UniProtKB - P04234 (CD3D_HUMAN)
T-cell surface glycoprotein CD3 delta chain
CD3D
Functioni
GO - Molecular functioni
- identical protein binding Source: CAFA
- protein heterodimerization activity Source: UniProtKB
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: GO_Central
- membrane organization Source: Reactome
- positive thymic T cell selection Source: UniProtKB
- regulation of immune response Source: Reactome
- T cell differentiation Source: GO_Central
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P04234 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-389948, PD-1 signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | P04234 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD3 delta chainAlternative name(s): T-cell receptor T3 delta chain CD_antigen: CD3d |
Gene namesi | Name:CD3D Synonyms:T3D |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1673, CD3D |
MIMi | 186790, gene |
neXtProti | NX_P04234 |
VEuPathDBi | HostDB:ENSG00000167286.9 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- alpha-beta T cell receptor complex Source: GO_Central
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- T cell receptor complex Source: MGI
Other locations
- clathrin-coated vesicle membrane Source: Reactome
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 105 | ExtracellularSequence analysisAdd BLAST | 84 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 171 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency 19 (IMD19)3 Publications
Keywords - Diseasei
SCIDOrganism-specific databases
DisGeNETi | 915 |
MalaCardsi | CD3D |
MIMi | 615617, phenotype |
OpenTargetsi | ENSG00000167286 |
Orphaneti | 169160, T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta |
PharmGKBi | PA26215 |
Miscellaneous databases
Pharosi | P04234, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364168 |
DrugBanki | DB09052, Blinatumomab DB00075, Muromonab |
DrugCentrali | P04234 |
Genetic variation databases
BioMutai | CD3D |
DMDMi | 115985 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000016487 | 22 – 171 | T-cell surface glycoprotein CD3 delta chainAdd BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 73 | 1 Publication | ||
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 149 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 160 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P04234 |
MassIVEi | P04234 |
MaxQBi | P04234 |
PaxDbi | P04234 |
PeptideAtlasi | P04234 |
PRIDEi | P04234 |
ProteomicsDBi | 2194 51692 [P04234-1] |
PTM databases
GlyGeni | P04234, 2 sites |
iPTMneti | P04234 |
PhosphoSitePlusi | P04234 |
SwissPalmi | P04234 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000167286, Expressed in thymus and 186 other tissues |
ExpressionAtlasi | P04234, baseline and differential |
Genevisiblei | P04234, HS |
Organism-specific databases
HPAi | ENSG00000167286, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with coreceptors CD4 and CD8 (PubMed:1396954, PubMed:12215456).
5 PublicationsBinary interactionsi
P04234
With | #Exp. | IntAct |
---|---|---|
SGTB [Q96EQ0] | 3 | EBI-3862416,EBI-744081 |
GO - Molecular functioni
- identical protein binding Source: CAFA
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107353, 18 interactors |
DIPi | DIP-42855N |
ELMi | P04234 |
IntActi | P04234, 6 interactors |
MINTi | P04234 |
STRINGi | 9606.ENSP00000300692 |
Miscellaneous databases
RNActi | P04234, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P04234 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04234 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 138 – 166 | ITAMPROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4XC, Eukaryota |
GeneTreei | ENSGT00940000153312 |
HOGENOMi | CLU_115449_0_0_1 |
InParanoidi | P04234 |
OMAi | YQPLRDH |
PhylomeDBi | P04234 |
TreeFami | TF335892 |
Family and domain databases
DisProti | DP00505 |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR015485, CD3D IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR032052, Ig_4 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit PTHR10570:SF5, PTHR10570:SF5, 1 hit |
Pfami | View protein in Pfam PF16680, Ig_4, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS51055, ITAM_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT
60 70 80 90 100
LLSDITRLDL GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD
110 120 130 140 150
PATVAGIIVT DVIATLLLAL GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ
160 170
PLRDRDDAQY SHLGGNWARN K
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YE18 | H0YE18_HUMAN | T-cell receptor T3 delta chain | CD3D | 132 | Annotation score: | ||
E9PMT5 | E9PMT5_HUMAN | CD3 delta | CD3D | 98 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049646 | 147 | Q → R. Corresponds to variant dbSNP:rs45510201EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045800 | 92 – 136 | MCQSC…RLSGA → T in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03934 Genomic DNA Translation: CAA27573.1 M12727, M12726 Genomic DNA Translation: AAA51792.1 CD014058 mRNA No translation available. AP001582 Genomic DNA No translation available. BC039035 mRNA Translation: AAH39035.1 BC070321 mRNA Translation: AAH70321.1 X01451 Genomic DNA Translation: CAA25683.1 |
CCDSi | CCDS41724.1 [P04234-2] CCDS8394.1 [P04234-1] |
PIRi | A94706, RWHUD1 |
RefSeqi | NP_000723.1, NM_000732.4 [P04234-1] NP_001035741.1, NM_001040651.1 [P04234-2] XP_016874032.1, XM_017018543.1 |
Genome annotation databases
Ensembli | ENST00000300692; ENSP00000300692; ENSG00000167286 [P04234-1] ENST00000392884; ENSP00000376622; ENSG00000167286 [P04234-2] |
GeneIDi | 915 |
KEGGi | hsa:915 |
UCSCi | uc001pss.2, human [P04234-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
CD3Dbase CD3D mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03934 Genomic DNA Translation: CAA27573.1 M12727, M12726 Genomic DNA Translation: AAA51792.1 CD014058 mRNA No translation available. AP001582 Genomic DNA No translation available. BC039035 mRNA Translation: AAH39035.1 BC070321 mRNA Translation: AAH70321.1 X01451 Genomic DNA Translation: CAA25683.1 |
CCDSi | CCDS41724.1 [P04234-2] CCDS8394.1 [P04234-1] |
PIRi | A94706, RWHUD1 |
RefSeqi | NP_000723.1, NM_000732.4 [P04234-1] NP_001035741.1, NM_001040651.1 [P04234-2] XP_016874032.1, XM_017018543.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XIW | X-ray | 1.90 | B/F | 23-100 | [»] | |
6JXR | electron microscopy | 3.70 | d | 1-171 | [»] | |
SMRi | P04234 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107353, 18 interactors |
DIPi | DIP-42855N |
ELMi | P04234 |
IntActi | P04234, 6 interactors |
MINTi | P04234 |
STRINGi | 9606.ENSP00000300692 |
Chemistry databases
ChEMBLi | CHEMBL2364168 |
DrugBanki | DB09052, Blinatumomab DB00075, Muromonab |
DrugCentrali | P04234 |
PTM databases
GlyGeni | P04234, 2 sites |
iPTMneti | P04234 |
PhosphoSitePlusi | P04234 |
SwissPalmi | P04234 |
Genetic variation databases
BioMutai | CD3D |
DMDMi | 115985 |
Proteomic databases
jPOSTi | P04234 |
MassIVEi | P04234 |
MaxQBi | P04234 |
PaxDbi | P04234 |
PeptideAtlasi | P04234 |
PRIDEi | P04234 |
ProteomicsDBi | 2194 51692 [P04234-1] |
Protocols and materials databases
ABCDi | P04234, 1 sequenced antibody |
Antibodypediai | 4581, 811 antibodies |
Genome annotation databases
Ensembli | ENST00000300692; ENSP00000300692; ENSG00000167286 [P04234-1] ENST00000392884; ENSP00000376622; ENSG00000167286 [P04234-2] |
GeneIDi | 915 |
KEGGi | hsa:915 |
UCSCi | uc001pss.2, human [P04234-1] |
Organism-specific databases
CTDi | 915 |
DisGeNETi | 915 |
GeneCardsi | CD3D |
HGNCi | HGNC:1673, CD3D |
HPAi | ENSG00000167286, Group enriched (blood, lymphoid tissue) |
MalaCardsi | CD3D |
MIMi | 186790, gene 615617, phenotype |
neXtProti | NX_P04234 |
OpenTargetsi | ENSG00000167286 |
Orphaneti | 169160, T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta |
PharmGKBi | PA26215 |
VEuPathDBi | HostDB:ENSG00000167286.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4XC, Eukaryota |
GeneTreei | ENSGT00940000153312 |
HOGENOMi | CLU_115449_0_0_1 |
InParanoidi | P04234 |
OMAi | YQPLRDH |
PhylomeDBi | P04234 |
TreeFami | TF335892 |
Enzyme and pathway databases
PathwayCommonsi | P04234 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-389948, PD-1 signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | P04234 |
Miscellaneous databases
BioGRID-ORCSi | 915, 113 hits in 871 CRISPR screens |
ChiTaRSi | CD3D, human |
EvolutionaryTracei | P04234 |
GeneWikii | CD3D |
GenomeRNAii | 915 |
Pharosi | P04234, Tclin |
PROi | PR:P04234 |
RNActi | P04234, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167286, Expressed in thymus and 186 other tissues |
ExpressionAtlasi | P04234, baseline and differential |
Genevisiblei | P04234, HS |
Family and domain databases
DisProti | DP00505 |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR015485, CD3D IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR032052, Ig_4 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit PTHR10570:SF5, PTHR10570:SF5, 1 hit |
Pfami | View protein in Pfam PF16680, Ig_4, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS51055, ITAM_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD3D_HUMAN | |
Accessioni | P04234Primary (citable) accession number: P04234 Secondary accession number(s): A8MVP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | March 20, 1987 | |
Last modified: | February 10, 2021 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries