S100B

Functionⁱ

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.2 Publications

Miscellaneous

In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	19 – 32	1; low affinityAdd BLAST		14
Calcium bindingⁱ	62 – 73	2; high affinityAdd BLAST		12

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10913138
calcium ion binding
Source: ProtInc
Traceable author statementⁱ
- 8202493
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10913138
RAGE receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15033494
S100 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10913138
- 9519411
tau protein binding Source: UniProtKB
zinc ion binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astrocyte differentiation Source: Ensembl
axonogenesis
Source: ProtInc
Traceable author statementⁱ
- 8202493
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8202493
cellular response to hypoxia Source: Ensembl
central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 8202493
innate immune response Source: Reactome
learning or memory Source: UniProtKB
long-term synaptic potentiation Source: Ensembl
memory Source: Ensembl
negative regulation of skeletal muscle cell differentiation Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 15033494
positive regulation of myelination Source: Ensembl
regulation of cell shape Source: Ensembl
regulation of neuronal synaptic plasticity Source: Ensembl
response to glucocorticoid Source: Ensembl
response to methylmercury Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding, Zinc

Ligand

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-933542 TRAF6 mediated NF-kB activation

Reactomeⁱ

R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

Protein family/group databases

TCDBⁱ	8.A.81.1.4 the s100 calcium-binding protein (s100) family

TCDBⁱ

8.A.81.1.4 the s100 calcium-binding protein (s100) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein S100-B Alternative name(s): S-100 protein beta chain S-100 protein subunit beta S100 calcium-binding protein B
Gene namesⁱ	Name:S100B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160307.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10500 S100B
MIMⁱ	176990 gene
neXtProtⁱ	NX_P04271

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6285
Open Targets More...OpenTargetsⁱ	ENSG00000160307
PharmGKBⁱ	PA34912

Chemistry databases

ChEMBLⁱ	CHEMBL4300
Drug and drug target database More...DrugBankⁱ	DB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide DB01373 Calcium DB04464 N-Formylmethionine DB00768 Olopatadine DB05343 ONO-2506

Polymorphism and mutation databases

BioMutaⁱ	S100B
DMDMⁱ	134138

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity1 Publication
ChainⁱPRO_0000143966	2 – 92	Protein S100-BAdd BLAST		91

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	Blocked amino end (Ser); alternate1 Publication		1
Modified residueⁱ	2	N-acetylserine; alternateBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P04271
PaxDbⁱ	P04271
PeptideAtlas More...PeptideAtlasⁱ	P04271
PRIDEⁱ	P04271
ProteomicsDBⁱ	51695
TopDownProteomicsⁱ	P04271

PTM databases

iPTMnetⁱ	P04271
PhosphoSitePlusⁱ	P04271

Expressionⁱ

Tissue specificityⁱ

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Gene expression databases

Bgeeⁱ	ENSG00000160307
CleanExⁱ	HS_S100B
ExpressionAtlasⁱ	P04271 baseline and differential
Genevisibleⁱ	P04271 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000073 CAB078196 HPA015768

HPAⁱ

CAB000073
CAB078196
HPA015768

Interactionⁱ

Subunit structureⁱ

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with CACYBP in a calcium-dependent manner. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with S100A6. The S100B dimer interacts with two molecules of CAPZA1. Interacts with AGER. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		21	EBI-458391,EBI-458391
AGER	Q15109	5	EBI-458391,EBI-1646426
MDM2	Q00987	2	EBI-458391,EBI-389668
S100A1	P23297	21	EBI-458391,EBI-743686
S100A1	Q5T7Y6	5	EBI-458391,EBI-11746600
S100A11	P31949	5	EBI-458391,EBI-701862
S100A2	P29034	10	EBI-458391,EBI-752230
S100A4	P26447	7	EBI-458391,EBI-717058
S100A6	P06703	5	EBI-458391,EBI-352877
S100P	P25815	6	EBI-458391,EBI-743700
SPG21	Q9NZD8	5	EBI-458391,EBI-742688
TP53	P04637	2	EBI-458391,EBI-366083

Show more details

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112193, 32 interactors
IntActⁱ	P04271, 20 interactors
Molecular INTeraction database More...MINTⁱ	P04271
STRINGⁱ	9606.ENSP00000291700

Chemistry databases

BindingDBⁱ

P04271

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 19	Combined sources	17
Beta strandⁱ	21 – 24	Combined sources	4
Helixⁱ	30 – 40	Combined sources	11
Turnⁱ	42 – 44	Combined sources	3
Beta strandⁱ	47 – 49	Combined sources	3
Helixⁱ	51 – 61	Combined sources	11
Beta strandⁱ	65 – 69	Combined sources	5
Helixⁱ	71 – 85	Combined sources	15
Helixⁱ	86 – 88	Combined sources	3
Turnⁱ	89 – 91	Combined sources	3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1MQ1	NMR	-	A/B	2-92	[»]
	1UWO	NMR	-	A/B	2-92	[»]
	2H61	X-ray	1.90	A/B/C/D/E/F/G/H	1-92	[»]
	2M49	NMR	-	B/D	2-92	[»]
	2PRU	NMR	-	A/B	2-92	[»]
	3CZT	X-ray	1.40	X	1-92	[»]
	3D0Y	X-ray	1.50	A/B	1-92	[»]
	3D10	X-ray	1.65	A/B	1-92	[»]
	3HCM	X-ray	2.00	A/B	1-92	[»]
	4XYN	X-ray	2.55	A/B/C/D	1-92	[»]
	5CSF	X-ray	2.40	A/B	1-92	[»]
	5CSI	X-ray	2.13	A/B	1-92	[»]
	5CSJ	X-ray	2.70	A/B	1-92	[»]
	5CSN	X-ray	2.95	A/B	1-92	[»]
	5D7F	X-ray	1.30	A/B	1-92	[»]
ProteinModelPortalⁱ	P04271
SMRⁱ	P04271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04271

EvolutionaryTraceⁱ

P04271

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 48	EF-hand 1PROSITE-ProRule annotationAdd BLAST		36
Domainⁱ	49 – 84	EF-hand 2PROSITE-ProRule annotationAdd BLAST		36

Sequence similaritiesⁱ

Belongs to the S-100 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IYFX Eukaryota ENOG41127J0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119034
HOVERGENⁱ	HBG001479
InParanoidⁱ	P04271
OMAⁱ	CCHEFFE
PhylomeDBⁱ	P04271
TreeFamⁱ	TF332727

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05027 S-100B, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR028481 S100-B IPR001751 S100/CaBP-9k_CS IPR013787 S100_Ca-bd_sub
PANTHERⁱ	PTHR11639:SF17 PTHR11639:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00036 EF-hand_1, 1 hit PF01023 S_100, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 1 hit SM01394 S_100, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 1 hit PS00303 S100_CABP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04271-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE 
        60         70         80         90 
QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE

Length:92

Mass (Da):10,713

Last modified:January 23, 2007 - v2

Checksum:ⁱ43815AC212A3AD6B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M59488, M59487 Genomic DNA Translation: AAA60367.1 CR542123 mRNA Translation: CAG46920.1 AP000339 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09267.1 CH471079 Genomic DNA Translation: EAX09268.1 CH471079 Genomic DNA Translation: EAX09269.1 CH471079 Genomic DNA Translation: EAX09270.1 BC001766 mRNA Translation: AAH01766.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13736.1
PIRⁱ	A38364 BCHUIB
NCBI Reference Sequences More...RefSeqⁱ	NP_006263.1, NM_006272.2 XP_016883913.1, XM_017028424.1
UniGeneⁱ	Hs.422181

Genome annotation databases

Ensemblⁱ	ENST00000291700; ENSP00000291700; ENSG00000160307 ENST00000397648; ENSP00000380769; ENSG00000160307
GeneIDⁱ	6285
KEGGⁱ	hsa:6285
UCSC genome browser More...UCSCⁱ	uc002zju.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P04271	Protein S100-B		RABIT		92
Protein S100 (Fragment)		HUMAN		92
Protein S100		PANTR		92
Protein S100		PONAB		92
Protein S100		SAIBB		92
+12

Protein	Similar proteins		Species	Score	Length
P04271	Protein S100-B		RABIT		92
Protein S100 (Fragment)		HUMAN		92
Protein S100		PANTR		92
Protein S100		PONAB		92
Protein S100		SAIBB		92
+32

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M59488, M59487 Genomic DNA Translation: AAA60367.1 CR542123 mRNA Translation: CAG46920.1 AP000339 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09267.1 CH471079 Genomic DNA Translation: EAX09268.1 CH471079 Genomic DNA Translation: EAX09269.1 CH471079 Genomic DNA Translation: EAX09270.1 BC001766 mRNA Translation: AAH01766.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13736.1
PIRⁱ	A38364 BCHUIB
NCBI Reference Sequences More...RefSeqⁱ	NP_006263.1, NM_006272.2 XP_016883913.1, XM_017028424.1
UniGeneⁱ	Hs.422181

