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Protein

Myoglobin

Gene

Mb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1
Metal bindingi94Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-8981607 Intracellular oxygen transport

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:Mb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96922 Mb

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000533192 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP04247
PeptideAtlasiP04247
PRIDEiP04247

2D gel databases

SWISS-2DPAGEiP04247

PTM databases

iPTMnetiP04247
PhosphoSitePlusiP04247

Expressioni

Gene expression databases

BgeeiENSMUSG00000018893 Expressed in 165 organ(s), highest expression level in masseter muscle
CleanExiMM_MB
ExpressionAtlasiP04247 baseline and differential
GenevisibleiP04247 MM

Interactioni

Protein-protein interaction databases

IntActiP04247, 5 interactors
MINTiP04247
STRINGi10090.ENSMUSP00000019037

Structurei

3D structure databases

ProteinModelPortaliP04247
SMRiP04247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000070111
HOVERGENiHBG107340
InParanoidiP04247
KOiK21892
OMAiLFRNDIA
OrthoDBiEOG091G0OAO
PhylomeDBiP04247
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002335 Myoglobin
PANTHERiPTHR11442:SF5 PTHR11442:SF5, 1 hit
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00613 MYOGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P04247-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL
60 70 80 90 100
KSEEDMKGSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE IIIEVLKKRH SGDFGADAQG AMSKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,070
Last modified:January 23, 2007 - v3
Checksum:i8EE1EE3FFEE36AF0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK58A0A2R8VK58_MOUSE
Myoglobin
Mb
83Annotation score:
A0A2R8W6F8A0A2R8W6F8_MOUSE
Myoglobin
Mb
99Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116L → K AA sequence (PubMed:4043406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA Translation: AAH25172.1
X04405, X04417 Genomic DNA Translation: CAA27994.1
CCDSiCCDS27597.1
PIRiA25799 MYMS
RefSeqiNP_001157519.1, NM_001164047.1
NP_001157520.1, NM_001164048.1
NP_038621.2, NM_013593.3
UniGeneiMm.404074

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893
ENSMUST00000229423; ENSMUSP00000155115; ENSMUSG00000018893
GeneIDi17189
KEGGimmu:17189
UCSCiuc007wmx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA Translation: AAH25172.1
X04405, X04417 Genomic DNA Translation: CAA27994.1
CCDSiCCDS27597.1
PIRiA25799 MYMS
RefSeqiNP_001157519.1, NM_001164047.1
NP_001157520.1, NM_001164048.1
NP_038621.2, NM_013593.3
UniGeneiMm.404074

3D structure databases

ProteinModelPortaliP04247
SMRiP04247
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04247, 5 interactors
MINTiP04247
STRINGi10090.ENSMUSP00000019037

PTM databases

iPTMnetiP04247
PhosphoSitePlusiP04247

2D gel databases

SWISS-2DPAGEiP04247

Proteomic databases

PaxDbiP04247
PeptideAtlasiP04247
PRIDEiP04247

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893
ENSMUST00000229423; ENSMUSP00000155115; ENSMUSG00000018893
GeneIDi17189
KEGGimmu:17189
UCSCiuc007wmx.2 mouse

Organism-specific databases

CTDi4151
MGIiMGI:96922 Mb

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000070111
HOVERGENiHBG107340
InParanoidiP04247
KOiK21892
OMAiLFRNDIA
OrthoDBiEOG091G0OAO
PhylomeDBiP04247
TreeFamiTF332967

Enzyme and pathway databases

ReactomeiR-MMU-8981607 Intracellular oxygen transport

Miscellaneous databases

ChiTaRSiMb mouse
PROiPR:P04247
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018893 Expressed in 165 organ(s), highest expression level in masseter muscle
CleanExiMM_MB
ExpressionAtlasiP04247 baseline and differential
GenevisibleiP04247 MM

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002335 Myoglobin
PANTHERiPTHR11442:SF5 PTHR11442:SF5, 1 hit
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00613 MYOGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYG_MOUSE
AccessioniPrimary (citable) accession number: P04247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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