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Protein

Basic salivary proline-rich protein 1

Gene

PRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Basic salivary proline-rich protein 1
Short name:
Salivary proline-rich protein
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000251655.6

Human Gene Nomenclature Database

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HGNCi
HGNC:9337 PRB1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
180989 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04280

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5542

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33699

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRB1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002212917 – 392Basic salivary proline-rich protein 1Add BLAST376
ChainiPRO_000037244117 – 91Proline-rich peptide II-2Add BLAST75
ChainiPRO_0000022130275 – 392Basic peptide IB-6Add BLAST118
ChainiPRO_0000022131337 – 392Peptide P-HAdd BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17Pyrrolidone carboxylic acid2 Publications1
Modified residuei40Phosphoserine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40O-linked (Hex) serine; alternate1 Publication1
Glycosylationi87O-linked (HexNAc...) serine1 Publication1
Modified residuei92Phosphoserine1 Publication1
Modified residuei150Phosphoserine; alternate1 Publication1
Glycosylationi150O-linked (Hex) serine; alternate1 Publication1
Glycosylationi330O-linked (HexNAc...) serine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated. O-glycosylation on Ser-87 is prevalent in head and neck cancer patients. O-Glycosylation on Ser-330 has a 5 times prevalence in head and neck cancers.1 Publication
Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P3 position is mostly lysine. The endoprotease may be of microbial origin.1 Publication
Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Besides on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P04280

PeptideAtlas

More...
PeptideAtlasi
P04280

PRoteomics IDEntifications database

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PRIDEi
P04280

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51701

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P04280

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04280

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04280

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000251655 Expressed in 25 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRB1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111534, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420826

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04280

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 721Add BLAST20
Repeati73 – 922Add BLAST20
Repeati93 – 1123Add BLAST20
Repeati114 – 1334Add BLAST20
Repeati134 – 1535Add BLAST20
Repeati154 – 1736Add BLAST20
Repeati175 – 1947Add BLAST20
Repeati195 – 2148Add BLAST20
Repeati215 – 2349Add BLAST20
Repeati236 – 25510Add BLAST20
Repeati256 – 27511Add BLAST20
Repeati276 – 29512Add BLAST20
Repeati297 – 31613Add BLAST20
Repeati317 – 33614Add BLAST20
Repeati338 – 35715Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 35715 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]-[NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]-[PSR]Add BLAST305

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04280

KEGG Orthology (KO)

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KOi
K13911

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026086 Pro-rich

The PANTHER Classification System

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PANTHERi
PTHR23203 PTHR23203, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15240 Pro-rich, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01412 Pro-rich, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P04280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP
60 70 80 90 100
PPPPGKPQGP PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP
110 120 130 140 150
PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS
160 170 180 190 200
PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ
210 220 230 240 250
GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP QGPPQQGGNR
260 270 280 290 300
PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK
310 320 330 340 350
PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARSPPG KPQGPPQQEG
360 370 380 390
NNPQGPPPPA GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ
Length:392
Mass (Da):38,562
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31F4D7B21F335CAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1R1G3V1R1_HUMAN
Basic salivary proline-rich protein...
PRB1 hCG_26567
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SET1A0A0D9SET1_HUMAN
Basic salivary proline-rich protein...
PRB1 hCG_26567
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1M9G3V1M9_HUMAN
Basic salivary proline-rich protein...
PRB1
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRP6A0A0G2JRP6_HUMAN
Basic salivary proline-rich protein...
PRB1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JR74A0A0G2JR74_HUMAN
Basic salivary proline-rich protein...
PRB1
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM13A0A0G2JM13_HUMAN
Basic salivary proline-rich protein...
PRB1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQ42A0A0G2JQ42_HUMAN
Basic salivary proline-rich protein...
PRB1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMN8A0A0G2JMN8_HUMAN
Basic salivary proline-rich protein...
PRB1
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18 – 33NLNED…PSLIA → SCVGFYSVFLFSLCPL in AAA36502 (PubMed:6089212).CuratedAdd BLAST16
Sequence conflicti40S → P in AAA36502 (PubMed:6089212).Curated1
Sequence conflicti85 – 86DK → GKR in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti128K → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti216 – 217PG → R in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti271R → Q in AAB27288 (PubMed:8317492).Curated1
Sequence conflicti274Q → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti278G → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti307Q → T in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti326A → P in AAB27289 (PubMed:8317492).Curated1
Sequence conflicti330S → C in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti385 – 386GR → DK in AAA36503 (PubMed:6089212).Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There are allele M (medium) and allele S (short) which contain 12 and 9 approximate tandem repeats repectively.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01969393 – 153Missing in allele M. Add BLAST61
Natural variantiVAR_005562106 – 319Missing 1 PublicationAdd BLAST214
Natural variantiVAR_005561106 – 299Missing . Add BLAST194
Natural variantiVAR_019694134 – 255Missing in allele S. Add BLAST122
Natural variantiVAR_080188337S → A5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K03204 mRNA Translation: AAA60185.1
K03205 mRNA Translation: AAA60186.1
K03206 mRNA Translation: AAA60187.1
S52986 Genomic DNA Translation: AAA13341.2
M97220 Genomic DNA Translation: AAB05816.1
K02575 Genomic DNA Translation: AAA36502.1
K02576 Genomic DNA Translation: AAA36503.1
X07516 Genomic DNA Translation: CAA30394.2
X07517 Genomic DNA Translation: CAA30395.2
S62928 Genomic DNA Translation: AAB27288.2
S62941 Genomic DNA Translation: AAB27289.1
AC010176 Genomic DNA No translation available.
AC078950 Genomic DNA No translation available.
AC126171 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96233.1

Protein sequence database of the Protein Information Resource

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PIRi
B40750 PIHUB6
C38355
D40750

NCBI Reference Sequences

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RefSeqi
NP_005030.2, NM_005039.3
NP_955385.1, NM_199353.2
NP_955386.1, NM_199354.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631726

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5542

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03204 mRNA Translation: AAA60185.1
K03205 mRNA Translation: AAA60186.1
K03206 mRNA Translation: AAA60187.1
S52986 Genomic DNA Translation: AAA13341.2
M97220 Genomic DNA Translation: AAB05816.1
K02575 Genomic DNA Translation: AAA36502.1
K02576 Genomic DNA Translation: AAA36503.1
X07516 Genomic DNA Translation: CAA30394.2
X07517 Genomic DNA Translation: CAA30395.2
S62928 Genomic DNA Translation: AAB27288.2
S62941 Genomic DNA Translation: AAB27289.1
AC010176 Genomic DNA No translation available.
AC078950 Genomic DNA No translation available.
AC126171 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96233.1
PIRiB40750 PIHUB6
C38355
D40750
RefSeqiNP_005030.2, NM_005039.3
NP_955385.1, NM_199353.2
NP_955386.1, NM_199354.2
UniGeneiHs.631726

3D structure databases

ProteinModelPortaliP04280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111534, 4 interactors
STRINGi9606.ENSP00000420826

PTM databases

iPTMnetiP04280
PhosphoSitePlusiP04280

Polymorphism and mutation databases

BioMutaiPRB1

Proteomic databases

PaxDbiP04280
PeptideAtlasiP04280
PRIDEiP04280
ProteomicsDBi51701
TopDownProteomicsiP04280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5542
KEGGihsa:5542

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5542
DisGeNETi5542
EuPathDBiHostDB:ENSG00000251655.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PRB1
HGNCiHGNC:9337 PRB1
MIMi180989 gene
neXtProtiNX_P04280
PharmGKBiPA33699

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

InParanoidiP04280
KOiK13911

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5542

Protein Ontology

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PROi
PR:P04280

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000251655 Expressed in 25 organ(s), highest expression level in lung
CleanExiHS_PRB1

Family and domain databases

InterProiView protein in InterPro
IPR026086 Pro-rich
PANTHERiPTHR23203 PTHR23203, 6 hits
PfamiView protein in Pfam
PF15240 Pro-rich, 2 hits
SMARTiView protein in SMART
SM01412 Pro-rich, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04280
Secondary accession number(s): G5E9X6
, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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