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Protein

Keratin, type II cytoskeletal 6B

Gene

KRT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are at least six isoforms of human type II keratin-6 (K6).
There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei414Stutter1

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 6B
Alternative name(s):
Cytokeratin-6B
Short name:
CK-6B
Keratin-6B
Short name:
K6B
Type-II keratin Kb10
Gene namesi
Name:KRT6B
Synonyms:K6B, KRTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185479.5
HGNCiHGNC:6444 KRT6B
MIMi148042 gene
neXtProtiNX_P04259

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Pachyonychia congenita 4 (PC4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
See also OMIM:615728
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023062472E → K in PC4. 3 PublicationsCorresponds to variant dbSNP:rs60627726EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi3854
GeneReviewsiKRT6B
MalaCardsiKRT6B
MIMi615728 phenotype
OpenTargetsiENSG00000185479
Orphaneti2309 Pachyonychia congenita
PharmGKBiPA30232

Protein family/group databases

Allergomei415 Hom s 5

Polymorphism and mutation databases

BioMutaiKRT6B
DMDMi238054404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000637322 – 564Keratin, type II cytoskeletal 6BAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP04259
PaxDbiP04259
PeptideAtlasiP04259
PRIDEiP04259
ProteomicsDBi51693
TopDownProteomicsiP04259

PTM databases

iPTMnetiP04259
PhosphoSitePlusiP04259
SwissPalmiP04259

Expressioni

Tissue specificityi

Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Gene expression databases

BgeeiENSG00000185479 Expressed in 107 organ(s), highest expression level in gingiva
CleanExiHS_KRT6B
GenevisibleiP04259 HS

Organism-specific databases

HPAiCAB000130
HPA045697
HPA061168

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.

Binary interactionsi

Protein-protein interaction databases

BioGridi110052, 37 interactors
IntActiP04259, 33 interactors
MINTiP04259
STRINGi9606.ENSP00000252252

Structurei

3D structure databases

ProteinModelPortaliP04259
SMRiP04259
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 476IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 162HeadAdd BLAST161
Regioni163 – 198Coil 1AAdd BLAST36
Regioni199 – 217Linker 1Add BLAST19
Regioni218 – 309Coil 1BAdd BLAST92
Regioni310 – 333Linker 12Add BLAST24
Regioni334 – 472Coil 2Add BLAST139
Regioni473 – 564TailAdd BLAST92

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiP04259
KOiK07605
OMAiFASFREC
OrthoDBiEOG091G09KR
PhylomeDBiP04259
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA
60 70 80 90 100
CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF
110 120 130 140 150
GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL
160 170 180 190 200
QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE
210 220 230 240 250
QGTKTVRQNL EPLFEQYINN LRRQLDNIVG ERGRLDSELR NMQDLVEDLK
260 270 280 290 300
NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA
310 320 330 340 350
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA
360 370 380 390 400
EAESWYQTKY EELQITAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK
410 420 430 440 450
QCANLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE
460 470 480 490 500
LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNISVVQ STVSSGYGGA
510 520 530 540 550
SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRATGGGLS SVGGGSSTIK
560
YTTTSSSSRK SYKH
Length:564
Mass (Da):60,067
Last modified:May 26, 2009 - v5
Checksum:iFFA4C351FBF09F09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89 – 90GS → AG in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti116 – 117AG → PA in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti119 – 121AGG → LC in AAA59466 (PubMed:2410904).Curated3
Sequence conflicti159 – 160VR → IG in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti255D → V in AAA59466 (PubMed:2410904).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126521N → S2 PublicationsCorresponds to variant dbSNP:rs428894Ensembl.1
Natural variantiVAR_021266227N → S2 PublicationsCorresponds to variant dbSNP:rs652423Ensembl.1
Natural variantiVAR_021267365I → V2 PublicationsCorresponds to variant dbSNP:rs437014Ensembl.1
Natural variantiVAR_023062472E → K in PC4. 3 PublicationsCorresponds to variant dbSNP:rs60627726EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42592
, L42584, L42585, L42586, L42587, L42588, L42589, L42590 Genomic DNA Translation: AAC41768.1
L42612 mRNA Translation: AAC41771.1
L00205
, M11229, L00198, L00199, L00200, L00201, L00202, L00203, L00204 Genomic DNA Translation: AAA59466.1
AC055736 Genomic DNA No translation available.
BC034535 mRNA Translation: AAH34535.1
CCDSiCCDS8828.1
PIRiI61767 KRHUEB
I61771
RefSeqiNP_005546.2, NM_005555.3
UniGeneiHs.708950

Genome annotation databases

EnsembliENST00000252252; ENSP00000252252; ENSG00000185479
GeneIDi3854
KEGGihsa:3854
UCSCiuc001sak.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42592
, L42584, L42585, L42586, L42587, L42588, L42589, L42590 Genomic DNA Translation: AAC41768.1
L42612 mRNA Translation: AAC41771.1
L00205
, M11229, L00198, L00199, L00200, L00201, L00202, L00203, L00204 Genomic DNA Translation: AAA59466.1
AC055736 Genomic DNA No translation available.
BC034535 mRNA Translation: AAH34535.1
CCDSiCCDS8828.1
PIRiI61767 KRHUEB
I61771
RefSeqiNP_005546.2, NM_005555.3
UniGeneiHs.708950

3D structure databases

ProteinModelPortaliP04259
SMRiP04259
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110052, 37 interactors
IntActiP04259, 33 interactors
MINTiP04259
STRINGi9606.ENSP00000252252

Protein family/group databases

Allergomei415 Hom s 5

PTM databases

iPTMnetiP04259
PhosphoSitePlusiP04259
SwissPalmiP04259

Polymorphism and mutation databases

BioMutaiKRT6B
DMDMi238054404

Proteomic databases

EPDiP04259
PaxDbiP04259
PeptideAtlasiP04259
PRIDEiP04259
ProteomicsDBi51693
TopDownProteomicsiP04259

Protocols and materials databases

DNASUi3854
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252252; ENSP00000252252; ENSG00000185479
GeneIDi3854
KEGGihsa:3854
UCSCiuc001sak.3 human

Organism-specific databases

CTDi3854
DisGeNETi3854
EuPathDBiHostDB:ENSG00000185479.5
GeneCardsiKRT6B
GeneReviewsiKRT6B
HGNCiHGNC:6444 KRT6B
HPAiCAB000130
HPA045697
HPA061168
MalaCardsiKRT6B
MIMi148042 gene
615728 phenotype
neXtProtiNX_P04259
OpenTargetsiENSG00000185479
Orphaneti2309 Pachyonychia congenita
PharmGKBiPA30232
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiP04259
KOiK07605
OMAiFASFREC
OrthoDBiEOG091G09KR
PhylomeDBiP04259
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GenomeRNAii3854
PROiPR:P04259
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185479 Expressed in 107 organ(s), highest expression level in gingiva
CleanExiHS_KRT6B
GenevisibleiP04259 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C6B_HUMAN
AccessioniPrimary (citable) accession number: P04259
Secondary accession number(s): P48669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 26, 2009
Last modified: September 12, 2018
This is version 180 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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