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Protein

Semenogelin-1

Gene

SEMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.1 Publication
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157 Antimicrobial peptides
R-HSA-977225 Amyloid fiber formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semenogelin-1
Alternative name(s):
Cancer/testis antigen 103
Semenogelin I
Short name:
SGI
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEMG1
Synonyms:SEMG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124233.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10742 SEMG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182140 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi239C → G: Abrogates binding to EPPIN and do not inhibit spem motility. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6406

Open Targets

More...
OpenTargetsi
ENSG00000124233

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35664

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEMG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003235124 – 462Semenogelin-1Add BLAST439
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003235268 – 159Alpha-inhibin-92Add BLAST92
PeptideiPRO_0000032353108 – 159Seminal basic proteinAdd BLAST52
PeptideiPRO_0000032354108 – 138Alpha-inhibin-31Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi239Interchain

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Transglutaminase substrate.
Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04279

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04279

PeptideAtlas

More...
PeptideAtlasi
P04279

PRoteomics IDEntifications database

More...
PRIDEi
P04279

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51699
51700 [P04279-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04279

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P04279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seminal vesicle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124233 Expressed in 34 organ(s), highest expression level in seminal vesicle

CleanEx database of gene expression profiles

More...
CleanExi
HS_SEMG1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04279 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042476
HPA064892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112306, 32 interactors

Protein interaction database and analysis system

More...
IntActi
P04279, 7 interactors

Molecular INTeraction database

More...
MINTi
P04279

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P04279

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati70 – 1293-1Add BLAST60
Repeati141 – 2002-1Add BLAST60
Repeati201 – 2602-2Add BLAST60
Repeati381 – 4393-2Add BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 439Repeat-rich regionBy similarityAdd BLAST370
Regioni164 – 283Interaction with EPPIN1 PublicationAdd BLAST120
Regioni261 – 3802 X 60 AA tandem repeats, type 1Add BLAST120

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semenogelin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KG9B Eukaryota
ENOG4110SI0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162560

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054194

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04279

Identification of Orthologs from Complete Genome Data

More...
OMAi
HGRKANK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03E6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04279

TreeFam database of animal gene trees

More...
TreeFami
TF342360

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008836 Semenogelin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05474 Semenogelin, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P04279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP HGQKGQHYSG
60 70 80 90 100
QKGKQQTESK GSFSIQYTYH VDANDHDQSR KSQQYDLNAL HKTTKSQRHL
110 120 130 140 150
GGSQQLLHNK QEGRDHDKSK GHFHRVVIHH KGGKAHRGTQ NPSQDQGNSP
160 170 180 190 200
SGKGISSQYS NTEERLWVHG LSKEQTSVSG AQKGRKQGGS QSSYVLQTEE
210 220 230 240 250
LVANKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP AHQDKLQHGS
260 270 280 290 300
KDIFSTQDEL LVYNKNQHQT KNLNQDQQHG RKANKISYQS SSTEERRLHY
310 320 330 340 350
GENGVQKDVS QSSIYSQTEE KAQGKSQKQI TIPSQEQEHS QKANKISYQS
360 370 380 390 400
SSTEERRLHY GENGVQKDVS QRSIYSQTEK LVAGKSQIQA PNPKQEPWHG
410 420 430 440 450
ENAKGESGQS TNREQDLLSH EQKGRHQHGS HGGLDIVIIE QEDDSDRHLA
460
QHLNNDRNPL FT
Length:462
Mass (Da):52,131
Last modified:January 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i760F48EFCF2FA702
GO
Isoform 2 (identifier: P04279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-371: Missing.

Note: No experimental confirmation available.
Show »
Length:402
Mass (Da):45,322
Checksum:i4D7F264E7C7FC15D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100L → Q in AAP82463 (PubMed:14629036).Curated1
Sequence conflicti235 – 237QTS → LRT in AAO20112 (PubMed:14562960).Curated3
Sequence conflicti235 – 237QTS → LRT in AAO20113 (PubMed:14562960).Curated3
Sequence conflicti321K → L AA sequence (PubMed:2757795).Curated1
Sequence conflicti423K → N in CAA87636 (PubMed:1517240).Curated1
Sequence conflicti423K → N in AAA18168 (PubMed:1517240).Curated1
Sequence conflicti457R → Q (Ref. 4) Curated1
Sequence conflicti457R → Q (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05365058E → G. Corresponds to variant dbSNP:rs11559137Ensembl.1
Natural variantiVAR_00561079S → T Less common genetic variant. 2 PublicationsCorresponds to variant dbSNP:rs2301366Ensembl.1
Natural variantiVAR_053651108H → R. Corresponds to variant dbSNP:rs2233884Ensembl.1
Natural variantiVAR_022679372R → L1 PublicationCorresponds to variant dbSNP:rs2233887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004385312 – 371Missing in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04440 mRNA Translation: AAB59506.1
Z47556 Genomic DNA Translation: CAA87636.1
M81650 Genomic DNA Translation: AAA18168.1
AY256465 Genomic DNA Translation: AAP82462.1
AY256466 Genomic DNA Translation: AAP82463.1
AY256467 Genomic DNA Translation: AAP82464.1
AY256468 Genomic DNA Translation: AAP82465.1
AY256469 Genomic DNA Translation: AAP82466.1
BT007177 mRNA Translation: AAP35841.1
AL049767 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75871.1
BC007096 mRNA Translation: AAH07096.1
BC055416 mRNA Translation: AAH55416.1
AY174423 Genomic DNA Translation: AAO20112.1
AY174424 Genomic DNA Translation: AAO20113.1
AY174437 Genomic DNA Translation: AAO20126.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13345.1 [P04279-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
B43412 WTHUB

NCBI Reference Sequences

More...
RefSeqi
NP_002998.1, NM_003007.4 [P04279-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1968

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372781; ENSP00000361867; ENSG00000124233 [P04279-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6406

UCSC genome browser

More...
UCSCi
uc002xni.3 human [P04279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04440 mRNA Translation: AAB59506.1
Z47556 Genomic DNA Translation: CAA87636.1
M81650 Genomic DNA Translation: AAA18168.1
AY256465 Genomic DNA Translation: AAP82462.1
AY256466 Genomic DNA Translation: AAP82463.1
AY256467 Genomic DNA Translation: AAP82464.1
AY256468 Genomic DNA Translation: AAP82465.1
AY256469 Genomic DNA Translation: AAP82466.1
BT007177 mRNA Translation: AAP35841.1
AL049767 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75871.1
BC007096 mRNA Translation: AAH07096.1
BC055416 mRNA Translation: AAH55416.1
AY174423 Genomic DNA Translation: AAO20112.1
AY174424 Genomic DNA Translation: AAO20113.1
AY174437 Genomic DNA Translation: AAO20126.1
CCDSiCCDS13345.1 [P04279-1]
PIRiB43412 WTHUB
RefSeqiNP_002998.1, NM_003007.4 [P04279-1]
UniGeneiHs.1968

3D structure databases

ProteinModelPortaliP04279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112306, 32 interactors
IntActiP04279, 7 interactors
MINTiP04279
STRINGi9606.ENSP00000361867

PTM databases

iPTMnetiP04279
PhosphoSitePlusiP04279

Polymorphism and mutation databases

BioMutaiSEMG1
DMDMi134426

Proteomic databases

MaxQBiP04279
PaxDbiP04279
PeptideAtlasiP04279
PRIDEiP04279
ProteomicsDBi51699
51700 [P04279-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6406
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372781; ENSP00000361867; ENSG00000124233 [P04279-1]
GeneIDi6406
KEGGihsa:6406
UCSCiuc002xni.3 human [P04279-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6406
DisGeNETi6406
EuPathDBiHostDB:ENSG00000124233.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SEMG1
HGNCiHGNC:10742 SEMG1
HPAiHPA042476
HPA064892
MIMi182140 gene
neXtProtiNX_P04279
OpenTargetsiENSG00000124233
PharmGKBiPA35664

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410KG9B Eukaryota
ENOG4110SI0 LUCA
GeneTreeiENSGT00940000162560
HOVERGENiHBG054194
InParanoidiP04279
OMAiHGRKANK
OrthoDBiEOG091G03E6
PhylomeDBiP04279
TreeFamiTF342360

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Semenogelin_I

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6406
PMAP-CutDBiP04279

Protein Ontology

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PROi
PR:P04279

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000124233 Expressed in 34 organ(s), highest expression level in seminal vesicle
CleanExiHS_SEMG1
GenevisibleiP04279 HS

Family and domain databases

InterProiView protein in InterPro
IPR008836 Semenogelin
PfamiView protein in Pfam
PF05474 Semenogelin, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEMG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04279
Secondary accession number(s): Q53ZV0
, Q53ZV1, Q53ZV2, Q6X4I9, Q6Y809, Q6Y822, Q6Y823, Q86U64, Q96QM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 1, 1990
Last modified: December 5, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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