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1MQ1	NMR	-	A/B	2-92	[»]
	1UWO	NMR	-	A/B	2-92	[»]
	2H61	X-ray	1.90	A/B/C/D/E/F/G/H	1-92	[»]
	2M49	NMR	-	B/D	2-92	[»]
	2PRU	NMR	-	A/B	2-92	[»]
	3CZT	X-ray	1.40	X	1-92	[»]
	3D0Y	X-ray	1.50	A/B	1-92	[»]
	3D10	X-ray	1.65	A/B	1-92	[»]
	3HCM	X-ray	2.00	A/B	1-92	[»]
	4XYN	X-ray	2.55	A/B/C/D	1-92	[»]
	5CSF	X-ray	2.40	A/B	1-92	[»]
	5CSI	X-ray	2.13	A/B	1-92	[»]
	5CSJ	X-ray	2.70	A/B	1-92	[»]
	5CSN	X-ray	2.95	A/B	1-92	[»]
	5D7F	X-ray	1.30	A/B	1-92	[»]
ProteinModelPortalⁱ	P04271
SMRⁱ	P04271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112193, 32 interactors
IntActⁱ	P04271, 20 interactors
Molecular INTeraction database More...MINTⁱ	P04271
STRINGⁱ	9606.ENSP00000291700

Chemistry databases

BindingDBⁱ	P04271
ChEMBLⁱ	CHEMBL4300
Drug and drug target database More...DrugBankⁱ	DB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide DB01373 Calcium DB04464 N-Formylmethionine DB00768 Olopatadine DB05343 ONO-2506

Protein family/group databases

TCDBⁱ	8.A.81.1.4 the s100 calcium-binding protein (s100) family

TCDBⁱ

8.A.81.1.4 the s100 calcium-binding protein (s100) family

PTM databases

iPTMnetⁱ	P04271
PhosphoSitePlusⁱ	P04271

Polymorphism and mutation databases

BioMutaⁱ	S100B
DMDMⁱ	134138

Proteomic databases

EPDⁱ	P04271
PaxDbⁱ	P04271
PeptideAtlas More...PeptideAtlasⁱ	P04271
PRIDEⁱ	P04271
ProteomicsDBⁱ	51695
TopDownProteomicsⁱ	P04271

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6285
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000291700; ENSP00000291700; ENSG00000160307 ENST00000397648; ENSP00000380769; ENSG00000160307
GeneIDⁱ	6285
KEGGⁱ	hsa:6285
UCSC genome browser More...UCSCⁱ	uc002zju.2 human

Organism-specific databases

CTDⁱ	6285
DisGeNET More...DisGeNETⁱ	6285
EuPathDBⁱ	HostDB:ENSG00000160307.9
GeneCardsⁱ	S100B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10500 S100B
Human Protein Atlas More...HPAⁱ	CAB000073 CAB078196 HPA015768
MIMⁱ	176990 gene
neXtProtⁱ	NX_P04271
Open Targets More...OpenTargetsⁱ	ENSG00000160307
PharmGKBⁱ	PA34912
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IYFX Eukaryota ENOG41127J0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119034
HOVERGENⁱ	HBG001479
InParanoidⁱ	P04271
OMAⁱ	CCHEFFE
PhylomeDBⁱ	P04271
TreeFamⁱ	TF332727

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-933542 TRAF6 mediated NF-kB activation

Reactomeⁱ

R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

Miscellaneous databases

ChiTaRSⁱ	S100B human
EvolutionaryTraceⁱ	P04271
GeneWikiⁱ	S100B
GenomeRNAiⁱ	6285
Protein Ontology More...PROⁱ	PR:P04271
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160307
CleanExⁱ	HS_S100B
ExpressionAtlasⁱ	P04271 baseline and differential
Genevisibleⁱ	P04271 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05027 S-100B, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR028481 S100-B IPR001751 S100/CaBP-9k_CS IPR013787 S100_Ca-bd_sub
PANTHERⁱ	PTHR11639:SF17 PTHR11639:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00036 EF-hand_1, 1 hit PF01023 S_100, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 1 hit SM01394 S_100, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 1 hit PS00303 S100_CABP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S100B_HUMAN
Accessionⁱ	P04271Primary (citable) accession number: P04271 Secondary accession number(s): D3DSN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04271 (S100B_HUMAN)

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Protein S100-B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