Protein S100-B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium-dependent protein binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice."
    Reeves R.H., Yao J., Crowley M.R., Buck S., Zhang X., Yarowsky P., Gearhart J.D., Hilt D.C.
    Proc. Natl. Acad. Sci. U.S.A. 91:5359-5363(1994) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
  • "Structural and functional insights into RAGE activation by multimeric S100B."
    Ostendorp T., Leclerc E., Galichet A., Koch M., Demling N., Weigle B., Heizmann C.W., Kroneck P.M., Fritz G.
    EMBO J. 26:3868-3878(2007) [PubMed] [Europe PMC] [Abstract]
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
  • "Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
    Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., Trigg S.A., Tam S.

    , Ghamsari L., Sahni N., Yi S., Rodriguez M.D., Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.
    Cell 164:805-817(2016) [PubMed] [Europe PMC] [Abstract]
  • "Pooled-matrix protein interaction screens using Barcode Fusion Genetics."
    Yachie N., Petsalaki E., Mellor J.C., Weile J., Jacob Y., Verby M., Ozturk S.B., Li S., Cote A.G., Mosca R., Knapp J.J., Ko M., Yu A., Gebbia M., Sahni N., Yi S., Tyagi T., Sheykhkarimli D.

    , Roth J.F., Wong C., Musa L., Snider J., Liu Y.C., Yu H., Braun P., Stagljar I., Hao T., Calderwood M.A., Pelletier L., Aloy P., Hill D.E., Vidal M., Roth F.P.
    Mol. Syst. Biol. 12:863-863(2016) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
• RAGE receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells."
    Hsieh H.L., Schafer B.W., Weigle B., Heizmann C.W.
    Biochem. Biophys. Res. Commun. 316:949-959(2004) [PubMed] [Europe PMC] [Abstract]
• S100 protein binding Source: UniProtKBInferred from physical interactionⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form."
    Smith S.P., Shaw G.S.
    Structure 6:211-222(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR.
• tau protein binding Source: UniProtKB
• zinc ion binding Source: UniProtKB

GO - Biological processⁱ

• astrocyte differentiation Source: Ensembl
• axonogenesis Source: ProtIncTraceable author statementⁱ
  • "Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice."
    Reeves R.H., Yao J., Crowley M.R., Buck S., Zhang X., Yarowsky P., Gearhart J.D., Hilt D.C.
    Proc. Natl. Acad. Sci. U.S.A. 91:5359-5363(1994) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: Ensembl
• central nervous system development Source: ProtIncTraceable author statementⁱ
  • "Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice."
    Reeves R.H., Yao J., Crowley M.R., Buck S., Zhang X., Yarowsky P., Gearhart J.D., Hilt D.C.
    Proc. Natl. Acad. Sci. U.S.A. 91:5359-5363(1994) [PubMed] [Europe PMC] [Abstract]
• innate immune response Source: Reactome
• learning or memory Source: UniProtKB
• long-term synaptic potentiation Source: Ensembl
• memory Source: Ensembl
• negative regulation of skeletal muscle cell differentiation Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKBInferred from direct assayⁱ
  • "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells."
    Hsieh H.L., Schafer B.W., Weigle B., Heizmann C.W.
    Biochem. Biophys. Res. Commun. 316:949-959(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myelination Source: Ensembl
• regulation of cell shape Source: Ensembl
• regulation of neuronal synaptic plasticity Source: Ensembl
• response to glucocorticoid Source: Ensembl
• response to methylmercury Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• calcium-dependent protein binding Source: UniProtKBInferred from direct assayⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
  • "Structural and functional insights into RAGE activation by multimeric S100B."
    Ostendorp T., Leclerc E., Galichet A., Koch M., Demling N., Weigle B., Heizmann C.W., Kroneck P.M., Fritz G.
    EMBO J. 26:3868-3878(2007) [PubMed] [Europe PMC] [Abstract]
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
  • "Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
    Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., Trigg S.A., Tam S.

    , Ghamsari L., Sahni N., Yi S., Rodriguez M.D., Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.
    Cell 164:805-817(2016) [PubMed] [Europe PMC] [Abstract]
  • "Pooled-matrix protein interaction screens using Barcode Fusion Genetics."
    Yachie N., Petsalaki E., Mellor J.C., Weile J., Jacob Y., Verby M., Ozturk S.B., Li S., Cote A.G., Mosca R., Knapp J.J., Ko M., Yu A., Gebbia M., Sahni N., Yi S., Tyagi T., Sheykhkarimli D.

    , Roth J.F., Wong C., Musa L., Snider J., Liu Y.C., Yu H., Braun P., Stagljar I., Hao T., Calderwood M.A., Pelletier L., Aloy P., Hill D.E., Vidal M., Roth F.P.
    Mol. Syst. Biol. 12:863-863(2016) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
• RAGE receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells."
    Hsieh H.L., Schafer B.W., Weigle B., Heizmann C.W.
    Biochem. Biophys. Res. Commun. 316:949-959(2004) [PubMed] [Europe PMC] [Abstract]
• S100 protein binding Source: UniProtKBInferred from physical interactionⁱ
  • "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo."
    Deloulme J.C., Assard N., Mbele G.O., Mangin C., Kuwano R., Baudier J.
    J. Biol. Chem. 275:35302-35310(2000) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form."
    Smith S.P., Shaw G.S.
    Structure 6:211-222(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR.
• tau protein binding Source: UniProtKB

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE 
        60         70         80         90 
QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. Human chromosome 21
   Human chromosome 21: entries, gene names and cross-references to MIM