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Protein

Basic salivary proline-rich protein 1

Gene

PRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Basic salivary proline-rich protein 1
Short name:
Salivary proline-rich protein
Cleaved into the following 3 chains:
Gene namesi
Name:PRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000251655.6
HGNCiHGNC:9337 PRB1
MIMi180989 gene
neXtProtiNX_P04280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5542
PharmGKBiPA33699

Polymorphism and mutation databases

BioMutaiPRB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000002212917 – 392Basic salivary proline-rich protein 1Add BLAST376
ChainiPRO_000037244117 – 91Proline-rich peptide II-2Add BLAST75
ChainiPRO_0000022130275 – 392Basic peptide IB-6Add BLAST118
ChainiPRO_0000022131337 – 392Peptide P-HAdd BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Pyrrolidone carboxylic acid2 Publications1
Modified residuei40Phosphoserine; alternate1 Publication1
Glycosylationi40O-linked (Hex) serine; alternate1 Publication1
Glycosylationi87O-linked (HexNAc...) serine1 Publication1
Modified residuei92Phosphoserine1 Publication1
Modified residuei150Phosphoserine; alternate1 Publication1
Glycosylationi150O-linked (Hex) serine; alternate1 Publication1
Glycosylationi330O-linked (HexNAc...) serine1

Post-translational modificationi

O-glycosylated. O-glycosylation on Ser-87 is prevalent in head and neck cancer patients. O-Glycosylation on Ser-330 has a 5 times prevalence in head and neck cancers.1 Publication
Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P3 position is mostly lysine. The endoprotease may be of microbial origin.1 Publication
Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Besides on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP04280
PeptideAtlasiP04280
PRIDEiP04280
ProteomicsDBi51701
TopDownProteomicsiP04280

PTM databases

iPTMnetiP04280
PhosphoSitePlusiP04280

Expressioni

Gene expression databases

BgeeiENSG00000251655 Expressed in 25 organ(s), highest expression level in lung
CleanExiHS_PRB1

Interactioni

Protein-protein interaction databases

BioGridi111534, 4 interactors
STRINGi9606.ENSP00000420826

Structurei

3D structure databases

ProteinModelPortaliP04280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 721Add BLAST20
Repeati73 – 922Add BLAST20
Repeati93 – 1123Add BLAST20
Repeati114 – 1334Add BLAST20
Repeati134 – 1535Add BLAST20
Repeati154 – 1736Add BLAST20
Repeati175 – 1947Add BLAST20
Repeati195 – 2148Add BLAST20
Repeati215 – 2349Add BLAST20
Repeati236 – 25510Add BLAST20
Repeati256 – 27511Add BLAST20
Repeati276 – 29512Add BLAST20
Repeati297 – 31613Add BLAST20
Repeati317 – 33614Add BLAST20
Repeati338 – 35715Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 35715 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]-[NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]-[PSR]Add BLAST305

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoidiP04280
KOiK13911

Family and domain databases

InterProiView protein in InterPro
IPR026086 Pro-rich
PANTHERiPTHR23203 PTHR23203, 6 hits
PfamiView protein in Pfam
PF15240 Pro-rich, 3 hits
SMARTiView protein in SMART
SM01412 Pro-rich, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P04280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP
60 70 80 90 100
PPPPGKPQGP PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP
110 120 130 140 150
PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS
160 170 180 190 200
PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ
210 220 230 240 250
GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP QGPPQQGGNR
260 270 280 290 300
PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK
310 320 330 340 350
PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARSPPG KPQGPPQQEG
360 370 380 390
NNPQGPPPPA GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ
Length:392
Mass (Da):38,562
Last modified:March 28, 2018 - v3
Checksum:i31F4D7B21F335CAF
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1R1G3V1R1_HUMAN
Basic salivary proline-rich protein...
PRB1 hCG_26567
178Annotation score:
A0A0D9SET1A0A0D9SET1_HUMAN
Basic salivary proline-rich protein...
PRB1 hCG_26567
151Annotation score:
G3V1M9G3V1M9_HUMAN
Basic salivary proline-rich protein...
PRB1
330Annotation score:
A0A0G2JRP6A0A0G2JRP6_HUMAN
Basic salivary proline-rich protein...
PRB1
198Annotation score:
A0A0G2JQ42A0A0G2JQ42_HUMAN
Basic salivary proline-rich protein...
PRB1
178Annotation score:
A0A0G2JM13A0A0G2JM13_HUMAN
Basic salivary proline-rich protein...
PRB1
416Annotation score:
A0A0G2JMN8A0A0G2JMN8_HUMAN
Basic salivary proline-rich protein...
PRB1
333Annotation score:
A0A0G2JR74A0A0G2JR74_HUMAN
Basic salivary proline-rich protein...
PRB1
580Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 33NLNED…PSLIA → SCVGFYSVFLFSLCPL in AAA36502 (PubMed:6089212).CuratedAdd BLAST16
Sequence conflicti40S → P in AAA36502 (PubMed:6089212).Curated1
Sequence conflicti85 – 86DK → GKR in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti128K → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti216 – 217PG → R in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti271R → Q in AAB27288 (PubMed:8317492).Curated1
Sequence conflicti274Q → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti278G → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti307Q → T in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti326A → P in AAB27289 (PubMed:8317492).Curated1
Sequence conflicti330S → C in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti385 – 386GR → DK in AAA36503 (PubMed:6089212).Curated2

Polymorphismi

The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There are allele M (medium) and allele S (short) which contain 12 and 9 approximate tandem repeats repectively.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01969393 – 153Missing in allele M. Add BLAST61
Natural variantiVAR_005562106 – 319Missing 1 PublicationAdd BLAST214
Natural variantiVAR_005561106 – 299Missing . Add BLAST194
Natural variantiVAR_019694134 – 255Missing in allele S. Add BLAST122
Natural variantiVAR_080188337S → A5 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03204 mRNA Translation: AAA60185.1
K03205 mRNA Translation: AAA60186.1
K03206 mRNA Translation: AAA60187.1
S52986 Genomic DNA Translation: AAA13341.2
M97220 Genomic DNA Translation: AAB05816.1
K02575 Genomic DNA Translation: AAA36502.1
K02576 Genomic DNA Translation: AAA36503.1
X07516 Genomic DNA Translation: CAA30394.2
X07517 Genomic DNA Translation: CAA30395.2
S62928 Genomic DNA Translation: AAB27288.2
S62941 Genomic DNA Translation: AAB27289.1
AC010176 Genomic DNA No translation available.
AC078950 Genomic DNA No translation available.
AC126171 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96233.1
PIRiB40750 PIHUB6
C38355
D40750
RefSeqiNP_005030.2, NM_005039.3
NP_955385.1, NM_199353.2
NP_955386.1, NM_199354.2
UniGeneiHs.631726

Genome annotation databases

GeneIDi5542
KEGGihsa:5542

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03204 mRNA Translation: AAA60185.1
K03205 mRNA Translation: AAA60186.1
K03206 mRNA Translation: AAA60187.1
S52986 Genomic DNA Translation: AAA13341.2
M97220 Genomic DNA Translation: AAB05816.1
K02575 Genomic DNA Translation: AAA36502.1
K02576 Genomic DNA Translation: AAA36503.1
X07516 Genomic DNA Translation: CAA30394.2
X07517 Genomic DNA Translation: CAA30395.2
S62928 Genomic DNA Translation: AAB27288.2
S62941 Genomic DNA Translation: AAB27289.1
AC010176 Genomic DNA No translation available.
AC078950 Genomic DNA No translation available.
AC126171 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96233.1
PIRiB40750 PIHUB6
C38355
D40750
RefSeqiNP_005030.2, NM_005039.3
NP_955385.1, NM_199353.2
NP_955386.1, NM_199354.2
UniGeneiHs.631726

3D structure databases

ProteinModelPortaliP04280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111534, 4 interactors
STRINGi9606.ENSP00000420826

PTM databases

iPTMnetiP04280
PhosphoSitePlusiP04280

Polymorphism and mutation databases

BioMutaiPRB1

Proteomic databases

PaxDbiP04280
PeptideAtlasiP04280
PRIDEiP04280
ProteomicsDBi51701
TopDownProteomicsiP04280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5542
KEGGihsa:5542

Organism-specific databases

CTDi5542
DisGeNETi5542
EuPathDBiHostDB:ENSG00000251655.6
GeneCardsiPRB1
HGNCiHGNC:9337 PRB1
MIMi180989 gene
neXtProtiNX_P04280
PharmGKBiPA33699
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP04280
KOiK13911

Miscellaneous databases

GeneWikiiPRB1
GenomeRNAii5542
PROiPR:P04280
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000251655 Expressed in 25 organ(s), highest expression level in lung
CleanExiHS_PRB1

Family and domain databases

InterProiView protein in InterPro
IPR026086 Pro-rich
PANTHERiPTHR23203 PTHR23203, 6 hits
PfamiView protein in Pfam
PF15240 Pro-rich, 3 hits
SMARTiView protein in SMART
SM01412 Pro-rich, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRP1_HUMAN
AccessioniPrimary (citable) accession number: P04280
Secondary accession number(s): G5E9X6
, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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