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Protein

Keratin, type II cytoskeletal 1

Gene

KRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.2 Publications

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Caution

A peptide corresponding to residues 278 to 289 was isolated as part of plant proteomics studies and was originally thought to be of plant origin (PubMed:18602030, PubMed:19412582, PubMed:16529377). However, it was later shown that it is likely to be human type II keratin, a common contaminant in proteomic analyses (PubMed:23895828).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei433Stutter1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • structural constituent of epidermis Source: CAFA

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP04264

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 1
Alternative name(s):
67 kDa cytokeratin
Cytokeratin-1
Short name:
CK-1
Hair alpha protein
Keratin-1
Short name:
K1
Type-II keratin Kb1
Gene namesi
Name:KRT1
Synonyms:KRTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167768.4
HGNCiHGNC:6412 KRT1
MIMi139350 gene
neXtProtiNX_P04264

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Intermediate filament, Keratin, Membrane

Pathology & Biotechi

Involvement in diseasei

Epidermolytic hyperkeratosis (EHK)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
See also OMIM:113800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017820155V → D in EHK. 1 PublicationCorresponds to variant dbSNP:rs57959072EnsemblClinVar.1
Natural variantiVAR_003853155V → G in EHK. 1 PublicationCorresponds to variant dbSNP:rs57959072EnsemblClinVar.1
Natural variantiVAR_003854161L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs57695159EnsemblClinVar.1
Natural variantiVAR_003855186S → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs60022878EnsemblClinVar.1
Natural variantiVAR_017821188N → K in EHK. 2 PublicationsCorresponds to variant dbSNP:rs59429455EnsemblClinVar.1
Natural variantiVAR_003856188N → S in EHK. 3 PublicationsCorresponds to variant dbSNP:rs58928370EnsemblClinVar.1
Natural variantiVAR_017822188N → T in EHK; severe. 1 PublicationCorresponds to variant dbSNP:rs58928370EnsemblClinVar.1
Natural variantiVAR_003857193S → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs60937700EnsemblClinVar.1
Natural variantiVAR_017823214L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs61549035EnsemblClinVar.1
Natural variantiVAR_017824340D → V in EHK. 1 PublicationCorresponds to variant dbSNP:rs58062863EnsemblClinVar.1
Natural variantiVAR_071986478E → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs59089201EnsemblClinVar.1
Natural variantiVAR_017827482Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs58420087EnsemblClinVar.1
Natural variantiVAR_071987485L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607430EnsemblClinVar.1
Natural variantiVAR_017828486L → P in EHK. 2 PublicationsCorresponds to variant dbSNP:rs56914602EnsemblClinVar.1
Natural variantiVAR_071988490E → K in EHK. 1 PublicationCorresponds to variant dbSNP:rs60279707EnsemblClinVar.1
Natural variantiVAR_003861490E → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs60279707EnsemblClinVar.1
Ichthyosis hystrix, Curth-Macklin type (IHCM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
See also OMIM:146590
Keratoderma, palmoplantar, non-epidermolytic (NEPPK)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by well-demarcated hyperkeratosis is present over the palms and soles. A red band is frequently present at the periphery of the keratosis. It is usually non-transgredient, with a sharp demarcation of the lesions at the wrists.
See also OMIM:600962
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01781974K → I in NEPPK. 1 PublicationCorresponds to variant dbSNP:rs57977969EnsemblClinVar.1
Ichthyosis annular epidermolytic (AEI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
See also OMIM:607602
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017825479I → F in AEI. 2 PublicationsCorresponds to variant dbSNP:rs61218439EnsemblClinVar.1
Keratoderma, palmoplantar, striate 3 (SPPK3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by thickening of the stratum corneum and epidermal layers on palms and soles. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
See also OMIM:607654

Keywords - Diseasei

Disease mutation, Ichthyosis, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi3848
MalaCardsiKRT1
MIMi113800 phenotype
146590 phenotype
600962 phenotype
607602 phenotype
607654 phenotype
OpenTargetsiENSG00000167768
Orphaneti281139 Annular epidermolytic ichthyosis
312 Autosomal dominant epidermolytic ichthyosis
281190 Congenital reticular ichthyosiform erythroderma
2199 Epidermolytic palmoplantar keratoderma
79503 Ichthyosis hystrix of Curth-Macklin
50942 Striate palmoplantar keratoderma
PharmGKBiPA30199

Polymorphism and mutation databases

BioMutaiKRT1
DMDMi238054406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000637092 – 644Keratin, type II cytoskeletal 1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Omega-N-methylarginineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei45Omega-N-methylarginineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei82Omega-N-methylarginine1 Publication1
Modified residuei276N6,N6-dimethyllysine1 Publication1
Modified residuei344PhosphoserineCombined sources1
Modified residuei518Omega-N-methylarginineBy similarity1
Modified residuei588Omega-N-methylarginineBy similarity1

Post-translational modificationi

Undergoes deimination of some arginine residues (citrullination).2 Publications

Keywords - PTMi

Citrullination, Methylation, Phosphoprotein

Proteomic databases

EPDiP04264
PaxDbiP04264
PeptideAtlasiP04264
PRIDEiP04264
ProteomicsDBi12658
51694

2D gel databases

REPRODUCTION-2DPAGEiP04264
SWISS-2DPAGEiP04264

PTM databases

iPTMnetiP04264
PhosphoSitePlusiP04264
SwissPalmiP04264

Expressioni

Tissue specificityi

The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Gene expression databases

BgeeiENSG00000167768 Expressed in 114 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRT1
GenevisibleiP04264 HS

Organism-specific databases

HPAiCAB002153
HPA017917
HPA062908

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Heterodimer with KRT10 (PubMed:27595935). Two heterodimers of KRT1 and KRT10 form a heterotetramer (PubMed:27595935). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (PubMed:17956333). Interacts with C1QBP; the association represents a cell surface kininogen receptor (PubMed:21544310). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110046, 73 interactors
IntActiP04264, 53 interactors
MINTiP04264
STRINGi9606.ENSP00000252244

Structurei

Secondary structure

1644
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04264
SMRiP04264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 493IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 179HeadAdd BLAST178
Regioni180 – 215Coil 1AAdd BLAST36
Regioni216 – 234Linker 1Add BLAST19
Regioni235 – 326Coil 1BAdd BLAST92
Regioni327 – 350Linker 12Add BLAST24
Regioni351 – 489Coil 2Add BLAST139
Regioni490 – 644TailAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 151Gly/Phe/Ser-richAdd BLAST150
Compositional biasi502 – 641Gly/Ser-richAdd BLAST140

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiP04264
KOiK07605
OMAiIRMSGEC
OrthoDBiEOG091G09KR
PhylomeDBiP04264
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032449 Keratin_2_1_tail
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 2 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PF16210 Keratin_2_tail, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04264-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQFSSRSG YRSGGGFSSG SAGIINYQRR TTSSSTRRSG GGGGRFSSCG
60 70 80 90 100
GGGGSFGAGG GFGSRSLVNL GGSKSISISV ARGGGRGSGF GGGYGGGGFG
110 120 130 140 150
GGGFGGGGFG GGGIGGGGFG GFGSGGGGFG GGGFGGGGYG GGYGPVCPPG
160 170 180 190 200
GIQEVTINQS LLQPLNVEID PEIQKVKSRE REQIKSLNNQ FASFIDKVRF
210 220 230 240 250
LEQQNQVLQT KWELLQQVDT STRTHNLEPY FESFINNLRR RVDQLKSDQS
260 270 280 290 300
RLDSELKNMQ DMVEDYRNKY EDEINKRTNA ENEFVTIKKD VDGAYMTKVD
310 320 330 340 350
LQAKLDNLQQ EIDFLTALYQ AELSQMQTQI SETNVILSMD NNRSLDLDSI
360 370 380 390 400
IAEVKAQYED IAQKSKAEAE SLYQSKYEEL QITAGRHGDS VRNSKIEISE
410 420 430 440 450
LNRVIQRLRS EIDNVKKQIS NLQQSISDAE QRGENALKDA KNKLNDLEDA
460 470 480 490 500
LQQAKEDLAR LLRDYQELMN TKLALDLEIA TYRTLLEGEE SRMSGECAPN
510 520 530 540 550
VSVSVSTSHT TISGGGSRGG GGGGYGSGGS SYGSGGGSYG SGGGGGGGRG
560 570 580 590 600
SYGSGGSSYG SGGGSYGSGG GGGGHGSYGS GSSSGGYRGG SGGGGGGSSG
610 620 630 640
GRGSGGGSSG GSIGGRGSSS GGVKSSGGSS SVKFVSTTYS GVTR
Length:644
Mass (Da):66,039
Last modified:May 26, 2009 - v6
Checksum:iCE5DDE97388F5017
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201L → M in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti206Q → K in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti238L → S in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti344 – 345SL → QF in AAA36153 (PubMed:2581964).Curated2
Sequence conflicti403R → H in BAG36698 (PubMed:14702039).Curated1
Sequence conflicti404V → M in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti447L → M in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti463R → C in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti466Q → H in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti504S → T in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti511 – 512TI → SM in AAA36153 (PubMed:2581964).Curated2
Sequence conflicti564G → S in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti613I → S in AAA36153 (PubMed:2581964).Curated1
Sequence conflicti638T → S in AAA36153 (PubMed:2581964).Curated1

