UniProtKB - P04271 (S100B_HUMAN)
Protein S100-B
S100B
Functioni
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
2 PublicationsMiscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 32 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 62 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 64 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 66 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 68 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 73 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: GO_Central
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- RAGE receptor binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
- tau protein binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- axonogenesis Source: ProtInc
- central nervous system development Source: ProtInc
- learning or memory Source: UniProtKB
- memory Source: Ensembl
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- regulation of neuronal synaptic plasticity Source: Ensembl
Keywordsi
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P04271 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-879415, Advanced glycosylation endproduct receptor signaling R-HSA-933542, TRAF6 mediated NF-kB activation |
SignaLinki | P04271 |
SIGNORi | P04271 |
Protein family/group databases
TCDBi | 8.A.81.1.4, the s100 calcium-binding protein (s100) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-BAlternative name(s): S-100 protein beta chain S-100 protein subunit beta S100 calcium-binding protein B |
Gene namesi | Name:S100B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10500, S100B |
MIMi | 176990, gene |
neXtProti | NX_P04271 |
VEuPathDBi | HostDB:ENSG00000160307 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: UniProtKB
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6285 |
OpenTargetsi | ENSG00000160307 |
PharmGKBi | PA34912 |
Miscellaneous databases
Pharosi | P04271, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4300 |
DrugBanki | DB06941, (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide DB07004, 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide DB05343, Arundic acid DB01373, Calcium DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB04464, N-Formylmethionine DB00768, Olopatadine |
DrugCentrali | P04271 |
Genetic variation databases
BioMutai | S100B |
DMDMi | 134138 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000143966 | 2 – 92 | Protein S100-BAdd BLAST | 91 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | Blocked amino end (Ser); alternate1 Publication | 1 | |
Modified residuei | 2 | N-acetylserine; alternateBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-1454 CPTAC-1455 |
EPDi | P04271 |
jPOSTi | P04271 |
MassIVEi | P04271 |
PaxDbi | P04271 |
PeptideAtlasi | P04271 |
PRIDEi | P04271 |
ProteomicsDBi | 51695 |
TopDownProteomicsi | P04271 |
PTM databases
iPTMneti | P04271 |
PhosphoSitePlusi | P04271 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160307, Expressed in C1 segment of cervical spinal cord and 191 other tissues |
ExpressionAtlasi | P04271, baseline and differential |
Genevisiblei | P04271, HS |
Organism-specific databases
HPAi | ENSG00000160307, Group enriched (brain, choroid plexus) |
Interactioni
Subunit structurei
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38.
Interacts with CACYBP in a calcium-dependent manner.
Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting.
Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1.
Interacts with AGER.
Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
Interacts with TPPP; this interaction inhibits TPPP dimerization (PubMed:33831707).
6 PublicationsBinary interactionsi
P04271
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- RAGE receptor binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
- tau protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112193, 178 interactors |
IntActi | P04271, 54 interactors |
MINTi | P04271 |
STRINGi | 9606.ENSP00000291700 |
Chemistry databases
BindingDBi | P04271 |
Miscellaneous databases
RNActi | P04271, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P04271 |
BMRBi | P04271 |
SMRi | P04271 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04271 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 48 | EF-hand 1CuratedAdd BLAST | 36 | |
Domaini | 49 – 84 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S4HJ, Eukaryota |
GeneTreei | ENSGT00940000161997 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P04271 |
OMAi | VTMVTIC |
OrthoDBi | 1574989at2759 |
PhylomeDBi | P04271 |
TreeFami | TF332727 |
Family and domain databases
CDDi | cd05027, S-100B, 1 hit |
DisProti | DP01738 |
IDEALi | IID00410 |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028481, S100-B IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE
60 70 80 90
QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8MRB1 | A8MRB1_HUMAN | Protein S100-B | S100B | 94 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59488, M59487 Genomic DNA Translation: AAA60367.1 CR542123 mRNA Translation: CAG46920.1 AP000339 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09267.1 CH471079 Genomic DNA Translation: EAX09268.1 CH471079 Genomic DNA Translation: EAX09269.1 CH471079 Genomic DNA Translation: EAX09270.1 BC001766 mRNA Translation: AAH01766.1 |
CCDSi | CCDS13736.1 |
PIRi | A38364, BCHUIB |
RefSeqi | NP_006263.1, NM_006272.2 XP_016883913.1, XM_017028424.1 |
Genome annotation databases
Ensembli | ENST00000291700.9; ENSP00000291700.4; ENSG00000160307.10 ENST00000397648.1; ENSP00000380769.1; ENSG00000160307.10 |
GeneIDi | 6285 |
KEGGi | hsa:6285 |
MANE-Selecti | ENST00000291700.9; ENSP00000291700.4; NM_006272.3; NP_006263.1 |
UCSCi | uc002zju.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59488, M59487 Genomic DNA Translation: AAA60367.1 CR542123 mRNA Translation: CAG46920.1 AP000339 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09267.1 CH471079 Genomic DNA Translation: EAX09268.1 CH471079 Genomic DNA Translation: EAX09269.1 CH471079 Genomic DNA Translation: EAX09270.1 BC001766 mRNA Translation: AAH01766.1 |
CCDSi | CCDS13736.1 |
PIRi | A38364, BCHUIB |
RefSeqi | NP_006263.1, NM_006272.2 XP_016883913.1, XM_017028424.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MQ1 | NMR | - | A/B | 2-92 | [»] | |
1UWO | NMR | - | A/B | 2-92 | [»] | |
2H61 | X-ray | 1.90 | A/B/C/D/E/F/G/H | 1-92 | [»] | |
2M49 | NMR | - | B/D | 2-92 | [»] | |
2PRU | NMR | - | A/B | 2-92 | [»] | |
3CZT | X-ray | 1.40 | X | 1-92 | [»] | |
3D0Y | X-ray | 1.50 | A/B | 1-92 | [»] | |
3D10 | X-ray | 1.65 | A/B | 1-92 | [»] | |
3HCM | X-ray | 2.00 | A/B | 1-92 | [»] | |
4XYN | X-ray | 2.55 | A/B/C/D | 1-92 | [»] | |
5CSF | X-ray | 2.40 | A/B | 1-92 | [»] | |
5CSI | X-ray | 2.13 | A/B | 1-92 | [»] | |
5CSJ | X-ray | 2.70 | A/B | 1-92 | [»] | |
5CSN | X-ray | 2.95 | A/B | 1-92 | [»] | |
5D7F | X-ray | 1.30 | A/B | 1-92 | [»] | |
AlphaFoldDBi | P04271 | |||||
BMRBi | P04271 | |||||
SMRi | P04271 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112193, 178 interactors |
IntActi | P04271, 54 interactors |
MINTi | P04271 |
STRINGi | 9606.ENSP00000291700 |
Chemistry databases
BindingDBi | P04271 |
ChEMBLi | CHEMBL4300 |
DrugBanki | DB06941, (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide DB07004, 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide DB05343, Arundic acid DB01373, Calcium DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB04464, N-Formylmethionine DB00768, Olopatadine |
DrugCentrali | P04271 |
Protein family/group databases
TCDBi | 8.A.81.1.4, the s100 calcium-binding protein (s100) family |
PTM databases
iPTMneti | P04271 |
PhosphoSitePlusi | P04271 |
Genetic variation databases
BioMutai | S100B |
DMDMi | 134138 |
Proteomic databases
CPTACi | CPTAC-1454 CPTAC-1455 |
EPDi | P04271 |
jPOSTi | P04271 |
MassIVEi | P04271 |
PaxDbi | P04271 |
PeptideAtlasi | P04271 |
PRIDEi | P04271 |
ProteomicsDBi | 51695 |
TopDownProteomicsi | P04271 |
Protocols and materials databases
ABCDi | P04271, 1 sequenced antibody |
Antibodypediai | 3474, 1741 antibodies from 45 providers |
DNASUi | 6285 |
Genome annotation databases
Ensembli | ENST00000291700.9; ENSP00000291700.4; ENSG00000160307.10 ENST00000397648.1; ENSP00000380769.1; ENSG00000160307.10 |
GeneIDi | 6285 |
KEGGi | hsa:6285 |
MANE-Selecti | ENST00000291700.9; ENSP00000291700.4; NM_006272.3; NP_006263.1 |
UCSCi | uc002zju.2, human |
Organism-specific databases
CTDi | 6285 |
DisGeNETi | 6285 |
GeneCardsi | S100B |
HGNCi | HGNC:10500, S100B |
HPAi | ENSG00000160307, Group enriched (brain, choroid plexus) |
MIMi | 176990, gene |
neXtProti | NX_P04271 |
OpenTargetsi | ENSG00000160307 |
PharmGKBi | PA34912 |
VEuPathDBi | HostDB:ENSG00000160307 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4HJ, Eukaryota |
GeneTreei | ENSGT00940000161997 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P04271 |
OMAi | VTMVTIC |
OrthoDBi | 1574989at2759 |
PhylomeDBi | P04271 |
TreeFami | TF332727 |
Enzyme and pathway databases
PathwayCommonsi | P04271 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-879415, Advanced glycosylation endproduct receptor signaling R-HSA-933542, TRAF6 mediated NF-kB activation |
SignaLinki | P04271 |
SIGNORi | P04271 |
Miscellaneous databases
BioGRID-ORCSi | 6285, 12 hits in 1077 CRISPR screens |
ChiTaRSi | S100B, human |
EvolutionaryTracei | P04271 |
GeneWikii | S100B |
GenomeRNAii | 6285 |
Pharosi | P04271, Tchem |
PROi | PR:P04271 |
RNActi | P04271, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160307, Expressed in C1 segment of cervical spinal cord and 191 other tissues |
ExpressionAtlasi | P04271, baseline and differential |
Genevisiblei | P04271, HS |
Family and domain databases
CDDi | cd05027, S-100B, 1 hit |
DisProti | DP01738 |
IDEALi | IID00410 |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028481, S100-B IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S100B_HUMAN | |
Accessioni | P04271Primary (citable) accession number: P04271 Secondary accession number(s): D3DSN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families