UniProtKB - P04272 (ANXA2_BOVIN)
Annexin A2
ANXA2
Functioni
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
By similarityMiscellaneous
GO - Molecular functioni
- calcium channel activity Source: AgBase
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- cytoskeletal protein binding Source: InterPro
- phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central
- phosphatidylserine binding Source: AgBase
- phospholipase A2 inhibitor activity Source: GO_Central
- protease binding Source: GO_Central
- virion binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: Ensembl
- biomineral tissue development Source: AgBase
- calcium ion import Source: AgBase
- calcium ion transmembrane transport Source: AgBase
- collagen fibril organization Source: Ensembl
- fibrinolysis Source: Ensembl
- mRNA transcription by RNA polymerase II Source: Ensembl
- negative regulation of low-density lipoprotein particle receptor catabolic process Source: Ensembl
- positive regulation of low-density lipoprotein particle clearance Source: Ensembl
- positive regulation of low-density lipoprotein particle receptor binding Source: Ensembl
- positive regulation of low-density lipoprotein receptor activity Source: Ensembl
- positive regulation of receptor-mediated endocytosis involved in cholesterol transport Source: Ensembl
- positive regulation of receptor recycling Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of neurogenesis Source: Ensembl
Keywordsi
Ligand | Calcium, Calcium/phospholipid-binding |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation R-BTA-75205, Dissolution of Fibrin Clot |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A2Alternative name(s): Annexin II Annexin-2 Calpactin I heavy chain Calpactin-1 heavy chain Chromobindin-8 Lipocortin II Placental anticoagulant protein IV Short name: PAP-IV Protein I p36 |
Gene namesi | Name:ANXA2 Synonyms:ANX2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000009615 |
Subcellular locationi
Extracellular region or secreted
Other locations
- Melanosome By similarity
Note: In the lamina beneath the plasma membrane.
Cytosol
- cytosol Source: AgBase
Endosome
- early endosome Source: Ensembl
- endosome Source: UniProtKB
Extracellular region or secreted
- extracellular membrane-bounded organelle Source: AgBase
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: AgBase
- RNA polymerase II transcription regulator complex Source: Ensembl
Plasma Membrane
- basolateral plasma membrane Source: Ensembl
- extrinsic component of plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
- plasma membrane protein complex Source: Ensembl
- sarcolemma Source: Ensembl
Other locations
- basement membrane Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: AgBase
- melanosome Source: UniProtKB-SubCell
- membrane Source: AgBase
- myelin sheath adaxonal region Source: Ensembl
- Schmidt-Lanterman incisure Source: Ensembl
- vesicle Source: AgBase
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000067469 | 2 – 339 | Annexin A2Add BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 | |
Modified residuei | 24 | Phosphotyrosine; by SRCBy similarity | 1 | |
Modified residuei | 26 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 49 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 49 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 49 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 152 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 184 | PhosphoserineBy similarity | 1 | |
Modified residuei | 199 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 227 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P04272 |
PeptideAtlasi | P04272 |
PRIDEi | P04272 |
PTM databases
iPTMneti | P04272 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000009615, Expressed in placenta and 102 other tissues |
Interactioni
Subunit structurei
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity).
Interacts with ATP1B1 (By similarity).
Interacts with DYSF (By similarity).
Interacts with COCH.
Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR.
Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity).
Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity).
Interacts with S100A4 (By similarity).
By similarityGO - Molecular functioni
- cytoskeletal protein binding Source: InterPro
- protease binding Source: GO_Central
Protein-protein interaction databases
IntActi | P04272, 1 interactor |
STRINGi | 9913.ENSBTAP00000012655 |
Structurei
Secondary structure
3D structure databases
SMRi | P04272 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 33 – 104 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 105 – 176 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 189 – 261 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 265 – 336 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 24 | S100A10-binding siteSequence analysisAdd BLAST | 23 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000154257 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | P04272 |
OMAi | RTEFKRQ |
OrthoDBi | 856254at2759 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002389, ANX2 |
PANTHERi | PTHR10502:SF18, PTHR10502:SF18, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00198, ANNEXINII |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | E → G in AAI02517 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14056 mRNA Translation: AAA30421.1 BT021010 mRNA Translation: AAX09027.1 BC102516 mRNA Translation: AAI02517.1 |
PIRi | A03081, LUBO36 |
RefSeqi | NP_777141.1, NM_174716.1 |
Genome annotation databases
Ensembli | ENSBTAT00000012655; ENSBTAP00000012655; ENSBTAG00000009615 |
GeneIDi | 282689 |
KEGGi | bta:282689 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Red velvet - Issue 86 of September 2007 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14056 mRNA Translation: AAA30421.1 BT021010 mRNA Translation: AAX09027.1 BC102516 mRNA Translation: AAI02517.1 |
PIRi | A03081, LUBO36 |
RefSeqi | NP_777141.1, NM_174716.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4X9P | X-ray | 2.01 | A | 1-339 | [»] | |
SMRi | P04272 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P04272, 1 interactor |
STRINGi | 9913.ENSBTAP00000012655 |
Chemistry databases
ChEMBLi | CHEMBL3308972 |
PTM databases
iPTMneti | P04272 |
Proteomic databases
PaxDbi | P04272 |
PeptideAtlasi | P04272 |
PRIDEi | P04272 |
Genome annotation databases
Ensembli | ENSBTAT00000012655; ENSBTAP00000012655; ENSBTAG00000009615 |
GeneIDi | 282689 |
KEGGi | bta:282689 |
Organism-specific databases
CTDi | 302 |
VEuPathDBi | HostDB:ENSBTAG00000009615 |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000154257 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | P04272 |
OMAi | RTEFKRQ |
OrthoDBi | 856254at2759 |
TreeFami | TF105452 |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation R-BTA-75205, Dissolution of Fibrin Clot |
Gene expression databases
Bgeei | ENSBTAG00000009615, Expressed in placenta and 102 other tissues |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002389, ANX2 |
PANTHERi | PTHR10502:SF18, PTHR10502:SF18, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00198, ANNEXINII |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA2_BOVIN | |
Accessioni | P04272Primary (citable) accession number: P04272 Secondary accession number(s): Q3ZCC7, Q5E9B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries