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Protein

Protein S100-B

Gene

S100B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.2 Publications

Miscellaneous

In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 321; low affinityAdd BLAST14
Calcium bindingi62 – 732; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: ProtInc
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB
  • tau protein binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

Protein family/group databases

TCDBi8.A.81.1.4 the s100 calcium-binding protein (s100) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-B
Alternative name(s):
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium-binding protein B
Gene namesi
Name:S100B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160307.9
HGNCiHGNC:10500 S100B
MIMi176990 gene
neXtProtiNX_P04271

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6285
OpenTargetsiENSG00000160307
PharmGKBiPA34912

Chemistry databases

ChEMBLiCHEMBL4300
DrugBankiDB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
DB01373 Calcium
DB04464 N-Formylmethionine
DB00768 Olopatadine
DB05343 ONO-2506

Polymorphism and mutation databases

BioMutaiS100B
DMDMi134138

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001439662 – 92Protein S100-BAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ser); alternate1 Publication1
Modified residuei2N-acetylserine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP04271
PaxDbiP04271
PeptideAtlasiP04271
PRIDEiP04271
ProteomicsDBi51695
TopDownProteomicsiP04271

PTM databases

iPTMnetiP04271
PhosphoSitePlusiP04271

Expressioni

Tissue specificityi

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Gene expression databases

BgeeiENSG00000160307 Expressed in 177 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_S100B
ExpressionAtlasiP04271 baseline and differential
GenevisibleiP04271 HS

Organism-specific databases

HPAiCAB000073
CAB078196
HPA015768

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112193, 35 interactors
IntActiP04271, 20 interactors
MINTiP04271
STRINGi9606.ENSP00000291700

Chemistry databases

BindingDBiP04271

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04271
SMRiP04271
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04271

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYFX Eukaryota
ENOG41127J0 LUCA
GeneTreeiENSGT00760000119034
HOVERGENiHBG001479
InParanoidiP04271
OMAiCCHEFFE
PhylomeDBiP04271
TreeFamiTF332727

Family and domain databases

CDDicd05027 S-100B, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028481 S100-B
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF17 PTHR11639:SF17, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE
60 70 80 90
QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE
Length:92
Mass (Da):10,713
Last modified:January 23, 2007 - v2
Checksum:i43815AC212A3AD6B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MRB1A8MRB1_HUMAN
Protein S100-B
S100B
94Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59488, M59487 Genomic DNA Translation: AAA60367.1
CR542123 mRNA Translation: CAG46920.1
AP000339 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09267.1
CH471079 Genomic DNA Translation: EAX09268.1
CH471079 Genomic DNA Translation: EAX09269.1
CH471079 Genomic DNA Translation: EAX09270.1
BC001766 mRNA Translation: AAH01766.1
CCDSiCCDS13736.1
PIRiA38364 BCHUIB
RefSeqiNP_006263.1, NM_006272.2
XP_016883913.1, XM_017028424.1
UniGeneiHs.422181

Genome annotation databases

EnsembliENST00000291700; ENSP00000291700; ENSG00000160307
ENST00000397648; ENSP00000380769; ENSG00000160307
GeneIDi6285
KEGGihsa:6285
UCSCiuc002zju.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59488, M59487 Genomic DNA Translation: AAA60367.1
CR542123 mRNA Translation: CAG46920.1
AP000339 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09267.1
CH471079 Genomic DNA Translation: EAX09268.1
CH471079 Genomic DNA Translation: EAX09269.1
CH471079 Genomic DNA Translation: EAX09270.1
BC001766 mRNA Translation: AAH01766.1
CCDSiCCDS13736.1
PIRiA38364 BCHUIB
RefSeqiNP_006263.1, NM_006272.2
XP_016883913.1, XM_017028424.1
UniGeneiHs.422181

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MQ1NMR-A/B2-92[»]
1UWONMR-A/B2-92[»]
2H61X-ray1.90A/B/C/D/E/F/G/H1-92[»]
2M49NMR-B/D2-92[»]
2PRUNMR-A/B2-92[»]
3CZTX-ray1.40X1-92[»]
3D0YX-ray1.50A/B1-92[»]
3D10X-ray1.65A/B1-92[»]
3HCMX-ray2.00A/B1-92[»]
4XYNX-ray2.55A/B/C/D1-92[»]
5CSFX-ray2.40A/B1-92[»]
5CSIX-ray2.13A/B1-92[»]
5CSJX-ray2.70A/B1-92[»]
5CSNX-ray2.95A/B1-92[»]
5D7FX-ray1.30A/B1-92[»]
ProteinModelPortaliP04271
SMRiP04271
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112193, 35 interactors
IntActiP04271, 20 interactors
MINTiP04271
STRINGi9606.ENSP00000291700

Chemistry databases

BindingDBiP04271
ChEMBLiCHEMBL4300
DrugBankiDB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
DB01373 Calcium
DB04464 N-Formylmethionine
DB00768 Olopatadine
DB05343 ONO-2506

Protein family/group databases

TCDBi8.A.81.1.4 the s100 calcium-binding protein (s100) family

PTM databases

iPTMnetiP04271
PhosphoSitePlusiP04271

Polymorphism and mutation databases

BioMutaiS100B
DMDMi134138

Proteomic databases

EPDiP04271
PaxDbiP04271
PeptideAtlasiP04271
PRIDEiP04271
ProteomicsDBi51695
TopDownProteomicsiP04271

Protocols and materials databases

DNASUi6285
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291700; ENSP00000291700; ENSG00000160307
ENST00000397648; ENSP00000380769; ENSG00000160307
GeneIDi6285
KEGGihsa:6285
UCSCiuc002zju.2 human

Organism-specific databases

CTDi6285
DisGeNETi6285
EuPathDBiHostDB:ENSG00000160307.9
GeneCardsiS100B
HGNCiHGNC:10500 S100B
HPAiCAB000073
CAB078196
HPA015768
MIMi176990 gene
neXtProtiNX_P04271
OpenTargetsiENSG00000160307
PharmGKBiPA34912
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYFX Eukaryota
ENOG41127J0 LUCA
GeneTreeiENSGT00760000119034
HOVERGENiHBG001479
InParanoidiP04271
OMAiCCHEFFE
PhylomeDBiP04271
TreeFamiTF332727

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

Miscellaneous databases

ChiTaRSiS100B human
EvolutionaryTraceiP04271
GeneWikiiS100B
GenomeRNAii6285
PROiPR:P04271
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160307 Expressed in 177 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_S100B
ExpressionAtlasiP04271 baseline and differential
GenevisibleiP04271 HS

Family and domain databases

CDDicd05027 S-100B, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028481 S100-B
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF17 PTHR11639:SF17, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS100B_HUMAN
AccessioniPrimary (citable) accession number: P04271
Secondary accession number(s): D3DSN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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