 – 158 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 159 – 163 | Virion surfaceUniRule annotation | 5 | |
Transmembranei | 164 – 184 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 185 – 216 | IntravirionUniRule annotationAdd BLAST | 32 | |
Transmembranei | 217 – 237 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 238 – 250 | Virion surfaceUniRule annotationAdd BLAST | 13 | |
Transmembranei | 251 – 271 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 272 – 280 | IntravirionUniRule annotation | 9 | |
Transmembranei | 281 – 301 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 302 – 318 | Virion surfaceUniRule annotationAdd BLAST | 17 | |
Transmembranei | 319 – 339 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 340 – 473 | IntravirionUniRule annotationAdd BLAST | 134 |
GO - Cellular componenti
- host cell endosome membrane Source: UniProtKB-SubCell
- host cell Golgi membrane Source: UniProtKB-UniRule
- host cell nuclear inner membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: CAFA
- integral component of membrane Source: UniProtKB-UniRule
- viral envelope Source: UniProtKB-UniRule
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115775 | 1 – 473 | Envelope glycoprotein MAdd BLAST | 473 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 59 | Interchain (with gN)UniRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P04288 |
Interactioni
Subunit structurei
Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 971418, 1 interactor |
Family & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae glycoprotein M family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
HAMAPi | MF_04035, HSV_GM, 1 hit |
InterProi | View protein in InterPro IPR000785, Herpes_glycop_M |
Pfami | View protein in Pfam PF01528, Herpes_glycop, 1 hit |
PRINTSi | PR00333, HSVINTEGRLMP |
i Sequence
Sequence statusi: Complete.
P04288-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA
60 70 80 90 100
SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV
110 120 130 140 150
LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL
160 170 180 190 200
QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL
210 220 230 240 250
MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP
260 270 280 290 300
GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC
310 320 330 340 350
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR
360 370 380 390 400
HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE
410 420 430 440 450
DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI
460 470
YDTVGGYDPE PAEDPVYSTV RRW
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 77 | R → C in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 105 | V → A in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 279 | V → M in STRAIN: 17 syn+. | 1 | |
Natural varianti | 448 | D → E in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 462 | A → T in strain: Nonneuroinvasive mutant HF10. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32346.1 X03839 Genomic DNA Translation: CAA27451.1 DQ889502 Genomic DNA Translation: ABI63472.1 FJ593289 Genomic DNA Translation: ACM62232.1 M19120 Genomic DNA Translation: AAA45821.2 |
PIRi | A03736, WMBE51 |
RefSeqi | YP_009137084.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703379 |
KEGGi | vg:2703379 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32346.1 X03839 Genomic DNA Translation: CAA27451.1 DQ889502 Genomic DNA Translation: ABI63472.1 FJ593289 Genomic DNA Translation: ACM62232.1 M19120 Genomic DNA Translation: AAA45821.2 |
PIRi | A03736, WMBE51 |
RefSeqi | YP_009137084.1, NC_001806.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 971418, 1 interactor |
Chemistry databases
ChEMBLi | CHEMBL2364696 |
DrugCentrali | P04288 |
Protein family/group databases
TCDBi | 9.B.212.1.1, the human simplex virus-1 gm protein (hsv-gm) family |
Proteomic databases
PRIDEi | P04288 |
Genome annotation databases
GeneIDi | 2703379 |
KEGGi | vg:2703379 |
Miscellaneous databases
PROi | PR:P04288 |
Family and domain databases
HAMAPi | MF_04035, HSV_GM, 1 hit |
InterProi | View protein in InterPro IPR000785, Herpes_glycop_M |
Pfami | View protein in Pfam PF01528, Herpes_glycop, 1 hit |
PRINTSi | PR00333, HSVINTEGRLMP |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GM_HHV11 | |
Accessioni | P04288Primary (citable) accession number: P04288 Secondary accession number(s): B9VQD7, Q09IC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | March 20, 1987 | |
Last modified: | December 2, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families