Polymorphismi

There are two size variants of KRT1, termed allele 1A and allele 1B with allelic frequencies of 0.61 and 0.39. Allele 1B lacks 7 residues compared to allele 1A.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01781974K → I in NEPPK. 1 PublicationCorresponds to variant dbSNP:rs57977969EnsemblClinVar.1
Natural variantiVAR_017820155V → D in EHK. 1 PublicationCorresponds to variant dbSNP:rs57959072EnsemblClinVar.1
Natural variantiVAR_003853155V → G in EHK. 1 PublicationCorresponds to variant dbSNP:rs57959072EnsemblClinVar.1
Natural variantiVAR_003854161L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs57695159EnsemblClinVar.1
Natural variantiVAR_038627176 – 197Missing in palmoplantar keratoderma; and mild ichthyosis largely limited to the flexural areas. Add BLAST22
Natural variantiVAR_003855186S → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs60022878EnsemblClinVar.1
Natural variantiVAR_017821188N → K in EHK. 2 PublicationsCorresponds to variant dbSNP:rs59429455EnsemblClinVar.1
Natural variantiVAR_003856188N → S in EHK. 3 PublicationsCorresponds to variant dbSNP:rs58928370EnsemblClinVar.1
Natural variantiVAR_017822188N → T in EHK; severe. 1 PublicationCorresponds to variant dbSNP:rs58928370EnsemblClinVar.1
Natural variantiVAR_003857193S → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs60937700EnsemblClinVar.1
Natural variantiVAR_017823214L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs61549035EnsemblClinVar.1
Natural variantiVAR_003858312I → V. 1
Natural variantiVAR_003859330I → T. 1
Natural variantiVAR_017824340D → V in EHK. 1 PublicationCorresponds to variant dbSNP:rs58062863EnsemblClinVar.1
Natural variantiVAR_003860358Y → N2 PublicationsCorresponds to variant dbSNP:rs1050872EnsemblClinVar.1
Natural variantiVAR_038628454A → S. Corresponds to variant dbSNP:rs17678945EnsemblClinVar.1
Natural variantiVAR_038629459 – 466Missing in palmoplantar keratoderma; and mild ichthyosis largely limited to the flexural areas. 8
Natural variantiVAR_071986478E → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs59089201EnsemblClinVar.1
Natural variantiVAR_017825479I → F in AEI. 2 PublicationsCorresponds to variant dbSNP:rs61218439EnsemblClinVar.1
Natural variantiVAR_017826479I → T in AEI and EHK. 3 PublicationsCorresponds to variant dbSNP:rs57837128EnsemblClinVar.1
Natural variantiVAR_017827482Y → C in EHK. 1 PublicationCorresponds to variant dbSNP:rs58420087EnsemblClinVar.1
Natural variantiVAR_071987485L → P in EHK. 1 PublicationCorresponds to variant dbSNP:rs267607430EnsemblClinVar.1
Natural variantiVAR_017828486L → P in EHK. 2 PublicationsCorresponds to variant dbSNP:rs56914602EnsemblClinVar.1
Natural variantiVAR_071988490E → K in EHK. 1 PublicationCorresponds to variant dbSNP:rs60279707EnsemblClinVar.1
Natural variantiVAR_003861490E → Q in EHK. 1 PublicationCorresponds to variant dbSNP:rs60279707EnsemblClinVar.1
Natural variantiVAR_003862537G → C1 Publication1
Natural variantiVAR_003864560 – 566Missing in allele 1B. 1 Publication7
Natural variantiVAR_003863633K → R5 PublicationsCorresponds to variant dbSNP:rs14024EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98776 Genomic DNA Translation: AAB47721.1
AF237621 Genomic DNA Translation: AAF60327.1
AF304164 Genomic DNA Translation: AAG41947.1
AK313986 mRNA Translation: BAG36698.1
AC055716 Genomic DNA No translation available.
BC063697 mRNA Translation: AAH63697.1
M10938 mRNA Translation: AAA36153.1
CCDSiCCDS8836.1
PIRiA22940 KRHU2
RefSeqiNP_006112.3, NM_006121.3
UniGeneiHs.80828

Genome annotation databases

EnsembliENST00000252244; ENSP00000252244; ENSG00000167768
GeneIDi3848
KEGGihsa:3848
UCSCiuc001sau.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98776 Genomic DNA Translation: AAB47721.1
AF237621 Genomic DNA Translation: AAF60327.1
AF304164 Genomic DNA Translation: AAG41947.1
AK313986 mRNA Translation: BAG36698.1
AC055716 Genomic DNA No translation available.
BC063697 mRNA Translation: AAH63697.1
M10938 mRNA Translation: AAA36153.1
CCDSiCCDS8836.1
PIRiA22940 KRHU2
RefSeqiNP_006112.3, NM_006121.3
UniGeneiHs.80828

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZRYX-ray3.30B370-489[»]
ProteinModelPortaliP04264
SMRiP04264
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110046, 73 interactors
IntActiP04264, 53 interactors
MINTiP04264
STRINGi9606.ENSP00000252244

PTM databases

iPTMnetiP04264
PhosphoSitePlusiP04264
SwissPalmiP04264

Polymorphism and mutation databases

BioMutaiKRT1
DMDMi238054406

2D gel databases

REPRODUCTION-2DPAGEiP04264
SWISS-2DPAGEiP04264

Proteomic databases

EPDiP04264
PaxDbiP04264
PeptideAtlasiP04264
PRIDEiP04264
ProteomicsDBi12658
51694

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252244; ENSP00000252244; ENSG00000167768
GeneIDi3848
KEGGihsa:3848
UCSCiuc001sau.1 human

Organism-specific databases

CTDi3848
DisGeNETi3848
EuPathDBiHostDB:ENSG00000167768.4
GeneCardsiKRT1
H-InvDBiHIX0036813
HGNCiHGNC:6412 KRT1
HPAiCAB002153
HPA017917
HPA062908
MalaCardsiKRT1
MIMi113800 phenotype
139350 gene
146590 phenotype
600962 phenotype
607602 phenotype
607654 phenotype
neXtProtiNX_P04264
OpenTargetsiENSG00000167768
Orphaneti281139 Annular epidermolytic ichthyosis
312 Autosomal dominant epidermolytic ichthyosis
281190 Congenital reticular ichthyosiform erythroderma
2199 Epidermolytic palmoplantar keratoderma
79503 Ichthyosis hystrix of Curth-Macklin
50942 Striate palmoplantar keratoderma
PharmGKBiPA30199
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiP04264
KOiK07605
OMAiIRMSGEC
OrthoDBiEOG091G09KR
PhylomeDBiP04264
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP04264

Miscellaneous databases

ChiTaRSiKRT1 human
GeneWikiiKeratin_1
GenomeRNAii3848
PROiPR:P04264
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167768 Expressed in 114 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRT1
GenevisibleiP04264 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032449 Keratin_2_1_tail
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 2 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PF16210 Keratin_2_tail, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C1_HUMAN
AccessioniPrimary (citable) accession number: P04264
Secondary accession number(s): B2RA01
, P85925, P86104, Q14720, Q6GSJ0, Q9H298
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 26, 2009
Last modified: November 7, 2018
This is version 221 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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